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61. 发明授权

US09107891B2 Method for alleviating fear memory 有权
标题翻译：缓解恐惧记忆的方法
公开(公告)号：US09107891B2
公开(公告)日：2015-08-18
申请号：US14129794
申请日：2012-06-29
申请人： Masayuki Sekiguchi , Daisuke Yamada , Jiro Takeo , Wakako Seki , Keiji Wada
发明人： Masayuki Sekiguchi , Daisuke Yamada , Jiro Takeo , Wakako Seki , Keiji Wada
IPC分类号： A01N65/00 , A61K31/202 , A61K36/00 , A23L1/30 , A61K31/557 , A61K35/612 , G01N33/68
CPC分类号： A61K31/202 , A23L33/115 , A23V2002/00 , A61K31/557 , A61K35/612 , A61K36/00 , G01N33/6893 , G01N33/6896 , G01N2800/301 , A61K2300/00 , A23V2200/322 , A23V2250/1882
摘要： The present invention provides new methods of intervention for anxiety associated disorders, in particular, trauma-derived disorders such as PTSD, and therapeutic or prophylactic agents for anxiety associated disorders that can be used as foods, beverages, and dietary supplements, for example, and which contain as an active ingredient n-3 polyunsaturated fatty acids contained in krill oil or fish oil, for example. The present invention further provides methods for alleviating fear memory or methods for preventing its formation by adjusting the proportion of n-3 polyunsaturated fatty acids to n-6 polyunsaturated fatty acids as ingested.
摘要翻译：本发明提供了用于焦虑相关疾病，特别是创伤衍生疾病如PTSD的新干预方法，以及可用作食物，饮料和膳食补充剂的焦虑相关疾病的治疗或预防剂，例如，其包含例如磷虾油或鱼油中所含的n-3种多不饱和脂肪酸作为活性成分。本发明还提供了通过调节n-3多不饱和脂肪酸与摄取的n-6多不饱和脂肪酸的比例来减轻恐惧记忆或防止其形成的方法。

62. 发明申请

US20140121276A1 METHOD FOR ALLEVIATING FEAR MEMORY 有权
标题翻译：掌握恐惧记忆的方法
公开(公告)号：US20140121276A1
公开(公告)日：2014-05-01
申请号：US14129794
申请日：2012-06-29
申请人： Masayuki Sekiguchi , Daisuke Yamada , Jiro Takeo , Wakako Seki , Keiji Wada
发明人： Masayuki Sekiguchi , Daisuke Yamada , Jiro Takeo , Wakako Seki , Keiji Wada
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A23L33/115 , A23V2002/00 , A61K31/557 , A61K35/612 , A61K36/00 , G01N33/6893 , G01N33/6896 , G01N2800/301 , A61K2300/00 , A23V2200/322 , A23V2250/1882
摘要： The present invention provides new methods of intervention for anxiety associated disorders, in particular, trauma-derived disorders such as PTSD, and therapeutic or prophylactic agents for anxiety associated disorders that can be used as foods, beverages, and dietary supplements, for example, and which contain as an active ingredient n-3 polyunsaturated fatty acids contained in krill oil or fish oil, for example. The present invention further provides methods for alleviating fear memory or methods for preventing its formation by adjusting the proportion of n-3 polyunsaturated fatty acids to n-6 polyunsaturated fatty acids as ingested.
摘要翻译：本发明提供了用于焦虑相关疾病，特别是创伤衍生疾病如PTSD的新干预方法，以及可用作食物，饮料和膳食补充剂的焦虑相关疾病的治疗或预防剂，例如，其包含例如磷虾油或鱼油中所含的n-3种多不饱和脂肪酸作为活性成分。本发明还提供了通过调节n-3多不饱和脂肪酸与摄取的n-6多不饱和脂肪酸的比例来减轻恐惧记忆或防止其形成的方法。

