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61. 发明授权

US5391381A Dispenser capable of delivering plurality of drug units 失效
标题翻译：能够递送多个药物单元的分配器
公开(公告)号：US5391381A
公开(公告)日：1995-02-21
申请号：US60372
申请日：1993-05-11
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00 , A61K9/24
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

62. 发明授权

US5320598A Iontophoretic delivery device and method of hydrating same 失效
公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

63. 发明授权

US5298017A Layered electrotransport drug delivery system 失效
标题翻译：分层电运输药物输送系统
公开(公告)号：US5298017A
公开(公告)日：1994-03-29
申请号：US998154
申请日：1992-12-29
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially suited to agent delivery through body surfaces exposed to body fluids. A method of delivering an agent through a body surface exposed to body fluids is also disclosed.
摘要翻译：一种具有分层结构和外围绝缘的离子电渗疗剂输送装置，其中通过所述装置的两个相对的表面进行离子转运。该装置特别适用于通过暴露于体液的身体表面的药剂递送。还公开了通过暴露于体液的身体表面递送药剂的方法。

64. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

65. 发明授权

US5232705A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：药物递送模式的剂型
公开(公告)号：US5232705A
公开(公告)日：1993-08-03
申请号：US864824
申请日：1992-04-01
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

66. 发明授权

US5200196A Improvement in pulsed drug therapy 失效
标题翻译：改善脉冲药物治疗
公开(公告)号：US5200196A
公开(公告)日：1993-04-06
申请号：US640469
申请日：1991-01-11
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

67. 发明授权

US5169383A Control membrane for electrotransport drug delivery 失效
标题翻译：电转运药物控制膜
公开(公告)号：US5169383A
公开(公告)日：1992-12-08
申请号：US571577
申请日：1990-09-07
申请人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
发明人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
IPC分类号： A61J1/20 , A61M37/00 , A61N20060101 , A61N1/30
CPC分类号： A61N1/0444 , A61N1/044
摘要： A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no electrical current is flowing and yet provides minimal impedance to electrically-assisted agent delivery. The membrane is useful both as a control membrane in an iontophoretic agent delivery device and as a test membrane for testing the performance characteristics of an iontophoretic agent delivery device in vitro.
摘要翻译： PCT No.PCT / US89 / 04318 Sec。 371 1990年9月7日第 102（e）1990年9月7日PCT PCT 1989年10月2日PCT公布。出版物WO90 / 0382500 日本1990年04月19日提供了能够控制药剂从离子电渗输送装置中释放的速率的膜。当没有电流流动时，该膜抑制剂量从输送装置释放，并且对电辅助剂递送提供最小的阻抗。膜可用作离子电渗剂递送装置中的对照膜以及用于在体外测试离子电渗疗法递送装置的性能特征的测试膜。

68. 发明授权

US5156850A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：用于药物递送时间变化的剂型
公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

69. 发明授权

US5110597A Multi-unit delivery system 失效
标题翻译：多单元交付系统
公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

70. 发明授权

US5045059A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US5045059A
公开(公告)日：1991-09-03
申请号：US568457
申请日：1990-08-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。透皮型药物输送装置粘附在窗户的外表面上。药物由输送装置通过窗口输送到流动的IV流体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

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