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61. 发明授权

US09072059B2 Interference control 有权
标题翻译：干扰控制
公开(公告)号：US09072059B2
公开(公告)日：2015-06-30
申请号：US13518476
申请日：2009-12-23
申请人： Klaus Ingemann Pedersen , Luis Garcia
发明人： Klaus Ingemann Pedersen , Luis Garcia
IPC分类号： H04B7/00 , H04W52/24
CPC分类号： H04W52/243
摘要： When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.
摘要翻译：当确定从与其他接入节点相关联的传输到与第一接入节点相关联的传输的总干扰水平的第一估计超过预定目标最大值时; 然后根据所述第一估计超过所述目标最大值的程度，选择一个或多个所述其他接入节点，以向其请求以降低干扰传输的传输功率，和/或选择一个请求任何一个或多个所述其他接入节点以降低干扰传输的传输功率。

62. 发明授权

US08934932B2 Communication network and method 有权
标题翻译：通信网络和方法
公开(公告)号：US08934932B2
公开(公告)日：2015-01-13
申请号：US13322997
申请日：2009-05-29
申请人： Klaus Ingemann Pedersen , Luis Garcia
发明人： Klaus Ingemann Pedersen , Luis Garcia
IPC分类号： H04W16/10
CPC分类号： H04W16/10
摘要： In a communication network including a plurality of base stations, a method including the steps of: sending a signal from said base station indicating that it will enter a period of inactivity, to at least one other base station; storing at that least one current parameter(s) relating to interference between base stations and/or updating said parameter(s) for forward use. The parameter(s) may relate to interference between first base station and at least one operationally neighboring base station and may be Background Interference Matrix (BIM) data.
摘要翻译：在包括多个基站的通信网络中，一种方法包括以下步骤：向至少一个其他基站发送指示其将进入非活动时段的来自所述基站的信号; 存储与基站之间的干扰有关的至少一个当前参数和/或更新所述参数以供正向使用。参数可以涉及第一基站与至少一个操作上相邻的基站之间的干扰，并且可以是背景干扰矩阵（BIM）数据。

63. 发明申请

US20140107186A1 CAPSID-FREE AAV VECTORS, COMPOSITIONS, AND METHODS FOR VECTOR PRODUCTION AND GENE DELIVERY 有权
标题翻译：不含CAPSID的AAV矢量，组合物和方法用于矢量生产和基因分送
公开(公告)号：US20140107186A1
公开(公告)日：2014-04-17
申请号：US14004379
申请日：2012-03-12
申请人： Luis Garcia , Cyriaque Beley , Thomas Voit , Robert Michael Kotin
发明人： Luis Garcia , Cyriaque Beley , Thomas Voit , Robert Michael Kotin
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2750/14143 , C12N2750/14171 , C12N2800/24
摘要： An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
摘要翻译：一种分离的线性核酸分子，其以以下顺序包含：第一腺相关病毒（AAV）倒置末端重复（ITR），目的核苷酸序列和第二AAV ITR，其中所述核酸分子缺乏AAV衣壳蛋白编码序列。所述核酸分子可以重复施用于宿主而不引发免疫应答。还提供了用于产生和纯化该核酸分子的方法及其用于治疗目的的用途。

64. 发明授权

US08586560B2 Exon skipping therapy for dysferlinopathies 失效
标题翻译：外显子跳跃治疗偏头痛
公开(公告)号：US08586560B2
公开(公告)日：2013-11-19
申请号：US13501892
申请日：2010-10-18
申请人： Nicolas Levy , Martin Krahn , Marc Bartoli , Luis Garcia
发明人： Nicolas Levy , Martin Krahn , Marc Bartoli , Luis Garcia
IPC分类号： C12N15/11 , C12N15/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2320/33
摘要： The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.
摘要翻译：本发明涉及恢复突变的dysferlin的功能的方法，其包括防止编码导致所述dysferlin功能障碍的氨基酸序列的一个或多个外显子的剪接的步骤。特别地，防止外显子32的剪接。本发明还涉及在有需要的患者中治疗偏头痛的方法，该方法包括给所述患者施用与编码氨基酸序列的一个或多个外显子正确剪接所必需的核酸序列互补的反义寡核苷酸的步骤导致所述功能障碍。特别地，防止外显子32的剪接。

