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61. 发明申请

US20130218227A1 CRITERIA FOR OPTIMAL ELECTRICAL RESYNCHRONIZATION DERIVED FROM MULTIPOLAR LEADS OR MULTIPLE ELECTRODES DURING BIVENTRICULAR PACING 有权
公开(公告)号：US20130218227A1
公开(公告)日：2013-08-22
申请号：US13464279
申请日：2012-05-04
申请人： Subham Ghosh , Robert W. Stadler
发明人： Subham Ghosh , Robert W. Stadler
IPC分类号： A61N1/37
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371
摘要： Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Employing sums of the measured activation times to select one of the left ventricular electrodes for delivery of subsequent pacing pulses.

62. 发明授权

US08428718B2 Method and apparatus for detecting change in intrathoracic electrical impedance 有权
标题翻译：检测胸腔内电阻抗变化的方法和装置
公开(公告)号：US08428718B2
公开(公告)日：2013-04-23
申请号：US13177912
申请日：2011-07-07
申请人： Robert W. Stadler , Li Wang
发明人： Robert W. Stadler , Li Wang
IPC分类号： A61B5/053
CPC分类号： A61B5/0538 , A61B5/0537 , A61B5/4875 , A61B5/686 , A61B5/7275 , A61N1/362 , A61N1/3627 , A61N1/36521 , G06F12/0862 , G06F12/0877
摘要： A method and apparatus for detection of changes in impedance a patient that includes generating measured impedances, generating an adaptive baseline trend of the measured impedances corresponding to a first time period, generating a short term trend of the measured impedances corresponding to a second time period less than the first time period, determining changes in relative position of the short term trend and the baseline trend, the determined changes in relative position corresponding to determining intersecting of the baseline trend by the short term trend, determining differences between the baseline trend and calculated period average impedances, and accumulating, in response to determining no intersecting of the baseline trend by the short term trend, the determined differences between the baseline trend and the calculated period average impedances.
摘要翻译：一种用于检测患者阻抗变化的方法和装置，包括产生测量的阻抗，产生对应于第一时间段的所测量的阻抗的自适应基线趋势，产生对应于第二时间段的所测量的阻抗的短期趋势确定短期趋势相对位置的变化和基准趋势，确定相对位置的变化对应于基线趋势与短期趋势的相交，确定基线趋势与计算周期之间的差异平均阻力和累积，以确定基准趋势与短期趋势的相交，确定基线趋势与计算的周期平均阻抗之间的差异。

63. 发明授权

US08306618B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08306618B2
公开(公告)日：2012-11-06
申请号：US12763499
申请日：2010-04-20
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/37
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

64. 发明授权

US08306614B2 Method of dual EGM sensing and heart rate estimation in implanted cardiac devices 有权
标题翻译：植入心脏装置中双重EGM感测和心率估计的方法
公开(公告)号：US08306614B2
公开(公告)日：2012-11-06
申请号：US13080807
申请日：2011-04-06
申请人： Robert W. Stadler , Carissa Lynn Bellardine Black
发明人： Robert W. Stadler , Carissa Lynn Bellardine Black
IPC分类号： A61N1/00
CPC分类号： A61B5/04525 , A61B5/02438 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3622 , A61N1/3962
摘要： A method and apparatus for monitoring a patient's heart rate sense first cardiac events in a heart chamber using a first cardiac electrode pair and sense second cardiac events in the heart chamber using a second cardiac electrode pair. The method includes estimating a first heart rate using the first cardiac events, comparing the first heart rate to a heart rate threshold and estimating a second heart rate using the second cardiac events in response to the first heart rate exceeding the heart rate threshold.
摘要翻译：用于监测患者心率的方法和装置使用第一心脏电极对感测心室中的第一心脏事件，并使用第二心电极对感测心室中的第二心脏事件。该方法包括使用第一心脏事件估计第一心率，将第一心率与心率阈值进行比较，并且响应于超过心率阈值的第一心率估计使用第二心脏事件的第二心率。

65. 发明申请

US20120108990A1 METHOD AND APPARATUS FOR REDUCING NOISE IN A MEDICAL DEVICE 有权
标题翻译：用于减少医疗设备中的噪声的方法和装置
公开(公告)号：US20120108990A1
公开(公告)日：2012-05-03
申请号：US12915093
申请日：2010-10-29
申请人： Robert W. Stadler , Richard P.M. Houben , Tim Dirk Jan Jongen
发明人： Robert W. Stadler , Richard P.M. Houben , Tim Dirk Jan Jongen
IPC分类号： A61B5/0428
CPC分类号： A61N1/3702 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing a cardiac signal, detecting a cardiac event in response to the sensed signal, determining whether an interval associated with the cardiac signal is less than an interval threshold, determining a noise metric in response to an interval associated with the cardiac signal being less than the interval threshold, determining whether the noise metric is greater than a noise metric threshold, and determining whether to inhibit detecting in response to determining whether an interval associated with the cardiac signal is less than the interval threshold and determining whether the noise metric is greater than the noise metric threshold.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测心脏信号，响应于感测信号检测心脏事件，确定与心脏信号相关联的间隔是否小于间隔阈值，确定噪声响应于与所述心脏信号相关联的间隔小于所述间隔阈值的度量，确定所述噪声度量是否大于噪声度量阈值，以及响应于确定与所述心脏信号相关联的间隔是否是禁止检测小于间隔阈值并确定噪声度量是否大于噪声度量阈值。

