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61. 发明申请

WO1993000052A1 TREATMENT OF DISEASES BY SITE-SPECIFIC INSTILLATION OF CELLS OR SITE-SPECIFIC TRANSFORMATION OF CELLS AND KITS THEREFOR 审中-公开
标题翻译：通过特异性保护细胞或细胞的位点特异性转化来治疗疾病或病原体
公开(公告)号：WO1993000052A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005243
申请日：1992-06-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NABEL, Elizabeth, G. , NABEL, Gary, J.
IPC分类号： A61F02/06
CPC分类号： A61K9/0024 , A61B17/22 , A61B2017/22082 , A61B2017/22084 , A61K48/00 , A61L29/16 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61L2300/802 , Y02A50/471
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
摘要翻译：公开了一种直接治疗疾病特定部位的方法。该方法基于通过导管插入到使用遗传修饰或正常细胞或其他载体系统的离散血管段的蛋白质递送。表达重组治疗剂或诊断性蛋白质的内皮细胞位于血管壁或患者血管灌注的组织中。该技术提供细胞或载体的转移和体内重组基因的表达，并允许引入用于治疗疾病的治疗或诊断价值的蛋白质。

62. 发明申请

WO1992005796A1 PEPTIDE INHIBITORS OF NEUTROPHIL ACTIVATION PROTEINS 审中-公开
标题翻译：中性激活蛋白肽肽抑制剂
公开(公告)号：WO1992005796A1
公开(公告)日：1992-04-16
申请号：PCT/US1991007560
申请日：1991-10-09
申请人： SRI INTERNATIONAL , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： SRI INTERNATIONAL , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , JOHNSON, Paul, H. , CASTOR, William, C. , SMITH, Elizabeth, M.
IPC分类号： A61K37/00
CPC分类号： C07K14/575 , A61K38/00
摘要： Peptides having neutrophil activation protein inhibitory activity are disclosed. These peptides correspond to the first from 10 to 19 amino acids at the NH2 end of CTAP-III.
摘要翻译：公开了具有嗜中性粒细胞活化蛋白抑制活性的肽。这些肽对应于CTAP-III的NH 2末端的10至19个氨基酸的第一个。

63. 发明申请

WO1992005273A1 GENE THERAPY FOR CYSTIC FIBROSIS 审中-公开
标题翻译：基因治疗CYSTIC FIBROSIS
公开(公告)号：WO1992005273A1
公开(公告)日：1992-04-02
申请号：PCT/US1991006660
申请日：1991-09-16
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , COLLINS, Francis S. , WILSON, James, M.
IPC分类号： C12P21/06
CPC分类号： B82Y5/00 , A01K2217/05 , A01K2267/0306 , A61K38/00 , A61K48/00 , C07K14/4712 , C07K16/18 , C07K16/28 , C12N15/8509
摘要： The present invention comprises gene therapy for treating cystic fibrosis (CF). Delivery and expression of a single copy of a normal CFTR gene leads to stable correction of the Cl channel regulation defect present in CF epithelial cells. The present invention includes recombinant viral and plasmid vectors, alternative CFTR gene delivery strategies, and transduced CF cells and cell lines carrying a recombinant gene for functional CFTR. CF epithelial complementation through transduction of the present invention also provides an assay for determining the validity of other putative CF mutations.
摘要翻译：本发明包括治疗囊性纤维化（CF）的基因疗法。正常CFTR基因的单拷贝的递送和表达导致CF上皮细胞中存在的Cl通道调节缺陷的稳定校正。本发明包括重组病毒和质粒载体，替代的CFTR基因递送策略，以及携带用于功能性CFTR的重组基因的转导的CF细胞和细胞系。通过本发明的转导的CF上皮互补还提供了用于确定其它推定的CF突变的有效性的测定法。

64. 发明申请

WO1990005541A1 IMMUNOTHERAPY INVOLVING CD28 STIMULATION 审中-公开
标题翻译：涉及CD28刺激的免疫治疗
公开(公告)号：WO1990005541A1
公开(公告)日：1990-05-31
申请号：PCT/US1989005304
申请日：1989-11-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BRISTOL-MYERS SQUIBB COMPANY
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BRISTOL-MYERS SQUIBB COMPANY , THOMPSON, Craig, B. , JUNE, Carl, H. , LEDBETTER, Jeffrey, A. , LINDSTEN, Tullia
IPC分类号： A61K39/395
CPC分类号： A61K39/02 , A61K35/17 , A61K38/00 , A61K2039/505 , A61K2039/5158 , C07K14/70521 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/54 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N5/0636 , C12N2501/51 , C12N2501/515
摘要： A method of immunotherapy stimulates the T cell CD28 surface molecule to enhance T cell proliferation and increase overall lymphokine levels or to increase cellular production of human TH1 lymphokines or both. The method is selective for the induction of activated T cell mediated immune responses and enhances immune function even in the presence of immunosuppressants.
摘要翻译：免疫治疗的方法刺激T细胞CD28表面分子增强T细胞增殖并增加总淋巴细胞因子水平或增加人TH1淋巴因子或两者的细胞产生。该方法对于诱导活化的T细胞介导的免疫应答是有选择性的，即使在免疫抑制剂的存在下也增强免疫功能。

