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61. 发明申请

US20080262582A1 IMPLANTABLE MEDICAL ELECTRICAL LEAD AND CONNECTOR ASSEMBLY 有权
标题翻译：可植入医用电线和连接器总成
公开(公告)号：US20080262582A1
公开(公告)日：2008-10-23
申请号：US11737927
申请日：2007-04-20
申请人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
发明人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
IPC分类号： A61N1/05 , H02H3/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3752 , A61N2001/083
摘要： An implantable system that includes a lead and an implantable signal generator wherein the plurality of electrical contacts and the plurality of insulating regions on the lead, and the plurality of electrical connectors and the plurality of electrical insulators in the connector block are configured so that each of the plurality of electrical contacts form operable connections to the electronic circuitry through each of the plurality of electrical connector, and the insulating regions and the electrical insulators electrically isolate adjacent operable connections. Leads, and methods are also disclosed.
摘要翻译：一种包括引线和可植入信号发生器的可植入系统，其中所述多个电触点和所述引线上的所述多个绝缘区域以及所述连接器块中的所述多个电连接器和所述多个绝缘体被配置为使得每个多个电触头通过多个电连接器中的每一个形成与电子电路的可操作连接，并且绝缘区域和电绝缘体电隔离相邻的可操作连接。引线和方法也被公开。

62. 发明申请

US20070203545A1 User interface with 3D environment for configuring stimulation therapy 有权
标题翻译：用户界面与3D环境配置刺激疗法
公开(公告)号：US20070203545A1
公开(公告)日：2007-08-30
申请号：US11591281
申请日：2006-10-31
申请人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
发明人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/3605 , A61N1/3606 , A61N1/36082 , A61N1/36125 , A61N1/36146 , A61N1/36153 , A61N1/36157 , A61N1/36192 , G06F3/04815 , G06F3/04817 , G06F3/0482 , G06F19/00 , G06F19/321 , G06F19/325 , G16H50/50
摘要： The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient.
摘要翻译：本公开描述了允许用户通过定义三维（3D）刺激场来配置电刺激治疗的方法和系统。在将刺激引线植入患者体内之后，临床医生操纵3D环境中的3D刺激场以包围病人的所需解剖区域。以这种方式，临床医生确定要刺激的解剖区域，并且系统产生必需的刺激参数。在一些情况下，显示代表植入引线的引线图标，以显示临床医生铅的相对于患者的3D解剖区域。

63. 发明申请

US20070203543A1 Stimulation templates for configuring stimulation therapy 有权
标题翻译：用于配置刺激疗法的刺激模板
公开(公告)号：US20070203543A1
公开(公告)日：2007-08-30
申请号：US11591193
申请日：2006-10-31
申请人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
发明人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36071
摘要： The disclosure describes a method and system that generates stimulation parameters by selecting one or more stimulation parameters according to a stimulation field defined by a user. The system includes a memory that stores a plurality of stimulation templates for multiple electrode configurations of an electrical lead. A processor selects one or more volumetric stimulation templates that best match, e.g., fill, the three-dimensional stimulation field defined by the clinician. Each stimulation template is associated with a set of stimulation parameters that can be used to deliver stimulation therapy to a patient.
摘要翻译：本公开描述了通过根据用户定义的刺激字段选择一个或多个刺激参数来生成刺激参数的方法和系统。该系统包括存储多个用于电引线的多个电极配置的刺激模板的存储器。处理器选择一个或多个与临床医生定义的三维刺激场最匹配，例如填充的体积刺激模板。每个刺激模板与可用于向患者递送刺激疗法的一组刺激参数相关联。

64. 发明申请

US20070203540A1 Electrical and activation field models for programming a stimulation lead with complex electrode array geometry 有权
标题翻译：用于通过复杂电极阵列几何编程刺激引线的电和激活场模型
公开(公告)号：US20070203540A1
公开(公告)日：2007-08-30
申请号：US11591187
申请日：2006-10-31
申请人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
发明人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. A programmer is configured to generate an electrical field model from selected stimulation parameters and patient anatomy data. The electrical field model indicates how the electrical field propagation would occur in the patient during therapy. In addition, the programmer may be configured to generate an activation field model from the electrical field model and a neuron model. The activation field indicates which neurons within the electrical field will be activated during the therapy. Either of these field models may be presented to the user via a user interface that also displays a representation of the lead implanted within the patient. The user interface may allow the user to adjust the stimulation therapy by manipulating displayed field or activation model representations.
摘要翻译：本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。编程器被配置为从所选择的刺激参数和患者解剖数据生成电场模型。电场模型指示治疗期间患者的电场传播如何发生。此外，程序员可以被配置为从电场模型和神经元模型生成激活场模型。激活区域指示在治疗期间电场内的哪些神经元将被激活。这些现场模型中的任何一个可以经由还显示植入患者体内的引线的表示的用户界面呈现给用户。用户界面可以允许用户通过操纵显示的场或激活模型表示来调整刺激疗法。

