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61. 发明申请

US20110184301A1 HEART FAILURE DETECTOR 审中-公开
标题翻译：心脏故障检测器
公开(公告)号：US20110184301A1
公开(公告)日：2011-07-28
申请号：US13121844
申请日：2008-09-30
申请人： Nils Holmström , Michael Broomé , Andreas Blomqvist
发明人： Nils Holmström , Michael Broomé , Andreas Blomqvist
IPC分类号： A61B5/0472 , A61B5/0452
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0472 , A61B5/053 , A61N1/36578
摘要： In an apparatus and method for detecting incipient heart failure of a patient. Impedance signals reflecting volume changes of the right ventricle and/or the right atrium of a heart of the patient are obtained. The impedance signals are processed to determine a first impedance parameter substantially reflecting a volume of the right ventricle, and a heart failure status is determined based on the first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of the heart failure status.
摘要翻译：在用于检测患者的初期心力衰竭的装置和方法中。获得反映患者心脏的右心室和/或右心房体积变化的阻抗信号。处理阻抗信号以确定基本上反映右心室体积的第一阻抗参数，并且基于第一阻抗参数确定心力衰竭状态，其中减小的第一阻抗参数被确定为恶化的指示心力衰竭状态。

62. 发明申请

US20110106232A1 METHOD AND DEVICE FOR ESTIMATING A MYOCARDIAL PERFORMANCE PARAMETER 有权
标题翻译：估计心肌性能参数的方法和装置
公开(公告)号：US20110106232A1
公开(公告)日：2011-05-05
申请号：US13002599
申请日：2008-08-28
申请人： Michael Broomé , Andreas Blomqvist
发明人： Michael Broomé , Andreas Blomqvist
IPC分类号： A61N1/00
CPC分类号： A61B5/02028 , A61B5/053 , A61B5/0538 , A61B5/6846 , A61B5/686 , A61B5/7235 , A61B5/7239 , A61N1/36521 , A61N1/3682
摘要： An implantable medical device applies an electric signal to at least a portion of a heart in a subject. A resulting electric signal is collected from the heart and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/or cardiac therapy adjustment.
摘要翻译：可植入医疗装置将电信号施加到受试者的心脏的至少一部分。所得到的电信号从心脏收集并与所应用的信号一起用于确定心源性阻抗信号。处理阻抗信号以估计等体积收缩时间，等体积弛豫时间和心脏周期的排出时间。这三个时间参数用于计算心脏的Tei指数。 Tei指数可用作心脏诊断和/或心脏治疗调整中的心肌性能参数。

63. 发明申请

US20100331909A1 ANTI-ARRHYTHMIA IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：抗甲状腺植入式医疗器械
公开(公告)号：US20100331909A1
公开(公告)日：2010-12-30
申请号：US12920906
申请日：2008-03-31
申请人： Karin Järverus , Andreas Blomqvist , Carl Wikefeldt
发明人： Karin Järverus , Andreas Blomqvist , Carl Wikefeldt
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0464 , A61B5/053 , A61N1/3622 , A61N1/36585 , A61N1/37258 , A61N1/3962
摘要： An implantable medical device has a detector for detecting an arrhythmia event of a subject's heart and generating an arrhythmia signal based on the detected event. An impedance determining unit determines impedance data representative of blood aggregation level of blood present in a cavity, such as heart chamber, of the subject. An anti-arrhythmia unit of the device is arranged for applying electric anti-arrhythmia treatment to at least a portion of the heart. This unit is conditionally operable based on the arrhythmia signal and the impedance data. The risk blood aggregates and clots obstructing blood vessels following anti-arrhythmia treatment is significant reduces by conditioning the treatment based on the aggregation level representing impedance data.
摘要翻译：可植入医疗装置具有用于检测受试者心脏的心律不齐事件的检测器，并且基于检测到的事件产生心律失常信号。阻抗确定单元确定表示存在于受试者的腔室（例如心室）中的血液的血液聚集水平的阻抗数据。该装置的抗心律不齐装置被布置成对心脏的至少一部分进行电抗心律失常治疗。该单元基于心律失常信号和阻抗数据有条件地操作。抗心律失常治疗后阻塞血管的血液聚集体和凝块的危险性通过基于代表阻抗数据的聚集水平进行治疗来显着降低。

