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61. 发明申请

US20130198876A1 INDUCED MALIGNANT STEM CELLS OR PRE-INDUCTION CANCER STEM CELLS CAPABLE OF SELFREPLICATION OUTSIDE OF AN ORGANISM, PRODUCTION METHOD FOR SAME, AND PRACTICAL APPLICATION FOR SAME 审中-公开
标题翻译：诱导性恶性肿瘤细胞或预诱导癌细胞可以在有机体外部产生抗体，其生产方法及其实际应用
公开(公告)号：US20130198876A1
公开(公告)日：2013-08-01
申请号：US13699431
申请日：2011-05-25
申请人： Tetsuya Ishikawa
发明人： Tetsuya Ishikawa
IPC分类号： C12N5/095 , A61K39/00 , G01N33/50 , C12N15/85
CPC分类号： C12N5/0695 , A01K2207/12 , A01K2267/0331 , A61K39/0011 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2510/00 , G01N33/5011 , G01N33/5073 , G01N33/574
摘要： The present invention provides an induced cancer cell capable of self-replication in vitro which is useful in cancer therapy research and the research for cancer-related drug discovery, processes for production thereof, cancer cells induced by the malignant cells, and applications of these cells.The present invention provides an induced cancer stem cell capable of proliferation (self-replication) in vitro, wherein the induced cancer stem cell has the following two characteristics: (1) expressing the six genes (self-renewal related genes) POU5F1, NANOG, SOX2, ZFP42, LIN28, and TERT selected from a certain group of genes; and (2) having an aberration which is either (a) a mutation in an endogenous tumor suppressor gene or (b) increased expression of an endogenous cancer-related gene.
摘要翻译：本发明提供能够在体外自我复制的诱导癌细胞，其可用于癌症治疗研究和癌症相关药物发现研究，其生产方法，由恶性细胞诱导的癌细胞以及这些细胞的应用。本发明提供了能够在体外增殖（自身复制）的诱导型癌干细胞，其中诱导的癌干细胞具有以下两个特征：（1）表达六种基因（自我更新相关基因）POU5F1，NANOG，选自某组基因的SOX2，ZFP42，LIN28和TERT; 和（2）具有（a）内源性肿瘤抑制基因中的突变或（b）内源性癌症相关基因的表达增加的像差。

62. 发明授权

US08480212B2 Printing apparatus 失效
标题翻译：印刷装置
公开(公告)号：US08480212B2
公开(公告)日：2013-07-09
申请号：US12876773
申请日：2010-09-07
申请人： Masakazu Tsukuda , Tetsuya Ishikawa , Kanto Kurasawa , Yoshitaka Okamura , Takashi Nojima
发明人： Masakazu Tsukuda , Tetsuya Ishikawa , Kanto Kurasawa , Yoshitaka Okamura , Takashi Nojima
IPC分类号： B41J2/175
CPC分类号： B41J2/1752 , B41J2/17509 , B41J25/34
摘要： A fail-safe capability is realized that not only forestalls the execution by the user of the head replacement operation in an erroneous sequence while the printing apparatus is in operation but also prevents the splashing of ink even if the user attempts to inadvertently replace the print head. For this purpose, the ink supply and the opening and closing of the print head replacement cover are performed by a predetermined rotation of one drive source.
摘要翻译：实现了故障安全功能，不仅在打印设备运行时不仅防止了用户头部更换操作的执行，而且防止了即使用户无意中更换打印头，也可以防止溅墨。为此，墨水供应和打印头更换盖的打开和关闭通过一个驱动源的预定旋转来执行。

63. 发明申请

US20130071931A1 PROCESS FOR HEPATIC DIFFERENTIATION FROM INDUCED HEPATIC STEM CELLS, AND INDUCED HEPATIC PROGENITOR CELLS DIFFERENTIATED THEREBY 审中-公开
标题翻译：诱导性肝细胞干细胞分化过程及其诱导的HEPICAL PROGENITOR CELLS差异化
公开(公告)号：US20130071931A1
公开(公告)日：2013-03-21
申请号：US13564803
申请日：2012-08-02
申请人： Tetsuya Ishikawa
发明人： Tetsuya Ishikawa
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N5/0671 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/115 , C12N2501/15 , C12N2501/237 , C12N2501/39 , C12N2501/727 , C12N2533/54 , C12N2533/90
摘要： A method for hepatic differentiation of a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is presented. More specifically, a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is cultured for 1 to 4 weeks in the presence of a TGF-β inhibitor, whereby the hepatic differentiation of the stem cell is realized.
摘要翻译：提出了选自胚胎干细胞，诱导多能干细胞或诱导的肝干细胞的干细胞的肝分化方法。更具体地说，在TGF-β1的存在下，将选自胚胎干细胞，诱导的多能干细胞或诱导的肝干细胞的干细胞培养1〜4周。抑制剂，从而实现干细胞的肝分化。

