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61. 发明授权

US08642076B2 Lipid containing formulations 有权
标题翻译：含脂质配方
公开(公告)号：US08642076B2
公开(公告)日：2014-02-04
申请号：US13211094
申请日：2011-08-16
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier
IPC分类号： A61K9/48
CPC分类号： C07C219/06 , A61K9/1272 , A61K9/1273 , A61K31/325 , A61K47/34 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25
摘要： Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
摘要翻译：描述了用于施用基于核酸的疗法，例如缔合复合物如脂质体和脂质复合物的组合物和方法。

62. 发明授权

US08272370B2 Fuel injector 有权
标题翻译：喷油器
公开(公告)号：US08272370B2
公开(公告)日：2012-09-25
申请号：US11991047
申请日：2006-08-01
申请人： Martin Maier , Johann Bayer , Christian Suenkel , Wolfgang Koschwitz
发明人： Martin Maier , Johann Bayer , Christian Suenkel , Wolfgang Koschwitz
IPC分类号： F02M51/06 , F02M61/16
CPC分类号： F02M51/061 , F02M61/168 , F02M2200/8061
摘要： A fuel injector for fuel injection systems of internal combustion engines is described. The fuel injector includes an electromagnetic actuating element having a magnetic coil, a core and a valve jacket as the outer magnetic circuit component and a movable valve-closure member which interacts with a valve-seat surface assigned to a valve-seat member. The core and a connecting tube in an inner opening of a thin-walled valve sleeve and the valve jacket on the outer circumference of the valve sleeve are firmly connected to the valve sleeve by pressing them therein/thereon. The fixed press connection between two of these metallic components of the fuel injector is characterized in that at least one of the component partners has a structure including grooves in its press area and/or the particular press area has an inlet rounding in at least one transition to an adjacent component section.
摘要翻译：描述了用于内燃机的燃料喷射系统的燃料喷射器。燃料喷射器包括电磁致动元件，该电磁致动元件具有作为外部磁路部件的电磁线圈，芯部和阀套，以及与分配给阀座部件的阀座表面相互作用的可动阀闭合部件。在薄壁阀套的内开口中的芯和连接管与阀套的外周上的阀套通过将其压入/在其上而牢固地连接到阀套上。燃料喷射器的这些金属部件中的两个之间的固定压力连接的特征在于，至少一个部件对准件具有包括其压制区域中的凹槽的结构和/或特定压制区域在至少一个过渡部中具有四舍五入到相邻的部件部分。

63. 发明授权

US08237525B2 Device having a shape memory element 有权
标题翻译：具有形状记忆元件的装置
公开(公告)号：US08237525B2
公开(公告)日：2012-08-07
申请号：US11793086
申请日：2005-10-05
申请人： Anh-Tuan Hoang , Martin Maier , Guenther Hohl
发明人： Anh-Tuan Hoang , Martin Maier , Guenther Hohl
IPC分类号： H01F7/00 , H01H55/00
CPC分类号： H01L41/12 , F02M51/0603 , F02M61/08 , F02M2200/22
摘要： Conventional devices have a valve needle and a shape memory element which, by the application of a controllable magnetic field, executes a control stroke travel that operates the actuator, and having a coil that excites the magnetic field which is situated in a magnet housing which, at its end face, is bordered with respect to an actuating axis by a front wall in each case, the front walls having a through opening radially within the coil. It is a disadvantage that the magnetic field excited around the coil is conducted unfavorably, so that at most a slight magnetic field develops in the shape memory element. The shape memory element has a magnetic field flowing through it, in the direction of its longitudinal extension, if at all. Since the shape memory element has a high magnetic resistance and is developed to be very long in the axial direction, only a very weak magnetic field can be induced in the shape memory element. In response to the magnetic field that is weak at most, the shape memory element can generate only a very slight lift of the valve needle. In the device according to the present invention, a strong magnetic field is conducted through the shape memory elements, and in this way, a large control stroke travel is achieved. The shape memory element(s) is/are positioned generally only in the through opening(s).
摘要翻译：常规装置具有阀针和形状记忆元件，其通过施加可控磁场来执行操作致动器的控制行程行程，并且具有激励位于磁体壳体中的磁场的线圈，在其端面处，在每种情况下通过前壁相对于致动轴线相邻，前壁具有径向在线圈内的通孔。不利的是，线圈周围激发的磁场是不利的，因此在形状记忆元件中最多产生轻微的磁场。形状记忆元件具有在其纵向延伸的方向上流经的磁场，如果有的话。由于形状记忆元件具有高磁阻并且在轴向上被显影为非常长，所以在形状记忆元件中只能产生非常弱的磁场。响应于至多为弱的磁场，形状记忆元件可以仅产生非常轻微的阀针的提升。在根据本发明的装置中，通过形状记忆元件传导强磁场，从而实现了大的控制行程行程。形状记忆元件通常仅定位在通孔中。

