专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明公开

EP1633742A1 INDOL-DERIVATE ALS SEROTONIN-WIEDERAUFNAHME-INHIBITOREN 审中-公开
标题翻译：吲哚衍生物ALS serotonin-WIEDERAUFNAHME-INHIBITOREN
公开(公告)号：EP1633742A1
公开(公告)日：2006-03-15
申请号：EP04734520.2
申请日：2004-05-24
申请人： Merck Patent GmbH
发明人： HEINRICH, Timo , BÖTTCHER, Henning , SCHIEMANN, Kai , HÖLZEMANN, Günter , VAN AMSTERDAM, Christoph , BARTOSZYK, Gerd , LEIBROCK, Joachim , SEYFRIED, Christoph
IPC分类号： C07D405/12 , C07D405/14 , A61K31/4045 , A61P25/00
CPC分类号： C07D405/12 , C07D405/14
摘要： The invention relates to compounds of formula (I) used for producing drugs for treating diseases related to a serotonin receptor and/or a serotonin reabsorption, in particular for producing drugs like anxiolitic, antidepressive, neuroleptic and/or antihypertensive drugs and/or for positively influencing obsessional compulsive troubles, sleep disorders, tardive dyskinesia, learning troubles, gerontal memory loss, eating disorders such as bulimia and/or irritable bowel syndrome and/or sexual function troubles. Said compounds are associated with to a 5-HT1A receptor.
摘要翻译：本发明涉及用于生产用于治疗与5-羟色胺受体和/或5-羟色胺再吸收相关的疾病的药物，特别是用于生产类似抗焦虑药，抗抑郁药，精神安定药和/或抗高血压药的药物和/或用于治疗影响强迫症，睡眠障碍，迟发性运动障碍，学习困难，老年记忆丧失，进食障碍如贪食症和/或肠易激综合征和/或性功能障碍。所述化合物与5-HT1A受体结合。

62. 发明公开

EP1633741A1 INDOL-DERIVATE ALS SEROTONIN-WIEDERAUFNAHME-INHIBITOREN 审中-公开
标题翻译：吲哚衍生物血清素回收抑制剂
公开(公告)号：EP1633741A1
公开(公告)日：2006-03-15
申请号：EP04734515.2
申请日：2004-05-24
申请人： Merck Patent GmbH
发明人： HEINRICH, Timo , BÖTTCHER, Henning , SCHIEMANN, Kai , HÖLZEMANN, Günter , VAN AMSTERDAM, Christoph , BARTOSZYK, Gerd , LEIBROCK, Joachim , SEYFRIED, Christoph
IPC分类号： C07D405/12 , A61K31/4045 , A61P25/00
CPC分类号： C07D405/12
摘要： Disclosed are compounds of formula (I), the use thereof for producing a medicament utilized for treating diseases related to the serotonin receptor and/or serotonin reuptake, especially for producing a medicament utilized as an anxiolytic, antidepressant, neuroleptic, and/or antihypertensive and/or for positively influencing obsessive-compulsive behavior (OCD), sleeping disorders, tardive dyskinesia, learning disorders, age-related memory defects, eating disorders such as bulimia, and/or sexual dysfunctions. The inventive compounds bond to the 5-HT1A receptor.

63. 发明公开

EP1611126A1 CHROMENONINDOLE 有权
公开(公告)号：EP1611126A1
公开(公告)日：2006-01-04
申请号：EP04718300.9
申请日：2004-03-08
申请人： Merck Patent GmbH
发明人： SCHIEMANN, Kai , BÖTTCHER, Henning , HEINRICH, Timo , HÖLZEMANN, Günter , VAN AMSTERDAM, Christoph , BARTOSZYK, Gerd , LEIBROCK, Joachim , SEYFRIED, Christoph
IPC分类号： C07D405/12 , A61K31/495
CPC分类号： C07D405/12
摘要： The invention relates to the chromenone indole derivatives of formula (I), wherein R1, R2, R3, R, A and B are defined as in claim 1 and to the pharmaceutically useful prodrugs, derivatives, solvates, stereoisomers and salts thereof. The inventive substances have particular effects on the central nervous system, in particularly they are 5 HT reuptake inhibitors and 5 HTx agonists and/or antagonists. They are characterized by an especially good bioavailability and excellent inhibition of 5 HT reuptake.
摘要翻译：本发明涉及式（I）的苯并吡喃酮吲哚衍生物，其中R1，R2，R3，R，A和B如权利要求1中所定义，并涉及其药学上有用的前药，衍生物，溶剂合物，立体异构体和盐。本发明的物质对中枢神经系统具有特殊的作用，特别是它们是5HT再摄取抑制剂和5HTx激动剂和/或拮抗剂。它们具有特别良好的生物利用度和优异的5HT再摄取抑制作用。

