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61. 发明公开

EP3053911A4 ADIPONECTIN RECEPTOR-ACTIVATING COMPOUND 有权
标题翻译： ADIPONECTINRECEPTOR激活化合物
公开(公告)号：EP3053911A4
公开(公告)日：2017-04-12
申请号：EP14847067
申请日：2014-09-30
申请人： UNIV TOKYO , RIKEN
发明人： KADOWAKI TAKASHI , YAMAUCHI TOSHIMASA , IWABU MIKI , IWABU MASATO , YOKOYAMA SHIGEYUKI , HONMA TERUKI
IPC分类号： C07D211/62 , A61K31/4468 , A61K31/4525 , A61K31/495 , A61K31/496 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , C07D215/12 , C07D295/16
CPC分类号： C07D409/12 , C07D211/46 , C07D211/58 , C07D215/12 , C07D295/108 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/192 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06
摘要： An AdipoR activator for activating both AdipoR1 and AdipoR2 is provided. A compound represented by the following formula (1), wherein A is a substituted or unsubstituted aryl group or the like, Y 1 is (CHR 2 ) a - or the like, X is CH or N, R 1 is a C 1-7 alkyl group, m is an integer of 0-4, Y 2 is *-O-CH 2 -CONH-, *-CONH-(CH 2 ) b -CO- or the like, Z is a cyclic group, B may be a substituent of the cyclic group represented by Z, and n is an integer of 0-3.

62. 发明公开

EP2562255A4 NUCLEIC ACID BASE ANALOG WITH QUENCHING CHARACTERISTICS AND FLUORESCENCE AND APPLICATION THEREOF 审中-公开
标题翻译：有模拟火灾和荧光性能技术及应用核酸碱基
公开(公告)号：EP2562255A4
公开(公告)日：2013-10-30
申请号：EP11772132
申请日：2011-04-21
申请人： RIKEN , TAGCYX BIOTECHNOLOGIES
发明人： HIRAO ICHIRO , HIRAO MICHIKO , YOKOYAMA SHIGEYUKI , MITSUI TSUNEO , YAMASHIGE RIE
IPC分类号： C12N15/09 , C07H19/044 , C07H19/073 , C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： G01N21/6486 , C07H19/044 , C12Q1/6818 , C12Q2525/117
摘要： It is an object of the present invention to provide quenching or fluorescent nucleic acid base analogs and applications thereof. The quencher of the present invention has a 2-nitropyrrole structure represented by Formula I: (in Formula I, R 1 and R 2 are groups independently selected from the group consisting of: ribose and deoxyribose; hydrogen, hydroxyl and SH groups, and halogens; substituted or unsubstituted alkyl, alkenyl, and alkynyl groups each having 2 to 10 carbon atoms; one or more five-membered heterocyclic rings, one or more six-membered heterocyclic rings, and one or more fused heterocyclic rings, these heterocylic rings containing nitrogen or sulfur, and one or more aromatic rings; sugars, sugar chains, amino acids, and peptides; and fluorescent molecules linked via linkers).

63. 发明公开

EP1857558A4 CELL-FREE PROTEIN SYNTHESIS SYSTEM FOR SYNTHESIZING GLYCOPROTEIN 审中-公开
标题翻译：无细胞蛋白质合成系统合成膜糖蛋白
公开(公告)号：EP1857558A4
公开(公告)日：2011-11-02
申请号：EP05806777
申请日：2005-11-15
申请人： RIKEN
发明人： IMATAKA HIROAKI , MIKAMI SATOSHI , YOKOYAMA SHIGEYUKI
IPC分类号： C12P21/02 , C12N15/09
CPC分类号： C12P21/005 , C12P21/02

64. 发明公开

EP1970445A4 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS 有权转让
标题翻译：方法对于核酸的复制和新的人工碱基对
公开(公告)号：EP1970445A4
公开(公告)日：2009-07-29
申请号：EP06834239
申请日：2006-12-07
申请人： RIKEN
发明人： HIRAO ICHIRO , YOKOYAMA SHIGEYUKI
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： C12P19/34 , C07H19/04 , C07H21/00 , C12Q1/6844 , C12Q2525/101 , C12Q2525/117 , C12Q2525/113
摘要： Disclosed are: a method for replication of a nucleic acid; and a novel artificial base pair. The method is characterized by using a deoxyribonucleoside 5'-phosphate having a hydroxyl group at Ϝ-position in the phosphate substituted by a group selected from the group consisting of an amino group, a methylamino group, a diemthylamino group, a mercapto group and a fluoro group as a substrate in a replication reaction. The novel artificial base pair is characterized in that a base pair is formed between 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analogue thereof and pyrrole-2-carbaldehyde (Pa) or an analogue thereof.