63. 发明申请

US20080015158A1 Inhibition of the Expression of Huntingtin Gene 失效
标题翻译：抑制Huntingtin基因的表达
公开(公告)号：US20080015158A1
公开(公告)日：2008-01-17
申请号：US10556711
申请日：2004-04-30
申请人： Kanazawa Ichiro , Liu Wanzhao , Yu-Lai Wang , Keiji Wada , Jun Goto , Miho Murata
发明人： Kanazawa Ichiro , Liu Wanzhao , Yu-Lai Wang , Keiji Wada , Jun Goto , Miho Murata
IPC分类号： A61K31/7105 , A61P25/14 , C07H21/04
CPC分类号： A61K31/7088 , A61K38/00 , C12N15/113 , C12N2310/14
摘要： It is intended to provide methods for suppressing the huntingtin gene expression by using a double-stranded RNA (dsRNA), huntingtin gene expression inhibitors to suppress the huntingtin gene expression, and preventives and/or remedies of Huntington's disease. Targeting against a specific sequence of mRNA at immediately upstream of CAG repeats in HD genes of Huntington's disease, the huntingtin gene expression is suppressed by using a dsRNA homologous to the sequence. In this invention, a short siRNA (short double-stranded RNA) having bp as short as around 21-23 bp can be effectively used as the dsRNA homologous to a specific RNA sequence in a region at immediately upstream of CAG repeats. The dsRNA of this present invention can be used as a huntingtin gene expression inhibitor, or a preventive and/or a remedy of Huntington's disease by administering or introducing into a living body or a living cell in mammals for the prevention and/or treatment of Huntington's disease.
摘要翻译：旨在提供通过使用双链RNA（dsRNA），亨廷汀蛋白酶基因表达抑制剂抑制亨廷顿蛋白基因表达来抑制亨廷顿蛋白基因表达的方法，以及亨廷顿疾病的预防和/或补救措施。针对亨廷顿氏病的HD基因中紧邻CAG重复上游的特异性mRNA序列，通过使用与该序列同源的dsRNA来抑制亨廷顿蛋白基因表达。在本发明中，具有短至约21-23bp的bp的短siRNA（短双链RNA）可以有效地用作在CAG重复的紧邻上游区域中与特定RNA序列同源的dsRNA。本发明的dsRNA可以作为亨廷顿舞蹈病基因表达抑制剂或亨廷顿舞蹈病的预防和/或治疗方法，通过将哺乳动物的活体或活细胞投予或引入，以预防和/或治疗亨廷顿病疾病。

64. 发明授权

US06026652A Air conditioning system having single bus line 失效
公开(公告)号：US06026652A
公开(公告)日：2000-02-22
申请号：US950288
申请日：1997-10-14
申请人： Keiji Wada
发明人： Keiji Wada
IPC分类号： F24F11/00
CPC分类号： F24F11/006 , F24F2011/0067
摘要： In an air conditioning system in which outdoor units and indoor units of plural air conditioning units are connected to one another through a single bus line, when signals of at least two air conditioners are output onto the bus line substantially at the same output timing, the signal output timing of at least one air conditioner is changed by timing changing means so that the output timings of the signals of the air conditioners are different from one another. Further, each of the outdoor units of the air conditioners is provided with operation data recording means for recording the operation data of the outdoor unit, operation data output means for outputting the operation data of a desired outdoor unit, and operation data transmitting means for transmitting the operation data recorded in the operation data recording means to another outdoor unit through the bus line.

65. 发明授权

US09947782B2 Semiconductor device and method for manufacturing same 有权
公开(公告)号：US09947782B2
公开(公告)日：2018-04-17
申请号：US13634860
申请日：2010-12-20
申请人： Shin Harada , Makoto Sasaki , Taro Nishiguchi , Kyoko Okita , Keiji Wada , Tomihito Miyazaki
发明人： Shin Harada , Makoto Sasaki , Taro Nishiguchi , Kyoko Okita , Keiji Wada , Tomihito Miyazaki
IPC分类号： H01L29/78 , H01L21/02 , H01L21/20 , H01L29/04 , H01L29/66 , H01L29/739 , H01L29/16
CPC分类号： H01L29/7802 , H01L21/02002 , H01L21/02008 , H01L21/2007 , H01L29/045 , H01L29/1608 , H01L29/66068 , H01L29/66333 , H01L29/7395
摘要： A semiconductor device has a semiconductor layer and a substrate. The semiconductor layer constitutes at least a part of a current path, and is made of silicon carbide. The substrate has a first surface supporting the semiconductor layer, and a second surface opposite to the first surface. Further, the substrate is made of silicon carbide having a 4H type single-crystal structure. Further, the substrate has a physical property in which a ratio of a peak strength in a wavelength of around 500 nm to a peak strength in a wavelength of around 390 nm is 0.1 or smaller in photoluminescence measurement. In this way, the semiconductor device is obtained to have a low on-resistance.

