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61. 发明申请

WO1991010472A1 BANDPASS FILTER CLOCK 审中-公开
标题翻译： BANDPASS过滤器时钟
公开(公告)号：WO1991010472A1
公开(公告)日：1991-07-25
申请号：PCT/US1991000366
申请日：1991-01-17
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , PAGLIOLO, Joseph, P. , ANDERSON, Russell, E. , WEISPFENNING, Richard, F. , BETZOLD, Robert, A.
IPC分类号： A61N01/36
CPC分类号： A61N1/368
摘要： A ventricular sense amplifier (30) for an implantable pulse generator has a digital logic (64) controlling the switching clock of switched capacitor bandpass filter (62) for minimization of transients during the period just preceding, during and following an atrial paced event. The timing is modified to discontinue switching during this period. This ensures that transients occurring as a result of functionally disconnecting and subsequently reconnecting the sensing lead with the sense amplifier are not propagated within the switched capacitor bandpass filter (62). An alternative approach is to increase the clocking rate during the blanked period to ensure that the transients created by the atrial pace or by disconnecting and reconnecting the sensing lead are rapidly processed by the switched capacitor bandpass filter and that processing is completed shortly following the atrial paced event. This alternative approach requires a gate at the sense amplifier output to disable propagation of any transients processed.
摘要翻译：用于可植入脉冲发生器的心室读出放大器（30）具有控制切换电容带通滤波器（62）的开关时钟的数字逻辑（64），用于在心房起搏事件之前，期间和之后的期间使瞬变最小化。在此期间修改了停止切换的时间。这确保了在开关电容器带通滤波器（62）内不传播作为功能断开并随后使感测放大器与感测放大器重新连接的瞬变。另一种方法是在空白期间增加时钟频率，以确保通过开关电容带通滤波器快速地处理由心房速度产生的瞬变或断开和重新连接感测引线的瞬变，并且在心房起搏后不久完成处理事件。这种替代方法需要在读出放大器输出端的栅极来禁止所处理的任何瞬变的传播。

62. 发明申请

WO1991008781A1 IMPLANTABLE CORONARY PERFUSION PUMP 审中-公开
标题翻译：可植入冠状泵
公开(公告)号：WO1991008781A1
公开(公告)日：1991-06-27
申请号：PCT/US1990007093
申请日：1990-12-04
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , CITRON, Paul
IPC分类号： A61M01/12
CPC分类号： A61M1/3613 , A61M1/1003 , A61M1/1008 , A61M1/1037 , A61M1/1044 , A61M1/106 , A61M1/122 , A61M1/127
摘要： A cardiac pump assist system to move blood from large arteries, such as the aorta (32), to small arteries (34) where additional blood flow is needed. The pump assist system includes a shunt (21) from the aorta (32) or other convenient source of oxygenated blood to the coronary artery (34, 36) which is supplemented by a pump. The pump is preferably of the type employing a trained muscle wrap (14) around a fluid chamber (16).
摘要翻译：心脏泵辅助系统将血液从大动脉（例如主动脉（32））移动到需要额外血液流动的小动脉（34）。泵辅助系统包括来自主动脉（32）的分流器（21）或其他方便的含氧血液源到冠状动脉（34,36），其由泵补充。泵优选地采用围绕流体室（16）的经过训练的肌肉包裹（14）的类型。

63. 发明申请

WO1991008016A1 NERVE ELECTRODE WITH BIOLOGICAL SUBSTRATE 审中-公开
标题翻译：神经电极与生物基质
公开(公告)号：WO1991008016A1
公开(公告)日：1991-06-13
申请号：PCT/US1990007089
申请日：1990-12-04
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , GRANDJEAN, Pierre-André , LEE, Philip
IPC分类号： A61N01/05
CPC分类号： A61B5/0408 , A61N1/0551
摘要： An electrode and method of making same characterized by a biological material used as a substrate. The electrode is used as a stimulation electrode, but could also be used to monitor electrical activity of neural tissues. The biological substrate is a chronically implantable material of treated human or animal tissue. The use of this material tends to prevent undue fibrosis and necrosis of the nerve tissue. An inner layer of a non-biological dielectric may be used to increase the resistivity of the structure. Similarly an inner layer of shielding material may also be used.