64. 发明申请

US20130023045A1 INDUCED HEPATIC STEM CELL AND PROCESS FOR PRODUCTION THEREOF, AND APPLICATIONS OF THE CELL 审中-公开
标题翻译：诱导性干细胞及其生产方法及细胞应用
公开(公告)号：US20130023045A1
公开(公告)日：2013-01-24
申请号：US13576194
申请日：2011-02-03
申请人： Tetsuya Ishikawa , Keitaro Hagiwara , Takahiro Ochiya
发明人： Tetsuya Ishikawa , Keitaro Hagiwara , Takahiro Ochiya
IPC分类号： C12N5/071 , C12N5/10
CPC分类号： A61K35/407 , C12N5/067 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2506/45 , C12N2510/00
摘要： The present invention relates to an induced hepatic stem cell defined as follows, a process for production thereof, and applications of the cell, which are useful in safety tests, toxicity tests, metabolism tests, drug interaction tests, antiviral activity tests, screening tests for pharmaceuticals such as hyperlipidemic therapeutics, hypertension therapeutics, low-molecular weight compound medicaments, and antibody medicaments, screening for targets in drug discovery, preparation of animal models, production of hepatocyte-produced proteins, and in regenerative medicine. The induced hepatic stem cell of the present invention is characterized by at least satisfying the following requirements (1)-(3): (1) it expresses at least 15 genes as selected from the group of the genes which are marker genes for an embryonic stem cell; (2) it has properties of a hepatocyte; and (3) it can be subjected to expansion culture or passage culture for at least 3 days.
摘要翻译：本发明涉及定义如下的诱导性肝干细胞，其制备方法和细胞的应用，其可用于安全性试验，毒性试验，代谢试验，药物相互作用试验，抗病毒活性试验，筛选试验药物如高脂血症治疗剂，高血压治疗剂，低分子量复合药物和抗体药物，筛选药物发现中的靶标，制备动物模型，生产肝细胞产生的蛋白质和再生医学。本发明的诱导肝干细胞的特征在于至少满足以下要求（1） - （3）：（1）其表达至少15个基因，其选自作为胚胎的标记基因的基因组干细胞; （2）具有肝细胞特性; 和（3）可以进行至少3天的膨胀培养或通道培养。

65. 发明申请

US20120320361A1 CLUSTER TOOL ARCHITECTURE FOR PROCESSING A SUBSTRATE 有权
标题翻译：用于处理基板的集群工具架构
公开(公告)号：US20120320361A1
公开(公告)日：2012-12-20
申请号：US13524854
申请日：2012-06-15
申请人： Tetsuya Ishikawa , Rick J. Roberts , Helen R. Armer , Leon Volfovski , Jay D. Pinson , Michael Rice , David H. Quach , Mohsen S. Salek , Robert Lowrance , John A. Backer , William Tyler Weaver , Charles Carlson , Chongyang Wang , Jeffrey Hudgens , Harald Herchem , Brian Lue
发明人： Tetsuya Ishikawa , Rick J. Roberts , Helen R. Armer , Leon Volfovski , Jay D. Pinson , Michael Rice , David H. Quach , Mohsen S. Salek , Robert Lowrance , John A. Backer , William Tyler Weaver , Charles Carlson , Chongyang Wang , Jeffrey Hudgens , Harald Herchem , Brian Lue
IPC分类号： G03B27/58
CPC分类号： H01L21/67225 , G03B27/32 , G03D13/006 , G03F7/40 , G05B19/41825 , G05B2219/40476 , G05B2219/45031 , G05B2219/49137 , H01L21/67109 , H01L21/6715 , H01L21/67161 , H01L21/67173 , H01L21/67178 , H01L21/67184 , H01L21/6719 , H01L21/67196 , H01L21/67742 , H01L21/67745 , H01L21/67748 , H01L21/67754 , H01L21/6831 , H01L21/6838 , H01L21/68707 , H01L22/26 , Y02P90/087 , Y10S414/135 , Y10S414/136 , Y10T29/53187 , Y10T29/5323
摘要： Embodiments of the invention generally include a robot assembly comprising a robot operable to position a substrate at one or more points within a plane, and a motion assembly having a motor operable to position the robot in a direction generally parallel to a first direction. The motion assembly comprises a robot support interface having the robot coupled thereto, and one or more walls that form an interior region in which the motor is enclosed. The walls define an elongated opening through which the robot support interface travels, and the motor is operable to move the robot support interface laterally in the elongated opening. The motion assembly further comprises one or more fan assemblies that are in fluid communication with the interior region. The fan assemblies are operable to create a subatmospheric pressure in the interior region thereby causing gas to flow through the elongated opening into the interior region.
摘要翻译：本发明的实施例通常包括机器人组件，其包括可操作以在平面内的一个或多个点处定位衬底的机器人，以及具有可操作以将机器人沿大致平行于第一方向的方向定位的电动机的运动组件。运动组件包括机器人支撑接口，其具有耦合到其上的机器人，以及一个或多个壁，其形成电机被封闭的内部区域。壁限定了机器人支撑接口行进的细长开口，电动机可操作以在细长的开口中横向移动机器人支撑界面。运动组件还包括与内部区域流体连通的一个或多个风扇组件。风扇组件可操作以在内部区域中产生低于大气压的压力，从而使气体通过细长的开口流入内部区域。