65. 发明申请

WO1989001034A1 ENCAPSULATION OF BIOLOGICAL MATERIALS IN SEMI-PERMEABLE MEMBRANES 审中-公开
标题翻译：生物材料在半透膜中的封装
公开(公告)号：WO1989001034A1
公开(公告)日：1989-02-09
申请号：PCT/US1988002413
申请日：1988-07-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NIGAM, Somesh, C. , WANG, Henry, Y.
IPC分类号： C12N11/04
CPC分类号： A61K9/5031 , A61K9/1652 , A61K9/5036 , C12N11/04
摘要： Material such as biological material is encapsulated within a semi-permeable membrane by suspending the material in a medium which comprises an effective amount of a gelling inducer; forming said suspension into a droplet of a size sufficient to envelop said material; and then forming a discrete capsule by contacting the outer surface portion of the droplet with a gelling solution comprising an effective amount of a gel forming polymer which gels upon contact with said gelling inducer.
摘要翻译：诸如生物材料的材料通过将材料悬浮在包含有效量的胶凝诱导剂的介质中而封装在半透膜内; 将所述悬浮液形成为足以包封所述材料的尺寸的液滴; 然后通过使液滴的外表面部分与包含有效量的凝胶形成聚合物的胶凝溶液接触来形成离散胶囊，所述胶凝形成聚合物在与所述胶凝诱导剂接触时凝胶化。

66. 发明申请

WO1998005254A1 METHOD AND APPARATUS FOR SEPARATION OF VENTRICULAR TACHYCARDIA FROM VENTRICULAR FIBRILLATION FOR IMPLANTABLE CARDIOVERTER DEFIBRILLATORS 审中-公开
标题翻译：用于分离静脉注射器的静脉注射器的方法和装置
公开(公告)号：WO1998005254A1
公开(公告)日：1998-02-12
申请号：PCT/US1997014015
申请日：1997-08-07
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CASWELL, Stephanie, A. , JENKINS, Janice, M. , DICARLO, Lorenzo, A.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61B05/046
CPC分类号： A61N1/3956
摘要： A method and apparatus for differntiating between ventricular tachycardia and ventricular fibrillation includes a pair of electrodes (20, 22) located on a single catheter (12) which, in conjunction with an implantable cardioverter device (14), utilize two channel ventricular algorithms for ventricular tachycardia and ventricular fibrillation separation. Two closely spaced unipolar electrograms demonstrate similar morphology and consistency during rhythms with broad coherent activation (such as sinus rhythm and ventricular tachycardia). Conversely, for incoherent rhythms (ventricular fibrillation and polymorphic ventricular tachycardia), activation between the electrodes proved to be dissimilar and inconsistent. The cross correlation of the two depolarizations measures similarity between electrogram morphology, and interquartile range measures consistency in a passage. The method and apparatus of the present invention is able to address the limitation of existing algorithms and provide accurate separation of ventricular fibrillation from other rhythms.
摘要翻译：用于区分室性心动过速和心室颤动的方法和装置包括位于单个导管（12）上的一对电极（20,22），其与可植入式心律转复器装置（14）一起利用用于心室的两个通道心室算法心动过速和心室颤动分离。两个紧密间隔的单极电图在具有广泛相干激活（如窦性心律和室性心动过速）的节律中表现出类似的形态和一致性。相反，对于非相干节律（心室颤动和多形性室性心动过速），电极之间的活化被证明是不相似的和不一致的。两个去极化的互相关性测量电描记图形态之间的相似性，并且四分位数范围测量通道中的一致性。本发明的方法和装置能够解决现有算法的局限性，并提供心室颤动与其他节律的精确分离。

67. 发明申请

WO1997045533A1 ENGINEERING ORAL TISSUES 审中-公开
标题翻译：工程口腔组织
公开(公告)号：WO1997045533A1
公开(公告)日：1997-12-04
申请号：PCT/US1997008977
申请日：1997-05-28
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MOONEY, David, J. , RUTHERFORD, Robert, Bruce
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12N05/06
CPC分类号： A61L27/3604 , A61K6/0038 , A61K35/12 , A61L27/3641 , A61L27/38 , C07K14/485 , C12N5/0068 , C12N5/0654 , C12N5/0697 , C12N2502/1311 , C12N2502/1323 , C12N2503/02 , C12N2533/40 , C12N2533/54 , C08L67/04
摘要： Disclosed are methods for regenerating dental and oral tissues from viable cells using ex vivo culture on a structural matrix. The regenerated oral tissues and tissue-matrix preparations thus provided have both clinical applications in dentistry and oral medicine and are also useful in in vitro toxicity and biocompatibility testing.
摘要翻译：公开了使用离体培养在结构基质上从活细胞再生牙科和口腔组织的方法。由此提供的再生的口腔组织和组织基质制剂在牙科和口服药物中具有临床应用，并且也可用于体外毒性和生物相容性测试。