64. 发明申请

US20120061119A1 Polymer compound and components produced using the compound 有权
标题翻译：高分子化合物和使用该化合物制备的组分
公开(公告)号：US20120061119A1
公开(公告)日：2012-03-15
申请号：US13199683
申请日：2011-09-07
申请人： Michael Schlipf , Claudia Stern , Martin Maier
发明人： Michael Schlipf , Claudia Stern , Martin Maier
IPC分类号： H01B3/42 , B32B1/08 , C08K7/14 , C08K3/04 , C08L71/10 , C08K7/06
CPC分类号： C08L27/18 , C08G2650/40 , C08L71/00 , H01B3/427 , H01B3/445 , Y10T428/139 , C08L2666/14 , C08L2666/04
摘要： In order to provide polymer compounds which are improved with respect to their properties in comparison with conventional PTFE, on the one hand, and compounds thereof with additional high performance polymers, on the other hand, it is suggested that a polymer compound comprise a proportion of a fully fluorinated, thermoplastic polymer material as well as a proportion of at least one additional high performance polymer different thereto and selected from the group consisting of polyether ketone, polyether ether ketone and polyether aryl ketone as well as copolymers and derivatives of these polymers and copolymers, wherein the compound displays a homogeneous distribution of the proportions of the polymers and the polymer material.
摘要翻译：为了提供与常规PTFE相比其改进的聚合物化合物，另一方面，另一方面，提出了一种高分子化合物，另一方面，高分子化合物包含一定比例的完全氟化的热塑性聚合物材料以及至少一种另外的与聚醚酮，聚醚醚酮和聚醚芳基酮不同的高性能聚合物以及这些聚合物和共聚物的共聚物和衍生物，其中所述化合物显示所述聚合物和所述聚合物材料的比例的均匀分布。

65. 发明授权

US08106022B2 Carbohydrate conjugates as delivery agents for oligonucleotides 有权
标题翻译：碳水化合物缀合物作为寡核苷酸的递送剂
公开(公告)号：US08106022B2
公开(公告)日：2012-01-31
申请号：US12328528
申请日：2008-12-04
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K47/28 , A61K31/70 , A61K31/7004 , A61K31/7052 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/22 , A61K47/543 , A61K47/549 , A61K47/60 , A61K48/00 , C07H21/02 , Y02A50/385 , Y02A50/411 , Y02A50/467 , Y02P20/55
摘要： The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(RN) or S; X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R; R is LG, -Linker-LG, or has the structure shown below: LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
摘要翻译：本发明提供包含至少一个式（I）亚基的iRNA试剂：其中：A和B各自独立地为O，N（RN）或S; X和Y各自独立地为H，OH，羟基保护基，磷酸基，磷酸二酯基，活化磷酸酯基，活化亚磷酸酯基，亚磷酰胺，固体载体，-P（Z'）（ Z“）O-核苷，-P（Z'）（Z”）O-寡核苷酸，脂质，PEG，类固醇，亲脂性，聚合物，-P（Z'）（Z“）O-Linker- OP（Z'“）（Z”“） - 寡核苷酸，寡核苷酸，-P（Z'）（Z”） - 式（I），-P（Z'）（Z“） - 链接器R R是LG，-Linker-LG，或具有如下结构：每次出现LG独立为碳水化合物，例如单糖，二糖，三糖，四糖，寡糖，多糖; 乙烯基，丙基，异丙基，丁基或苄基各自独立地为N，和Z'，Z“，Z”“和Z”“各自独立地为O或S.