66. 发明授权

US08279577B2 Substrate support having fluid channel 有权
标题翻译：具有流体通道的基板支撑
公开(公告)号：US08279577B2
公开(公告)日：2012-10-02
申请号：US12849012
申请日：2010-08-02
申请人： Andrew Nguyen , Wing Lau Cheng , Hiroji Hanawa , Semyon Kats , Kartik Ramaswamy , Yan Ye , Kwok Manus Wong , Daniel J. Hoffman , Tetsuya Ishikawa , Brian C. Lue
发明人： Andrew Nguyen , Wing Lau Cheng , Hiroji Hanawa , Semyon Kats , Kartik Ramaswamy , Yan Ye , Kwok Manus Wong , Daniel J. Hoffman , Tetsuya Ishikawa , Brian C. Lue
IPC分类号： H01T23/00
CPC分类号： C23C14/564 , C23C16/4404 , H01J37/16 , H01J37/32504 , H01J37/32862 , H01J37/32871 , H01J2237/022 , H01L21/6875 , H01L21/68757 , Y10T428/24 , Y10T428/31678
摘要： A support for a substrate processing chamber comprises a chuck having a substrate receiving surface, and a base comprising an upper wall comprising a recessed trench having (i) an attachment face at a first depth, and (ii) a fluid channel at a second depth. A lower wall is seated in the recessed trench and attached to the attachment face of the upper wall, to close the fluid channel. A fluid inlet is provided to supply a heat transfer fluid to the fluid channel and a fluid outlet provided to discharge the heat transfer fluid from the fluid channel.
摘要翻译：用于衬底处理室的支撑件包括具有衬底接收表面的卡盘，以及包括上壁的基座，该上壁包括凹槽，所述凹槽具有（i）第一深度处的附接面，以及（ii）第二深度处的流体通道。下壁位于凹槽中并附着到上壁的附接面，以封闭流体通道。提供流体入口以将传热流体供应到流体通道和设置用于从流体通道排出传热流体的流体出口。

