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61. 发明授权

US08460745B2 Apparatus and methods for loading a drug eluting medical device 有权
标题翻译：用于装载药物洗脱医疗装置的装置和方法
公开(公告)号：US08460745B2
公开(公告)日：2013-06-11
申请号：US12884503
申请日：2010-09-17
申请人： James Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
发明人： James Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
IPC分类号： B05D7/22 , B05D1/18 , A61F2/06 , B65B31/02 , A61L33/00
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译：公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。可以对中空支架的外表面执行支架清洁步骤。

62. 发明申请

US20120295937A1 NITROXIDE THERAPY FOR THE TREATMENT OF VON HIPPEL - LINDAU DISEASE (VHL) AND RENAL CLEAR CELL CARCINOMA (RCC) 有权
标题翻译：治疗呕吐的硝基治疗 - 林达病（VHL）和肾细胞癌（RCC）
公开(公告)号：US20120295937A1
公开(公告)日：2012-11-22
申请号：US13512665
申请日：2010-11-30
申请人： W. Marston Linehan , Tracey A. Rouault , James Mitchell , Murali K. Cherukuri
发明人： W. Marston Linehan , Tracey A. Rouault , James Mitchell , Murali K. Cherukuri
IPC分类号： A61K31/445 , A61P9/12 , A61P35/00
CPC分类号： A61K31/40 , A61K31/421 , A61K31/445
摘要： The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2α.
摘要翻译：本发明提供了治疗方法，其包括向被怀疑具有或具有与降低的VHL或升高的HIF-2α相关的病症的风险的受试者施用稳定的氮氧自由基。

63. 发明授权

US08066760B2 Stent with movable crown 有权
标题翻译：支架与活动冠
公开(公告)号：US08066760B2
公开(公告)日：2011-11-29
申请号：US11379161
申请日：2006-04-18
申请人： James Mitchell
发明人： James Mitchell
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61F2/91 , A61F2/915 , A61L31/04
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of movable crown portions. When the stent is expanded, the crown portions move to a diameter recoil prevention position. One embodiment of the invention includes crown portions that translate from a concave to a convex configuration with respect to the strut portions of the stent during expansion of the stent. Another embodiment of the invention includes a method reducing diameter recoil of stent upon expansion of the stent.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个可移动冠部的支架。当支架膨胀时，冠部移动到直径反冲防止位置。本发明的一个实施例包括冠部，其在支架膨胀期间相对于支架的支柱部分从凹形平移到凸形。本发明的另一个实施例包括在扩张支架时减小支架的直径反冲的方法。

64. 发明申请

US20100042761A1 Observing an internal link via a second link 有权
标题翻译：通过第二个链接观察内部链接
公开(公告)号：US20100042761A1
公开(公告)日：2010-02-18
申请号：US12228493
申请日：2008-08-13
申请人： Syed Islam , James Mitchell
发明人： Syed Islam , James Mitchell
IPC分类号： G06F3/00 , G06F1/12 , G06F12/06
CPC分类号： G06F11/27 , H01L25/065 , H01L2924/0002 , H01L2924/00
摘要： In one embodiment, the present invention includes a method for selecting first data received in a first die of a multi-chip package (MCP) from a second die of the MCP via an intra-package link for output from a selector during a first clock period of a first clock signal, selecting second data transmitted from the second die to the first die for output from the selector during a second clock period, and transmitting the first and second data from the MCP via an external link. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括一种用于从MCP的第二管芯经由内部封装链路选择在多芯片封装（MCP）的第一管芯中接收的第一数据的方法，用于在第一时钟期间从选择器输出选择从第二管芯发送到第一管芯的第二数据，以在第二时钟周期期间从选择器输出，以及经由外部链路从MCP发送第一和第二数据。描述和要求保护其他实施例。

