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61. 发明申请

WO2009031075A2 ANTENNA SELECTION TRAINING PROTOCOL FOR WIRELESS MEDICAL APPLICATIONS 审中-公开
标题翻译：无线医疗应用的天线选择培训协议
公开(公告)号：WO2009031075A2
公开(公告)日：2009-03-12
申请号：PCT/IB2008/053435
申请日：2008-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , WANG, Dong
发明人： WANG, Dong
IPC分类号： H04B7/06 , H04B7/08
CPC分类号： H04B7/061 , G01R33/3692
摘要： In a medical imaging setting, wireless local devices such as probes and local coils are used. As environmental variables may change, signals from the main imaging machine from different locations around the imaging suite are transmitted and received. In determining which of a plurality of locations is best for receiving, a main machine antenna system (26) transmits training request packets from various locations. A wireless transceiver (24) located on a local probe device (22) responds to each training request packet that it receives. By evaluating the responses, the imager can determine which antenna locations are best. A sleep mode and a double-check mechanism are included to improve power consumption, performance, and communication reliability.
摘要翻译：在医学成像设置中，使用诸如探针和局部线圈的无线本地设备。随着环境变量的变化，来自成像套件周围不同位置的主要成像设备的信号被发送和接收。在确定多个位置中的哪一个最适合于接收时，主机天线系统（26）从各个位置发送训练请求分组。位于本地探测设备（22）上的无线收发器（24）响应它接收到的每个训练请求分组。通过评估响应，成像仪可以确定哪个天线位置最好。包含睡眠模式和双重检查机制以提高功耗，性能和通信可靠性。

62. 发明申请

WO2008110998A2 METHOD AND SYSTEM OF INTERLEAVING FOR A MULTIPLE-INPUT MULTIPLE-OUTPUT MULTI-BAND OFDM COMMUNICATION SYSTEM 审中-公开
标题翻译：多输入多输出多频带OFDM通信系统的交织方法和系统
公开(公告)号：WO2008110998A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/050903
申请日：2008-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , YANG, Jun , WANG, Dong
发明人： YANG, Jun , WANG, Dong
IPC分类号： H04L27/26
CPC分类号： H04L1/0071 , H03M13/275 , H04L1/06
摘要： A multiple-input multiple-output multi-band OFDM transmission system (400) employs a data interleaving arrangement that is backwards compatible with specifications for a legacy interleaver. In one embodiment, an input data stream is parsed into two or more separate data streams by a round robin parser (310) and each of the separate data streams is shifted by a corresponding number of symbols and then interleaved by a legacy interleaver (340i). In another embodiment, data for a plurality (N*i) of symbols is split into N sequential groups of data, each group corresponding to one of N MIMO spatial streams, each stream including data for i symbols. Each group is then interleaved by a legacy interleaver (520i). In a third embodiment, an input data stream is interleaved by a scaled version of the legacy interleaver (610), and then parsed by a round-robin parser (620).
摘要翻译：多输入多输出多频带OFDM传输系统（400）采用与传统交织器的规范向后兼容的数据交织布置。在一个实施例中，由循环解析器（310）将输入数据流解析成两个或更多个单独的数据流，并且每个单独的数据流移位相应数量的符号，然后由传统交织器（340i）交织，。在另一个实施例中，用于多个（N×i）个符号的数据被分成N个连续的数据组，每个组对应于N个MIMO空间流中的一个，每个流包括用于i个符号的数据。然后每个组由传统交织器（520i）交织。在第三实施例中，输入数据流由传统交织器（610）的缩放版本交织，然后由循环解析器（620）解析。

63. 发明申请

WO2008017029A3 DRUG CARRIERS, THEIR SYNTHESIS, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2008017029A3
公开(公告)日：2008-02-07
申请号：PCT/US2007/075073
申请日：2007-08-02
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , WANG, Dong , REINHARDT, Richard, A. , LIU, Xin-Ming
发明人： WANG, Dong , REINHARDT, Richard, A. , LIU, Xin-Ming
IPC分类号： A61K47/40 , A61K47/48 , A61K47/30
摘要： Drug carriers, methods of synthesizing, and methods of use thereof are provided.