66. 发明授权

US08846531B2 Method of manufacturing an ohmic electrode containing titanium, aluminum and silicon on a silicon carbide surface 有权
标题翻译：在碳化硅表面上制造含有钛，铝和硅的欧姆电极的方法
公开(公告)号：US08846531B2
公开(公告)日：2014-09-30
申请号：US13387097
申请日：2010-07-30
申请人： Hideto Tamaso , Keiji Wada
发明人： Hideto Tamaso , Keiji Wada
IPC分类号： H01L21/44 , H01L29/66 , H01L29/45 , H01L21/04 , H01L29/78 , H01L29/16
CPC分类号： H01L21/0485 , H01L29/1608 , H01L29/45 , H01L29/66068 , H01L29/7802
摘要： To provide a method of manufacturing a semiconductor device that can be in contact with both of an n-type SiC region and a p-type SiC region and can suppress increase in contact resistance due to oxidation, a method of manufacturing a semiconductor device includes the steps of preparing a SiC layer, and forming an ohmic electrode on a main surface of the SiC layer. The step of forming the ohmic electrode includes the steps of forming a conductor layer which will become the ohmic electrode on the main surface of the SiC layer, and performing heat treatment such that the conductor layer becomes the ohmic electrode. After the step of performing the heat treatment, a temperature of the ohmic electrode when a surface of the ohmic electrode is exposed to an atmosphere containing oxygen is set to 100° C. or lower.
摘要翻译：为了提供可以与n型SiC区域和p型SiC区域接触的半导体器件的制造方法，并且可以抑制由于氧化引起的接触电阻的增加，所以制造半导体器件的方法包括：制备SiC层的步骤，在SiC层的主表面上形成欧姆电极。形成欧姆电极的步骤包括以下步骤：在SiC层的主表面上形成将成为欧姆电极的导体层，并进行使导体层变成欧姆电极的热处理。在进行热处理的步骤之后，当欧姆电极的表面暴露于含氧的气氛时，欧姆电极的温度设定为100℃以下。

67. 发明授权

US5711365A Shell molding apparatus 失效
标题翻译：外壳成型设备
公开(公告)号：US5711365A
公开(公告)日：1998-01-27
申请号：US626605
申请日：1996-04-02
申请人： Akio Shimizu , Taiti Yoshikawa , Hiroshi Suzuki , Shigeyuki Kinoshita , Keiji Wada , Yasuo Kawai
发明人： Akio Shimizu , Taiti Yoshikawa , Hiroshi Suzuki , Shigeyuki Kinoshita , Keiji Wada , Yasuo Kawai
IPC分类号： B22C13/08 , B22C17/00 , B22C15/02
CPC分类号： B22C17/00 , B22C13/08 , Y10T29/4927 , Y10T29/49272
摘要： A shell molding apparatus includes a lower die and an upper die. The lower die includes a plurality of shell molding inserts, each having the shape of a halved cylinder, spiny insert receiving recesses which are formed in undercut portions formed by curved surfaces of adjacent shell molding inserts, and spiny inserts retractably provided in the spiny insert receiving recesses, each spiny insert having a curved surface of the same curvature as the curved surface of the shell molding insert and provided with many protrusions on the curved surface. The upper die has a plurality of continuously formed recesses corresponding to the plurality of shell molding inserts of the lower die. The shell molding apparatus further includes a spiny insert actuating mechanism for projecting/retracting spiny inserts by operating withdrawal pins connected to the spiny inserts, a stopper mechanism for positioning the withdrawal pins at a position where the withdrawal pins exhibit the same thermal expansion, and a thermal expansion absorbing mechanism for the withdrawal pins. The shell molding apparatus further includes a sand releasing mechanism for preventing shell sand from stagnating between spiny insert receiving recesses and the spiny inserts, resulting in smooth performance of the spiny inserts.
摘要翻译：壳体成型装置包括下模和上模。下模具包括多个壳体模制插入件，每个壳体模制插入件具有半圆柱形的形状，多个插入件容纳凹槽，其形成在由相邻的外壳模制插入件的弯曲表面形成的底切部分中，以及可旋转地设置在多刺插入件凹槽，每个多刺插入物具有与壳模制插件的弯曲表面相同曲率的曲面，并且在弯曲表面上设置有许多突起。上模具具有多个连续形成的与下模的多个外壳模制插件对应的凹槽。外壳成型装置还包括用于通过连接到多刺插入件的操作提取销来突出/缩回多刺插入件的多刺插入致动机构，用于将取出销定位在提升销呈现相同热膨胀的位置的止动机构，以及退火针的热膨胀吸收机构。外壳成型设备还包括一个防砂壳，用于防止壳砂停滞在多刺插入物容纳凹槽和多刺插入物之间，从而使多刺插入物的平滑性能得以实现。

