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61. 发明授权

US08143274B2 1-(2H)-isoquinolone derivative 失效
标题翻译： 1-（2H） - 异喹诺酮衍生物
公开(公告)号：US08143274B2
公开(公告)日：2012-03-27
申请号：US10588611
申请日：2005-02-07
申请人： Kazuo Hattori , Satoshi Niizuma , Takehiro Okada , Hiroyuki Eda , Kenji Tatsuno , Miyuki Yoshida
发明人： Kazuo Hattori , Satoshi Niizuma , Takehiro Okada , Hiroyuki Eda , Kenji Tatsuno , Miyuki Yoshida
IPC分类号： C07D217/24 , A61K31/47
CPC分类号： C07D217/24
摘要： The present invention provides: a compound represented by the following formula (I): [wherein Y1 and Y4 represent a hydrogen atom or a halogen atom; either one of Y2 and Y3 represents —NR1R2, and the other represents a hydrogen atom or a halogen atom; X represents an aryl group or a heteroaryl group that may be substituted; R1 represents a hydrogen atom, or a C1-8 alkyl group that may be substituted; and R2 represents a C1-8 alkyl group that is substituted with one or more substituents, —COOR3, —COR4, —COSR5, —CONR6R7, —NR22R23, or —C═NR24R25; or R1 and R2, together with a nitrogen atom to which they are bonded, may form a 4- to 10-membered hetero ring containing at least one nitrogen atom (wherein the hetero ring may be substituted with one or more substituents selected from Group C)], a prodrug thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical, a pharmaceutical composition, or the like, which comprises the compound.
摘要翻译：本发明提供：由下式（I）表示的化合物：[其中Y 1和Y 4表示氢原子或卤素原子; Y2和Y3中的任一个表示-NR1R2，另一个表示氢原子或卤素原子; X表示可被取代的芳基或杂芳基; R1表示氢原子或可被取代的C1-8烷基; 并且R 2表示被一个或多个取代基-COOR 3，-COR 4，-COSR 5，-CONR 6 R 7，-NR 22 R 23或-C≡NR24 R 25取代的C 1-8烷基; 或R 1和R 2与它们所键合的氮原子一起可以形成含有至少一个氮原子的4至10元杂环（其中杂环可以被一个或多个选自C组的取代基取代）]，其前药，或其药学上可接受的盐; 以及包含该化合物的药物，药物组合物等。

62. 发明授权

US07820693B2 1-(2H)-isoquinolone derivative 有权
标题翻译： 1-（2H） - 异喹诺酮衍生物
公开(公告)号：US07820693B2
公开(公告)日：2010-10-26
申请号：US11816910
申请日：2006-02-22
申请人： Kazuo Hattori , Satoshi Niizuma , Miyako Masubuchi , Kohei Koyama , Osamu Kondoh , Toshiyuki Tsukaguchi , Takehiro Okada
发明人： Kazuo Hattori , Satoshi Niizuma , Miyako Masubuchi , Kohei Koyama , Osamu Kondoh , Toshiyuki Tsukaguchi , Takehiro Okada
IPC分类号： A61K31/47 , C07D401/10
CPC分类号： C07D491/04 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.
摘要翻译：本发明提供具有高抗肿瘤活性的化合物，其可用于对增殖性疾病如癌症有效的治疗和预防剂; 其制造方法; 用于这种生产的中间体化合物; 和包含这种化合物的药物组合物。本发明提供由式（1）表示的化合物：其中X表示可被取代的芳基或杂芳基，Cy表示4-至7-元单环杂环或8-至10-元稠合杂环可以被取代的环，Z表示O，S或NRa; 或其前药; 或其药学上可接受的盐; 以及包含该化合物的药物和药物组合物。