66. 发明申请

US20120000994A1 DEVICE FOR INJECTING FUEL 审中-公开
标题翻译：注射燃料的装置
公开(公告)号：US20120000994A1
公开(公告)日：2012-01-05
申请号：US13138122
申请日：2009-11-27
申请人： Juergen Graner , Martin Maier , Michael Huebel , Guenther Hohl
发明人： Juergen Graner , Martin Maier , Michael Huebel , Guenther Hohl
IPC分类号： F02M61/16
CPC分类号： F02M51/0682 , F02M51/0696 , F02M2200/707 , H01F7/066
摘要： A device for injecting pressurized fuel includes an electrodynamic actuator having a movably situated coil, an outwardly opening needle which opens and closes a cross section on a valve seat, a connecting device which connects the needle to the movably situated coil, a pressure chamber which is situated at the needle upstream from the valve seat and contains pressurized fuel, a low-pressure chamber from which, fuel is dischargeable, and a gap seal which is provided at an outer peripheral region of the needle, the gap seal (16) providing a connection between the pressure chamber and the low-pressure chamber.
摘要翻译：用于注入加压燃料的装置包括具有可移动定位的线圈的电动致动器，用于打开和关闭阀座上的横截面的向外开口的针，将针连接到可移动定位的线圈的连接装置，位于所述针阀上游的所述针头并且包含加压燃料，低压室，燃料可从其排出;以及间隙密封件，其设置在所述针的外周区域处，所述间隙密封件提供压力室和低压室之间的连接。

67. 发明授权

US07963149B2 Method and device for determining hydraulic leakage rate in liquid-conveying sections, in particular, injection valves of internal combustion engines 有权
标题翻译：用于确定液体输送部分，特别是内燃机的喷射阀中的液压泄漏率的方法和装置
公开(公告)号：US07963149B2
公开(公告)日：2011-06-21
申请号：US12090516
申请日：2006-10-12
申请人： Martin Maier , Frank Mozer , Eberhard Waibler
发明人： Martin Maier , Frank Mozer , Eberhard Waibler
IPC分类号： G01M3/02 , G01M3/16
CPC分类号： G01M3/2876 , F02M65/00 , F02M65/006
摘要： A method and device for determining the hydraulic leakage rate of liquid-conveying parts, in particular injection valves for internal combustion engines, place the liquid-conveying part into a test body, and the liquid-conveying part is charged with a test liquid under a particular pressure, and a carrier gas stream is provided in a flow duct of the test body, and a vapor mixture behind the liquid-conveying part is conducted to an analyzer, and a measurement and analysis are carried out, using the analyzer, of the hydraulic leakage rate of the liquid-conveying part via the concentration of test liquid in the vapor mixture, the carrier gas stream being brought in via a nozzle element close to the leakage point of the liquid-conveying part, and/or a heating of the vapor mixture being provided behind the liquid-conveying part for complete conversion into the gas phase. The testing device is particularly suitable for leakage measurement in fuel injection valves used in fuel injection systems of mixture-compressing externally ignited internal combustion engines.
摘要翻译：一种用于确定液体输送部件，特别是用于内燃机的喷射阀的液压泄漏率的方法和装置，将液体输送部件放入测试体中，并且在液体输送部件的下面装入测试液体特定的压力，并且在测试体的流动管道中设置载气流，并且将液体输送部件后面的蒸汽混合物传导到分析器，并且使用分析仪进行测量和分析，通过蒸汽混合物中的测试液体的浓度，液体输送部分的液压泄漏速率，载气流经由靠近液体输送部分的泄漏点的喷嘴元件引入，和/或蒸气混合物设置在液体输送部分的后面，以完全转化为气相。该测试装置特别适用于在混合压缩外部点燃的内燃机的燃料喷射系统中使用的燃料喷射阀中的泄漏测量。