65. 发明申请

US20070203538A1 User interface with an atlas for configuring stimulation therapy 审中-公开
标题翻译：用户界面，用于配置刺激疗法的图集
公开(公告)号：US20070203538A1
公开(公告)日：2007-08-30
申请号：US11591176
申请日：2006-10-31
申请人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
发明人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
IPC分类号： A61N1/00
CPC分类号： A61N1/37247
摘要： The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by selecting a structure of an anatomical region represented by an atlas. The atlas is a reference anatomical region of a reference anatomy that a clinician may use to identify structures of a patient anatomy that the clinician desires to stimulate during therapy. Selecting structures from the atlas may not provide the most efficacious stimulation therapy to the patient because of slight differences between the atlas and the patient anatomical region approximated by the atlas. However, structure selection may be efficient for the clinician, and allow the system to generate stimulation parameters that are adequate to treat the patient. The atlas may be most suitable for both axi-symmetric or three-dimensional leads having a complex electrode array geometry that allow greater flexibility in creating stimulation fields.
摘要翻译：本公开描述了允许用户通过选择由图集表示的解剖区域的结构来配置电刺激治疗的方法和系统。图谱是参考解剖结构的参考解剖区域，临床医生可以用来识别临床医生期望在治疗期间刺激的患者解剖结构。从图集中选择结构可能不能为患者提供最有效的刺激疗法，因为图集和由图集近似的患者解剖区域之间的轻微差异。然而，结构选择对于临床医生来说可能是有效的，并且允许系统产生足以治疗患者的刺激参数。图谱可能最适合于具有复杂电极阵列几何形状的轴对称或三维引线，从而允许创建刺激场的更大灵活性。

66. 发明授权

US08478421B2 Medical device electrical lead design for preventing transmittance of unsafe currents to a patient 有权
标题翻译：医疗器械电气引线设计，用于防止不安全电流对患者的透射
公开(公告)号：US08478421B2
公开(公告)日：2013-07-02
申请号：US12709224
申请日：2010-02-19
申请人： Richard T. Stone
发明人： Richard T. Stone
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61B2090/0481 , A61N1/0534 , A61N1/0551 , A61N1/056 , A61N1/086
摘要： An electrical lead including a conductor assembly, an electrode, and a thermally sensitive material. The conductor assembly has one or more conductors. The electrode is in electrical communication with one of the conductors and has an outer contact adapted for contacting adjacent body tissue of a patient. The thermally sensitive material is electrically connected between the one conductor and the electrode outer contact, and is configured to exhibit high impedance in the presence of currents considered unsafe to the patient, thereby preventing the unsafe currents from flowing through the thermally sensitive material and through the electrode outer contact potentially causing the adjacent body tissue to increase in temperature to an unsafe level. The unsafe currents cause the thermally sensitive material to increase in temperature, thereby causing the material to transition to a high impedance state.
摘要翻译：包括导体组件，电极和热敏材料的电引线。导体组件具有一个或多个导体。电极与导体中的一个电连通，并且具有适于接触患者的相邻身体组织的外部接触。感热材料电连接在一个导体和电极外触点之间，并且被配置为在存在被认为对患者不安全的电流的情况下呈现高阻抗，由此防止不安全电流流过热敏材料并通过电极外部接触可能导致相邻的身体组织将温度升高到不安全的水平。不安全的电流导致热敏材料的温度升高，从而导致材料转变到高阻抗状态。

67. 发明授权

US08433422B2 Implantable medical electrical lead and connector assembly 有权
标题翻译：可植入医用电线和连接器组件
公开(公告)号：US08433422B2
公开(公告)日：2013-04-30
申请号：US11737927
申请日：2007-04-20
申请人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
发明人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3752 , A61N2001/083
摘要： An implantable system that includes a lead and an implantable signal generator wherein the plurality of electrical contacts and the plurality of insulating regions on the lead, and the plurality of electrical connectors and the plurality of electrical insulators in the connector block are configured so that each of the plurality of electrical contacts form operable connections to the electronic circuitry through each of the plurality of electrical connector, and the insulating regions and the electrical insulators electrically isolate adjacent operable connections. Leads, and methods are also disclosed.
摘要翻译：一种包括引线和可植入信号发生器的可植入系统，其中所述多个电触点和所述引线上的所述多个绝缘区域以及所述连接器块中的所述多个电连接器和所述多个绝缘体被配置为使得每个多个电触头通过多个电连接器中的每一个形成与电子电路的可操作连接，并且绝缘区域和电绝缘体电隔离相邻的可操作连接。引线和方法也被公开。

