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61. 发明授权

US07501123B2 Human G-protein chemokine receptor (CCR5) HDGNR10 有权
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US07501123B2
公开(公告)日：2009-03-10
申请号：US11518949
申请日：2006-09-12
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/2866 , C07K14/7158 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/715
摘要： The present invention relates to a human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this human protein and these human antibodies.
摘要翻译：本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该人类蛋白质和这些人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

62. 发明授权

US07411051B2 Antibodies to HDPPA04 polypeptide 失效
标题翻译： HDPPA04多肽的抗体
公开(公告)号：US07411051B2
公开(公告)日：2008-08-12
申请号：US11001793
申请日：2004-12-02
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/00
CPC分类号： C07K14/47
摘要： The present invention relates to antibodies that specifically bind HDPPA04 polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said HDPPA04. Also encompassed by the invention are host cells and hybridomas for producing said antibodies. The invention further encompasses methods for detecting said HDPPA04 polypeptides using said antibodies.
摘要翻译：本发明涉及特异性结合HDPPA04多肽的抗体，其可用于诊断和治疗与所述HDPPA04有关的疾病，病症和/或病症。本发明还包括用于产生所述抗体的宿主细胞和杂交瘤。本发明还包括使用所述抗体检测所述HDPPA04多肽的方法。

63. 发明授权

US07402312B2 Antibodies to vascular endothelial growth factor 2 (VEGF-2) 失效
标题翻译：血管内皮生长因子2（VEGF-2）的抗体
公开(公告)号：US07402312B2
公开(公告)日：2008-07-22
申请号：US10992196
申请日：2004-11-19
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , C07K14/475 , C07K16/22 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention also relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明还涉及用于预防，治疗或改善疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的一种或多种VEGF-2抗体或其片段或变体。

64. 发明授权

US07393934B2 Human G-protein chemokine receptor (CCR5) HDGNR10 有权
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US07393934B2
公开(公告)日：2008-07-01
申请号：US10994679
申请日：2004-11-23
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/28 , C12N15/13
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

65. 发明授权

US07368531B2 Human secreted proteins 失效
标题翻译：人体分泌的蛋白质
公开(公告)号：US07368531B2
公开(公告)日：2008-05-06
申请号：US10100683
申请日：2002-03-19
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1/00
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5008 , G01N33/5044 , G01N33/505 , G01N33/5052 , G01N33/5058 , G01N33/5064 , G01N33/5088 , G01N33/68
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding the polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to the human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing the polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽和编码该多肽的分离的核酸分子，其可用于诊断和治疗与人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

66. 发明授权

US07223724B1 Use of vascular endothelial growth factor to treat photoreceptor cells 失效
标题翻译：使用血管内皮生长因子治疗感光细胞
公开(公告)号：US07223724B1
公开(公告)日：2007-05-29
申请号：US09499468
申请日：2000-02-07
申请人： Ralph Alderson , Robert Melder , Viktor Roschke , Steven M. Ruben , Craig A. Rosen
发明人： Ralph Alderson , Robert Melder , Viktor Roschke , Steven M. Ruben , Craig A. Rosen
IPC分类号： A01N37/18 , A01N25/00
CPC分类号： A61K38/1866 , A61K48/00 , C07K16/22 , C07K2317/74 , C12N2799/026 , Y10S514/963 , Y10S514/964 , Y10S514/969
摘要： The present invention is directed to VEGF-2 polynucleotides and polypeptides and methods of using such polynucleotides and polypeptides. In particular, provided are methods of treating retinal disorders with VEGF-2 polynucleotides and polypeptides.
摘要翻译：本发明涉及VEGF-2多核苷酸和多肽以及使用这些多核苷酸和多肽的方法。特别地，提供了用VEGF-2多核苷酸和多肽治疗视网膜病症的方法。

67. 发明授权

US06951924B2 Antibodies against secreted protein HTEBYII 失效
标题翻译：针对分泌蛋白HTEBYII的抗体
公开(公告)号：US06951924B2
公开(公告)日：2005-10-04
申请号：US10058993
申请日：2002-01-30
申请人： Craig A. Rosen , Steven M. Ruben , ZhiZhen Zeng
发明人： Craig A. Rosen , Steven M. Ruben , ZhiZhen Zeng
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

68. 发明授权

US06878687B1 Protein HMAAD57 失效
标题翻译：蛋白HMAAD57
公开(公告)号：US06878687B1
公开(公告)日：2005-04-12
申请号：US09621011
申请日：2000-07-20
申请人： Steven M. Ruben , Craig A. Rosen , George Komatsoulis , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , George Komatsoulis , Yanggu Shi
IPC分类号： A61K38/00 , C07K14/47 , G01N33/68 , C07H21/04 , C07K14/00
CPC分类号： G01N33/5005 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

69. 发明授权

US06774216B2 Antibodies to secreted protein HCEJQ69 有权
标题翻译：分泌蛋白HCEJQ69的抗体
公开(公告)号：US06774216B2
公开(公告)日：2004-08-10
申请号：US10115123
申请日：2002-04-04
申请人： Steven M. Ruben , Craig A. Rosen , David W. LaFleur
发明人： Steven M. Ruben , Craig A. Rosen , David W. LaFleur
IPC分类号： C07K1618
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

70. 发明授权

US06531447B1 Secreted protein HEMCM42 有权
标题翻译：分泌蛋白HEMCM42
公开(公告)号：US06531447B1
公开(公告)日：2003-03-11
申请号：US09690454
申请日：2000-10-18
申请人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

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