65. 发明授权

US07473726B2 Fire-resistant polyamide composition 有权
标题翻译：耐火聚酰胺组合物
公开(公告)号：US07473726B2
公开(公告)日：2009-01-06
申请号：US10524565
申请日：2003-08-08
申请人： James Mitchell , Daniele Galli
发明人： James Mitchell , Daniele Galli
IPC分类号： C08K5/5313 , C08K5/3477
CPC分类号： C08K5/34928 , C08G69/02 , C08G69/08 , C08G69/14 , C08K5/5313 , C08L77/00 , C08L77/02 , C08L77/06 , C08L101/005 , C08L2201/02
摘要： The invention relates to a fire-resistant composition containing at least one star polyamide and a flame retardancy system comprising a phosphinate and a melamine reaction product. The inventive composition can be used to produce elements having a low flame-spread rating upon combustion as well as satisfactory mechanical properties. Said composition is particularly suitable for producing molded elements that are used in the field of electrical and electronic connector technology.
摘要翻译：本发明涉及含有至少一种星型聚酰胺和包含次膦酸盐和三聚氰胺反应产物的阻燃体系的耐火组合物。本发明的组合物可用于生产燃烧时具有低火焰蔓延等级的元件以及令人满意的机械性能。所述组合物特别适用于生产用于电气和电子连接器技术领域的模制元件。

66. 发明申请

US20070244543A1 Stent With Movable Crown 有权
标题翻译：支架与移动冠
公开(公告)号：US20070244543A1
公开(公告)日：2007-10-18
申请号：US11379161
申请日：2006-04-18
申请人： James Mitchell
发明人： James Mitchell
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61F2/91 , A61F2/915 , A61L31/04
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of movable crown portions. When the stent is expanded, the crown portions move to a diameter recoil prevention position. One embodiment of the invention includes crown portions that translate from a concave to a convex configuration with respect to the strut portions of the stent during expansion of the stent. Another embodiment of the invention includes a method reducing diameter recoil of stent upon expansion of the stent.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个可移动冠部的支架。当支架膨胀时，冠部移动到直径反冲防止位置。本发明的一个实施例包括冠部，其在支架膨胀期间相对于支架的支柱部分从凹形平移到凸形。本发明的另一个实施例包括在扩张支架时减小支架的直径反冲的方法。

67. 发明申请

US20070089435A1 Predicting maintenance in a refrigeration system 审中-公开
标题翻译：预测制冷系统的维护
公开(公告)号：US20070089435A1
公开(公告)日：2007-04-26
申请号：US11256638
申请日：2005-10-21
申请人： Abtar Singh , Thomas Mathews , Stephen Woodworth , Pawan Churiwal , James Mitchell
发明人： Abtar Singh , Thomas Mathews , Stephen Woodworth , Pawan Churiwal , James Mitchell
IPC分类号： G01K13/00 , G05D23/32
CPC分类号： F25B49/005 , F25B2500/06
摘要： A method for predicting maintenance in a refrigeration system includes counting occurrences of a compressor operating event and calculating a cumulative total of the compressor operating events. The method also comprises comparing the cumulative total with an operating threshold and estimating a time period until the cumulative total exceeds the operating threshold. The method may be executed by a controller or stored in a computer-readable medium.
摘要翻译：一种用于预测制冷系统中的维护的方法包括计算压缩机运行事件的发生并计算压缩机运行事件的累积总和。该方法还包括将累积总数与运行阈值进行比较，并估计累积总数超过运行阈值的时间段。该方法可以由控制器执行或存储在计算机可读介质中。