64. 发明申请

WO2008007150A1 PREPARATION OF PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物的制备
公开(公告)号：WO2008007150A1
公开(公告)日：2008-01-17
申请号：PCT/GB2007/050407
申请日：2007-07-13
申请人： UNILEVER PLC , ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
发明人： ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
IPC分类号： A61K9/16 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
摘要翻译：一种制备包含水不溶性对乙酰氨基酚或NSAID的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性对乙酰氨基酚或NSAID，ii）水溶性载体，和iii）溶剂，并且b）喷雾干燥该混合物以除去该溶剂或每种溶剂，并获得载体中对乙酰氨基酚或NSAID的基本上无溶剂的纳米分散体。

65. 发明申请

WO2008006716A2 IMPROVEMENTS RELATING TO PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：关于药物组合物的改进
公开(公告)号：WO2008006716A2
公开(公告)日：2008-01-17
申请号：PCT/EP2007/056564
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER N.V. , DUNCALF, David, John , ELPHICK, Andrew, James , FOSTER, Alison, Jayne , LONG, James , RANNARD, Steven, Paul , WANG, Dong
发明人： DUNCALF, David, John , ELPHICK, Andrew, James , FOSTER, Alison, Jayne , LONG, James , RANNARD, Steven, Paul , WANG, Dong
IPC分类号： A61K9/16 , A61K31/496
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译：一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的沙坦ii）水溶性载体，iii）每种沙坦的溶剂和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。

66. 发明申请

WO2008006713A3 IMPROVEMENTS RELATING TO ANTI-PARASITIC COMPOSITIONS 审中-公开
公开(公告)号：WO2008006713A3
公开(公告)日：2008-01-17
申请号：PCT/EP2007/056561
申请日：2007-06-29
申请人： UNILEVER PLC , UNILEVER N.V. , DUNCALF, David, John , ESSA, Asha, Hassan , FOSTER, Alison, Jayne , LONG, James , RANNARD, Steven, Paul , WANG, Dong
发明人： DUNCALF, David, John , ESSA, Asha, Hassan , FOSTER, Alison, Jayne , LONG, James , RANNARD, Steven, Paul , WANG, Dong
IPC分类号： A61K9/16 , A61K31/496
摘要： The present invention relates to nanodisperse antiparasitcs and provides a composition comprising at least one water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the water-insoluble anti-parasitic drug (preferably an Artemisinin-type drug or a quinine type drug) is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000nm. The invention further provides an aqueous dispersion of a water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the anti-parasitic drug is in nano-disperse form having a peak diameter of the nano- disperse form below 1000nm, the invention further subsists in a process for preparing an anti-parasitic composition comprising a water insoluble anti-parasitc agent and a water-soluble carrier, which comprises the steps of either: a) providing an emulsion comprising a solution of the anti-parasitic agent in a water-immiscible solvent for the same, and an aqueous solution of the carrier, or providing a mixture comprising at least one non-aqueous solvent optional water a water-soluble carrier material soluble in the mixture and a water-insoluble anti- parasitic agent soluble in the mixture, and, b) drying the emulsion (preferably by spray drying) to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the anti-parasitic agent in the carrier.

67. 发明申请

WO2007056904A1 MICROARRAYS FOR GENOTYPING AND METHODS OF USE 审中-公开
标题翻译：用于基因组的微阵列和使用方法
公开(公告)号：WO2007056904A1
公开(公告)日：2007-05-24
申请号：PCT/CN2006/000237
申请日：2006-02-20
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVESITY , GAO, Huafang , LI, Ze , WANG, Dong , LIU, Yanhua , LIU, Xiang , JIANG, Yangzhou , ZHAO, Chuanzan , LI, Li , LAN, Gengxin , GUO, Tao , CAI, Bin , XING, Wanli , ZHOU, Yuxiang , CHENG, Jing
发明人： GAO, Huafang , LI, Ze , WANG, Dong , LIU, Yanhua , LIU, Xiang , JIANG, Yangzhou , ZHAO, Chuanzan , LI, Li , LAN, Gengxin , GUO, Tao , CAI, Bin , XING, Wanli , ZHOU, Yuxiang , CHENG, Jing
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q2600/156
摘要： The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
摘要翻译：本发明提供了用于检测多个核酸样品中多态性位点处的基因型的微阵列，其包含衍生自样品的第一组核酸片段和衍生自多个固定在其上的参考文献的第二组核酸片段。本发明还提供了一种微阵列，其包含固定在微阵列表面上的一组核酸片段，其中通过不对称PCR扩增扩增含有多态性的样品中的区域，来从样品衍生出核酸片段。还提供了使用和制造微阵列的方法。

