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61. 发明授权

US07097826B2 Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals 有权
标题翻译：用于MR造影剂和放射性药物的二氢卟酚和细菌二氢卟酚基二官能氨基苯基DTPA和N2S2共轭物
公开(公告)号：US07097826B2
公开(公告)日：2006-08-29
申请号：US10177129
申请日：2002-06-21
申请人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
IPC分类号： A61B5/055
CPC分类号： A61K51/0485 , A61K41/0071 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K51/0478 , C07D471/22 , C07D487/22
摘要： A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula: where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.
摘要翻译：包括光动力四吡咯化合物与多个放射性核素元素原子的化学组合的化合物，使得该化合物可用于增强MR成像，并且还可用作光动力学化合物用于光动力学治疗以治疗过度增生组织。优选的化合物具有以下结构式：其中R 1，R 2，R 2，R 3，R 3， R 5，R 5，R 5a，R 6，R 5，R 5，R 5， R 7，R 7a和R 8累积含有至少两个将与MR成像增强元件或离子复合或组合的官能团。该化合物旨在包括这种复合物和组合，并且包括使用这些化合物用于肿瘤和其它过度增生组织的MR成像和光动力治疗治疗。

62. 发明授权

US06989816B1 Methods and systems for providing human/computer interfaces 有权
标题翻译：提供人机界面的方法和系统
公开(公告)号：US06989816B1
公开(公告)日：2006-01-24
申请号：US10268117
申请日：2002-10-08
申请人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden
发明人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden
IPC分类号： G06K7/10 , G06K19/06 , G06K15/00 , G06K17/00
CPC分类号： G06F17/30876 , G06K7/0008 , G06K7/12 , G06K7/1443 , G06K19/06037
摘要： Providing interaction between a user with remote data stored on a network is disclosed. A physical medium has at least one hot spot encoded with linking data enabling access to remote data. The linking data is encoded according to a spectral encoding scheme. At least part of the linking data is visible and is blended with and appears to comprise at least part of an un-encoded graphic or text visible on the physical medium such that it is not apparent to a viewer of the physical medium that said linking data is encoded in said at least one hot spot. A sensor measures the hot spot and decodes the linking data. A transmitter coupled to the sensor transmits the linking data to a remote computer system. The remote computer system responds to the linking data to retrieve the remote data and present the remote data to the user.
摘要翻译：公开了一种用户与存储在网络上的远程数据之间的交互。物理介质至少有一个热点编码，链接数据使得能够访问远程数据。链接数据根据频谱编码方案进行编码。链接数据的至少一部分是可见的，并且与物理介质上可混合并且显示为包括可视化的未编码图形或文本的至少一部分，使得对物理介质的观察者不清楚所述链接数据被编码在所述至少一个热点中。传感器测量热点并解码链接数据。耦合到传感器的发射器将链接数据传输到远程计算机系统。远程计算机系统响应链接数据以检索远程数据并将远程数据呈现给用户。

63. 发明授权

US06952196B2 Methods and systems for providing programmable computerized interactors 有权
标题翻译：提供可编程计算机化交互器的方法和系统
公开(公告)号：US06952196B2
公开(公告)日：2005-10-04
申请号：US10402345
申请日：2003-03-27
申请人： Emily Weil , Greg Thomas , S. Joy Mountford , Thomas J. Dougherty , Daniel E. Cummings
发明人： Emily Weil , Greg Thomas , S. Joy Mountford , Thomas J. Dougherty , Daniel E. Cummings
IPC分类号： G06F3/00 , G09G5/00 , G10H1/26
CPC分类号： G06F3/002 , G10H1/26 , G10H2230/055
摘要： A computerized interactor system uses physical, three-dimensional objects as metaphors for input of user intent to a computer system. When one or more interactors are engaged with a detection field, the detection field reads an identifier associated with the object and communicates the identifier to a computer system. The computer system determines the meaning of the interactor based upon its identifier and upon a semantic context in which the computer system is operating. One specific embodiment of the present invention is a bead interactor system that is a user playable sound and light show system. When an interactor bead is positioned within the detection space of the bead interactor system, a sound sequence begins and continues to play unaltered until the bead interactor is removed or other bead interactors are positioned within or removed from the detection space. Each bead represents a different sound and the row and column location of the bead within the detection space controls how the sound is modified, e.g., louder or softer, higher pitched or lower pitched, the period of play, etc. In some embodiments, the beads are translucent in order to conduct light from light sources located under each bead receptacle. The available sounds are determined not only by the identity of the beads and their positioning within the detection space and their associated states or orientations, but also by sound data stored in an accompanying computer readable medium. Hence a user can access a variety of sound collections by simply installing a different computer readable medium.
摘要翻译：计算机化交互系统使用物理三维对象作为将用户意图输入到计算机系统的隐喻。当一个或多个交互者参与检测字段时，检测字段读取与对象相关联的标识符并将该标识符传送到计算机系统。计算机系统基于其标识符和计算机系统在其中运行的语义环境来确定交互器的意义。本发明的一个具体实施方式是作为用户可播放的声光系统的小珠交互系统。当相互作用珠位于珠交互作用系统的检测空间内时，声音序列开始并继续播放直到小珠交互器被去除或者其他小珠互动器位于检测空间内或从检测空间移除。每个珠表示不同的声音，并且检测空间内的珠的行和列位置控制声音如何被修改，例如更大或更柔和，更高的倾斜或更低的音高，播放的时间等。在一些实施例中，珠子是半透明的，以便从位于每个珠子容器下面的光源传导光。可用的声音不仅由珠子的身份及其在检测空间及其相关联的状态或取向中的定位以及存储在伴随的计算机可读介质中的声音数据决定。因此，用户可以通过简单地安装不同的计算机可读介质来访问各种声音集合。

