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61. 发明授权

US08367065B2 Targeted polymeric prodrugs containing multifunctional linkers 失效
标题翻译：含有多功能接头的靶向聚合物前药
公开(公告)号：US08367065B2
公开(公告)日：2013-02-05
申请号：US12402839
申请日：2009-03-12
申请人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
发明人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
IPC分类号： A61K47/48 , A61K31/4015 , A61K31/4025 , A61K31/444 , A61K31/44 , A61K31/7088 , A61K39/395 , C07H21/02 , C07K16/00 , C07K17/02 , C07D207/40 , C07D403/12
CPC分类号： C07K7/08 , A61K47/551 , A61K47/60 , A61K47/64 , C07D207/416 , C07D207/448 , C07D213/71 , C07D487/04 , C07K5/0821 , C07K7/06
摘要： The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供了含有多功能接头的单链抗体定向聚合前药。还公开了制备聚合物递送系统的方法和使用其的治疗哺乳动物的方法。

62. 发明申请

US20120296090A1 Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells 审中-公开
标题翻译：用于靶向乳腺肿瘤起始细胞的药物重新定位方法
公开(公告)号：US20120296090A1
公开(公告)日：2012-11-22
申请号：US13439626
申请日：2012-04-04
申请人： Stephen TC Wong , Hong Zhao , Guangxu Jin
发明人： Stephen TC Wong , Hong Zhao , Guangxu Jin
IPC分类号： G06F19/00 , C07D305/14 , C07C233/15 , C07D413/12
CPC分类号： G16H50/50 , Y02A90/26
摘要： Disclosed are systems biology-based methods for repositioning known pharmaceutical compounds to new indications, through the identification of network-based signatures. In particular, the invention provides new and useful methods for selecting drugs or combinations of drugs (and preferably previously-approved drugs) for use in new therapeutic indications. Also disclosed are methods for identifying anti-breast tumor initiating cell (TIC)-based therapeutics from within populations of target compounds. In illustrative embodiments, the invention provides methods and computer programs for the repositioning of FDA-approved pharmaceutical compounds to new indications using network-based signature analysis coupled with conventional in vitro and in vivo testing of identified drug candidates. The invention also allows identification of drugs or drug combinations for treating unmet medical needs including, for example, “orphan” diseases.
摘要翻译：公开了基于系统生物学的方法，通过识别基于网络的签名将已知药物化合物重新定位到新的指示。特别地，本发明提供用于选择用于新的治疗适应症的药物或药物组合（并优选先前认可的药物）的新的和有用的方法。还公开了用于从目标化合物群体内鉴定抗乳腺肿瘤起始细胞（TIC）的治疗剂的方法。在说明性实施例中，本发明提供了使用基于网络的签名分析与常规的体外和体内测定鉴定的候选药物来重新定位FDA批准的药物化合物到新的适应症的方法和计算机程序。本发明还允许鉴定用于治疗未满足的医疗需要的药物或药物组合，包括例如孤儿疾病。

63. 发明授权

US08299089B2 Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers 失效
标题翻译：用于治疗乳腺癌，结肠直肠癌，胰腺癌，卵巢癌和肺癌的7-乙基-10-羟基喜树碱的多臂聚合物缀合物
公开(公告)号：US08299089B2
公开(公告)日：2012-10-30
申请号：US12762434
申请日：2010-04-19
申请人： Hong Zhao , Maria Belen Rubio , Dechun Wu , Puja Sapra
发明人： Hong Zhao , Maria Belen Rubio , Dechun Wu , Puja Sapra
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： A61K31/121 , A61K31/4745 , A61K47/55 , A61K47/60 , C07D491/22 , C07D519/00
摘要： A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要翻译：公开了四臂聚乙二醇-7-乙基-10-羟基喜树碱缀合物。还公开了制备缀合物的方法和使用其的治疗哺乳动物的方法。

64. 发明申请

US20110059903A1 Formulations Comprising Linaclotide 有权
标题翻译：含有利那洛肽的制剂
公开(公告)号：US20110059903A1
公开(公告)日：2011-03-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： A61K38/12 , A61P1/00
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

65. 发明申请

US20100190991A1 SYNTHESIS OF THIOHYDANTOINS 有权
标题翻译：噻吩二酮的合成
公开(公告)号：US20100190991A1
公开(公告)日：2010-07-29
申请号：US12450423
申请日：2008-03-27
申请人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
发明人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
IPC分类号： C07D213/84 , C07D213/72
CPC分类号： C07D401/04 , C07C209/36 , C07C213/08 , C07C227/18 , C07C231/12 , C07C253/00 , C07C253/30 , C07C2601/04 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/72 , C07D213/74 , C07D213/76 , C07D213/84 , C07C211/52 , C07C217/58 , C07C255/46
摘要： A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
摘要翻译：提供已经发现可用于治疗前列腺癌的抗雄激素A52的新型合成。 A52以及结构相关的类似物可以通过本发明的途径制备。这种新的合成方案可用于制备千克量级的纯A52。