67. 发明申请

US20120235116A1 LIGHT EMITTING DIODE WITH ENHANCED QUANTUM EFFICIENCY AND METHOD OF FABRICATION 审中-公开
标题翻译：具有增强量子效率的发光二极管和制造方法
公开(公告)号：US20120235116A1
公开(公告)日：2012-09-20
申请号：US13387713
申请日：2010-07-30
申请人： Jie Su , Olga Kryliouk , Yuriy Melnik , Hidehiro Kojiri , Lu Chen , Tetsuya Ishikawa
发明人： Jie Su , Olga Kryliouk , Yuriy Melnik , Hidehiro Kojiri , Lu Chen , Tetsuya Ishikawa
IPC分类号： H01L33/04 , C30B25/02 , H01B1/02 , C30B25/08
CPC分类号： H01L33/06 , H01L33/04 , H01L33/325
摘要： One embodiment of a quantum well structure comprises an active region including active layers that comprise quantum wells and barrier layers wherein some or all of the active layers are p type doped. P type doping some or all of the active layers improves the quantum efficiency of III-V compound semiconductor light emitting diodes by locating the position of the P-N junction in the active region of the device thereby enabling the dominant radiative recombination to occur within the active region. In one embodiment, the quantum well structure is fabricated in a cluster tool having a hydride vapor phase epitaxial (HVPE) deposition chamber with a eutectic source alloy. In one embodiment, the indium gallium nitride (InGaN) layer and the magnesium doped gallium nitride (Mg—GaN) or magnesium doped aluminum gallium nitride (Mg—AlGaN) layer are grown in separate chambers by a cluster tool to avoid indium and magnesium cross contamination. Doping of group III-nitrides by hydride vapor phase epitaxy using group III-metal eutectics is also described. In one embodiment, a source is provided for HVPE deposition of a p-type or an n-type group III-nitride epitaxial film, the source including a liquid phase mechanical (eutectic) mixture with a group III species. In one embodiment, a method is provided for performing HVPE deposition of a p-type or an n-type group III-nitride epitaxial film, the method including using a liquid phase mechanical (eutectic) mixture with a group III species.
摘要翻译：量子阱结构的一个实施例包括有源区，包括有源层，其包括量子阱和阻挡层，其中一些或全部有源层是p型掺杂的。通过将PN结的位置定位在器件的有源区域中，P型掺杂部分或全部有源层提高了III-V族化合物半导体发光二极管的量子效率，从而能够在主动区域内发生主要的辐射复合。在一个实施例中，量子阱结构在具有共晶源合金的氢化物气相外延（HVPE）沉积室的簇工具中制造。在一个实施例中，氮化铟镓（InGaN）层和掺杂镁的氮化镓（Mg-GaN）或镁掺杂的氮化铝镓（Mg-AlGaN）层通过簇工具在分开的室中生长以避免铟和镁的交叉污染。还描述了使用III族金属共晶体通过氢化物气相外延掺杂的III族氮化物。在一个实施例中，提供了用于HVPE沉积p型或n型III族氮化物外延膜的源，该源包括具有III族的液相机械（共晶）混合物。在一个实施例中，提供了一种用于执行p型或n型III族氮化物外延膜的HVPE沉积的方法，该方法包括使用具有III族物质的液相机械（共晶）混合物。

68. 发明授权

US08267698B2 Connector unit with a clicking feeling 有权
标题翻译：连接器单元具有点击感
公开(公告)号：US08267698B2
公开(公告)日：2012-09-18
申请号：US12763352
申请日：2010-04-20
申请人： Tetsuya Ishikawa , Hiroaki Obikane , Yasufumi Yahiro
发明人： Tetsuya Ishikawa , Hiroaki Obikane , Yasufumi Yahiro
IPC分类号： H01R12/00 , H05K1/00
CPC分类号： H01R13/20 , H01R12/716
摘要： A connector unit which is capable of suppressing lowering of a clicking feeling, even if the fitting and removing of connectors to and from each other is repeated. A spring portion that receives a contact portion of each of plug contacts of a plug connector when a receptacle connector and the plug connector are fitted to each other is formed on each of receptacle contacts of the receptacle connector. A protrusion is formed on the contact portion of each plug contact. The spring portion is formed to have an auxiliary contact portion that is urged by the protrusion when both of the connectors are fitted to each other, and a recess that receives the protrusion when the both of the connectors are fitted to each other.
摘要翻译：即使重复连接器的安装和拆卸，也能够抑制咔嗒感的降低的连接器单元。当插座连接器和插头连接器彼此嵌合时，接收插头连接器的每个插头触点的接触部分的弹簧部分形成在插座连接器的每个插座触头上。在每个插头触点的接触部分上形成突起。弹簧部分形成为具有辅助接触部分，当两个连接器彼此嵌合时由突起推动的辅助接触部分和当两个连接器彼此嵌合时容纳突起的凹部。