64. 发明授权

US06534040B2 Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals 有权
标题翻译：用于MR造影剂和放射性药物的二氢卟酚和细菌氯胺基氨基苯基DTPA和N2S2缀合物
公开(公告)号：US06534040B2
公开(公告)日：2003-03-18
申请号：US09739155
申请日：2000-12-18
申请人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
IPC分类号： C07D48722
CPC分类号： A61K51/0478 , A61K41/0071 , A61K49/085 , A61K51/0485 , C07D471/22 , C07D487/22
摘要： Compositions that are a chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99, Gadolinium, Indium111 and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The invention further includes the method of using the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc99, In111 or Gd(III) complexes of compounds of the formula:
摘要翻译：组合物是卟啉，二氢卟酚，细菌色素和与放射性元素相关的四吡咯化合物如锝99，钆，铟111和放射性碘的化学组合。当元素可以形成阳离子时，化合物通常是具有卟啉或二氢卟酚结构的螯合物。当元素形成阴离子时，化合物通常是放射性元素与卟啉或二氢卟酚结构的直接化学组合。本发明还包括使用本发明的化合物用于诊断超增殖组织如肿瘤和新血管生长的成像的方法，其与湿性形式的年龄相关性黄斑变性相关联，以及制备该化合物的方法。本发明的MRI造影成像的化合物通常是下式化合物的Tc99，In111或Gd（III）络合物：

65. 发明授权

US06287488B1 Method for injection molding of high quality parts 失效
标题翻译：高品质零件注塑成型方法
公开(公告)号：US06287488B1
公开(公告)日：2001-09-11
申请号：US09240711
申请日：1999-02-02
申请人： Thomas J. Dougherty , Thomas C. Dougherty
发明人： Thomas J. Dougherty , Thomas C. Dougherty
IPC分类号： B29C4556
CPC分类号： B29C45/561 , B29C2045/567 , B29L2011/0016 , B29L2017/005
摘要： A method and apparatus for injection molding of high quality thermoplastic parts is such that a conventional movable mold half is mounted on a movable platen of the injection molding machine, and a special stationary mold half is mounted on the stationary platen. The stationary mold half includes a stationary plate secured to the stationary platen, with the stationary plate including stationary mold inserts. Each stationary mold insert has a stationary mold insert surface. An A-half parting line plate is movably attached to the stationary plate, with the A-half parting line plate being movable with respect to the stationary plate and the stationary mold inserts. A driving device, such as a hydraulic cylinder, is disposed between the stationary plate and the A-half parting line plate, with the driving device driving the A-half parting line plate toward and away from the stationary plate. A control circuit is provided for controlling the driving device to control a movement of the A-half parting line plate with respect to the stationary plate.
摘要翻译：用于注塑成型高品质热塑性部件的方法和装置是这样的：将传统的可移动半模安装在注射成型机的可移动压板上，并且在固定压板上安装特殊的固定半模。固定模具半部包括固定在固定压板上的固定板，固定板包括固定模具插入件。每个固定模具插入件具有固定的模具插入表面。一个半分割线板可移动地连接到固定板上，其中A半分割线板可相对于固定板和固定模具插入件移动。驱动装置如液压缸设置在固定板和A半分割线板之间，驱动装置驱动A-half分型线板朝向和远离固定板。提供控制电路用于控制驱动装置以控制半分离线板相对于固定板的移动。