64. 发明授权

EP1202966B1 PIPERIDINALKOHOLE 有权
公开(公告)号：EP1202966B1
公开(公告)日：2004-06-09
申请号：EP00964004.6
申请日：2000-08-08
申请人： MERCK PATENT GmbH
发明人： PRÜCHER, Helmut , BÖTTCHER, Henning , ACKERMANN, Karl-August , GOTTSCHLICH, Rudolf , GREINER, Hartmut , HARTING, Jürgen , BARTOSZYK, Gerd , SEYFRIED, Christoph , VAN AMSTERDAM, Christoph
IPC分类号： C07D211/18 , C07D409/06 , C07D405/06 , C07D417/06 , C07D401/06 , A61K31/445 , A61K31/4523 , A61P25/00 , A61P25/16 , A61P25/18
CPC分类号： C07D401/06 , C07D211/22 , C07D405/06 , C07D409/06 , C07D417/06

65. 发明公开

EP1397128A1 KAPPA-OPIATAGONISTEN FÜR DIE BEHANDLUNG VON ERKRANKUNGEN DER BLASE 有权
标题翻译： KAPPA阿片激动剂LOVELY泡沫的治疗
公开(公告)号：EP1397128A1
公开(公告)日：2004-03-17
申请号：EP02724228.8
申请日：2002-03-13
申请人： MERCK PATENT GmbH
发明人： JACOB, Jutta , WEBER, Frank , BARTOSZYK, Gerd , SEYFRIED, Christoph
IPC分类号： A61K31/40 , A61P13/10
CPC分类号： A61K31/40
摘要： The invention relates to the use of a medicament n-methyl-N-[(1S)-1-phenyl-2((3S)-3-hydroxypyrrolidin-1-yl)-ethyl]-2,2-diphenyl-acetamide or one of the pharmacologically acceptable salts thereof for the production of medicament formulations for the treatment of bladder diseases, particularly irritable bladder syndrome and the pains associated therewith.

66. 发明公开

EP1299099A2 NOVEL USE OF (R)-(-)-2- 5-(4-FLUOROPHENYL)-3-PYRIDYLMETHYLAMINOMETHYL]-CHROMANE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS 有权
标题翻译：（ - - ） - （R）的新用途2-（5-（4-氟苯基）-3- pyridylmethylaminomethyl）-CHROMANE和生理学上可接受的盐
公开(公告)号：EP1299099A2
公开(公告)日：2003-04-09
申请号：EP01902375.3
申请日：2001-02-01
申请人： MERCK PATENT GmbH
发明人： BARTOSZYK, Gerd , RUSS, Hermann , SEYFRIED, Christoph , WEBER, Frank
IPC分类号： A61K31/353 , A61P25/14 , A61P25/16
CPC分类号： A61K31/353 , A61K31/4433 , A61K45/06 , A61K2300/00
摘要： (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof is used for the manufacture of a medicament for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders. A preferred salt is (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane hydrochloride.

67. 发明授权

EP0931067B1 PIPERAZIN-DERIVATE MIT EINER SELEKTIVITÄT FÜR DEN D-4 REZEPTOR 失效
标题翻译：哌嗪衍生物的选择性为对D-4受体
公开(公告)号：EP0931067B1
公开(公告)日：2002-06-26
申请号：EP97944823.0
申请日：1997-09-03
申请人： MERCK PATENT GmbH
发明人： ARLT, Michael , BÖTTCHER, Henning , BARTOSZYK, Gerd , SEYFRIED, Christoph
IPC分类号： C07D213/38 , A61K31/495 , C07D401/12 , A61K31/505 , C07D405/12 , C07D409/12 , C07D295/06 , C07D239/42 , C07D409/14
CPC分类号： C07D213/74 , C07D213/38 , C07D239/42 , C07D295/073 , C07D295/096 , C07D295/155 , C07D401/12 , C07D405/12 , C07D409/12