68. 发明申请

US20090239814A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides 有权
标题翻译：碳水化合物缀合物作为寡核苷酸的递送剂
公开(公告)号：US20090239814A1
公开(公告)日：2009-09-24
申请号：US12328528
申请日：2008-12-04
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
IPC分类号： A61K31/715 , C07H17/02 , C12N5/06
CPC分类号： A61K47/28 , A61K31/70 , A61K31/7004 , A61K31/7052 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/22 , A61K47/543 , A61K47/549 , A61K47/60 , A61K48/00 , C07H21/02 , Y02A50/385 , Y02A50/411 , Y02A50/467 , Y02P20/55
摘要： The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(RN) or S; X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R; R is LG, -Linker-LG, or has the structure shown below: LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
摘要翻译：本发明提供包含至少一个式（I）亚基的iRNA试剂：其中：A和B各自独立地为O，N（RN）或S; X和Y各自独立地为H，OH，羟基保护基，磷酸基，磷酸二酯基，活化磷酸酯基，活化亚磷酸酯基，亚磷酰胺，固体载体，-P（Z'）（ Z'）（Z“）O - 寡核苷酸，脂质，PEG，类固醇，亲脂体，聚合物，-P（Z'）（Z”）O （Z'）（Z“） - （Z”）（Z“）（Z”）（Z“）（Z”）（Z“） - 或-Linker-R; R是LG，-Linker-LG，或具有如下结构：每次出现LG独立为碳水化合物，例如单糖，二糖，三糖，四糖，寡糖，多糖; 乙烯基，丙基，异丙基，丁基或苄基各自独立地为N， Z'，Z“，Z”“和Z”“各自独立地为O或S.

69. 发明申请

US20080314120A1 Method and Device for Determining Hydraulic Leakage Rate in Liquid-Conveying Sections, in Particular, Injection Valves of Internal Combustion Engines 有权
标题翻译：确定液体输送段液压泄漏率的方法和装置，特别是内燃机喷油阀
公开(公告)号：US20080314120A1
公开(公告)日：2008-12-25
申请号：US12090516
申请日：2006-10-12
申请人： Martin Maier , Frank Mozer , Eberhard Waibler
发明人： Martin Maier , Frank Mozer , Eberhard Waibler
IPC分类号： G01M3/02
CPC分类号： G01M3/2876 , F02M65/00 , F02M65/006
摘要： A method and device for determining the hydraulic leakage rate of liquid-conveying parts, in particular injection valves for internal combustion engines, place the liquid-conveying part into a test body, and the liquid-conveying part is charged with a test liquid under a particular pressure, and a carrier gas stream is provided in a flow duct of the test body, and a vapor mixture behind the liquid-conveying part is conducted to an analyzer, and a measurement and analysis are carried out, using the analyzer, of the hydraulic leakage rate of the liquid-conveying part via the concentration of test liquid in the vapor mixture, the carrier gas stream being brought in via a nozzle element close to the leakage point of the liquid-conveying part, and/or a heating of the vapor mixture being provided behind the liquid-conveying part for complete conversion into the gas phase. The testing device is particularly suitable for leakage measurement in fuel injection valves used in fuel injection systems of mixture-compressing externally ignited internal combustion engines.
摘要翻译：一种用于确定液体输送部件，特别是用于内燃机的喷射阀的液压泄漏率的方法和装置，将液体输送部件放入测试体中，并且在液体输送部件的下面装入测试液体特定的压力，并且在测试体的流动管道中设置载气流，并且将液体输送部件后面的蒸汽混合物传导到分析器，并且使用分析仪进行测量和分析，通过蒸汽混合物中的测试液体的浓度，液体输送部分的液压泄漏速率，载气流经由靠近液体输送部分的泄漏点的喷嘴元件引入，和/或蒸气混合物设置在液体输送部分的后面，以完全转化为气相。该测试装置特别适用于在混合压缩外部点燃的内燃机的燃料喷射系统中使用的燃料喷射阀中的泄漏测量。

70. 发明申请

US20080312268A1 Substituted tricyclic piperidone compounds 审中-公开
标题翻译：取代三环哌啶酮化合物
公开(公告)号：US20080312268A1
公开(公告)日：2008-12-18
申请号：US12143614
申请日：2008-06-20
申请人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
发明人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
IPC分类号： A61K31/439 , C07D221/22 , A61P25/32 , A61P25/30 , A61P25/00
CPC分类号： C07D471/08
摘要： Substituted tricyclic piperidone derivatives corresponding to Formula I: a method for producing such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug abuse, drug dependency, lethargy and/or anxiety.
摘要翻译：对应于式I的取代的三环哌啶酮衍生物：这种化合物的制备方法; 含有这些化合物的药物组合物，以及这些化合物用于治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物依赖性，嗜睡和/或焦虑症的用途。

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