64. 发明申请

US20100331719A1 METHOD AND IMPLANTABLE MEDICAL DEVICE (IMD) FOR MONITORING PERMEABILITY STATUS OF CELL MEMBRANES 有权
标题翻译：用于监测细胞膜渗透性状态的方法和可植入医疗装置（IMD）
公开(公告)号：US20100331719A1
公开(公告)日：2010-12-30
申请号：US12865169
申请日：2008-01-29
申请人： Andreas Blomqvist , Anna-Karin Alm , Jörgen Edvinsson , Kjell Norèn , Christopher Graae
发明人： Andreas Blomqvist , Anna-Karin Alm , Jörgen Edvinsson , Kjell Norèn , Christopher Graae
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0031 , A61B5/0538 , A61B5/4878 , A61N1/36521 , A61N1/36557 , A61N1/3702 , A61N1/37258
摘要： An implantable medical device comprises a signal generator for generating a current signal having a frequency in a frequency window slightly less than the β-dispersion frequency of a tissue and applying the signal over the tissue. A signal measurer measures the resulting voltage signal and an impedance parameter is calculated from the applied and measured signal by a parameter determiner. A status monitor monitors the permeability status of cell membranes in the tissue based on this impedance parameter.
摘要翻译：可植入医疗装置包括信号发生器，用于产生具有稍微小于组织的分散频率的频率窗口中的频率并将信号施加在组织上的电流信号。信号测量器测量所得到的电压信号，并且通过参数确定器从施加和测量的信号计算阻抗参数。状态监测器基于该阻抗参数监测组织中细胞膜的渗透性状态。

65. 发明申请

US20100324442A1 MONITORING MECHANICAL HEART PROPERTIES 有权
标题翻译：监测机械心脏特性
公开(公告)号：US20100324442A1
公开(公告)日：2010-12-23
申请号：US12526177
申请日：2007-02-21
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/145
摘要： In a method and system for monitoring mechanical properties of a heart in a subject, multiple cardiogenic impedance values reflective of the impedance of the heart in connection with a transition from inhalation to exhalation in the subject are determined. Correspondingly, multiple cardiogenic impedance values reflective of the impedance of the heart in connection with a transition from exhalation to inhalation are determined. The impedance values are collectively processed to form a trend parameter. The value determination and processing is performed over several respiratory cycles spaced apart in time to form a plurality of trend parameters over time. The mechanical properties of the heart are monitored by processing these different trend parameters. The data collection and optionally at least a part of the data processing is performed by an implantable medical device.
摘要翻译：在用于监测受试者心脏的机械性质的方法和系统中，确定了反映与受试者从吸入转移到呼气相关的心脏阻抗的多个心源阻抗值。相应地，确定反映与从呼气转移到吸入相关的心脏阻抗的多个心源阻抗值。阻抗值被统一处理以形成趋势参数。在几个时间间隔的呼吸循环中进行值确定和处理，以随时间形成多个趋势参数。通过处理这些不同的趋势参数来监测心脏的机械性质。数据收集和可选择的数据处理的至少一部分由可植入医疗装置执行。

