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61. 发明授权

US07452371B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07452371B2
公开(公告)日：2008-11-18
申请号：US09777091
申请日：2001-02-05
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

62. 发明授权

US07402171B2 Prosthetic valve that permits retrograde flow 有权
标题翻译：允许逆行流动的假体瓣膜
公开(公告)号：US07402171B2
公开(公告)日：2008-07-22
申请号：US10797449
申请日：2004-03-10
申请人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
发明人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration.
摘要翻译：提供了一种用于调节通过身体容器的流体流动的人造瓣膜。阀包括可膨胀的支撑框架和瓣膜小叶，并且包括至少一个开口，当阀处于关闭构型时允许通过阀的受控量的逆流流动。

63. 发明申请

US20080125798A1 THROMBUS REMOVAL DEVICE 有权
标题翻译： THROMBUS移除装置
公开(公告)号：US20080125798A1
公开(公告)日：2008-05-29
申请号：US11936525
申请日：2007-11-07
申请人： Thomas A. Osborne , Shyam Kuppurathanam
发明人： Thomas A. Osborne , Shyam Kuppurathanam
IPC分类号： A61B17/22
CPC分类号： A61B17/221 , A61B2017/00685 , A61B2017/00867 , A61B2017/2212 , A61B2217/005 , A61M1/0023
摘要： A thrombus removal device includes a shaft with a distal end and a proximal end, a sheath with a distal end and a proximal end, and a helical coil attached at a proximal end to the distal end of the shaft and is disposed within the lumen of the sheath in a closed configuration. The helical coil includes a plurality of body portions with turns spaced apart longitudinally and laterally to facilitate screwing the helical coil into a thrombus and also providing an open area into which the thrombus can be captured. A distal tip of the helical coil is provided with a loop, an angle of which is about the same as the angle of at least one body portion. The helical coil assumes an open configuration when the sheath is retracted proximally from the distal tip. An aspiration device may be provided in fluid communication with the center of the helical coil.
摘要翻译：血栓去除装置包括具有远端和近端的轴，具有远端和近端的护套，以及螺旋线圈，该螺旋线圈在近端附接到轴的远端，并且设置在腔的内腔内护套处于闭合状态。螺旋线圈包括多个主体部分，其具有纵向和横向隔开的匝，以便于将螺旋线圈拧入血栓并且还提供可以捕获血栓的开放区域。螺旋线圈的远端设置有环，其角度与至少一个主体部分的角度大致相同。当护套从远侧末端向近侧缩回时，螺旋线圈呈现打开构型。可以提供与螺旋线圈的中心流体连通的抽吸装置。

64. 发明授权

US07311697B2 Central venous catheter 有权
标题翻译：中央静脉导管
公开(公告)号：US07311697B2
公开(公告)日：2007-12-25
申请号：US10878752
申请日：2004-06-28
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/007 , A61M25/008 , A61M2025/004 , A61M2025/0056
摘要： A central venous catheter comprises a catheter body having a plurality of lumens extending longitudinally therein. At least one of the lumens extends longitudinally through the catheter body from its proximal end to an exit port at its distal end, and at least one other lumen extends longitudinally through the catheter body to a closed distal portion of the catheter body. The catheter body further includes a sideport positioned to establish communication between the closed-end lumen and an area exterior to the catheter body. The catheter body further includes a flexible member, such as a coiled spring, in the closed-end lumen in a space between the sideport and the closed end.
摘要翻译：中心静脉导管包括具有在其中纵向延伸的多个管腔的导管主体。至少一个管腔从导管主体的近端纵向延伸到其远端处的出口端口，并且至少一个其它管腔纵向延伸通过导管主体延伸到导管主体的封闭远端部分。导管主体还包括侧台，其被设置成在封闭端腔和导管主体外部的区域之间建立连通。导管主体还包括在侧端和闭合端之间的空间中的封闭端腔中的诸如螺旋弹簧的柔性构件。

