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61. 发明专利

DE60223151T2 未知
公开(公告)号：DE60223151T2
公开(公告)日：2008-08-07
申请号：DE60223151
申请日：2002-08-02
申请人： DAINIPPON SUMITOMO PHARMA CO
发明人： MURAOKA MASAMI , MATSUI KAZUKI , YAMAMOTO TAKAAKI , MORISHITA KOJI , YURI MASATOSHI , KATAYAMA SEIJI , OHASHI NAOHITO
IPC分类号： C07D401/04 , A61P7/12 , A61P13/00 , A61P13/02 , C07D401/14
摘要： An optically active form of the quinazolinone derivatives represented by the general formula (1): Äwherein Y represents a phenyl group or C2-C7 alkyl group; E represents -CH= or nitrogen atom; and R represents a C1-C4 alkyl group and so onÜ, or pharmaceutically acceptable salts thereof, has a selective antagonism for the M3 muscarinic receptor and depressant action on the frequency of rhythmic bladder contractions, and it is useful for the treatment of pollakiuria and urinary incontinence.

62. 发明专利

PT1424334E DERIVADO DE QUINAZOLINONA 未知
公开(公告)号：PT1424334E
公开(公告)日：2008-01-10
申请号：PT02755797
申请日：2002-08-02
申请人： DAINIPPON SUMITOMO PHARMA CO
发明人： OHASHI NAOHITO , MATSUI KAZUKI , MORISHITA KOJI , MURAOKA MASAMI , YAMAMOTO TAKAAKI , YURI MASATOSHI , KATAYAMA SEIJI
IPC分类号： C07D401/04 , A61P7/12 , A61P13/00 , A61P13/02 , C07D401/14

63. 发明专利

DE69926776T2 未知
公开(公告)号：DE69926776T2
公开(公告)日：2006-06-08
申请号：DE69926776
申请日：1999-10-07
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , MATSUI KAZUKI , MORISHITA KOJI , OHASHI NAOHITO
IPC分类号： C07D401/04 , A61K31/505 , A61P13/10
摘要： A compound given by general formula (1): Äwherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R and R represent independently hydrogen atom, lower alkyl group, etc., and R represents hydrogen atom, alkyl group, etc. Z represents a group given by formula: äwherein A and A represent independently hydrogen atom, alkyl group, etc. and G represents straight chain alkylene having 1-6 of the carbon number, etc.ü or a group given by formula: äwherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A represents hydrogen atom, alkyl group, etc.üÜ, its prodrug or pharmaceutically acceptable salt thereof is an antagonist against muscarinic receptor that is useful as anticholinergic medicaments, and therefore it is useful as pollakiuria or urinary incontinence remedy.

64. 发明专利

DE69633059T2 未知
公开(公告)号：DE69633059T2
公开(公告)日：2005-08-18
申请号：DE69633059
申请日：1996-05-28
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , IORIYA KATSUHISA , OHASHI NAOHITO
IPC分类号： C07D471/04 , A61K31/435
摘要： Naphthyridine derivative of the formula: wherein Ring A is substituted or unsubstituted pyridine, X is -N(R )-CO- (R is H, alkyl, substituted alkyl, etc.), Z is a direct bond, -NH-, C1-C2 alkylene, or -CH=CH-, Y is alkyl, substituted alkyl, aromatic group or substituted aromatic group, etc., B is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds having acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.

65. 发明专利

NZ335766A Naphthyridine derivatives and use as acyl-CoA cholesterol acyl transferase(ACAT) inhibitor as treatment of hyperlipidemia 未知
公开(公告)号：NZ335766A
公开(公告)日：2000-11-24
申请号：NZ33576697
申请日：1997-11-25
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , IORIYA KATSUHISA , OHASHI NAOHITO , YAGI HIDEKI
IPC分类号： C07D471/04 , A61K31/435
摘要： The specification describes a naphthyridine derivative or an acid addition salt thereof, which shows acyl-CoA: cholesterol acyl transferase (ACAT) inhibitory activity, and is useful as an agent for treatment of hyperlipidemia and atherosclerosis, and a use thereof. The naphthyridine derivative is of the formula: wherein Ring A is a substituted or unsubstituted pyridine ring, X is a group of the formula: wherein R2 is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, a cycloalkyl group, or a substituted cycloalkyl group, or a group of the formula: wherein R is a hydrogen atom or a group: -OR1 wherein (R1 is an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, or a substituted alkynyl group), Z is a direct bond, -NH-, an alkylene group having 1 to 2 carbon atoms, or -CH=CH-, Y is an aromatic group or a substituted aromatic group, L is an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, or a substituted aromatic group, or an acid addition salt thereof.

