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61. 发明授权

US5603954A Pentoxifylline therapy and method of use 失效
标题翻译：己酮可可碱治疗及使用方法
公开(公告)号：US5603954A
公开(公告)日：1997-02-18
申请号：US449621
申请日：1995-05-24
申请人： Patrick S. L. Wong , George V. Guittard , Atul D. Ayer
发明人： Patrick S. L. Wong , George V. Guittard , Atul D. Ayer
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K31/52
CPC分类号： A61K9/2031 , A61K31/52 , A61K9/0004 , A61K9/2054
摘要： A dosage form is disclosed for delivering pentoxifylline to a patient in need of pentoxifylline therapy. A method is discussed for delivery pentoxifylline to a patient at a dosage form controlled rate over an extended period of time.
摘要翻译：公开了用于将己酮可可碱递送至需要己酮可可碱治疗的患者的剂型。讨论了一种在长时间内以剂型形式控制的速率向病人递送己酮可可碱的方法。

62. 发明授权

US5417682A Device for administering active agent to biological environment 失效
标题翻译：将活性剂投与生物环境的装置
公开(公告)号：US5417682A
公开(公告)日：1995-05-23
申请号：US186046
申请日：1994-01-21
申请人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
发明人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
IPC分类号： A61K9/00 , A61K9/22 , A61K9/48
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.
摘要翻译：本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。

63. 发明授权

US5391381A Dispenser capable of delivering plurality of drug units 失效
标题翻译：能够递送多个药物单元的分配器
公开(公告)号：US5391381A
公开(公告)日：1995-02-21
申请号：US60372
申请日：1993-05-11
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00 , A61K9/24
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

64. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

65. 发明授权

US5223265A Osmotic device with delayed activation of drug delivery 失效
标题翻译：渗透装置延迟激活药物递送
公开(公告)号：US5223265A
公开(公告)日：1993-06-29
申请号：US819417
申请日：1992-01-10
申请人： Patrick S. L. Wong
发明人： Patrick S. L. Wong
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The delivery of the agent formulation from the dispensing device, once begun, is continued over a predetermined prolonged period of time.
摘要翻译：本发明涉及一种流体吸收药物递送装置，其可用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。一旦开始，药剂制剂从分配装置的输送在预定的较长时间内继续进行。

66. 发明授权

US5200196A Improvement in pulsed drug therapy 失效
标题翻译：改善脉冲药物治疗
公开(公告)号：US5200196A
公开(公告)日：1993-04-06
申请号：US640469
申请日：1991-01-11
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

67. 发明授权

US5200195A Process for improving dosage form delivery kinetics 失效
标题翻译：改善剂型输送动力学的方法
公开(公告)号：US5200195A
公开(公告)日：1993-04-06
申请号：US804137
申请日：1991-12-06
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

68. 发明授权

US5190765A Therapy delayed 失效
标题翻译：治疗延迟
公开(公告)号：US5190765A
公开(公告)日：1993-03-02
申请号：US799451
申请日：1991-11-26
申请人： Frank Jao , Patrick S. L. Wong , Hoa T. Huynh , Kathy McChesney , Pamela K. Wat
发明人： Frank Jao , Patrick S. L. Wong , Hoa T. Huynh , Kathy McChesney , Pamela K. Wat
IPC分类号： A61K9/00 , A61K31/275 , A61K31/277 , A61K31/401 , A61K31/4422 , A61K31/554 , A61K38/55
CPC分类号： A61K9/0004 , A61K31/275 , A61K31/277 , A61K31/401 , A61K31/4422 , A61K31/554 , A61K38/556
摘要： A dosage form is disclosed comprising means for delaying the delivery of drug from the dosage form following the administration of the dosage form to a patient in need of drug therapy.
摘要翻译：公开了一种剂型，其包括在将剂型施用给需要药物治疗的患者之后延迟药物从剂型递送的方法。

69. 发明授权

US5110597A Multi-unit delivery system 失效
标题翻译：多单元交付系统
公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

70. 发明授权

US5023088A Multi-unit delivery system 失效
标题翻译：多单元交货系统
公开(公告)号：US5023088A
公开(公告)日：1991-06-11
申请号：US495825
申请日：1990-03-19
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

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