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61. 发明申请

US20050038023A1 Pyrazole compounds useful as protein kinase inhibitors 失效
标题翻译：用作蛋白激酶抑制剂的吡唑化合物
公开(公告)号：US20050038023A1
公开(公告)日：2005-02-17
申请号：US10632428
申请日：2003-08-01
申请人： David Bebbington , Jean-Damien Charrier , Julian Golec , Andrew Miller , Ronald Knegtel
发明人： David Bebbington , Jean-Damien Charrier , Julian Golec , Andrew Miller , Ronald Knegtel
IPC分类号： C12N9/99 , A61K20060101 , A61K31/435 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/00 , A61P20060101 , A61P1/00 , A61P3/08 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/18 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07D43/14
CPC分类号： C07D403/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula IIIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx, Ry, R2; and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译：本发明描述了式IIIa的新型吡唑化合物：其中R 1是T环D，其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R x，R y，R 2; 和R 2'如说明书中所述。这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。

62. 发明授权

US06586175B1 Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene 失效
标题翻译：对人类UDP-葡糖醛酸基转移酶2B7（UGT2B7）基因进行基因分型
公开(公告)号：US06586175B1
公开(公告)日：2003-07-01
申请号：US09356806
申请日：1999-07-20
申请人： Margaret Galvin , Andrew Miller , Laura Penny , Michael Riedy
发明人： Margaret Galvin , Andrew Miller , Laura Penny , Michael Riedy
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
摘要翻译：在改变UGT2B活性的人UGT2B4，UGT2B7和UGT2B15基因中鉴定遗传多态性。包含多态性序列的核酸用于筛选患者UGT2B底物改变的代谢，潜在的药物 - 药物相互作用以及不良/副作用，以及由环境或职业暴露于毒素引起的疾病。核酸用于建立用于药物代谢的动物，细胞和体外模型。

63. 发明授权

US6131817A Plastic card transport apparatus and inspection system 失效
标题翻译：塑胶卡运输仪器和检验系统
公开(公告)号：US6131817A
公开(公告)日：2000-10-17
申请号：US168856
申请日：1998-10-09
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： G06K13/07 , G06K13/00
CPC分类号： G06K13/07
摘要： A plastic card transport apparatus and a plastic card inspection system. A group of lower support wheels is positioned with their circumferential surfaces aligned to define a card transport path having a plurality of card operation locations therealong. The wheels support a plastic card by its lower edge as the plastic card is transported along the card transport path from a first one of the card operation locations to a second one of the card operation locations. A drive source continuously drives selected ones of the lower support wheels to move the plastic card along the card transport path between card operation locations. A controller is responsive to a control signal to drive a selected one of the lower support wheel members, adjacent a first one of the card operation locations, to move the plastic card along the card transport path from that first one of the card operation locations to an adjacent one of the continuously driven lower support wheels, to transport the plastic card to a second one of the card operation locations. The plastic card inspection system includes such a plastic card transport apparatus to transport the plastic cards from a plastic card input location to a plastic card inspection location for inspection, and then to a plastic card output location selected on the basis of the inspection results. The cards are discharged to a tray having a fiber material on its side surfaces to align the cards as they are discharged.
摘要翻译：塑料卡运输设备和塑料卡检查系统。一组下支撑轮定位成其周向表面对齐以限定其上具有多个卡操作位置的卡传送路径。当塑料卡沿着卡传送路径从卡操作位置中的第一个传送到卡操作位置的第二个时，轮由其下边缘支撑塑料卡。驱动源连续地驱动下支撑轮中的选定的一个以沿着卡操作位置之间的卡传送路径移动塑料卡。控制器响应于控制信号来驱动与所述卡操作位置中的第一个相邻的所述下支撑轮构件中的所选择的一个，以将所述塑料卡沿着所述卡传送路径从所述卡操作位置中的所述一个操作位置移动到连续驱动的下支撑轮中的相邻一个，以将塑料卡传送到卡操作位置中的第二个。塑料卡检查系统包括这样的塑料卡运输装置，用于将塑料卡从塑料卡输入位置运输到塑料卡检查位置进行检查，然后根据检查结果选择塑料卡输出位置。卡在其侧表面上被排出到具有纤维材料的托盘，以便在排出卡时对准卡。

64. 发明授权

US5460390A Sparking brake pad for in-line roller skates 失效
标题翻译：用于在线溜冰鞋的起动刹车片
公开(公告)号：US5460390A
公开(公告)日：1995-10-24
申请号：US167761
申请日：1993-11-18
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A63C17/14 , A63C17/26
CPC分类号： A63C17/26 , A63C17/1436 , A63C17/06 , A63C2203/14
摘要： A sparking brake pad for use with an in-line roller skate is disclosed. The brake pad consists of a material having a high coefficient of friction and a flame retardant compound. A spark emitter is disposed within the brake pad such that when the brake pad is urged against a road surface it will reduce the speed of a roller skater and produce a burst of sparks.
摘要翻译：公开了一种与在线溜冰鞋一起使用的火花刹车片。制动片由具有高摩擦系数的材料和阻燃化合物构成。火花发射器设置在制动衬块内，使得当刹车片被推向路面时，它将降低滚轴溜冰者的速度并产生一阵火花。

65. 发明申请

US20220279932A1 PORTABLE HEAD SUPPORT 有权
公开(公告)号：US20220279932A1
公开(公告)日：2022-09-08
申请号：US17826337
申请日：2022-05-27
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A47C16/00 , A47C7/38
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.