65. 发明公开

EP1961817A4 METHOD FOR PRODUCTION OF PROTEIN HAVING NON-NATURAL TYPE AMINO ACID INTEGRATED THEREIN 有权
标题翻译：方法用于生产具有集成的蛋白质THEREIN不是天然氨基酸
公开(公告)号：EP1961817A4
公开(公告)日：2009-07-15
申请号：EP06833846
申请日：2006-11-24
申请人： RIKEN
发明人： YOKOYAMA SHIGEYUKI , SAKAMOTO KENSAKU , IRAHA FUMIE
IPC分类号： C12N15/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02
CPC分类号： C12P21/02 , C12N9/93 , C12N2510/02
摘要： Disclosed is a method for production of a protein having a non-natural type amino acid integrated therein. The method is characterized by employing either of a prokaryote-derived aaRS* or a eukaryote-type aaRS* and using any one of a prokaryotic cell and a eukaryotic cell as a host cell. The method comprises the steps of: (a) introducing both of a gene encoding a prokaryote-derived mutant aminoacyl tRNA synthetase having an increased specificity to a non-natural type amino acid that is similar to a given natural type amino acid compared to the natural type amino acid and a tRNA gene for a non-natural amino acid that can bind to the above-mentioned non-natural amino acid in the presence of the prokaryote-derived mutant aminoacyl tRNA synthetase into a prokaryotic cell capable of expressing both of a gene encoding a eukaryotic aminoacyl tRNA synthetase having a specificity to the natural type amino acid and a tRNA gene capable of binding to the natural type amino acid in the presence of the eukaryotic aminoacyl tRNA synthetase; and (b) knocking-out a gene encoding an endogenous aminoacyl tRNA synthetase having a specificity to the natural type amino acid and an endogenous tRNA gene capable of binding to the natural type amino acid in the presence of the endogenous aminoacyl tRNA synthetase, both of the genes being present inherently in the prokaryotic cell.

66. 发明公开

EP1835282A4 METHOD OF PREPARING SAMPLE FOR MALDI MASS SPECTROMETRY AND REAGENT COMPOSITION THEREFOR 审中-公开
标题翻译：制造用于MALDI质谱的探索与试剂成分THEREFOR
公开(公告)号：EP1835282A4
公开(公告)日：2008-12-24
申请号：EP06701964
申请日：2006-01-04
申请人： RIKEN
发明人： HIROTA HIROSHI , ASANUMA MIWAKO , FUKUZAWA SEKETSU , YOKOYAMA SHIGEYUKI
IPC分类号： H01J49/16 , G01N33/68 , H01J49/00
CPC分类号： G01N33/6851 , H01J49/0418
摘要： A simple and easy and efficient method of preparing a sample capable of inhibiting any ion suppression by impurities, such as inorganic salts and surfactants, contained in the sample in the measurement according to matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). An analyte and matrix molecules are cocrystallized in the presence of porous microparticles. Preferably, this cocrystallization is carried out by bringing the analyte, matrix molecules and porous microparticles into contact with each other on a target plate and thereafter drying the mixture. The porous microparticles consist of an ion exchanger having an average particle diameter of up to 50 µm, preferably a strongly basic anion exchanger.

67. 发明公开

EP1557469A4 METHOD OF EXPRESSING PROTEIN HAVING UNNATURAL AMINO ACID INTEGRATED THEREINTO 有权
标题翻译：方法蛋白其中集成有非天然氨基酸表达的
公开(公告)号：EP1557469A4
公开(公告)日：2005-12-14
申请号：EP03809875
申请日：2003-10-31
申请人： RIKEN , JAPAN SCIENCE & TECH AGENCY
发明人： YOKOYAMA SHIGEYUKI , SHIROUZU MIKAKO , SAKAMOTO AYAKO , SAKAMOTO KENSAKU
IPC分类号： A61K48/00 , C12N9/00 , C12N15/85 , C12N5/10
CPC分类号： C12N9/93 , A61K48/00
摘要： A method of expressing a protein having an unnatural amino acid integrated thereinto characterized by comprising expressing (A) a mutant tyrosyl tRNA synthase which is a mutant of Escherichia coli-origin tyrosyl tRNA synthase and has an elevated specificity for a unnatural tyrosine derivative compared with the specificity for tyrosine, (B) a suppressor tRNA originating in an eubacterium belonging to the genus Bacillus, Mycoplasma or Staphylococcus which is capable of binding to the above tyrosine derivative in the presence of the above mutant TyrRS, and (C) a desired protein gene having a nonsense mutation at a desired site in animal cells to thereby incorporate the above tyrosine derivative into the nonsense mutation site in the above protein.