66. 发明专利

DE69415391D1 未知
公开(公告)号：DE69415391D1
公开(公告)日：1999-02-04
申请号：DE69415391
申请日：1994-05-25
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , MATSUI KAZUKI , HASEGAWA HIROHIKO , KOJIMA ATSUYUKI
IPC分类号： A61K31/505 , A61K31/535 , C07D239/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D453/02 , C07D471/04 , C07D495/04 , C07D239/80 , C07D407/14
摘要： This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R represents a hydrogen or chlorine atom; R represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula:

67. 发明专利

AU5780896A Novel naphthyridine derivatives 未知
公开(公告)号：AU5780896A
公开(公告)日：1996-12-18
申请号：AU5780896
申请日：1996-05-28
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , IORIYA KATSUHISA , OHASHI NAOHITO
IPC分类号： C07D471/04 , A61K31/435
摘要： Naphthyridine derivative of the formula: wherein Ring A is substituted or unsubstituted pyridine, X is -N(R )-CO- (R is H, alkyl, substituted alkyl, etc.), Z is a direct bond, -NH-, C1-C2 alkylene, or -CH=CH-, Y is alkyl, substituted alkyl, aromatic group or substituted aromatic group, etc., B is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds having acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.

68. 发明专利

ES2295382T3 DERIVADO DE QUINAZOLINONA. 未知
公开(公告)号：ES2295382T3
公开(公告)日：2008-04-16
申请号：ES02755797
申请日：2002-08-02
申请人： DAINIPPON SUMITOMO PHARMA CO
发明人： MURAOKA MASAMI , MATSUI KAZUKI , YAMAMOTO TAKAAKI , MORISHITA KOJI , YURI MASATOSHI , KATAYAMA SEIJI
IPC分类号： C07D401/04 , A61P7/12 , A61P13/00 , A61P13/02 , C07D401/14
摘要： Forma ópticamente activa (+) de un derivado de quinazolinona representado por la fórmula general (1): en la que Y representa un grupo fenilo o un grupo alquilo de C2-C7; E representa un grupo de la fórmula -CH=, o un átomo de nitrógeno; y R representa un átomo de flúor, un grupo alquilo de C1-C4, un grupo alcoxi de C1-C4, un grupo trifluorometoxi o un grupo 2, 2, 2-trifluoroetoxi, o una sal farmacéuticamente aceptable de la misma.

69. 发明专利

AT376546T 未知
公开(公告)号：AT376546T
公开(公告)日：2007-11-15
申请号：AT02755797
申请日：2002-08-02
申请人： DAINIPPON SUMITOMO PHARMA CO
发明人： MURAOKA MASAMI , MATSUI KAZUKI , YAMAMOTO TAKAAKI , MORISHITA KOJI , YURI MASATOSHI , KATAYAMA SEIJI , OHASHI NAOHITO
IPC分类号： C07D401/04 , A61P7/12 , A61P13/00 , A61P13/02 , C07D401/14
摘要： An optically active form of the quinazolinone derivatives represented by the general formula (1): Äwherein Y represents a phenyl group or C2-C7 alkyl group; E represents -CH= or nitrogen atom; and R represents a C1-C4 alkyl group and so onÜ, or pharmaceutically acceptable salts thereof, has a selective antagonism for the M3 muscarinic receptor and depressant action on the frequency of rhythmic bladder contractions, and it is useful for the treatment of pollakiuria and urinary incontinence.

70. 发明专利

ES2244243T3 DEERIVADOS DE QUINAZOLINONA. 未知
公开(公告)号：ES2244243T3
公开(公告)日：2005-12-01
申请号：ES99970659
申请日：1999-10-07
申请人： SUMITOMO PHARMA
发明人： MURAOKA MASAMI , MATSUI KAZUKI , MORISHITA KOJI , OHASHI NAOHITO
IPC分类号： A61P13/10 , C07D401/04 , A61K31/505
摘要： Utilización de un compuesto representado por la fórmula general (1): [en la que T representa oxígeno o azufre; Y representa fenilo o fenilo sustituido; el anillo W representa benceno; R1 y R2 representan, independientemente, hidrógeno, alquilo inferior, halógeno, ciano, trifluorometilo, nitro, amino, amino sustituido, hidroxi, alcoxi inferior, alquiltio inferior, alquilsulfinilo inferior o alquilsulfonilo inferior; R3 representa hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, cicloalquilo, cicloalquilo sustituido, cicloalquilalquilo, aralquilo o aralquilo sustituido; Z representa un grupo representado por la fórmula: (CH2)n EN-A3 [en la que n representa 0, 1 ó 2, el anillo E representa un anillo heterocíclico de 4 a 8 elementos saturados que contiene uno o más átomos de nitrógeno, y A3 representa hidrógeno, alquilo, alquilo sustituido, cicloalquilo, heterociclilo saturado, cicloalquilalquilo, cicloalquenilaquilo, aralquilo, aralquilosustituido, heteroarilalquilo, heteroarilalquilo sustituido o -CH2R4 (en el que R4 representa alquenilo o alquinilo) o forma un anillo biciclo conjuntamente con el anillo E}].

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