64. 发明申请

WO1998027562A1 HIGH ENERGY DENSITY CAPACITORS AND COMPOUNDS FOR USE IN THEIR PREPARATION 审中-公开
标题翻译：高能量密度电容器及其制备中使用的化合物
公开(公告)号：WO1998027562A1
公开(公告)日：1998-06-25
申请号：PCT/US1997023602
申请日：1997-12-17
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BENZ, Michael, E. , DIDOMENICO, Edward , SPARER, Randall, V.
IPC分类号： H01G04/18
CPC分类号： H01G4/18 , Y10T428/31692
摘要： A high energy density capacitor comprising an organic polymeric dielectric material having a dielectric constant of at least about 7; wherein the organic polymeric dielectric material comprises polymerized alkyl (alpha-substituted)acrylate monomers having at least one dipole group; wherein when the monomers are polymerized, the dipole group is attached to the main polymeric chain through a heteroatom-containing linking group.
摘要翻译：一种高能量密度电容器，包括介电常数为至少约7的有机聚合物介电材料; 其中所述有机聚合物电介质材料包含具有至少一个偶极子基团的聚合的烷基（α-取代的）丙烯酸酯单体; 其中当单体聚合时，偶极基团通过含杂原子的连接基团与主聚合物链连接。

65. 发明申请

WO1998025669A1 METHOD AND APPARATUS FOR DIAGNOSIS AND TREATMENT OF ARRHYTHMIAS 审中-公开
标题翻译： ARRHYTHMIAS诊断和治疗方法与装置
公开(公告)号：WO1998025669A1
公开(公告)日：1998-06-18
申请号：PCT/US1997019032
申请日：1997-10-20
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , PRIEVE, Kathleen, Alice , GRAHAM, William, A., P. , PETERSON, David, Karl
IPC分类号： A61N01/362
CPC分类号： A61N1/3925 , A61N1/3621 , A61N1/37252
摘要： An implantable anti-arrhythmia device such as a defibrillator or anti-tachycardia pacemaker with an associated patient activator. The arrhythmia detection function is divided between the patient and the implanted device, rather than merely providing patient activation or a patient override. The implantable device is provided with a tachyarrhythmia recognition mechanism, which operates essentially continuously, and which, upon meeting a first set of criteria, will trigger delivery of an anti-arrhythmia therapy such as pacing, cardioversion or defibrillation. The patient is provided with an activator which informs the implanted device that the patient believes that anti-arrhythmia therapy is necessary. In response to receipt of the activation signal, the implanted device defines a time interval thereafter during which a second, less stringent set of arrhythmia detection criteria must be met, in response to which the device will deliver a cardioversion or defibrillation pulse.
摘要翻译：可植入的抗心律失常装置，例如除颤器或具有相关患者激活剂的抗心动过速起搏器。心律失常检测功能在患者和植入装置之间分开，而不仅仅是提供患者激活或患者超驰。可植入装置具有快速性心律失常识别机制，其基本上连续运行，并且在满足第一组标准时将触发诸如起搏，复律或除颤之类的抗心律失常治疗的递送。患者被提供有激活剂，其通知植入装置患者认为需要抗心律失常治疗。响应于接收到激活信号，植入的装置定义了之后的时间间隔，在此期间，必须满足第二个较不严格的心律失常检测标准，响应于该装置将递送心脏复律或除颤脉冲。

66. 发明申请

WO1998024386A1 ANNULOPLASTY DEVICE WITH REMOVABLE STIFFENING ELEMENT 审中-公开
标题翻译：具有可移除硬化元件的ANNULOPLASTY装置
公开(公告)号：WO1998024386A1
公开(公告)日：1998-06-11
申请号：PCT/US1997022107
申请日：1997-11-25
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MYERS, David, J.
IPC分类号： A61F02/24
CPC分类号： A61F2/2445 , Y10S623/90
摘要： A fully flexible annuloplasty ring is temporarily stiffened during implantation by inserting a withdrawable stiffening wire into a lumen of the ring.
摘要翻译：通过将可抽出的加强线插入环的管腔中，完全柔性瓣环成形术环在植入期间暂时僵硬。

67. 发明申请

WO1998015316A1 CONNECTOR FOR HARDSHELL RESERVOIRS 审中-公开
标题翻译： HARDSHELL储罐连接器
公开(公告)号：WO1998015316A1
公开(公告)日：1998-04-16
申请号：PCT/US1997017867
申请日：1997-10-02
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , VAN DRIEL, Michael, R.
IPC分类号： A61M39/12
CPC分类号： B29C33/44 , A61M1/3627 , A61M1/3632 , A61M39/12 , Y10S285/905
摘要： In a connector for a hardshell venous reservoir, improved positioning and better line holding ability is provided by forming a line-retaining barb on only the upper half of the connector. A dual-size or combo connector using this principle is also disclosed.
摘要翻译：在用于硬壳静脉储器的连接器中，通过仅在连接器的上半部形成线路保持倒钩来提供改进的定位和更好的线保持能力。还公开了使用该原理的双尺寸或组合连接器。

