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61. 发明申请

US20110034448A1 CARBONIC ANHYDRASE INHIBITOR SUSTAINED RELEASE INTRAOCULAR DRUG DELIVERY SYSTEMS 有权
标题翻译：碳氢化合物抑制剂持续释放室内药物输送系统
公开(公告)号：US20110034448A1
公开(公告)日：2011-02-10
申请号：US11931769
申请日：2007-10-31
申请人： James N. Chang , Patrick M. Hughes , Gerald W. Devries
发明人： James N. Chang , Patrick M. Hughes , Gerald W. Devries
IPC分类号： A61K31/433 , A61P27/02 , A61P27/06 , A61P9/10 , A61K31/542 , A61K31/382 , A61P29/00
CPC分类号： A61K9/0051 , A61F9/0008 , A61K48/0041
摘要： Biocompatible intraocular drug delivery systems include a carbonic anhydrase inhibitor therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three dimensional structure when released into an eye of a patient, or the therapeutic agent may have an altered three. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others.
摘要翻译：生物相容性眼内药物递送系统包括碳酸酐酶抑制剂治疗剂和植入物，微粒，多种植入物或微粒形式的聚合物组分及其组合。治疗剂以生物活性形式释放，例如，当释放到患者的眼睛中时，治疗剂可以保持其三维结构，或者治疗剂可以具有改变的三种。植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变等。

62. 发明授权

US07714024B2 Compositions and methods for the intraocular transport of therapeutic agents 有权
标题翻译：治疗剂眼内运输的组合物和方法
公开(公告)号：US07714024B2
公开(公告)日：2010-05-11
申请号：US11521872
申请日：2006-09-15
申请人： Patrick M. Hughes , Orest Olejnik , Joan-En Chang-Lin
发明人： Patrick M. Hughes , Orest Olejnik , Joan-En Chang-Lin
IPC分类号： A61K31/201 , A61K38/04
CPC分类号： A61K31/557 , A61K9/0048 , A61K31/498 , A61K31/513 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/551 , A61K47/64
摘要： Membrane transporter-targeted therapeutic agents and methods of making and using the same.
摘要翻译：膜转运体靶向治疗剂及其制备和使用方法。

63. 发明申请

US20090197847A1 Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods 审中-公开
公开(公告)号：US20090197847A1
公开(公告)日：2009-08-06
申请号：US12288886
申请日：2008-10-24
申请人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
发明人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
IPC分类号： A61K31/58
CPC分类号： A61K9/0048 , A61K31/573 , A61K47/36 , A61K47/40
摘要： Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in amounts effective in providing a desired therapeutic effect when placed in an eye, and one or more retinal friendly excipients that have a reduced toxicity relative to benzyl alcohol or polysorbate 80. In certain compositions, the excipient component of the compositions comprises one or more cyclodextrins or cyclodextrin derivatives. Methods of using the compositions to treat ocular conditions are also described.

64. 发明申请

US20080131372A1 SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION 有权
标题翻译：可持续释放内镜植入物和预防后遗症的方法
公开(公告)号：US20080131372A1
公开(公告)日：2008-06-05
申请号：US11927615
申请日：2007-10-29
申请人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
发明人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
IPC分类号： A61K31/498 , A61P27/16
CPC分类号： A61K31/498 , A61K9/0051 , A61K47/34
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

65. 发明申请

US20070238732A1 BRIMONIDINE AND TIMOLOL COMPOSITIONS 审中-公开
标题翻译：二氢INE嗪和槲皮素组合物
公开(公告)号：US20070238732A1
公开(公告)日：2007-10-11
申请号：US11681150
申请日：2007-03-01
申请人： Richard Graham , Rhett M. Schiffman , Brent A. Johnson , Patrick M. Hughes
发明人： Richard Graham , Rhett M. Schiffman , Brent A. Johnson , Patrick M. Hughes
IPC分类号： A61K31/5377 , A61K31/4164
CPC分类号： A61K9/0048 , A61K31/4164 , A61K31/498 , A61K31/535 , A61K31/5377 , A61K2300/00
摘要： Disclosed herein are compositions comprising brimonidine and timolol. Methods and medicaments related thereto are also disclosed.
摘要翻译：本文公开了包含溴莫尼定和噻吗洛尔的组合物。还公开了与之相关的方法和药物。

66. 发明授权

US07179482B2 Implant device with a retinoid for improved biocompatibility 有权
标题翻译：具有类视黄醇的植入装置，用于改善生物相容性
公开(公告)号：US07179482B2
公开(公告)日：2007-02-20
申请号：US10853401
申请日：2004-05-24
申请人： Orest Olejnik , Patrick M. Hughes , John S. Kent
发明人： Orest Olejnik , Patrick M. Hughes , John S. Kent
IPC分类号： A61F2/02 , A61F2/14 , A61F2/28
CPC分类号： A61L27/18 , A61K9/0051 , A61K31/07 , A61K31/192 , A61K31/455 , A61L27/54 , A61L2300/428 , A61L2300/442 , A61L2300/604 , Y10S514/953 , C08L67/04
摘要： An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.
摘要翻译：提供了一种植入装置，其包含用于改善组织中装置的生物相容性的类视黄醇。为了系统地或局部地释放组织中的治疗剂，该装置可以是生物腐蚀的，或者它可以是永久性植入物，其包括用类视黄醇处理以增加其生物相容性的表面。