66. 发明申请

US20100041381A1 METHOD FOR DIVERTING AN ISUP TALKPATH TO AN IP TALKPATH 审中-公开
标题翻译：将ISUP TALKPATH发送到IP TALKPATH的方法
公开(公告)号：US20100041381A1
公开(公告)日：2010-02-18
申请号：US12605218
申请日：2009-10-23
申请人： Jeffrey Rhodes , Hong Zhao
发明人： Jeffrey Rhodes , Hong Zhao
IPC分类号： H04M3/42
CPC分类号： H04W88/181 , H04W4/00 , H04W4/16 , H04W76/20
摘要： A method for improving the sound quality of voice signals transmitted during a call between two digital wireless telephones by diverting the call from a circuit switched network to a data network is disclosed. In accordance with the present invention, a call setup procedure using the circuit switched network is modified so that the calling party may determine the following information: I) whether the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and 2) whether both wireless telephones have access to the same data network. If the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and both wireless telephones have access to the same data network, the circuit switched network call setup procedure is abandoned before the called party answers the call and the call is completed using the data network. Completing the call by encoding voice signals using a common voice compression algorithm executed by the digital wireless telephones and by sending the encoded voice signals through a data network eliminates the drawbacks associated with the additional intermediate encoding which would have been required if the call had been completed using the circuit switched network.
摘要翻译：公开了一种通过将呼叫从电路交换网络转移到数据网络来改善在两个数字无线电话之间的呼叫期间发送的语音信号的声音质量的方法。根据本发明，对使用电路交换网络的呼叫建立过程进行修改，使呼叫方可以确定以下信息：I）被叫方的数字无线电话是否能够支持由主叫方的数字无线电话和2）无线电话是否可以访问相同的数据网络。如果被叫方的数字无线电话能够支持呼叫方的数字无线电话支持的语音压缩算法之一，并且两个无线电话都可以访问相同的数据网络，则在被叫方之前放弃电路交换网络呼叫建立过程应答呼叫，使用数据网络完成呼叫。通过使用由数字无线电话执行的公共语音压缩算法对语音信号进行编码并通过数据网络发送编码的语音信号来完成呼叫，消除了与已经完成呼叫所需的附加中间编码相关联的缺点使用电路交换网络。

67. 发明申请

US20090221471A1 PRODRUGS OF VANCOMYCIN WITH HYDROLYSIS RESISTANT POLYMER LINKAGES 审中-公开
标题翻译：具有抗水解聚合物链接的VANCOMYCIN的产品
公开(公告)号：US20090221471A1
公开(公告)日：2009-09-03
申请号：US12275775
申请日：2008-11-21
申请人： Richard B. Greenwald , Hong Zhao
发明人： Richard B. Greenwald , Hong Zhao
IPC分类号： A61K38/14 , C07K9/00 , A61P31/04
CPC分类号： A61K47/641 , A61K47/60
摘要： Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Vancomycin-polymer conjugates made by the methods and methods of treatment using the conjugates are also disclosed.
摘要翻译：公开了万古霉素 - 聚合物共轭物。在优选的方面，体外耐水解的聚合物残基选择性地连接到万古霉素和相关化合物的糖氨基和/或N-甲基氨基上。还公开了通过使用共轭物的方法和方法制备的万古霉素 - 聚合物缀合物。

68. 发明申请

US20090203706A1 LYSINE-BASED POLYMERIC LINKERS 审中-公开
标题翻译：基于LYSINE的聚合物链接器
公开(公告)号：US20090203706A1
公开(公告)日：2009-08-13
申请号：US12402980
申请日：2009-03-12
申请人： Hong Zhao , Prasanna Reddy
发明人： Hong Zhao , Prasanna Reddy
IPC分类号： A61K31/197 , C07C229/04 , C07D207/40 , C07D241/04 , A61K31/4025 , A61K31/496
CPC分类号： C08G65/329 , A61K47/60 , A61K47/645
摘要： The present invention provides polymeric linkers containing branching moieties. Methods of making the polymeric linkers and methods of making conjugates using the same are also disclosed.
摘要翻译：本发明提供含有支化部分的聚合物接头。还公开了制备聚合物连接体的方法和使用其制备共轭物的方法。

69. 发明授权

US07332164B2 Heterobifunctional polymeric bioconjugates 失效
标题翻译：异双功能聚合物生物共轭物
公开(公告)号：US07332164B2
公开(公告)日：2008-02-19
申请号：US10394393
申请日：2003-03-21
申请人： Richard B. Greenwald , Hong Zhao
发明人： Richard B. Greenwald , Hong Zhao
IPC分类号： A61K47/48 , A61K38/00
CPC分类号： A61K49/0041 , A61K47/60 , A61K49/0047
摘要： Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is Methods of making and using the compounds and conjugates described herein are also provided.
摘要翻译：公开了用于递送生物活性化合物（包括蛋白质，单克隆抗体等）的异双功能聚合物前药平台。一种优选的化合物是还提供制备和使用本文所述的化合物和缀合物的方法。

70. 发明申请

US20070197575A1 Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers 失效
标题翻译：用于治疗乳腺癌，结肠直肠癌，胰腺癌，卵巢癌和肺癌的7-乙基-10-羟基喜树碱的多臂聚合物缀合物
公开(公告)号：US20070197575A1
公开(公告)日：2007-08-23
申请号：US11704607
申请日：2007-02-09
申请人： Hong Zhao , Maria Rubio , Dechun Wu , Puja Sapra
发明人： Hong Zhao , Maria Rubio , Dechun Wu , Puja Sapra
IPC分类号： A61K31/4745
CPC分类号： A61K31/121 , A61K31/4745 , A61K47/55 , A61K47/60 , C07D491/22 , C07D519/00
摘要： A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要翻译：公开了四臂聚乙二醇-7-乙基-10-羟基喜树碱缀合物。还公开了制备缀合物的方法和使用其的治疗哺乳动物的方法。

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