66. 发明申请

US20120053477A1 METHOD AND APPARATUS FOR ENHANCING TREATABLE ARRHYTHMIA DETECTION SPECIFICITY BY USING ACCUMULATED PATIENT ACTIVITY 有权
标题翻译：通过使用累积患者活动来增强可治疗性脑膜炎检测特异性的方法和装置
公开(公告)号：US20120053477A1
公开(公告)日：2012-03-01
申请号：US12869180
申请日：2010-08-26
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
IPC分类号： A61B5/04
CPC分类号： A61B5/1118 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61N1/36542 , A61N1/3962
摘要： A method and apparatus for detecting a cardiac event in a medical device determine an activity level count from an activity sensor signal for each of a number of time segments, store an activity level count for each of the time segments in a histogram, and accumulate the stored activity level counts to determine a percentage of time segments having an activity level count above a given activity level count.
摘要翻译：用于检测医疗装置中的心脏事件的方法和装置根据多个时间段中的每一个的活动传感器信号确定活动水平计数，将每个时间段的活动水平计数存储在直方图中，并且累积存储的活动级别计数以确定具有高于给定活动级别计数的活动级别计数的时间段的百分比。

67. 发明授权

US08095206B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08095206B2
公开(公告)日：2012-01-10
申请号：US11742618
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for adjusting a sensing parameter in a medical device that includes a sensing electrode sensing cardiac signals, a processor to determine an adjusting characteristic associated with the cardiac signals sensed over a predetermined sensing window, and a control unit to update the sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于调整包括感测心脏信号的感测电极的医疗装置中的感测参数的方法和装置，用于确定与在预定感测窗口上感测到的心脏信号相关联的调整特性的处理器以及用于更新感测参数的控制单元响应于确定的调整特性。

68. 发明授权

US08050751B2 Periodic beat detection to detect artifacts in a cardiac electrogram 有权
标题翻译：定期拍摄检测心脏电图中的伪影
公开(公告)号：US08050751B2
公开(公告)日：2011-11-01
申请号：US12183950
申请日：2008-07-31
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
IPC分类号： A61B5/0464
CPC分类号： A61N1/3621 , A61B5/0464 , A61B5/7221 , A61B5/7239 , A61N1/36507 , A61N1/3925 , A61N1/3962
摘要： Techniques for determining whether artifacts are present in a cardiac electrogram are described. According to one example, a medical device senses a cardiac electrogram via electrodes. The medical device determines a derivative, e.g., a second order derivative, the electrogram. The medical device detects beats within the derivative, e.g., by comparing a rectified version of the derivative to one or more thresholds determined based on a maximum of the rectified derivative. The medical device determines whether the beats are periodic, and determines whether artifacts are present in the cardiac electrogram based on the determination of whether the beats are periodic. The medical device may further determine whether tachyarrhythmia is present and/or whether the cardiac rhythm of the patient is treatable based on the determination of whether the beats are periodic. For example, the medical device may determine that an electrogram is not treatable when the beats are periodic.
摘要翻译：描述了用于确定伪像是否存在于心电图中的技术。根据一个示例，医疗装置通过电极感测心电图。医疗设备确定导数，例如二阶导数，电描记图。医疗设备检测导数内的跳动，例如通过将导数的整流版本与基于校正导数的最大值确定的一个或多个阈值进行比较。医疗器械确定节拍是否是周期性的，并且基于确定节拍是否是周期性的确定来确定心脏电图中是否存在假象。医疗装置可以基于是否是周期性的确定来进一步确定是否存在快速性心律失常和/或患者的心律是否可治疗。例如，当节拍是周期性的时，医疗装置可以确定电描记图是不可治疗的。

69. 发明授权

US07991471B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US07991471B2
公开(公告)日：2011-08-02
申请号：US11461269
申请日：2006-07-31
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/368
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

70. 发明授权

US07734333B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07734333B2
公开(公告)日：2010-06-08
申请号：US11380815
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing a cardiac signal from a plurality of electrodes, determining amplitudes of the sensed cardiac signal during a predetermined sensing window, determining a noise to signal ratio corresponding to the determined amplitudes, and determining the sensed cardiac signal during the predetermined sensing window is corrupted by noise in response to the determined noise to signal ratio being greater than a noise to signal ratio threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括感测来自多个电极的心脏信号，确定在预定感测窗口期间检测到的心脏信号的幅度，确定对应于所确定的幅度的噪声信号比，以及确定响应于所确定的噪声信号比大于噪声信号比阈值，在预定感测窗口期间感测到的心脏信号被噪声破坏。

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