67. 发明授权

US06743437B2 Implant device with a retinoid for improved biocompatibility 失效
标题翻译：具有类视黄醇的植入装置，用于改善生物相容性
公开(公告)号：US06743437B2
公开(公告)日：2004-06-01
申请号：US10396179
申请日：2003-03-24
申请人： Orest Olejnik , Patrick M. Hughes , John S. Kent
发明人： Orest Olejnik , Patrick M. Hughes , John S. Kent
IPC分类号： A61F200
CPC分类号： A61L27/18 , A61K9/0051 , A61K31/07 , A61K31/192 , A61K31/455 , A61L27/54 , A61L2300/428 , A61L2300/442 , A61L2300/604 , Y10S514/953 , C08L67/04
摘要： An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.
摘要翻译：提供了一种植入装置，其包含用于改善组织中装置的生物相容性的类视黄醇。为了系统地或局部地释放组织中的治疗剂，该装置可以是生物腐蚀的，或者它可以是永久性植入物，其包括用类视黄醇处理以增加其生物相容性的表面。

68. 发明授权

US5581600A Service platform 失效
标题翻译：服务平台
公开(公告)号：US5581600A
公开(公告)日：1996-12-03
申请号：US211161
申请日：1994-03-21
申请人： Martin O. Watts , Dave M. Elliston , Patrick M. Hughes , Nicholas J. A. Forse
发明人： Martin O. Watts , Dave M. Elliston , Patrick M. Hughes , Nicholas J. A. Forse
IPC分类号： H04M3/42 , H04M20060101 , H04M3/493 , H04Q3/00 , H04M3/50
CPC分类号： H04M3/493 , H04Q3/0029 , H04Q3/0062 , H04M2201/40 , H04M2201/60
摘要： A service platform for the provision of automated speech based services over a telephone network comprises a speech processor including associated memory, to provide at least one of speech recognition, speaker recognition, speaker verification, speech synthesis; line interface means for terminating a number of telephony channels of the network; a speech bus to carry speech signals between the line interface means and the speech processor; a control processor to control the routing of speech signals over the speech bus; a control bus connecting the control means with the speech processor and the line interface; a separate memory holding speech processing software; and a data link connecting the memory means with the speech processing means and operable to load programs into the speech processor during rum time in the event that the appropriate software does not exist on the speech processor in a free state.
摘要翻译： PCT No.PCT / GB93 / 01273 Sec。 371日期1994年3月21日 102（e）1994年3月21日PCT提交1993年6月15日PCT公布。公开号WO93 / 26113 日期1993年12月23日用于通过电话网络提供自动基于语音的服务的服务平台包括包括相关联的存储器的语音处理器，以提供语音识别，说话者识别，说话者验证，语音合成中的至少一个; 线路接口装置，用于终止网络的多个电话信道; 语音总线，用于在线路接口装置和语音处理器之间携带语音信号; 控制处理器，用于通过语音总线控制语音信号的路由; 连接控制装置与语音处理器和线路接口的控制总线; 独立的存储语音处理软件; 以及数据链路，其将存储器装置与语音处理装置连接，并且可操作以在朗读时间期间将程序加载到语音处理器中，在适当的软件在语音处理器中不存在于空闲状态的情况下。

69. 发明授权

US5486971A Central hubs for flexible magnetic data discs formed of magnetically soft polyacetal compositions 失效
标题翻译：用于软质聚缩醛组合物形成的柔性磁数据盘的中心毂
公开(公告)号：US5486971A
公开(公告)日：1996-01-23
申请号：US996333
申请日：1992-12-23
申请人： Patrick M. Hughes
发明人： Patrick M. Hughes
IPC分类号： G11B23/00 , G11B23/03 , G11B23/113
CPC分类号： G11B23/0312 , G11B23/0035
摘要： Flexible sheet-like magnetic discs (so-called 37 floppy discs") are provided with a central hub formed of a magnetically soft polyacetal composition. The polyacetal composition necessarily includes a polyacetal resin and elemental iron particles homogeneously dispersed throughout the polyacetal resin in an amount sufficient to impart the desired soft magnetic properties to the inherently nonmagnetic polyacetal base resin. The polyacetal compositions of this invention are injection-moldable so that central hubs for flexible magnetic discs can be rapidly and economically produced.
摘要翻译：柔性片状磁盘（所谓的37软盘）具有由软质聚缩醛组合物形成的中心毂，该聚缩醛组合物必须包含均匀分散在整个聚缩醛树脂中的聚缩醛树脂和元素铁颗粒，足以赋予固有的非磁性聚缩醛基础树脂所需的软磁性能。本发明的聚缩醛组合物是可注射成型的，使得可以快速和经济地制造用于柔性磁盘的中心毂。

70. 发明授权

US5214555A Central hubs for flexible magnetic data discs formed of magnetically soft polyacetal compositions 失效
标题翻译：用于形成磁性软质聚合物组合物的柔性磁数据盘的中心波
公开(公告)号：US5214555A
公开(公告)日：1993-05-25
申请号：US683953
申请日：1991-04-12
申请人： Patrick M. Hughes
发明人： Patrick M. Hughes
IPC分类号： G11B23/00 , G11B23/03 , G11B23/113
CPC分类号： G11B23/0312 , G11B23/0035
摘要： Flexible sheet-like magnetic discs (so-called "floppy discs") are provided with a central hub formed of a magnetically soft polyacetal composition. The polyacetal composition necessarily includes a polyacetal resin and elemental iron particles homogeneously dispersed throughout the polyacetal resin in an amount sufficient to impart the desired soft magnetic properties to the inherently nonmagnetic polyacetal base resin. The polyacetal compositions of this invention are injection-moldable so that central hubs for flexible magnetic discs can be rapidly and economically produced.

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