65. 发明申请

US20070270905A1 Patent foramen ovale closure device and method 审中-公开
标题翻译：卵圆孔闭合装置及方法
公开(公告)号：US20070270905A1
公开(公告)日：2007-11-22
申请号：US11801665
申请日：2007-05-10
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/0061 , A61B2017/00893
摘要： A device and method for closure of a body channel of a patient, such as a patent foramen ovale. The device includes a frame member having a collapsed condition and an expanded condition. The frame member is sized and arranged to be percutaneously insertable into an area of the foramen ovale when in the collapsed condition, and to substantially span the foramen ovale when in the expanded condition. A promoter carried by the frame member, such as a clot-promoting composition and/or a tissue growth-promoting composition, is capable of promoting biological formation with the tissue bordering the foramen ovale to effect a closure of the foramen ovale.
摘要翻译：用于封闭患者身体通道的装置和方法，例如卵孔卵孔专利。该装置包括具有折叠状态和膨胀状态的框架构件。框架构件的尺寸和布置被设计成在处于折叠状态时经皮插入到卵圆孔的区域中，并且在处于扩张状态时基本跨越卵圆孔。由框架构件携带的促进剂如促进促凝组合物和/或组织生长促进组合物的促进剂能够促进与卵圆孔接触的组织的生物形成，从而实现卵圆孔的闭合。

66. 发明授权

US07172580B2 Hemostatic valve assembly 有权
标题翻译：止血阀组件
公开(公告)号：US07172580B2
公开(公告)日：2007-02-06
申请号：US11009587
申请日：2004-12-10
申请人： Christopher L. Hruska , Christopher G. Dixon , Aaron Barr , Ram H. Paul, Jr. , Alan A. Eller , Thomas A. Osborne
发明人： Christopher L. Hruska , Christopher G. Dixon , Aaron Barr , Ram H. Paul, Jr. , Alan A. Eller , Thomas A. Osborne
IPC分类号： A61M5/00
CPC分类号： A61M39/0613 , A61B17/3462 , A61B17/3498 , A61B2017/00477 , A61M39/0208 , A61M2039/0633 , A61M2039/064 , A61M2039/0686
摘要： An iris-type valve assembly comprises a base, a rotatable member, and an elongated elastomeric valve sheath. The distal end of the valve sheath is secured to the base, and the proximal end of the valve sheath is secured to the rotatable member. At least one of the valve sheath ends includes a flange that is secured to a valve-receiving surface of the base or the rotatable member. The base and the rotatable member are aligned to define a passageway therethrough for passage of an interventional device. The valve sheath is disposed along the passageway and has a longitudinal opening therethrough for passage of the interventional device. Upon rotation of the rotatable member relative to the base, the longitudinal opening of the valve sheath is selectively constrictable to comprise a seal around the interventional device.
摘要翻译：虹膜型阀组件包括基座，可旋转构件和细长的弹性阀门护套。阀套的远端固定在基座上，阀套的近端固定在可转动件上。阀套端部中的至少一个包括固定到基座或可旋转构件的阀接收表面的凸缘。基座和可旋转构件对齐以限定穿过其中的通道，用于介入装置的通过。阀套沿着通道设置并且具有穿过其的介入装置通过的纵向开口。当可旋转构件相对于基座旋转时，阀套的纵向开口选择性地可收缩以包括围绕介入装置的密封。

67. 发明授权

US06546280B2 Indwelling catheter 有权
标题翻译：留置导管
公开(公告)号：US06546280B2
公开(公告)日：2003-04-08
申请号：US09841394
申请日：2001-04-24
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B600
CPC分类号： A61M27/008 , A61F2/02 , A61F2/2493 , A61M25/0017 , A61M25/04
摘要： An elastically deformable indwelling catheter formed as a hollow spring having a coiled portion positioned between a first and a second substantially straight portion. The catheter may be straightened for insertion into a patient, wherein the catheter is allowed to resume its coiled shape. A flexible connector extending at least partially through the catheter is used to “lock” the catheter into its coiled shape. The flexible connector extends through the first substantially straight portion and the coiled portion and penetrates through the wall of the second substantially straight portion. The flexible connector is anchored in the first substantially straight portion and extends through the helically coiled portion, penetrates through the catheter wall of the second substantially straight portion and returns to the exterior of the first substantially straight portion. The flexible connector may be secured relative the catheter to prevent further elastic deformation of the spring portion.
摘要翻译：一种形成为中空弹簧的可弹性变形的留置导管，其具有位于第一和第二基本上直的部分之间的螺旋部分。导管可以被拉直以插入患者体内，其中允许导管恢复其线圈形状。使用至少部分地延伸穿过导管的柔性连接器将导管“锁定”成其卷绕形状。柔性连接器延伸通过第一基本上直的部分和螺旋部分并且穿过第二基本上直的部分的壁。柔性连接器被固定在第一基本上直的部分中并延伸穿过螺旋卷绕的部分，穿过第二基本上直的部分的导管壁并返回到第一基本直的部分的外部。柔性连接器可以相对于导管固定，以防止弹簧部分进一步的弹性变形。