66. 发明授权

US6076734A Methods and systems for providing human/computer interfaces 失效
公开(公告)号：US6076734A
公开(公告)日：2000-06-20
申请号：US948891
申请日：1997-10-10
申请人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
发明人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
IPC分类号： G06F17/30 , G06K7/00 , G06K7/12 , G06K19/06 , G06K7/10
CPC分类号： G06F17/30876 , G06K19/06037 , G06K7/0008 , G06K7/12 , G06K7/1443
摘要： The present invention teaches a variety of methods and systems for providing computer/human interfaces. According to one method, the user interfaces with an electronic device such as a computer system by engaging a sensor with desired regions of an encoded physical medium. The encoded physical medium is preferably chosen to provide intuitive meaning to the user, and is thus an improved metaphor for interfacing with the computer system. Suitable examples of the encoded physical medium include a data-linked book, magazine, globe, or article of clothing. Some or all of the selected regions have had certain information encoded therein, information suitable for interfacing and controlling the computer system. When the user engages the sensor with a region having certain encoded information, the certain encoded information is interpreted and an appropriate action taken. For example, the sensor or the computer system may provide suitable feedback to the user. The encoded physical medium may have text and/or graphic illustrations that draw the user in or provide meaningful clues or instructions perhaps related to the encoded information. The sensor may have at least one identification number (ID) providing information such as user identity, sensor type, access type, or language type. The sensor can transmit the certain decoded information together with the at least one ID to the computer system.

67. 发明授权

US5681668A Dual wall storage battery system having air passageways in the bottom of the battery 失效
标题翻译：双壁蓄电池系统在电池底部具有空气通道
公开(公告)号：US5681668A
公开(公告)日：1997-10-28
申请号：US466550
申请日：1995-06-06
申请人： Michael E. Reed , Thomas J. Dougherty , Mark S. Inkmann , Debra L. Smith , Michael T. Reher
发明人： Michael E. Reed , Thomas J. Dougherty , Mark S. Inkmann , Debra L. Smith , Michael T. Reher
IPC分类号： H01M2/02 , H01M2/10 , H01M10/50
CPC分类号： H01M2/1072 , H01M10/613 , H01M10/625 , H01M10/6562 , H01M10/6563 , H01M10/658
摘要： A battery shield for a storage battery includes first and second members which are dimensioned to fit around the battery, forming a shield structure, that is open at its top and encloses the battery on all four sides and on the bottom, forming a heat shield for protecting the battery from hot temperatures, the first and second members being hinged to a common base and are adapted to be pivoted about respective hinges outwardly away from another to an open position to facilitate installation of a battery in the shield and to then be moved upwardly and toward one another, in the manner of a "clamshell", to a closed position for enclosing the battery within the battery shield, the bottom of the storage battery having a plurality of transverse channels therein extending between opposing sides for permitting air flow around the bottom of the storage battery when the battery is enclosed within the battery shield.
摘要翻译：用于蓄电池的电池护罩包括第一和第二构件，第一和第二构件的尺寸适于围绕电池，形成屏蔽结构，该屏蔽结构在其顶部开口并且围绕所有四个侧面和底部封装电池，形成用于保护电池免受热的温度影响，第一和第二构件被铰接到共同的基座上并且适于围绕各自的铰链向外远离另一个枢转到打开位置，以便于将电池安装在屏蔽中并且然后向上移动并且以“蛤壳式”的方式朝向彼此相对于封闭位置以将电池封装在电池护罩内，蓄电池的底部具有多个横向通道，其在相对的两侧之间延伸以允许空气流动当电池被封闭在电池护罩内时，蓄电池的底部。