68. 发明公开

EP1479693A4 EGF/EGFR COMPLEX 审中-公开
标题翻译： EGF / EGFR-KOMPLEX
公开(公告)号：EP1479693A4
公开(公告)日：2005-07-27
申请号：EP02772848
申请日：2002-09-12
申请人： JAPAN SCIENCE & TECH AGENCY , RIKEN , MOCHIDA PHARM CO LTD
发明人： YOKOYAMA SHIGEYUKI , OGISO HIDEO , SHIROUZU MIKAKO , NUREKI OSAMU , ISHITANI RYUICHIRO , SAITO KAZUKI , MATSUSUE T , NAKAO NAOKI , MURAMATSU H , SHINOZAKI M
IPC分类号： C07K14/485 , C07K14/71 , C07K16/22 , C07K16/28 , G01N33/566
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/485 , C07K14/71 , C07K16/22 , C07K2299/00 , C07K2317/32 , C07K2317/34
摘要： The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR activity, a method for designing the substance regulating EGFR activity, a method for designing an EGFR variant or an EGF variant, a method for producing an EGFR variant or an EGF variant and an EGF variant or an EGFR variant obtainable by such method, a method for designing an epitope using the structure coordinates of the EGF-EGFR complex, a method for producing an anti-EGFR antibody or an anti-EGF antibody and an antibody obtainable by such method, a polypeptide or a salt thereof comprising a region that forms an EGFR dimerization site, and the like.
摘要翻译：本发明涉及表皮生长因子（EGF）和表皮生长因子受体（EGFR）的复合物的晶体，EGFR与调节EGFR活性的物质的复合物的晶体，这些晶体的结构坐标，方法用于筛选调节EGFR活性的物质的方法，用于设计调节EGFR活性的物质的方法，用于设计EGFR变体或EGF变体的方法，用于产生EGFR变体或EGF变体和EGF变体或EGFR变体的方法通过这样的方法获得的方法，使用EGF-EGFR复合物的结构坐标设计表位的方法，制备抗EGFR抗体或抗EGF抗体的方法和通过该方法获得的抗体，多肽或盐其包含形成EGFR二聚化位点的区域等。

69. 发明公开

EP2781599A4 NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN 无效转让
标题翻译：核酸片段结合靶蛋白
公开(公告)号：EP2781599A4
公开(公告)日：2015-06-17
申请号：EP12850348
申请日：2012-11-15
申请人： RIKEN , TAGCYX BIOTECHNOLOGIES
发明人： HIRAO ICHIRO , HIRAO MICHIKO , YAMASHIGE RIE , YOKOYAMA SHIGEYUKI
IPC分类号： C12N15/115 , A61K31/7115 , A61K48/00 , A61P9/00 , A61P43/00 , C07H21/02 , C07H21/04 , C12N9/00 , C12Q1/68 , C40B40/06 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C12N15/115 , A61K48/00 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N2310/12 , C12N2310/16 , C12N2310/33 , C12N2310/331 , C12N2320/13 , C12Q1/6869 , G01N33/5308 , C12Q2525/101 , C12Q2525/205
摘要： An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity against a target substance than those of nucleic acid aptamers obtained by conventional methods. The present invention provides a transcribable or replicable nucleic acid aptamer comprising a natural nucleotide and a non-natural nucleotide having an artificial base-pairable artificial base. The present invention also provides a method for sequencing a non-natural nucleotide-containing single-stranded nucleic acid molecule selected from a single-stranded nucleic acid library.

70. 发明公开

EP2584037A4 METHOD FOR CONSTRUCTING RECOMBINANT BACTERIUM FOR PRODUCING NON-NATIVE PROTEIN, AND UTILIZATION OF SAME 有权
标题翻译：处理对重组细菌的建设产生非天然蛋白质和使用此方法
公开(公告)号：EP2584037A4
公开(公告)日：2013-11-06
申请号：EP11795797
申请日：2011-06-16
申请人： RIKEN
发明人： YOKOYAMA SHIGEYUKI , MUKAI TAKAHITO , SAKAMOTO KENSAKU , MATSUMOTO AKIKO
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12P21/02
CPC分类号： C12N15/70 , C07K14/245 , C12N9/93 , C12N15/11 , C12N15/67 , C12P21/02 , Y02P20/52

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