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61. 发明授权

US08814845B2 Delivery of biological compounds to ischemic and/or infarcted tissue 有权
标题翻译：向缺血和/或梗死组织递送生物化合物
公开(公告)号：US08814845B2
公开(公告)日：2014-08-26
申请号：US13365914
申请日：2012-02-03
申请人： Vahid Saadat , Sekhar S. Rao
发明人： Vahid Saadat , Sekhar S. Rao
IPC分类号： A61M31/00
CPC分类号： A61B1/00165 , A61B1/00089 , A61B1/00096 , A61B1/00147 , A61B1/015 , A61B1/05 , A61B1/12 , A61B5/0084 , A61B5/6882 , A61B5/7282 , A61M25/0074 , A61M25/0082 , A61M25/0084
摘要： The delivery of biological compounds to ischemic and/or infarcted tissue are described herein where such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for identifying, locating, and/or accessing ischemic and/or infarcted tissue.
摘要翻译：在本文中描述了将生物化合物递送至缺血和/或梗死组织，其中这样的系统可以包括展开导管和可展开成扩展构型的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。此外，任何数量的治疗工具也可以通过展开导管并进入成像罩，以在组织上执行任何数量的程序，用于识别，定位和/或获取缺血和/或梗死组织。

62. 发明授权

US08588447B2 Methods and apparatus for transmitting vibrations 有权
公开(公告)号：US08588447B2
公开(公告)日：2013-11-19
申请号：US13551158
申请日：2012-07-17
申请人： Amir A. Abolfathi , Vahid Saadat , Loc X. Phan
发明人： Amir A. Abolfathi , Vahid Saadat , Loc X. Phan
IPC分类号： H04R25/00
CPC分类号： H04R25/606 , A61C5/00 , A61C8/0093 , A61C8/0098 , B33Y70/00 , B33Y80/00 , H04R1/46 , H04R3/04 , H04R25/554 , H04R25/602 , H04R25/604 , H04R2225/31 , H04R2225/67 , H04R2420/07 , H04R2460/01 , H04R2460/13
摘要： Methods and apparatus for transmitting vibrations via an electronic and/or transducer assembly through a tooth or teeth are disclosed herein. The assembly may be attached, adhered, or otherwise embedded into or upon a removable oral appliance to form a hearing aid assembly. Such an oral appliance may be a custom-made device. The electronic and transducer assembly may receive incoming sounds either directly or through a receiver to process and amplify the signals and transmit the processed sounds via a vibrating transducer element coupled to a tooth or other bone structure, such as the maxillary, mandibular, or palatine bone structure.

63. 发明申请

US20120296348A1 APPARATUS FOR MANIPULATING AND SECURING TISSUE 有权
标题翻译：用于操作和安全组织的装置
公开(公告)号：US20120296348A1
公开(公告)日：2012-11-22
申请号：US13491273
申请日：2012-06-07
申请人： Vahid Saadat , Richard C. Ewers , Cang C. Laduca , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Cang C. Laduca , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
IPC分类号： A61B17/04
CPC分类号： A61F5/0086 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/12013 , A61B17/1285 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably dispose through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置。在组织折叠在患者身体内部时，组织操作组件通常可以具有细长的管状构件，可滑动地配置穿过管状构件的接合构件和适于经由螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

64. 发明授权

US08257394B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08257394B2
公开(公告)日：2012-09-04
申请号：US11036866
申请日：2005-01-14
申请人： Vahid Saadat , Marvin C. Elmer
发明人： Vahid Saadat , Marvin C. Elmer
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00818 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0441 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism, either within the anchor itself or positioned proximally of the anchor, may allow for the uni-directional translation of the anchor while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates cinching of the tissue plication between the anchors, and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。在锚固件本身内或定位在近端处的锁定机构可以允许锚固件的单向平移，同时使锚固件被锁定在缝合线上，如果锚被拉动，推动或以其他方式被推入沿缝合方向相反。这种单向锚定锁定机构有助于锚定器之间的组织褶皱的收缩，并且可以在一个或多个锚定器中用于收紧组织褶皱。

65. 发明授权

US08216252B2 Tissue manipulation and securement system 有权
标题翻译：组织操纵和固定系统
公开(公告)号：US08216252B2
公开(公告)日：2012-07-10
申请号：US11070863
申请日：2005-03-01
申请人： Robert A. Vaughan , Cang C. Lam , Richard C. Ewers , Vahid Saadat
发明人： Robert A. Vaughan , Cang C. Lam , Richard C. Ewers , Vahid Saadat
IPC分类号： A61B17/08
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/06066 , A61B17/29 , A61B2017/00278 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/2923 , A61B2017/2927 , A61B2017/3488
摘要： Tissue manipulation and securement systems are described herein. A tissue manipulation assembly is pivotably coupled to the distal end of a tubular member and has a lower jaw member and an upper jaw member pivotably coupled to the lower jaw member. A reconfigurable launch tube is also pivotably coupled to the upper jaw member and is used to urge the jaw members from a low-profile configuration to an open configuration for receiving tissue. The tissue manipulation assembly may be advanced through a shape-lockable endoscopic device, a conventional endoscope, or directly by itself into a patient. A second tool can be used in combination with the tissue manipulation assembly to engage tissue and manipulate the tissue in conjunction with the tissue manipulation assembly.
摘要翻译：本文描述了组织操纵和固定系统。组织操作组件可枢转地联接到管状构件的远端，并且具有下颚构件和可枢转地联接到下颚构件的上颚构件。可重构的发射管也可枢转地联接到上钳口构件，并且用于将钳口构件从小轮廓构造推动到用于接收组织的打开构型。组织操作组件可以通过形状可锁定内窥镜装置，常规内窥镜，或者直接自身进入患者。第二工具可以与组织操作组件组合使用以接合组织并且与组织操作组件一起操作组织。