65. 发明申请

US20130189225A1 METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE 有权
标题翻译：提高靶向组织渗透效率的方法
公开(公告)号：US20130189225A1
公开(公告)日：2013-07-25
申请号：US13636596
申请日：2011-03-22
申请人： Thomas Voit , Luis Garcia , Jérôme Denard , Fedor Svinartchouk
发明人： Thomas Voit , Luis Garcia , Jérôme Denard , Fedor Svinartchouk
IPC分类号： A61K48/00 , A61K38/00 , A61K31/522 , A61K38/21
CPC分类号： C04B35/10 , A61K31/522 , A61K38/00 , A61K38/1709 , A61K38/21 , A61K45/06 , A61K48/0008 , A61K48/0058 , C04B35/14 , C04B35/565 , C04B35/622 , C07K14/005 , C07K16/081 , C07K16/18 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145 , C12N2750/14151 , C12N2810/6027 , A61K2300/00
摘要： Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
摘要翻译：提供了增加患者中腺相关病毒（AAV）载体靶组织穿透效率的方法。在某些方面，该方法涉及抑制血清蛋白半乳凝素3结合蛋白（G3BP）与AAV载体的相互作用。进一步提供的是通过施用包含G3BP的组合物来减少病毒的组织分布或用于中和由目的地移植或新移植的器官所携带的病毒的方法。

66. 发明申请

US20130182690A1 Carrier Selection 有权
标题翻译：载体选择
公开(公告)号：US20130182690A1
公开(公告)日：2013-07-18
申请号：US13808768
申请日：2010-07-08
申请人： Istvan Zsolt Kovacs , Frank Frederiksen , Luis Garcia
发明人： Istvan Zsolt Kovacs , Frank Frederiksen , Luis Garcia
IPC分类号： H04W72/04
CPC分类号： H04W72/0426 , H04W16/06 , H04W72/082
摘要： The invention relates generally to mobile communication networks. More particularly, the invention relates to interference management and carrier selection for transmitting data. There is provided a solution for improved selection of a cell-specific base carrier, the solution utilizing a timing framework for the carrier selection. The solution includes determining a maximum allowed time duration, and performing within the determined maximum allowed time duration: obtaining information related to one or more selected carriers from at least one neighboring base station, selecting the at least one cell-specific base carrier for data transmission on the basis of the obtained information, and informing the at least one neighboring base station of the selected cell specific base carrier.
摘要翻译：本发明一般涉及移动通信网络。更具体地，本发明涉及用于发送数据的干扰管理和载波选择。提供了一种用于改进小区特定基站载波选择的解决方案，该解决方案利用用于载波选择的定时框架。该解决方案包括确定最大允许持续时间，以及在所确定的最大允许持续时间内执行：从至少一个相邻基站获得与一个或多个选定载波相关的信息，选择所述至少一个小区特定基站载波进行数据传输基于所获得的信息，并且向所述至少一个相邻基站通知所选择的小区特定基站载波。

67. 发明申请

US20130072541A1 ADENO-ASSOCIATED VIRAL VECTOR FOR EXON SKIPPING IN A GENE ENCODING A DISPENSIBLE-DOMAIN PROTEIN 审中-公开
标题翻译：用于在编码不饱和蛋白质的基因中排除外植体的ADENO相关病毒载体
公开(公告)号：US20130072541A1
公开(公告)日：2013-03-21
申请号：US13458037
申请日：2012-04-27
申请人： Luis Garcia
发明人： Luis Garcia
IPC分类号： C12N5/10 , A61P21/00 , A61K31/713
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143
摘要： The invention concerns an adeno-associated viral vector comprising: a U7 type modified snRNA sequence; the native U7 promoter; at least one antisense sequence directed against at least one splice site of at least one exon, the said exon encoding a dispensable domain of dystrophin.
摘要翻译：本发明涉及腺相关病毒载体，其包含：U7型修饰的snRNA序列; 天然U7启动子; 至少一个针对至少一个外显子的至少一个剪接位点的反义序列，所述外显子编码肌营养不良蛋白的可分配区域。