68. 发明公开

EP1140898A1 AMID- UND HARNSTOFFDERIVATE ALS 5-HT REUPTAKEINHIBITOREN UND ALS 5-HT1B/1D LIGANDEN 有权
标题翻译：酰胺，和脲衍生物作为5HT REUPTAKEINHIBITOREN AND AS 5HT 1B / 1D配体
公开(公告)号：EP1140898A1
公开(公告)日：2001-10-10
申请号：EP98966851.2
申请日：1998-12-22
申请人： MERCK PATENT GmbH
发明人： MATZEN, Lisa , BÖTTCHER, Henning , VAN AMSTERDAM, Christoph , BARTOSZYK, Gerd , GREINER, Hartmut , HARTING, Jürgen , RAUTENBERG, Wilfried
IPC分类号： C07D401/04 , A61K31/40 , C07D401/06 , C07D209/14 , C07D401/14 , C07D209/16
CPC分类号： C07D401/04 , C07D209/14 , C07D209/16 , C07D401/06 , C07D401/14
摘要： The invention relates to amide and urea derivatives of formula (I): R1-(CH2)n-(Y)q-(Z)r-CO-NH-R2, wherein R1, n, Y, q, Z, r and R¿2? have the meanings indicated in claim 1. Said derivatives are potent 5-HT1B/1D antagonists and 5-HT-reuptake inhibitors and are useful for the treatment and the prophylaxis of anxiety conditions, depressions, schizophrenia, obsessive ideas, tardive dyskinesias, impairment of the learning faculty, age-related memory disorders, for positively influencing obsessive-compulsive disorders (OCD), and in treating and controlling the consequences of cerebral infarctions such as strokes and cerebral ischemias.

69. 发明公开

EP1140875A1 SULFONYLOXAZOLAMINE ALS THERAPEUTISCHE WIRKSTOFFE 审中-公开
标题翻译：磺酰氧胺唑啉ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP1140875A1
公开(公告)日：2001-10-10
申请号：EP99962190.7
申请日：1999-12-01
申请人： MERCK PATENT GmbH
发明人： GREINER, Hartmut , BARTOSZYK, Gerd , BÖTTCHER, Henning , BARNICKEL, Gerhard , CEZANNE, Bertram
IPC分类号： C07D263/48 , A61K31/42 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/24
CPC分类号： C07D263/48
摘要： The present invention relates to sulphonyloxazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, -(CH¿2?)n-Ar or alkenyl with 2-6 C atoms, R?1 and R2¿ together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF¿3?, NO2, Hal, OH, OA, NH2, NHA or NA2, A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, Hal is F, Cl, Br or I, n is 1 or 2 or the physiologically acceptable salts or solvates thereof. Said sulphonyloxazolamines are used as therapeutic active ingredients. The invention also relates to the use of sulphonyloxazolamines as therapeutic active ingredients and/or to the production of pharmaceutical preparations to combat diseases of the central nervous system. The invention further relates to a pharmaceutical preparation and the production thereof.
摘要翻译：本发明涉及通式（I）的磺酰基恶唑胺，其中R 1，R 2彼此独立地代表H，A， - （CH 2 2）n -Ar或具有2-6个C原子的烯基，R 1和R 2 A一起代表具有1-2个N，O和/或S原子的单核饱和杂环，Z代表H，A，CF 3，NO 2，Hal，OH，OA，NH 2，NHA或NA 2， Ar为Z-单取代或Z-二取代苯基，Hal为F，Cl，Br或I，n为1或2或其生理上可接受的盐或溶剂合物。所述磺酰恶唑胺用作治疗活性成分。本发明还涉及磺酰基恶唑胺作为治疗活性成分和/或用于制备抗中枢神经系统疾病的药物制剂的用途。本发明还涉及药物制剂及其制备。

70. 发明公开

EP0964863A1 OXAZOLIDINONE ALS 5-HT2A-ANTAGONISTEN 失效
标题翻译：恶唑烷酮的5-HT 2A拮抗剂
公开(公告)号：EP0964863A1
公开(公告)日：1999-12-22
申请号：EP98909397.0
申请日：1998-02-06
申请人： MERCK PATENT GmbH
发明人： BÖTTCHER, Henning , PRÜCHER, Helmut , GREINER, Helmut , BARTOSZYK, Gerd , SEYFRIED, Christoph
IPC分类号： A61K31 , A61P25 , A61P43 , C07D413 , C07D491 , C07D209 , C07D263 , C07D295
CPC分类号： C07D413/14
摘要： The invention relates to novel oxazolidine derivatives of formula (I), wherein R?1, R2 and R3¿ have the meaning cited in Claim 1. The invention further relates to the salts thereof and to a method for the production of the inventive compounds. The compounds of formula (I) act as 5-HT¿2A? antagonists having a reuptake-inhibiting, antidepressant or anxiolytic effect and can be used in the production of medicaments.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式