63. 发明授权

US07672112B2 Component-embedded substrate and component package using component-embedded substrate 有权
标题翻译：使用组件嵌入式基板的部件嵌入式基板和部件封装
公开(公告)号：US07672112B2
公开(公告)日：2010-03-02
申请号：US12369759
申请日：2009-02-12
申请人： Kazuo Hattori , Isamu Fujimoto , Shinichiro Kuroiwa , Satoru Noda
发明人： Kazuo Hattori , Isamu Fujimoto , Shinichiro Kuroiwa , Satoru Noda
IPC分类号： H01G4/228
CPC分类号： H05K1/0231 , H01G4/224 , H01G4/228 , H01G4/232 , H05K1/185 , H05K2201/10636 , Y02P70/611
摘要： A component-embedded substrate includes a chip capacitor. The chip capacitor includes a ceramic laminate body and a plurality of terminal electrodes. The component-embedded substrate has a first principal surface and a second principal surface. At least two of the plurality of terminal electrodes are connected to the first principal surface and define a first terminal electrode group, and at least two of the plurality of terminal electrodes are connected to the second principal surface and define a second terminal electrode group. One terminal electrode in the first terminal electrode group is electrically connected to one terminal electrode in the second terminal electrode group via the internal electrodes, and capacitance is provided by a pair of the terminal electrodes in the first terminal electrode group via the dielectric layer, and capacitance is provided by a pair of the terminal electrodes in the second terminal electrode group via the dielectric layer. A direction in which the internal electrodes are stacked is parallel or substantially parallel to the two principal surfaces.
摘要翻译：部件嵌入式基板包括片状电容器。片状电容器包括陶瓷层叠体和多个端子电极。部件嵌入式基板具有第一主表面和第二主表面。多个端子电极中的至少两个连接到第一主表面并限定第一端子电极组，并且多个端子电极中的至少两个连接到第二主表面并限定第二端子电极组。第一端子电极组中的一个端子电极经由内部电极与第二端子组中的一个端子电极电连接，并且电容由第一端子电极组中的一对端子电极经由电介质层提供，以及电容由第二端子电极组中的一对端子电极经由电介质层提供。内部电极层叠的方向平行或基本平行于两个主表面。

64. 发明申请

US20090201624A1 COMPONENT-EMBEDDED SUBSTRATE AND COMPONENT PACKAGE USING COMPONENT-EMBEDDED SUBSTRATE 有权
标题翻译：使用组件嵌入式基板的组件嵌入式基板和组件封装
公开(公告)号：US20090201624A1
公开(公告)日：2009-08-13
申请号：US12369759
申请日：2009-02-12
申请人： Kazuo Hattori , Isamu Fujimoto , Shinichiro Kuroiwa , Satoru Noda
发明人： Kazuo Hattori , Isamu Fujimoto , Shinichiro Kuroiwa , Satoru Noda
IPC分类号： H01G4/224 , H05K1/18
CPC分类号： H05K1/0231 , H01G4/224 , H01G4/228 , H01G4/232 , H05K1/185 , H05K2201/10636 , Y02P70/611
摘要： A component-embedded substrate includes a chip capacitor. The chip capacitor includes a ceramic laminate body and a plurality of terminal electrodes. The component-embedded substrate has a first principal surface and a second principal surface. At least two of the plurality of terminal electrodes are connected to the first principal surface and define a first terminal electrode group, and at least two of the plurality of terminal electrodes are connected to the second principal surface and define a second terminal electrode group. One terminal electrode in the first terminal electrode group is electrically connected to one terminal electrode in the second terminal electrode group via the internal electrodes, and capacitance is provided by a pair of the terminal electrodes in the first terminal electrode group via the dielectric layer, and capacitance is provided by a pair of the terminal electrodes in the second terminal electrode group via the dielectric layer. A direction in which the internal electrodes are stacked is parallel or substantially parallel to the two principal surfaces.
摘要翻译：部件嵌入式基板包括片状电容器。片状电容器包括陶瓷层叠体和多个端子电极。部件嵌入式基板具有第一主表面和第二主表面。多个端子电极中的至少两个连接到第一主表面并限定第一端子电极组，并且多个端子电极中的至少两个连接到第二主表面并限定第二端子电极组。第一端子电极组中的一个端子电极经由内部电极与第二端子组中的一个端子电极电连接，并且电容由第一端子电极组中的一对端子电极经由电介质层提供，以及电容由第二端子电极组中的一对端子电极经由电介质层提供。内部电极层叠的方向平行或基本平行于两个主表面。