66. 发明申请

US20170273465A1 PORTABLE HEAD SUPPORT 审中-公开
公开(公告)号：US20170273465A1
公开(公告)日：2017-09-28
申请号：US15078704
申请日：2016-03-23
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A47C16/00
CPC分类号： A47C16/00 , A47C7/383
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.

67. 发明授权

US09610447B2 Systems and methods for selecting pacing vectors based on site of latest activation for use with implantable cardiac rhythm management devices 有权
公开(公告)号：US09610447B2
公开(公告)日：2017-04-04
申请号：US13436578
申请日：2012-03-30
申请人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
发明人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
IPC分类号： A61N1/36 , A61N1/368
CPC分类号： A61N1/3686
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped with a multi-pole left ventricular (LV) lead and a right ventricular (RV) lead for identifying suitable pacing vectors. In one example, RV-LV delay times are measured while using different electrodes of the LV lead as cathodes for sensing. The LV electrode having the longest RV-LV delay time is identified and LV capture thresholds and diaphragmatic stimulation thresholds are measured for pacing vectors that employ that LV electrode as a cathode. Assuming at least one vector employing the selected LV electrode is found to have acceptable thresholds, the vector is selected for use in delivering pacing therapy with the selected LV electrode. If none of the pacing vectors employing the selected LV electrode has acceptable thresholds, another LV electrode is selected and the procedure is repeated. Examples with a multi-pole RV lead are also described.

68. 发明授权

US09067932B2 Pyrazolopyridine kinase inhibitors 有权
标题翻译：吡唑并吡啶激酶抑制剂
公开(公告)号：US09067932B2
公开(公告)日：2015-06-30
申请号：US13014505
申请日：2011-01-26
申请人： Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
发明人： Dean Boyall , Guy Brenchley , Chris Davis , Damien Fraysse , Julian Golec , Juan-Miguel Jimenez , Andrew Miller , Luca Settimo , Heather Twin , Stephen Young
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496
摘要： The present invention relates to compounds of pyrazolopyridine derivatives useful as inhibitors of protein kinase. In one embodiment the compounds of the present invention are represented by the following structural formula: or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的吡唑并吡啶衍生物的化合物。在一个实施方案中，本发明的化合物由以下结构式表示：或其药学上可接受的盐。

69. 发明授权

US08712862B2 System and method for enabling image recognition and searching of remote content on display 有权
标题翻译：用于在显示器上启用图像识别和搜索远程内容的系统和方法
公开(公告)号：US08712862B2
公开(公告)日：2014-04-29
申请号：US13618653
申请日：2012-09-14
申请人： Salih Burak Gokturk , Dan Chiao , Jacquie Phillips , Mark Moran , Vincent Vanhoucke , Azhar Khan , Xiaofan Lin , Munjal Shah , Andrew Miller , Navneet Dalal , Diem Vu
发明人： Salih Burak Gokturk , Dan Chiao , Jacquie Phillips , Mark Moran , Vincent Vanhoucke , Azhar Khan , Xiaofan Lin , Munjal Shah , Andrew Miller , Navneet Dalal , Diem Vu
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0623 , G06F17/30256 , G06K9/62 , G06N99/005 , G06Q30/0625 , G06Q30/0643 , G06Q30/08
摘要： Images are analyzed by programmatic mechanisms for accessing one or more remote web pages to retrieve content on display at the remote web pages. The retrieved images may be analyzed to determine information about an object shown in a corresponding image of the content on display. At least a portion of the object shown in the corresponding image of the content on display may be made selectable and associated with the determined information. This determined information may subsequently be used, in for example, search applications.
摘要翻译：图像通过用于访问一个或多个远程网页的程序化机制来分析，以在远程网页上显示的内容。可以分析检索到的图像以确定关于显示在内容的相应图像中所示的对象的信息。所显示的内容的相应图像中所示的对象的至少一部分可以被选择并与所确定的信息相关联。随后可以在例如搜索应用中使用该确定的信息。

70. 发明申请

US20120321472A1 DIRECTIONALLY CONTROLLABLE FLYING VEHICLE AND A PROPELLER MECHANISM FOR ACCOMPLISHING THE SAME 失效
标题翻译：方向控制的飞行车辆和用于实现其的螺旋桨机构
公开(公告)号：US20120321472A1
公开(公告)日：2012-12-20
申请号：US13589286
申请日：2012-08-20
申请人： Steven Davis , Andrew Miller
发明人： Steven Davis , Andrew Miller
IPC分类号： B64C11/06 , F04D29/36
CPC分类号： A63H27/12 , A63H30/04
摘要： A flying vehicle in accordance to an embodiment of the present invention includes a main propeller and a propeller control mechanism for flying the vehicle. The main propeller includes a central base that permits the propeller control mechanism to be connected to the drive shaft. The propeller control mechanism includes a propeller hub and a lower hub with offset knobs that are connected by a link. A returning spring is sandwiched between the hubs and tends to return the hubs to the offset position when a change in a driving torque of the drive shaft causes them to move. The spring and link work in concert to change the pitch and height of the propeller blades while substantially unchanging the tip path plane of the propeller blades.
摘要翻译：根据本发明的实施例的飞行器包括用于使车辆飞行的主螺旋桨和螺旋桨控制机构。主螺旋桨包括允许螺旋桨控制机构连接到驱动轴的中心基座。螺旋桨控制机构包括螺旋桨毂和具有通过连杆连接的偏移旋钮的下部轮毂。当驱动轴的驱动转矩的变化导致它们移动时，复位弹簧被夹在轮毂之间并且倾向于将轮毂返回到偏移位置。弹簧和连杆协调工作，以改变螺旋桨叶片的俯仰和高度，同时基本上不改变螺旋桨叶片的尖端路径平面。

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