66. 发明申请

US20100280394A1 MEDICAL DEVICE FOR ATRIAL FIBRILLATION PREDICTION 有权
标题翻译：用于ATRIAL FIBRILLATION预测的医疗设备
公开(公告)号：US20100280394A1
公开(公告)日：2010-11-04
申请号：US12810406
申请日：2008-01-28
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61N1/37 , A61B5/042 , A61B5/0205
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/0452 , A61B5/053 , A61B5/0809 , A61B5/4818 , A61B5/7239 , A61N1/3622
摘要： In a device and a method for providing correlated measures for predicting potential occurrence of atrial fibrillation, an impedance of the patient is measured to obtain impedance information; cardiogenic data is determined from the information; respiratory data is determined from the information; at least one hemodynamic measure is calculated from the cardiogenic data and at least one apnea measure is calculated from the respiratory data; the hemodynamic and apnea measures are correlated such that the correlated measures can be utilized for predicting potential occurrence of atrial fibrillation.
摘要翻译：在用于提供用于预测心房颤动的潜在发生的相关措施的装置和方法中，测量患者的阻抗以获得阻抗信息; 从信息确定心源生成数据; 从信息中确定呼吸数据; 从心源性数据计算出至少一种血液动力学测量，并根据呼吸数据计算至少一种呼吸暂停测量; 血流动力学和呼吸暂停测量是相关的，以便相关度量可用于预测房颤的潜在发生。

67. 发明申请

US20100100146A1 MEDICAL DEVICE COMPRISING AN IMPEDANCE MEASUREMENT MEANS TO MEASURE VISCERAL FAT 有权
标题翻译：包含阻抗测量的医疗设备意味着测量粘度FAT
公开(公告)号：US20100100146A1
公开(公告)日：2010-04-22
申请号：US12442744
申请日：2006-09-25
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/0537 , A61B5/0538 , A61N1/37258
摘要： A medical device having an impedance measurement circuit connected to at least two intracorporeal measurement electrodes arranged to measure the impedance of tissue inside the body of a patient. The impedance measurement circuit is adapted to apply a measurement current/voltage signal to the electrodes to measure and calculate the impedance of the measurement tissue, and to apply the calculated impedance value to a storage unit. The stored impedance values are used, by an analysis unit, to measure the amount of visceral fat of the tissue object inside the body of the patient.
摘要翻译：一种具有阻抗测量电路的医疗装置，该阻抗测量电路连接至至少两个体内测量电极，其布置成测量患者体内组织的阻抗。阻抗测量电路适于向电极施加测量电流/电压信号，以测量和计算测量组织的阻抗，并将计算的阻抗值应用于存储单元。存储的阻抗值由分析单元用于测量患者体内的组织物体的内脏脂肪的量。

68. 发明申请

US20100016915A1 MEDICAL DEVICE AND SYSTEM FOR DETERMINING A HEMODYNAMIC PARAMETER USING INTRACARDIAC IMPEDANCE 有权
标题翻译：用于确定使用内皮抑素的血液动力学参数的医疗装置和系统
公开(公告)号：US20100016915A1
公开(公告)日：2010-01-21
申请号：US12307970
申请日：2006-06-21
申请人： Andreas Blomqvist , Johan Svahn
发明人： Andreas Blomqvist , Johan Svahn
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/02028 , A61B5/053
摘要： In implantable medical devices such a pacemaker or cardioverter/defibrillators (ICDs) and systems including such a device and an external programmer a measure of a hemodynamic parameter such as the cardiac output, the stroke volume, or the contractility of a patient is used to trend heart failure or in an AV/VV optimization scheme. The implantable medical device is adapted to measure the cardiac impedance and the cardiac impedance data is used to determine impedance morphology curves, which, in turn, are used to compute a measure of the hemodynamic parameter.
摘要翻译：在诸如起搏器或心脏复律器/除颤器（ICD）和包括这种装置和外部程序员的系统的可植入医疗装置中，使用诸如心输出量，行程体积或患者的收缩性的血液动力学参数的度量趋势心力衰竭或AV / VV优化方案。可植入医疗装置适于测量心脏阻抗，并且心脏阻抗数据用于确定阻抗形态曲线，其又用于计算血液动力学参数的度量。

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