68. 发明申请

US20130045538A1 MODIFIED U7 SNRNAS FOR TREATMENT OF NEUROMUSCULAR DISEASES 有权
标题翻译：用于治疗神经性疾病的改良U7 SNRNA
公开(公告)号：US20130045538A1
公开(公告)日：2013-02-21
申请号：US13635356
申请日：2011-03-17
申请人： Luis Garcia , Denis Furling , Cyriaque Beley , Thomas Voit
发明人： Luis Garcia , Denis Furling , Cyriaque Beley , Thomas Voit
IPC分类号： C07H21/02 , C12N15/113 , C12N15/85 , C12N15/63 , C12N5/10
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/531 , C12N2320/33 , C12N2320/34 , C12N2320/50 , C12N2330/51
摘要： The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.
摘要翻译：本发明涉及一种改善在基于RNA的疗法的上下文中使用的工程化U7 snRNA的活性的方法; 特别是在外显子跳跃，外显子包含和mRNA消除策略。所产生的修饰的snRNA可用于治疗神经肌肉疾病，特别是Duchenne神经肌肉营养不良症，强直性营养不良DM1和脊髓性肌肉萎缩。

69. 发明授权

US08376489B2 Recovery print mode 有权
标题翻译：恢复打印模式
公开(公告)号：US08376489B2
公开(公告)日：2013-02-19
申请号：US13077438
申请日：2011-03-31
申请人： Sergio Puigardeu , Luis Garcia , M. Isabel Borrell , Ángel Martinez
发明人： Sergio Puigardeu , Luis Garcia , M. Isabel Borrell , Ángel Martinez
IPC分类号： B41J29/38
CPC分类号： B41J2/16579
摘要： In one embodiment, first printing is caused in response to a print job, applying ink upon a media utilizing a first row of printheads and a second row of printheads. The first row of printheads includes a plurality of printhead types. The second row of printheads is adjacent to the first row and includes at least one printhead of each of types. Failure of a first printhead within the first row is detected. The status of printheads included within the second row is analyzed. Second printing is caused applying ink upon the media utilizing the second row of printheads, and not the first row of printheads, in response to determining that printheads within the second row are operable to complete the print job.
摘要翻译：在一个实施例中，响应于打印作业而引起第一次打印，使用第一排打印头和第二排打印头将墨施加到介质上。第一排打印头包括多个打印头类型。第二排打印头与第一排相邻并且包括每种类型的至少一个打印头。检测到第一行内的第一打印头的故障。分析第二行内打印头的状态。响应于确定第二行中的打印头可操作以完成打印作业，使得利用第二排打印头而不是第一排打印头在介质上施加墨水。

70. 发明申请

US20120282960A1 Interference Control 有权
标题翻译：干扰控制
公开(公告)号：US20120282960A1
公开(公告)日：2012-11-08
申请号：US13518476
申请日：2009-12-23
申请人： Klaus Ingemann Pedersen , Luis Garcia
发明人： Klaus Ingemann Pedersen , Luis Garcia
IPC分类号： H04W52/24
CPC分类号： H04W52/243
摘要： When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.
摘要翻译：当确定从与其他接入节点相关联的传输到与第一接入节点相关联的传输的总干扰水平的第一估计超过预定目标最大值时; 然后根据所述第一估计超过所述目标最大值的程度，选择一个或多个所述其他接入节点，以向其请求以降低干扰传输的传输功率，和/或选择一个请求任何一个或多个所述其他接入节点以降低干扰传输的传输功率。

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