68. 发明授权

US5498710A Alkyl ether analogues of benzoporphyrin derivatives 失效
标题翻译：苯并卟啉衍生物的烷基醚类似物
公开(公告)号：US5498710A
公开(公告)日：1996-03-12
申请号：US231113
申请日：1994-04-22
申请人： Ravindra K. Pandey , Thomas J. Dougherty , Kevin M. Smith , Isabelle Meunier
发明人： Ravindra K. Pandey , Thomas J. Dougherty , Kevin M. Smith , Isabelle Meunier
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Compounds having properties superior to known photosensitizers defined by the following chemical formula: ##STR1## including R groups R.sup.1, R.sup.2, R.sup.3, and R.sup.4, wherein R.sup.1 and R.sup.2 are methyl or --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3 or are joined together to form the group D and wherein R.sup.3 and R.sup.4 are methyl or --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3 or are joined together to form the group D; provided that one of R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 are joined together to form the group D wherein one of the remaining R groups is methyl and one of the remaining R groups is --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3, where n is an integer of 5 through 7 and group D is: ##STR2## and R.sub.5 is independently at each occurrence --OR.sub.6 where R.sub.6 is lower alkyl of 1 through 7 carbon atoms or R.sub.6 is an amino acid residue.
摘要翻译：具有优于以下化学式定义的已知光敏剂的性质的化合物：包括R基团R 1，R 2，R 3和R 4的其中R 1和R 2是甲基或-CH（O-（CH 2）n CH 3）一起形成基团D，其中R 3和R 4是甲基或-CH（O-（CH 2）n CH 3）CH 3或连接在一起形成基团D; 条件是R 1和R 2或R 3和R 4中的一个连接在一起形成基团D，其中剩余的R基团之一是甲基，其余的R基团之一是-CH（O-（CH 2）n CH 3）CH 3，其中n 是5〜7的整数，D为：＆lt; IMAGE＆gt; R5各自独立地为-OR 6，其中R 6为1〜7个碳原子的低级烷基或者R6为氨基酸残基。

69. 发明授权

US5404129A Anti-theft battery system for vehicles 失效
标题翻译：汽车防盗电池系统
公开(公告)号：US5404129A
公开(公告)日：1995-04-04
申请号：US97795
申请日：1993-07-27
申请人： David J. Novak , Thomas J. Dougherty
发明人： David J. Novak , Thomas J. Dougherty
IPC分类号： B60R25/04 , H01M2/34
CPC分类号： B60R25/24 , B60R25/04 , B60R25/045 , H01M2/341
摘要： An anti-theft battery system for vehicles includes a control circuit which is connected in the starting circuit and responds to a starting current which exceeds a set point value to interrupt the starting circuit, thereby disconnecting the starter motor from the battery preventing starting of the vehicle, a reset circuit responsive to the control circuit which resets the control circuit after a delay interval to permit the starter motor to be connected to the vehicle battery, and an override circuit for generating an override signal for overriding the control circuit for a preselected interval of time to permit an authorized operator to start the vehicle, the override circuit including a small portable transmitter adapted to be carried by the vehicle operator and a receiver connected to the control circuit.
摘要翻译：用于车辆的防盗电池系统包括控制电路，该控制电路连接在启动电路中并且响应于超过设定值的起动电流以中断启动电路，从而将启动电动机与防止车辆启动的电池断开，响应于所述控制电路的复位电路，所述复位电路在延迟间隔之后复位所述控制电路以允许所述起动电动机连接到所述车辆电池;以及超控电路，用于产生用于超控所述控制电路的预置间隔的超控信号，允许授权操作员启动车辆的时间，该超驰电路包括适于由车辆操作员携带的小型便携式发射器和连接到控制电路的接收器。

70. 发明授权

US5149605A Dual lug battery plate construction 失效
标题翻译：双凸耳电池板结构
公开(公告)号：US5149605A
公开(公告)日：1992-09-22
申请号：US760930
申请日：1991-09-17
申请人： Thomas J. Dougherty
发明人： Thomas J. Dougherty
IPC分类号： H01M2/24 , H01M2/30
CPC分类号： H01M2/24 , H01M2/305
摘要： The present invention relates to a unique battery arrangement including battery plates having a pair of spaced apart battery lugs for both the positive and negative plates. While being spaced apart, the lugs are located generally adjacent one top edge of the plates; on opposite sides for the positive and negative plate constructions. The straps used to electrically connect the lugs are lower in height than those used on current battery designs, providing excellent current collection, efficient fusion with smaller lugs and resistance to vibration caused by separation of the lugs from the straps. The present invention also features plates having greater plate surface area, improved current carrying capability and reduced voltage drop. A weld element couples straps of like polarity, and in the preferred embodiment, at least a portion of the weld element is located intermediate the ends of the straps.
摘要翻译：本发明涉及一种独特的电池装置，其包括具有用于正极板和负极板的一对间隔开的电池接线片的电池板。在间隔开的同时，凸耳大致相邻于板的一个顶部边缘; 在正极和负极板结构的相对两侧。用于电连接凸耳的带子的高度低于当前电池设计中使用的带子，提供优异的电流收集，与较小的接线片的高效融合以及由凸耳与带子分离所产生的抵抗振动。本发明还具有具有更大的板表面积，改善的载流能力和降低的电压降的板。焊接元件连接相似极性的带，并且在优选实施例中，焊接元件的至少一部分位于带的端部之间。

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