68. 发明申请

US20070044126A1 Wireless video entertainment system 审中-公开
标题翻译：无线视频娱乐系统
公开(公告)号：US20070044126A1
公开(公告)日：2007-02-22
申请号：US11207037
申请日：2005-08-18
申请人： James Mitchell
发明人： James Mitchell
IPC分类号： H04N7/18
CPC分类号： B64D11/0015 , H04N7/18 , H04N7/181 , H04N21/2146
摘要： A system is provided for wireless video entertainment including sources of video, audio and/or data signals. A server processes and stores the video signal prior to transmission to a personal electronic device (“PED”) of a user. Transmission to the PED is wireless via a multi-band RF access module positioned in close proximity to the PED. The PED may be a laptop computer, cell phone, touch display unit or other device capable of receiving and processing a digitized video signal. The access module includes a RF power combiner for unique bundling and isolation of a plurality of video signals throughout the transmission process. An audio signal may be synchronized or isochronously transported with a video signal and transmitted via an audio module to a wireless audio receiver, such as a headset. Further, data signals for Internet and email use are provided. System and GUI software facilitate operation of the system.
摘要翻译：提供用于无线视频娱乐的系统，包括视频，音频和/或数据信号源。服务器在传输到用户的个人电子设备（“PED”）之前处理和存储视频信号。通过位于PED附近的多频RF接入模块，传输到PED是无线的。 PED可以是能够接收和处理数字化视频信号的膝上型计算机，手机，触摸显示单元或其他设备。访问模块包括用于在整个传输过程中独特捆绑和隔离多个视频信号的RF功率组合器。音频信号可以与视频信号同步或等时传输，并通过音频模块传输到诸如耳机的无线音频接收器。此外，提供了用于因特网和电子邮件使用的数据信号。系统和GUI软件便于系统的操作。

69. 发明申请

US20060111483A1 Fire-resistant polyamide composition 有权
标题翻译：耐火聚酰胺组合物
公开(公告)号：US20060111483A1
公开(公告)日：2006-05-25
申请号：US10524565
申请日：2003-08-08
申请人： James Mitchell , Daniele Galli
发明人： James Mitchell , Daniele Galli
IPC分类号： C08K5/49
CPC分类号： C08K5/34928 , C08G69/02 , C08G69/08 , C08G69/14 , C08K5/5313 , C08L77/00 , C08L77/02 , C08L77/06 , C08L101/005 , C08L2201/02
摘要： The invention relates to a fire-resistant composition containing at least one star polyamide and a flame retardancy system comprising a phosphinate and a melamine reaction product. The inventive composition can be used to produce elements having a low flame-spread rating upon combustion as well as satisfactory mechanical properties. Said composition is particularly suitable for producing moulded elements that are used in the field of electrical and electronic connector technology.
摘要翻译：本发明涉及含有至少一种星型聚酰胺和包含次膦酸盐和三聚氰胺反应产物的阻燃体系的耐火组合物。本发明的组合物可用于生产燃烧时具有低火焰蔓延等级的元件以及令人满意的机械性能。所述组合物特别适用于生产用于电气和电子连接器技术领域的模制元件。

70. 发明申请

US20060103935A1 Retroreflective article having at least one valve and method of making same 有权
标题翻译：具有至少一个阀的回射制品及其制造方法
公开(公告)号：US20060103935A1
公开(公告)日：2006-05-18
申请号：US10989667
申请日：2004-11-16
申请人： Paul Marecki , James Mitchell
发明人： Paul Marecki , James Mitchell
IPC分类号： G02B5/128
CPC分类号： G02B5/128 , A41D13/01 , A41D27/28 , A41D31/0094 , G02B5/124
摘要： A retroreflective article having at least one valve is disclosed. Each valve may include a channel extending from a first major surface to a second major surface of the retroreflective material, and at least one movable member proximate the channel. The at least one movable member is movable between a closed position and an open position. When in the closed position, the at least one movable member obstructs at least a portion of the channel. A method of making a retroreflective article having at least one valve is also disclosed.
摘要翻译：公开了具有至少一个阀的回射制品。每个阀可以包括从回射材料的第一主表面延伸到第二主表面的通道，以及靠近通道的至少一个可移动元件。所述至少一个可动构件可在关闭位置和打开位置之间移动。当处于关闭位置时，至少一个可动构件阻挡通道的至少一部分。还公开了制造具有至少一个阀的回射制品的方法。

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