66. 发明授权

US08192435B2 Devices and methods for tissue modification 有权
标题翻译：组织修饰的装置和方法
公开(公告)号：US08192435B2
公开(公告)日：2012-06-05
申请号：US11251199
申请日：2005-10-15
申请人： Jeffery L. Bleich , Edwin J. Hlavka , Vahid Saadat , Steven A. Spisak , David R. Miller , James Yurchenco
发明人： Jeffery L. Bleich , Edwin J. Hlavka , Vahid Saadat , Steven A. Spisak , David R. Miller , James Yurchenco
IPC分类号： A61B17/00
CPC分类号： A61B17/320758 , A61B1/3135 , A61B17/149 , A61B17/1659 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/1477 , A61B18/1487 , A61B90/04 , A61B90/361 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/00907 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2017/3445 , A61B2017/3447 , A61B2018/1407 , A61B2018/1425 , A61B2090/061 , A61B2090/08021 , A61F2/0045 , A61N1/0551 , A61N1/36017
摘要： Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures. The current invention includes specific tools that enable safe tissue modification in epidural space, including a barrier that separates the area where tissue modification will take place from adjacent vulnerable neural and vascular structures. In one variation, a tissue abrasion device is provided including a thin belt or ribbon with an abrasive cutting surface. The device optionally may be placed within a protective sheath that exposes the abrasive surface of the ribbon only in the area where tissue removal is desired.
摘要翻译：提供了用于选择性手术去除组织的方法和装置，例如用于扩大患病的脊柱结构。本发明包括能够在硬膜外腔中进行安全组织修复的特定工具，包括将相邻易受伤的神经和血管结构发生组织修饰的区域分开的屏障。在一个实施例中，提供了一种组织磨损装置，其包括具有研磨切割表面的薄带或带。该装置可选择地放置在保护套内，仅在期望组织移除的区域中暴露带的研磨表面。

67. 发明申请

US20110098708A9 POWERED TISSUE MODIFICATION DEVICES AND METHODS 有权
标题翻译：动力组织修改装置和方法
公开(公告)号：US20110098708A9
公开(公告)日：2011-04-28
申请号：US11406486
申请日：2006-04-17
申请人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
发明人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
IPC分类号： A61B17/00
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.
摘要翻译：用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

68. 发明授权

US07758571B2 Methods and apparatus for cryo-therapy 有权
标题翻译：冷冻治疗方法和装置
公开(公告)号：US07758571B2
公开(公告)日：2010-07-20
申请号：US10494487
申请日：2002-11-01
申请人： Vahid Saadat
发明人： Vahid Saadat
IPC分类号： A61B18/02 , A61F7/12
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2017/00867 , A61B2017/22001 , A61B2017/22038 , A61B2017/22051 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Methods and apparatus for cryo-therapy are disclosed herein. This includes a hollow guidewire disposed within a catheter having helical loops contacting tissue. A coolant delivery tube disposed within can have a coolant delivered from a proximal end into the guidewire lumen. The coolant flows back proximally through the guidewire while cooling the guidewire surface and cooling or cryogenically ablating the contacting tissue. To minimize guidewire exposure to surrounding fluids or tissue, insulative barriers can be attached to the guidewire. A coolant delivery tube and return lumen can be integrated from a single extrusion in various configurations. Expandable balloons can also be used to expand the loops of the guidewire to contact the tissue. Also, helical loops with a coolant delivery tube or stem disposed longitudinally within the loops can be used and the loops can also have a variable collapsible cooling region.
摘要翻译：本文公开了用于冷冻治疗的方法和装置。这包括设置在具有螺旋环接触组织的导管内的中空导丝。设置在其内的冷却剂输送管可以具有从近端输送到导丝管内腔的冷却剂。冷却剂通过导丝向后流回，同时冷却导丝表面并冷却或低温地消融接触组织。为了尽量减少对周围流体或组织的导线暴露，绝缘屏障可以附着在导丝上。冷却剂输送管和返回腔可以以各种配置从单个挤出机集成。也可以使用可膨胀气球来扩展导丝的环以接触组织。此外，可以使用具有纵向设置在环内的冷却剂输送管或杆的螺旋环，并且环也可以具有可变的可折叠冷却区域。

69. 发明授权

US07736378B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US07736378B2
公开(公告)日：2010-06-15
申请号：US10841245
申请日：2004-05-07
申请人： Tracy D. Maahs , Richard C. Ewers , Jesus Flores , Alexander Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang C. Lam
发明人： Tracy D. Maahs , Richard C. Ewers , Jesus Flores , Alexander Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang C. Lam
IPC分类号： A61B17/04
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中用于收紧组织折叠。

70. 发明授权

US07695493B2 System for optimizing anchoring force 有权
标题翻译：优化锚固力的系统
公开(公告)号：US07695493B2
公开(公告)日：2010-04-13
申请号：US10865736
申请日：2004-06-09
申请人： Vahid Saadat , Richard C. Ewers , Tracy D. Maahs , Alexander Khairkhahan , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Tracy D. Maahs , Alexander Khairkhahan , Kenneth J. Michlitsch
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：这里描述了用于优化锚固力的系统。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

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