65. 发明授权

US07014021B2 Fluid coupling 有权
标题翻译：流体联轴器
公开(公告)号：US07014021B2
公开(公告)日：2006-03-21
申请号：US10432602
申请日：2001-12-04
申请人： Katsumi Kimura , Kazuo Hattori , Hiroshi Ogata , Yoshinori Kataya , Kazuhiko Sugiyama
发明人： Katsumi Kimura , Kazuo Hattori , Hiroshi Ogata , Yoshinori Kataya , Kazuhiko Sugiyama
IPC分类号： F16H45/02 , F16D25/0638
CPC分类号： F16H61/14 , F16H45/02 , F16H2045/0284
摘要： A fluid coupling transmits power from a drive side to a driven side by utilizing kinetic energy of fluid such as oil. The fluid coupling comprises a pump impeller (4) provided on a drive shaft (1), a turbine impeller (5) provided on a driven shaft (9), a housing (20) fixed to the pump impeller (4) and surrounding the turbine impeller, and a multiple disc clutch provided between a drive shaft side and a driven shaft side. The multiple disc clutch is operated to couple the drive shaft (1) and the driven shaft (9) mechanically so that the drive shaft and the driven shaft are rotated at the same rotational speed. Thus, the fluid coupling can improve a power transmitting efficiency because of no slip between the rotational speed of the drive shaft and the rotational speed of the driven shaft.
摘要翻译：流体联轴器通过利用诸如油的流体的动能将动力从驱动侧传递到从动侧。流体联轴器包括设置在驱动轴（1）上的泵叶轮（4），设置在从动轴（9）上的涡轮机叶轮（5），固定到泵叶轮（4）的壳体（20）涡轮叶轮和设置在驱动轴侧和从动轴侧之间的多片离合器。多片离合器被操作以机械地联接驱动轴（1）和从动轴（9），使得驱动轴和从动轴以相同的转速旋转。因此，由于驱动轴的转速与从动轴的旋转速度之间没有滑动，所以流体联接可以提高动力传递效率。

66. 发明授权

US06211166B1 5′-deoxy-cytidine derivative administration to treat solid tumors 有权
标题翻译： 5'-脱氧胞苷衍生物给药治疗实体瘤
公开(公告)号：US06211166B1
公开(公告)日：2001-04-03
申请号：US09534156
申请日：2000-03-24
申请人： Kazuo Hattori , Tohru Ishikawa , Hideo Ishitsuka , Yasunori Kohchi , Nobuhiro Oikawa , Nobuo Shimma , Hitomi Suda
发明人： Kazuo Hattori , Tohru Ishikawa , Hideo Ishitsuka , Yasunori Kohchi , Nobuhiro Oikawa , Nobuo Shimma , Hitomi Suda
IPC分类号： A01N4304
CPC分类号： C07H19/06 , Y02P20/55
摘要： Novel 5′-deoxy-cytidine derivatives represented by the general formula (I) wherein R1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R2 is a hydrogen atom, or —CO—OR4 group [wherein R4 is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula —(CH2)n—Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R3 is a hydrogen atom, bromo, iodo, cyano, a C1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy.
摘要翻译：由通式（I）表示的新型5'-脱氧胞苷衍生物，其中R1是氢原子或在生理条件下容易水解的基团; R2是氢原子或-CO-OR4基团[其中R4是由1-15个碳原子组成的饱和或不饱和的直链或支链烃基，或式 - （CH2）nY（其中Y是环己基或苯基; n为0至4的整数）]; R3是氢原子，溴，碘，氰基，C1-4烷基[可以被卤素原子取代]，乙烯基或乙炔基[可以被卤原子取代，C1- 4烷基，环烷基，芳烷基或可能具有一个或多个杂原子的芳环]或可用于药物治疗，特别是肿瘤治疗的芳烷基。

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