68. 发明授权

US08380321B2 Programming interface with a cross-sectional view of a stimulation lead with complex electrode array geometry 有权
标题翻译：具有复杂电极阵列几何形状的刺激引线横截面视图的编程界面
公开(公告)号：US08380321B2
公开(公告)日：2013-02-19
申请号：US11591188
申请日：2006-10-31
申请人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
发明人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
IPC分类号： A61N1/08
CPC分类号： A61N1/0534 , A61N1/36071 , A61N1/36157 , A61N1/36185 , A61N1/37247
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. The disclosure also contemplates guided programming to select electrode combinations and parameter values to support efficacy. The techniques may be applied to a programming interface associated with a clinician programmer, a patient programmer, or both. A user interface permits a user to view electrodes from different perspectives relative to the lead. For example, the user interface provides a side view of a lead and a cross-sectional view of the lead. The user interface may include an axial control medium to select and/or view electrodes at different axial positions along the length of a lead, and a rotational control medium to select and/or view electrodes at different angular positions around a circumference of the lead.
摘要翻译：本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。本公开还考虑了引导编程以选择电极组合和参数值以支持功效。这些技术可以应用于与临床医生程序员，患者程序员或两者相关联的编程接口。用户界面允许用户从相对于铅的不同角度来观察电极。例如，用户界面提供引线的侧视图和引线的横截面图。用户界面可以包括轴向控制介质，用于选择和/或查看沿引线长度的不同轴向位置处的电极;以及旋转控制介质，用于选择和/或查看围绕引线圆周的不同角位置处的电极。

69. 发明授权

US07711436B2 Medical device electrical lead design for preventing transmittance of unsafe currents to a patient 有权
标题翻译：医疗器械电气引线设计，用于防止不安全电流对患者的透射
公开(公告)号：US07711436B2
公开(公告)日：2010-05-04
申请号：US11739386
申请日：2007-04-24
申请人： Richard T. Stone
发明人： Richard T. Stone
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61B2090/0481 , A61N1/0534 , A61N1/0551 , A61N1/056 , A61N1/086
摘要： An electrical lead including a conductor assembly, an electrode, and a thermally sensitive material. The conductor assembly has one or more conductors. The electrode is in electrical communication with one of the conductors and has an outer contact adapted for contacting adjacent body tissue of a patient. The thermally sensitive material is electrically connected between the one conductor and the electrode outer contact, and is configured to exhibit high impedance in the presence of currents considered unsafe to the patient, thereby preventing the unsafe currents from flowing through the thermally sensitive material and through the electrode outer contact potentially causing the adjacent body tissue to increase in temperature to an unsafe level. The unsafe currents cause the thermally sensitive material to increase in temperature, thereby causing the material to transition to a high impedance state.
摘要翻译：包括导体组件，电极和热敏材料的电引线。导体组件具有一个或多个导体。电极与导体中的一个电连通，并且具有适于接触患者的相邻身体组织的外部接触。感热材料电连接在一个导体和电极外触点之间，并且被配置为在存在被认为对患者不安全的电流的情况下呈现高阻抗，由此防止不安全电流流过热敏材料并通过电极外部接触可能导致相邻的身体组织将温度升高到不安全的水平。不安全的电流导致热敏材料的温度升高，从而导致材料转变到高阻抗状态。

70. 发明申请

US20090264789A1 THERAPY PROGRAM SELECTION 审中-公开
标题翻译：治疗方案选择
公开(公告)号：US20090264789A1
公开(公告)日：2009-10-22
申请号：US12431167
申请日：2009-04-28
申请人： Gregory F. Molnar , Richard T. Stone , Xuan Wei
发明人： Gregory F. Molnar , Richard T. Stone , Xuan Wei
IPC分类号： A61B5/0476 , A61M31/00 , A61N1/08 , A61B5/11 , G10L15/00
CPC分类号： A61N1/36135 , A61N1/36542 , A61N1/36585 , A61N1/37
摘要： A set of therapy parameter values is selected based on a patient state, where the patient state comprises a speech state or a mixed patient state including the speech state and at least one of a movement state or a sleep state. In this way, therapy delivery is tailored to the patient state, which may include one or more patient symptoms specific to the patient state. In some examples, a medical device determines whether the patient is in the speech state or a mixed patient state including the speech state based on a signal generated by a voice activity sensor. The voice activity sensor detects the use of the patient's voice, and may include a microphone, a vibration detector or an accelerometer.
摘要翻译：基于患者状态选择一组治疗参数值，其中患者状态包括语音状态或包括语音状态和运动状态或睡眠状态中的至少一个的混合患者状态。以这种方式，治疗递送适合于患者状态，其可以包括对患者状态特异的一个或多个患者症状。在一些示例中，医疗设备基于由语音活动传感器生成的信号来确定患者是处于语音状态还是包括语音状态的混合患者状态。语音活动传感器检测患者声音的使用，并且可以包括麦克风，振动检测器或加速度计。

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