69. 发明授权

US08235610B2 Printing apparatus and conveyance control method 有权
标题翻译：印刷装置和输送控制方法
公开(公告)号：US08235610B2
公开(公告)日：2012-08-07
申请号：US11842553
申请日：2007-08-21
申请人： Hiroyuki Saito , Haruyuki Yanagi , Kentaro Onuma , Tetsuya Ishikawa , Yuichiro Suzuki , Hiroyuki Kakishima , Michiharu Shoji
发明人： Hiroyuki Saito , Haruyuki Yanagi , Kentaro Onuma , Tetsuya Ishikawa , Yuichiro Suzuki , Hiroyuki Kakishima , Michiharu Shoji
IPC分类号： B41J13/03 , B41J13/00
CPC分类号： B41J13/0027 , B41J11/42 , B41J23/025
摘要： This invention relates to a printing apparatus and a conveyance control method capable of allowing even an arrangement having a plurality of conveyance rollers in a printing medium conveyance path to accurately control conveyance of a printing medium. According to this invention, a first encoder detects a conveyance amount by a first conveyance roller, provided in a conveyance path, for conveying a printing medium. A second encoder detects a conveyance amount by a second conveyance roller provided in the conveyance path in the conveyance direction of the printing medium at the downstream side of the first conveyance roller for conveying the printing medium. On the other hand, a signal output from the first or second encoder is selected on the basis of the position of the printing medium on the conveyance path. Conveyance of the printing medium is controlled on the basis of the selected output signal.
摘要翻译：本发明涉及一种打印设备和输送控制方法，其能够允许甚至在打印介质输送路径中具有多个传送辊的布置，以精确地控制打印介质的传送。根据本发明，第一编码器通过设置在输送路径中的第一输送辊检测输送量，用于输送打印介质。第二编码器通过设置在第一输送辊的下游侧的打印介质的传送方向上的输送路径中的第二输送辊检测输送量，用于输送打印介质。另一方面，基于打印介质在输送路径上的位置来选择从第一或第二编码器输出的信号。基于选择的输出信号来控制打印介质的输送。

70. 发明授权

US08181596B2 Cluster tool architecture for processing a substrate 有权
标题翻译：用于处理基板的集群工具架构
公开(公告)号：US08181596B2
公开(公告)日：2012-05-22
申请号：US12254750
申请日：2008-10-20
申请人： Tetsuya Ishikawa , Rick J. Roberts , Helen R. Armer , Leon Volfovski , Jay D. Pinson , Michael Rice , David H. Quach , Mohsen S. Salek , Robert Lowrance , John A. Backer , William Tyler Weaver , Charles Carlson , Chongyang Wang , Jeffrey Hudgens , Harald Herchen , Brian Lu
发明人： Tetsuya Ishikawa , Rick J. Roberts , Helen R. Armer , Leon Volfovski , Jay D. Pinson , Michael Rice , David H. Quach , Mohsen S. Salek , Robert Lowrance , John A. Backer , William Tyler Weaver , Charles Carlson , Chongyang Wang , Jeffrey Hudgens , Harald Herchen , Brian Lu
IPC分类号： B05C13/02 , C23C14/00 , H01L21/677
CPC分类号： H01L21/67225 , G03B27/32 , G03D13/006 , G03F7/40 , G05B19/41825 , G05B2219/40476 , G05B2219/45031 , G05B2219/49137 , H01L21/67109 , H01L21/6715 , H01L21/67161 , H01L21/67173 , H01L21/67178 , H01L21/67184 , H01L21/6719 , H01L21/67196 , H01L21/67742 , H01L21/67745 , H01L21/67748 , H01L21/67754 , H01L21/6831 , H01L21/6838 , H01L21/68707 , H01L22/26 , Y02P90/087 , Y10S414/135 , Y10S414/136 , Y10T29/53187 , Y10T29/5323
摘要： An apparatus for processing substrates using a multi-chamber processing system (e.g., a cluster tool) that has an increased system throughput, increased system reliability, a smaller system footprint, and a more repeatable wafer history. Embodiments provide for a cluster tool comprising first and second processing racks, each having two or more vertically stacked substrate processing chambers, a first robot assembly able to access the first processing rack from a first side, a second robot assembly able to access the first processing rack from a second side and the second processing rack from a first side, a third robot assembly able to access the second processing rack from a second side, and a fourth robot assembly able to access the first and second processing racks and to load substrates in a cassette.
摘要翻译：一种使用具有增加的系统吞吐量，增加的系统可靠性，更小的系统占用面积和更可重复的晶片历史的多室处理系统（例如，集群工具）处理衬底的设备。实施例提供了一种集群工具，其包括第一和第二处理机架，每个具有两个或更多个垂直堆叠的衬底处理室，能够从第一侧接近第一处理架的第一机器人组件，能够访问第一处理的第二机器人组件从第二侧起第二机架和从第二侧起第二处理齿条的第三机器人组件，以及能够从第二侧进入第二处理齿条的第三机器人组件，以及能够接近第一和第二处理机架并将基板装入的第四机器人组件一个盒子。

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