68. 发明申请

WO2007028289A1 A MICROVALVE CONTROLLED PRECISION FLUID DISPENSING APPARATUS WITH A SELF-PURGING FEATURE AND METHOD FOR USE 审中-公开
标题翻译：具有自取特征的微型控制精密液体分配装置和使用方法
公开(公告)号：WO2007028289A1
公开(公告)日：2007-03-15
申请号：PCT/CN2006/000055
申请日：2006-01-13
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , WANG, Dong , ZOU, Kun , CHENG, Jing
发明人： WANG, Dong , ZOU, Kun , CHENG, Jing
IPC分类号： B05B9/04 , B05B12/00 , B01L3/02 , G01N35/10 , G01N1/14 , G01N33/53 , G01N37/00 , C12Q1/00 , B41J2/01
CPC分类号： B41J2/17596 , B01J2219/0036 , B01J2219/00364 , B01L3/0265 , B01L2400/0478 , B01L2400/0622 , B41J2/175 , G01N2035/00247 , G01N2035/1041 , Y10T436/2575
摘要： An apparatus and methods for the precise, repeatable dispensing of small, sample fluid volumes, especially as related to the printing of microarrays for biological and/or chemical testing. A pressure tuning module meters fluid volumes for aspiration and dispensation and builds pressure for fluid dispensation, in conjunction with a microvalve that precisely controls the volume of the fluid dispensed under the built pressure. A pressure source can be switched in line to efficiently purge the apparatus of residual sample fluid. A working fluid can be optionally aspirated into the system, prior to aspirating the sample fluid, in order to maximize sample fluid recovery.
摘要翻译：用于精确，可重复分配小的样品流体体积的装置和方法，特别是与用于生物和/或化学测试的微阵列的印刷相关。压力调节模块计量用于抽吸和分配的流体体积，并建立用于流体分配的压力，以及精确控制在内置压力下分配的流体的体积的微型阀。压力源可以排成一行，以有效地吹扫残留样品液的装置。在抽吸样品流体之前，可以将工作流体任选地吸入系统，以使样品液体回收最大化。

69. 发明申请

WO2005001123A1 DNA CHIP BASED GENETIC TYPING 审中-公开
标题翻译：基于DNA芯片的遗传型
公开(公告)号：WO2005001123A1
公开(公告)日：2005-01-06
申请号：PCT/CN2003/000580
申请日：2003-07-18
申请人： TSINGHUA UNIVERSITY , CAPITAL BIOCHIP COMPANY, LTD. , GAO, Huafang , MA, Xuemei , ZHANG, Chi , CHEN, Qian , ZHOU, Yiming , WANG, Dong , ZHANG, Yizhe , TIAN, Yue , ZHANG, Rui , LAN, Gengxin , ZHOU, Yuxiang , CHENG, Jing
发明人： GAO, Huafang , MA, Xuemei , ZHANG, Chi , CHEN, Qian , ZHOU, Yiming , WANG, Dong , ZHANG, Yizhe , TIAN, Yue , ZHANG, Rui , LAN, Gengxin , ZHOU, Yuxiang , CHENG, Jing
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： This invention relates generally to the field of nucleic acid analysis. In particular, the invention provides a method for typing a target gene, using, inter alia, a chip comprising a support suitable for use in nucleic acid hybridization having immobilized thereon an oligonucleotide probe complementary to said target nucleotide sequence and at least one of the following oligonucleotide control probes: a positive control probe, a negative control probe, a hybridization control probe and an immobilization control probe. Oligonucleotide probes or probes arrays for typing a HLA target gene are also provided.
摘要翻译：本发明一般涉及核酸分析领域。特别地，本发明提供了一种用于对目标基因进行分型的方法，特别地，使用包含适合用于核酸杂交的载体的芯片，其上固定有与所述靶核苷酸序列互补的寡核苷酸探针和至少一种以下寡核苷酸对照探针：阳性对照探针，阴性对照探针，杂交对照探针和固定化对照探针。还提供了用于分型HLA靶基因的寡核苷酸探针或探针阵列。

70. 发明申请

WO2004062588A2 WATER-SOLUBLE POLYMERIC BONE-TARGETING DRUG DELIVERY SYSTEM 审中-公开
标题翻译：水溶性聚合物骨髓给药系统
公开(公告)号：WO2004062588A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000276
申请日：2004-01-06
申请人： UNIVERSITY OF UTAH , WANG, Dong , MILLER, Scott, C. , KOPECKOVA, Pavla , KOPECEK, Jindrich
发明人： WANG, Dong , MILLER, Scott, C. , KOPECKOVA, Pavla , KOPECEK, Jindrich
IPC分类号： A61K
CPC分类号： A61K31/785 , A61K47/542 , A61K47/548 , A61K47/552 , C07C237/26 , C07C2603/46
摘要： The present invention provides bone-targeting polymeric drug delivery systems based on HPMA and related copolymers and methods of making thereof. The water-soluble bone-targeting polymeric conjugates of the present invention comprise water-soluble copolymer backbones (P) which are linked, via a first spacer (S 1 ), with a bone-related therapeutic agents or drug (D) and, via a second spacer (S 2 ), with a bone-targeting moiety (T).
摘要翻译：本发明提供了基于HPMA和相关共聚物的骨靶向聚合物药物递送系统及其制备方法。本发明的水溶性骨靶向聚合物缀合物包含通过第一间隔物（S1）与骨相关的治疗剂或药物（D）连接的水溶性共聚物主链（P），并经由第二间隔物（S2），具有骨靶向部分（T）。

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