68. 发明申请

WO1998010433A1 MEDICAL ELECTRICAL LEAD AND REINFORCED SILICONE ELASTOMER COMPOSITIONS USED THEREIN 审中-公开
标题翻译：医用电导线和加固硅胶弹性体组合物
公开(公告)号：WO1998010433A1
公开(公告)日：1998-03-12
申请号：PCT/US1997014804
申请日：1997-08-25
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , PAULSEN, Mark, J. , MILLER, Jennifer, P. , EBERT, Michael, J.
IPC分类号： H01B03/46
CPC分类号： C08K9/06 , H01B3/28 , H01B3/46 , Y10T428/31663 , A61L31/06 , C08L83/04
摘要： A medical electrical lead and a reinforced silicone elastomer used therein. The silicone elastomer used therein is preferably made from a novel silica reinforced polysiloxane material, which after vulcanization by cross-linking exhibits improved mechanical properties. The medical electrical lead features an electrode at a distal end thereof, a connector at a proximal end thereof and an elongated electrical conductor extending between the electrode and the connector, the conductor in electrical contact with the electrode at a distal end and in electrical contact with the connector at a proximal end, the conductor comprised of a plurality of wires or wire bundles wound in a multifilar coil configuration.
摘要翻译：其中使用医用电线和增强硅酮弹性体。其中使用的硅氧烷弹性体优选由新型二氧化硅增强聚硅氧烷材料制成，其在通过交联硫化后显示出改善的机械性能。医疗电引线在其远端具有电极，在其近端处具有连接器，并且在电极和连接器之间延伸的细长电导体，导体在远端处与电极电接触并与电极接触所述连接器在近端处，所述导体包括以多线圈构造缠绕的多根线或线束。

69. 发明申请

WO1998008551A1 BIOCOMPATIBLE MEDICAL ARTICLE AND METHOD 审中-公开
标题翻译：生物医学文章和方法
公开(公告)号：WO1998008551A1
公开(公告)日：1998-03-05
申请号：PCT/US1996013783
申请日：1996-08-29
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , CAHALAN, Linda, L. , CAHALAN, Patrick, T. , VERHOEVEN, Michel , HENDRIKS, Marc , FOUACHE, Benedicte
IPC分类号： A61L33/00
CPC分类号： A61L33/0088 , A61L27/28 , A61L33/0029 , C08L79/02
摘要： A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface a silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
摘要翻译：具有金属或玻璃表面的医疗制品具有表面具有改善的生物相容性的粘附涂层。通过首先将具有侧链乙烯基官能团的硅烷化合物施加到表面上，使得硅烷粘附到表面，然后在单独的步骤中，用所施加的乙烯基硅烷在表面上形成接枝聚合物，使得侧链乙烯基官能度的乙烯基硅烷通过与聚合物共价键结合到接枝聚合物中。然后可以将生物分子共价连接到基底层。

70. 发明申请

WO1998002209A2 MINIMALLY INVASIVE IMPLANTABLE DEVICE FOR MONITORING PHYSIOLOGIC EVENTS 审中-公开
标题翻译：用于监测生理事件的最小的入侵可植入设备
公开(公告)号：WO1998002209A2
公开(公告)日：1998-01-22
申请号：PCT/US1997012443
申请日：1997-07-09
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , WARKENTIN, Dwight, H. , RIFF, Kenneth, M. , LEE, Brian, B. , CARNEY, James, K. , TURI, Gregg
IPC分类号： A61N01/375
CPC分类号： A61N1/375
摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described in several embodiments. This implant (31) preferably has a segmented looping memory (34) for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device (30A) or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode (32a, 32b) spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.
摘要翻译：在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。该植入物（31）优选地具有用于存储触发的生理事件的分段循环存储器（34）。设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。优选地，该装置可以在没有微处理器的情况下工作。包括外部设备（30A）或其他患者激活的手动触发器。自动触发器和手动设置触发器可能具有不同的大小。优选的生理事件是ECG信号。电极（32a，32b）的间距可能很重要。可以向设备提供附加的传感器。与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

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