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61. 发明专利

DE69804100D1 未知
公开(公告)号：DE69804100D1
公开(公告)日：2002-04-11
申请号：DE69804100
申请日：1998-06-15
申请人： SCHERING CORP
发明人： CHEN XING , POIRIER MARC , WONG YEE-SHING , WU GUANG-ZHONG
IPC分类号： C07D401/04 , C07D401/12
摘要： The invention relates to a process for preparing a compound of the formula I comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR5R6 to obtain an amide; (b) reacting the amide with a compound of formula 3 3 in the presence of a strong base to obtain a compound of formula 4 4 (c) converting a compound of formula 4 to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula 7a or 7b, respectively: 7a 7b (e) cyclizing a compound of formula 7a or 7b; wherein R1-R7 are as defined in the specification.

62. 发明专利

CA2406384A1 SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS 未知
公开(公告)号：CA2406384A1
公开(公告)日：2001-10-25
申请号：CA2406384
申请日：2001-04-17
申请人： SCHERING CORP
发明人： POIRIER MARC , WONG YEE-SHING , WU GEORGE G
IPC分类号： C07B61/00 , C07D213/79 , C07D221/16
摘要： A process is provided for preparing a compound having the formula (I) comprising: (a) reacting a compound having the formula (II) with an isocyana te having the formula R1NCO to produce a compound having the formula (III); (b) optionally hydrolyzing the compound of formula (III) to form an amide having the formula (IV); (c) reacting the compound of formula (III) or the amide of formula (IV) with a compound having the formula (V) in the presence of a strong base to produce a compound having the formula (VI); and (d) cyclizing the compound of formula (VI) to obtain the compound of formula (I), wherein R is H or Cl; M is selected from the group consisting of Li, Na, K, MgX, ZnRA, and Al(RA)2; RA is alkyl; X is halo; R1 is selected from the group consistin g of alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, and heterocycloalkylalkyl; and L is a leaving group. Also provided is a process for preparing a compound having th e formula (VIII) comprising reacting a compound having the formula (II) with C O2 and a protonating agent to obtain the compound of formula (VIII), wherein M is selected from the group consisting of Li, Na, K, MgX, ZnRA, and Al(RA)2, wherein RA is alkyl and X is halo.

63. 发明专利

HK1023773A1 SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS 未知
公开(公告)号：HK1023773A1
公开(公告)日：2000-09-22
申请号：HK00102941
申请日：2000-05-17
申请人： SCHERING CORP
发明人： POIRIER MARC , WONG YEE-SHING , WU GUANG-ZHONG , CHEN XING
IPC分类号： C07C17/093 , C07C17/16 , C07C25/02 , C07C25/06 , C07C33/46 , C07D213/81 , C07D221/16 , C07D , C07C

64. 发明专利

CA2351693A1 SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS 未知
公开(公告)号：CA2351693A1
公开(公告)日：2000-06-02
申请号：CA2351693
申请日：1999-11-18
申请人： SCHERING CORP
发明人： CASEY MICHAEL , BERNARD CHARLES F , CHEN FRANK XING , GROGAN DENISE C , WILLIAMS ROBERT P , POIRIER MARC , WONG YEE-SHING , WU GEORGE G
IPC分类号： C07D213/75 , C07D221/16 , C07D213/81
摘要： A process for preparing a compound having formula (I) by (A) reacting a compound having formula (II), wherein R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having formula (IIa); and (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). The imines and a process for preparing a compound having formul a (III) are disclosed.

65. 发明专利

ZA985207B Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds 未知
公开(公告)号：ZA985207B
公开(公告)日：1999-04-07
申请号：ZA985207
申请日：1998-06-15
申请人： SCHERING CORP
发明人： CHEN XING , POIRIER MARC , WONG YEE-SHING , WU GUANG-ZHONG
IPC分类号： C07D401/04 , C07D
摘要： The invention relates to a process for preparing a compound of the formula I comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR5R6 to obtain an amide; (b) reacting the amide with a compound of formula 3 3 in the presence of a strong base to obtain a compound of formula 4 4 (c) converting a compound of formula 4 to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula 7a or 7b, respectively: 7a 7b (e) cyclizing a compound of formula 7a or 7b; wherein R1-R7 are as defined in the specification.