68. 发明授权

US5371188A Neuronal nicotinic acetylcholine receptor compositions 失效
标题翻译：神经元烟碱乙酰胆碱受体组成
公开(公告)号：US5371188A
公开(公告)日：1994-12-06
申请号：US898185
申请日：1992-06-12
申请人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann
发明人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566 , C07K13/00
CPC分类号： C07K14/70571 , G01N33/944 , G01N2500/04
摘要： The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明涉及由神经元激动剂和非激动剂结合亚基组成的神经元烟碱乙酰胆碱受体家族，以及编码这种亚基的DNA序列。这些新型神经元烟碱乙酰胆碱受体亚基包括激动剂结合亚基α2，α3，α4和α5，加上非激动剂结合亚单位β2，β3和β4。含有本发明的DNA序列的代表性cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

69. 发明授权

US5344648A Central nervous system activator and taste enhancing food additive 失效
标题翻译：中枢神经系统激活剂和味觉增强食品添加剂
公开(公告)号：US5344648A
公开(公告)日：1994-09-06
申请号：US847040
申请日：1992-04-14
申请人： Masanobu Haga , Keiji Wada
发明人： Masanobu Haga , Keiji Wada
IPC分类号： A23L1/212 , A23L1/30 , A61K31/34 , A61K31/35 , A61K36/00 , A61K36/75 , A61K36/752 , A61K36/754 , A61K36/756 , A61P25/26 , A61K35/78
CPC分类号： A61K36/75 , A61K36/752 , A61K36/754 , A61K36/756
摘要： A central nervous system activator comprising a body or a dried product of a plant belonging to Rutaceae, or an extraction product selected from the group consisting of a lower alkane insoluble portion thereof, a lower fatty acid ester extract of the lower alkane insoluble portion, a lower fatty acid ester-halogenated lower alkane soluble portion of the lower fatty acid ester extract, a limonin fraction of the lower fatty acid ester-halogenated lower alkane soluble portion, and an obacunone fraction of the lower fatty acid ester-halogenated lower alkane soluble portion and a central nervous system activator comprising a limonoid. Further, a taste enhancing food additive comprising the above plant body or dried product or extraction product, or limonoid.
摘要翻译： PCT No.PCT / JP91 / 00965 Sec。 371日期：1992年4月14日 102（e）日期1992年4月14日PCT提交1991年7月19日PCT公布。公开号WO92 / 03143 日本1993年3月5日。一种中枢神经系统激活剂，其包含属于芸香科的植物的主体或干燥产物，或选自下列烷烃不溶部分的提取产物，低级烷烃不溶部分，低级脂肪酸酯提取物低级烷烃不溶部分，低级脂肪酸酯卤代低级烷烃可溶部分的低级脂肪酸酯提取物，低级脂肪酸酯卤代低级烷烃可溶部分的柠檬苦素部分和低级脂肪酸的可乐酮级分酯卤化低级烷烃可溶部分和包含柠檬醛的中枢神经系统活化剂。此外，含有上述植物体或干燥产物或提取产物或柠檬醛的增味食品添加剂。

70. 发明授权

US6126080A Air conditioner 失效
标题翻译：冷气机
公开(公告)号：US6126080A
公开(公告)日：2000-10-03
申请号：US948272
申请日：1997-10-09
申请人： Keiji Wada
发明人： Keiji Wada
IPC分类号： F24F11/00 , G05D23/00
CPC分类号： F24F11/006 , F24F2011/0067
摘要： In an air conditioner including an outdoor unit and plural indoor units, the outdoor unit is provided with an indoor unit operation setting mechanism for setting the driving operation of the indoor units, and the indoor unit operation setting mechanism is provided with operation control parameter changing means for changing the storage content of storage means of each indoor unit and/or master/slave setting means for automatically performing the master/slave setting operation of the indoor units.
摘要翻译：在具有室外机和多台室内机的空调机中，室外机设置有室内机操作设定机构，用于设定室内机的驾驶操作，室内机操作设定机构具备操作控制参数改变单元用于改变每个室内单元和/或主/从设置装置的存储装置的存储内容，用于自动执行室内单元的主/从设置操作。

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