68. 发明授权

US06371961B1 Rapid exchange stent delivery balloon catheter 失效
标题翻译：快速交换支架输送球囊导管
公开(公告)号：US06371961B1
公开(公告)日：2002-04-16
申请号：US08967521
申请日：1997-11-11
申请人： Thomas A. Osborne , Scott E. Eells
发明人： Thomas A. Osborne , Scott E. Eells
IPC分类号： A61F1100
CPC分类号： A61F2/958 , A61B90/39 , A61M25/104 , A61M2025/0183 , A61M2025/1056
摘要： A rapid exchange stent delivery balloon catheter which allows exchange from a balloon angioplasty catheter to a stent delivery catheter without the need to replace the angioplasty catheter wire guide with an exchange-length wire guide before exchanging the catheters. The stent delivery catheter of the present invention includes a relatively short wire guide shaft which is bonded to the catheter shaft only at a location distal to the inflation lumen.
摘要翻译：快速交换支架输送球囊导管，其允许从球囊血管成形术导管到支架输送导管的交换，而不需要在更换导管之前用交换长度导线引导器替换血管成形术导管导线器。本发明的支架输送导管包括相对较短的线引导轴，其仅在远离膨胀腔的位置处结合到导管轴。

69. 发明授权

US5221269A Guide for localizing a nonpalpable breast lesion 失效
标题翻译：本地化不可接受的乳腺炎指南
公开(公告)号：US5221269A
公开(公告)日：1993-06-22
申请号：US597575
申请日：1990-10-15
申请人： Richard H. Miller , Brian L. Bates , Todd A. Hall , Thomas A. Osborne
发明人： Richard H. Miller , Brian L. Bates , Todd A. Hall , Thomas A. Osborne
IPC分类号： A61M25/01 , A61B17/00 , A61B19/00 , A61F2/00
CPC分类号： A61B90/39 , A61B2017/00349 , A61B2090/3908 , A61B2090/3987 , A61F2210/0019
摘要： A medical device for localizing a nonpalpable breast lesion. The device includes a tubular introducer needle and a wire guide positioned therein for inserting into a breast to the site of the lesion. The wire guide includes a distal portion having a preformed, resilient helical coil configuration for locking into position about the lesion. The distal portion includes a superelastic metallic alloy for maintaining the helical coil configuration after repeated extensions from and retractions into the needle passageway. The needle is inserted with the wire guide positioned therein into the breast to the site of the lesion and from the distal portion of the needle. The distal end of the needle includes a plurality of indentations for enhancing the ultrasound visualization thereof. As the distal portion of the wire guide emerges from the needle, the acuate distal end of the wire guide cuts into and scribes a helical path about the tissue distal to the lesion. The remainder of the distal portion of the wire guide follows the path scribed by the acuate distal tip and locks about the tissue distal to the lesion. Should the needle and wire guide not be appropriately positioned, the distal portion of the wire guide is retracted into the passageway of the needle to reposition the needle and guide. After desired positioning, the needle is removed with the wire guide remaining in a locked position distally about the lesion for guiding the surgeon to the lesion site during subsequent surgery.

70. 发明授权

US5129890A Hydrophilically coated flexible wire guide 失效
标题翻译：水性涂层柔性电线指南
公开(公告)号：US5129890A
公开(公告)日：1992-07-14
申请号：US648923
申请日：1991-02-01
申请人： Brian L. Bates , Thomas A. Osborne
发明人： Brian L. Bates , Thomas A. Osborne
IPC分类号： A61M25/01 , A61L29/00 , A61M25/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09166
摘要： A wire guide comprising an elongate central core and a coil formed of radiopaque material which is positioned substantially concentrically with the elongate central core. The wire guide also comprises a polymer sleeve which encloses the elongated central core. The guide wire further comprises a hydrophilic coating which substantially encloses the polymer sleeve.

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