66. 发明专利

AU8056898A Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds 未知
公开(公告)号：AU8056898A
公开(公告)日：1999-01-04
申请号：AU8056898
申请日：1998-06-15
申请人： SCHERING CORP
发明人： CHEN XING , POIRIER MARC , WONG YEE-SHING , WU GUANG-ZHONG
IPC分类号： C07D401/04 , C07D401/12
摘要： The invention relates to a process for preparing a compound of the formula I comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR5R6 to obtain an amide; (b) reacting the amide with a compound of formula 3 3 in the presence of a strong base to obtain a compound of formula 4 4 (c) converting a compound of formula 4 to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula 7a or 7b, respectively: 7a 7b (e) cyclizing a compound of formula 7a or 7b; wherein R1-R7 are as defined in the specification.

67. 发明专利

ES2412981T3 Síntesis exo- y diastereo-selectiva de análogos de himbacina 未知
公开(公告)号：ES2412981T3
公开(公告)日：2013-07-15
申请号：ES10001846
申请日：2006-01-12
申请人： SCHERING CORP , MERCK SHARP & DOHME
发明人： WU GEORGE G , SUDHAKAR ANANTHA , WANG TAO , XIE JI , CHEN FRANK XING , POIRIER MARC , HUANG MINGSHENG , SABESEN VIJAY , KWOK DAW-LONG , CUI JIAN , YANG XIAOJING , THIRUVENGADAM TIRUVETTIPURAM K , LIAO JING
IPC分类号： C07F9/58
摘要： procedimiento de preparación del Compuesto 16:**Fórmula** comprendiendo dicho procedimiento las etapas de: **Fórmula** (a) tratar N-óxido de 5-bromo-2-metilpiridina con un anhídrido para producir el Compuesto 35:**Fórmula** (b) tratar el Compuesto 35 con un alcohol a temperatura elevada para producir el Compuesto 36:**Fórmula** (c) tratar el Compuesto 36 con un reactivo con grupo saliente para producir el Compuesto 37: **Fórmula** (d) tratar el Compuesto 37 con un reactivo fosfito para producir el Compuesto 38 o una sal del mismo:**Fórmula**

68. 发明专利

AT533748T 未知
公开(公告)号：AT533748T
公开(公告)日：2011-12-15
申请号：AT10001106
申请日：2003-10-01
申请人： SCHERING CORP
发明人： CHEN FRANK X , WONG YEE-SHING , ECKERT JEFFREY M , ZOU NANFEI , LIANG FENG , KIM-MEADE AGNES S , POIRIER MARC , THIRUVENGADAM TIRUVETTIPURAM K , WU GEORGE G
IPC分类号： C07D221/16 , C07D401/14
摘要： A process for the preparation of a compound represented by formula I is disclosed.

69. 发明专利

AT530516T 未知
公开(公告)号：AT530516T
公开(公告)日：2011-11-15
申请号：AT10001844
申请日：2006-01-12
申请人： SCHERING CORP
发明人： WU GEORGE G , SUDHAKAR ANANTHA , WANG TAO , XIE JI , CHEN FRANK XING , POIRIER MARC , HUANG MINGSHENG , SABESEN VIJAY , KWOK DAW-LONG , CUI JIAN , YANG XIAOJING , THIRUVENGADAM TIRUVETTIPURAM K , LIAO JING
IPC分类号： C07C205/55 , C07C205/44 , C07C309/08
摘要： This application discloses compounds which are useful in the preparation of himbacine analogs as well as processes for their preparation:

70. 发明专利

CA2768838A1 ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES 未知
公开(公告)号：CA2768838A1
公开(公告)日：2011-02-03
申请号：CA2768838
申请日：2010-07-27
申请人： SCHERING CORP
发明人： TRAVERSE JOHN , LEONG WILLIAM W , MILLER STEVEN P , ALBANEZE-WALKER JENNIFER , HUNTER THOMAS J , WANG LIJUN , LIAO HONGBIAO , ARASAPPAN ASHOK , TRZASKA SCOTT T , SMITH RANDI M , LEKHAL AZZEDDINE , BOGEN STEPHANE L , KONG JIANSHE , BENNETT FRANK , NJOROGE F GEORGE , POIRIER MARC , KUO SHEN-CHUN , CHEN YONGGANG , MATTHEWS KENNETH S , DEMONCHAUX PATRICE , FERREIRA AMADEO
IPC分类号： C07C315/00 , C07C237/02 , C07D209/52 , C07K5/06
摘要： Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.

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