68. 发明申请

WO1997039799A1 METHOD FOR CARDIAC ARRHYTHMIA DETECTION 审中-公开
标题翻译：心脏心律失常检测方法
公开(公告)号：WO1997039799A1
公开(公告)日：1997-10-30
申请号：PCT/US1997006728
申请日：1997-04-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , STEVENSON, Shelly, A. , JENKINS, Janice, M. , THOMPSON, Julie, A. , DICARLO, Lorenzo, A.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61N01/362
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Using only ventricular and atrial rate criteria, there is ambiguity in the case of atrial tachycardia (AT) with retrograde conduction. The introduction of dual chamber sensing in anti-tachycardia devices allows for computational inexpensive measurements of VA intervals. The present invention addresses problems arising in tachycardia with confounding 1:1 relationships. According to the present invention, using atrial and ventricular rates only, all 1:1 tachycardia would be classified as VT, resulting in false shocks. Specificity of ambiguous 1:1 tachycardia can be potentially increased using VA interval measurements (82), at the cost of minimum loss in sensitivity for VT detection. The applied algorithm imposes little in additional computation for dual chamber sensing ICDs and greatly reduces the possibility of false shocks in 1:1 atrial tachycardia.
摘要翻译：仅使用心室和心房率标准，在具有逆行传导的房性心动过速（AT）的情况下存在歧义。在抗心动过速装置中引入双室感测允许计算廉价的VA间隔测量。本发明解决了以1:1混合关系在心动过速中出现的问题。根据本发明，仅使用心房和心室率，所有1：1的心动过速将被分类为VT，导致假震荡。使用VA间隔测量（82）可能潜在地增加模糊1：1心动过速的特异性，以VT检测的灵敏度最小损失为代价。所应用的算法对双腔感应ICD的附加计算几乎不起作用，并大大降低了1：1心房心动过速的假震动的可能性。

69. 发明申请

WO1997039681A1 DEFIBRILLATOR CONTROL SYSTEM 审中-公开
标题翻译：减速器控制系统
公开(公告)号：WO1997039681A1
公开(公告)日：1997-10-30
申请号：PCT/US1997006740
申请日：1997-04-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MORRIS, Milton, M. , JENKINS, Janice, M. , DICARLO, Lorenzo, A.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61B05/046
CPC分类号： A61B5/7264 , A61B5/046 , A61N1/3956 , Y10S128/92
摘要： A pattern recognition system for use in an implantable cardioverter defibrillator that is capable of responding correctly to abnormal activity of the heart efficiently and specifically. The system of the present invention first establishes a template representing the point above which or below which actual sample values, as obtained via a sampler (12), would be remarkable. Against the median are compared sampled values within a window having a pre-programmed length. For each cycle, a comparison is made between the template median and every value sampled within this pre-programmed window. Each cycle is then individually diagnosed by a trained classifier (16) such that if a selected value is above a particular pre-established threshold or below a particular pre-established threshold it will be classified as diseased. A plurality of specific cycles must be classified "diseased" in order for a final diagnosis to be made that the individual is experiencing arrhythmia. The system of the present invention is also capable of differentiating between types of disease and can classify the disease as being either ventricular tachycardia or venticular fibrillation.
摘要翻译：一种用于植入式心律转复除颤器的模式识别系统，其能够有效且具体地对心脏的异常活动作出正确的响应。本发明的系统首先建立一个模板，该模板表示在通过采样器（12）获得的实际样本值之上或之下的点以下的点将是显着的。对于中值，在具有预编程长度的窗口内比较采样值。对于每个周期，在模板中位数和在此预编程窗口中采样的每个值之间进行比较。每个周期然后由训练有素的分类器（16）单独诊断，使得如果所选择的值高于特定的预先建立的阈值或低于特定的预先建立的阈值，则将其分类为患病的。必须将多个特定周期分类为“患病”，以便进行最终诊断以证明个体正在经历心律失常。本发明的系统还能够区分疾病类型，并且可以将疾病分类为室性心动过速或通气性纤颤。

70. 发明申请

WO1997038138A1 ATTENUATED RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：减轻呼吸道感染病毒
公开(公告)号：WO1997038138A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005588
申请日：1997-04-03
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MAASSAB, Hunein, F. , HERLOCHER, M., Louise
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12Q01/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18564
摘要： Attenuated respiratory syncytial viruses (RSV) and in particular temperature sensitive RSV are provided. The viruses of the present invention may be used in pharmaceutical compositions such as vaccines. Methods of making and using such pharmaceutical compositions are also provided.
摘要翻译：提供了减毒的呼吸道合胞病毒（RSV），特别是温度敏感的RSV。本发明的病毒可用于疫苗等药物组合物中。还提供了制备和使用这些药物组合物的方法。

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