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61. 发明授权

US5461433A Highly hydrous soft contact lens and a treating solution for contact lenses 失效
标题翻译：高含水软性隐形眼镜和隐形眼镜治疗液
公开(公告)号：US5461433A
公开(公告)日：1995-10-24
申请号：US290099
申请日：1994-08-15
申请人： Nobuo Nakabayashi , Kazuhiko Ishihara , Yoshishige Murata , Nobuharu Nakada , Takeo Matsumoto , Yasumi Koinuma
发明人： Nobuo Nakabayashi , Kazuhiko Ishihara , Yoshishige Murata , Nobuharu Nakada , Takeo Matsumoto , Yasumi Koinuma
IPC分类号： C08F230/02 , C11D3/00 , C11D3/37 , G02B1/04 , G02C13/00 , B08B11/00 , C08K5/05
CPC分类号： C11D3/37 , C08F230/02 , C11D3/0078 , G02B1/043 , Y10S525/937
摘要： A highly hydrous soft contact lens comprising a copolymer which contains as an ingredient a monomer having constitution similar to that of phospholipid represented by the following general formula: ##STR1## n is an integer of 1-20, and, R.sub.2, R.sub.3 and R.sub.4 are the same or different groups and alkyl or hydroxyalkyl of 1-8 carbon atoms.Further, a treating solution for contact lenses which comprises a polymer containing as an ingredient the above monomer and a solvent which can dissolve the polymer.
摘要翻译：一种高含水软性隐形眼镜，其包含共聚物，其含有具有与由以下通式表示的磷脂类似的结构的单体作为成分：图像Y是CH 2，CH 2 O，CH 2 CH 2 O，CH 2 CH 2 CH 2 CH 2 O，n 是1-20的整数，R2，R3和R4是相同或不同的基团和1-8个碳原子的烷基或羟烷基。此外，本发明提供一种隐形眼镜用处理液，其包含含有作为上述单体的成分的聚合物和可溶解聚合物的溶剂。

62. 发明授权

US5064446A Method of preparing high purity light gas by multiple-step gas separation 失效
标题翻译：多级气体分离制备高纯度轻质气体的方法
公开(公告)号：US5064446A
公开(公告)日：1991-11-12
申请号：US199319
申请日：1988-05-26
申请人： Yoshihiro Kusuki , Kazuhiko Ishihara
发明人： Yoshihiro Kusuki , Kazuhiko Ishihara
IPC分类号： B01D53/22 , C01B3/50 , C01B23/00
CPC分类号： C01B23/0047 , B01D53/226 , C01B23/00 , C01B3/501 , C01B2203/0405 , C01B2203/0475 , C01B2210/0031 , Y02P20/152
摘要： A purified light gas consisting of hydrogen or helium and having a high purity of, for example, 99.99% or more is prepared from a feed gas containing at least 90 molar % or more of H.sub.2 or He and substantially no CO.sub.2 by gas-separating the feed gas through a plurality of gas-separating membrane modules each comprising at least one polymeric gas-separating membrane and having a gas-permeating ratio P.sub.A /P.sub.CH4 of 100 or more, wherein P.sub.A is a permeating rate of the light gas and P.sub.CH4 is a permeating rate of methane gas, in such a manner that each fraction of the feed gas permeated through and delivered from a preceding membrane module is fed to a next membrane module under the pressure, per se, of the delivered fraction of the feed gas without pressurizing the delivered fraction.
摘要翻译：由氢或氦构成的纯度高达99.99％以上的纯净气体由含有H 2或者H 2至少为90摩尔％以上的原料气体和通过气体分离通过多个气体分离膜模块进料气体，每个气体分离膜组件包含至少一个聚合气体分离膜，气体渗透比PA / PCH4为100或更大，其中PA为轻气体的渗透速率，PCH4为以这样一种方式，使进入气体的每一部分渗透通过并从前一膜组件传送的方式，在进料气体的输送部分本身的压力下进料到下一个膜组件，而不加压传递的分数。

63. 发明授权

US09138511B2 Bioabsorbable blend for temporary scaffolding of the blood vessel wall 有权
标题翻译：用于血管壁临时支架的生物可吸收混合物
公开(公告)号：US09138511B2
公开(公告)日：2015-09-22
申请号：US14319184
申请日：2014-06-30
申请人： Suntech Co., Ltd. , Hyung-Il Kim , Kazuhiko Ishihara
发明人： Hyung-Il Kim , Kazuhiko Ishihara
IPC分类号： A61F2/82 , A61L31/04 , A61L27/26 , A61L27/50 , A61L31/14 , A61L27/14
CPC分类号： A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
摘要翻译：开发了能够耐受血管壁的机械强度并适用于制造心血管装置的包含聚（L-丙交酯）（PLLA）和含磷酸胆碱基团的共聚物（PPCP）的生物可吸收混合物。混合物作为支架，用于在血管愈合期间支持血管壁，并且在血管愈合完成后在体内经历生物降解。此外，共混物可以防止血栓的形成和吸附。

64. 发明申请

US20140371395A1 BIOABSORBABLE BLEND FOR TEMPORARY SCAFFOLDING OF THE BLOOD VESSEL WALL 有权
公开(公告)号：US20140371395A1
公开(公告)日：2014-12-18
申请号：US14319184
申请日：2014-06-30
申请人： Hyung-Il Kim , Kazuhiko Ishihara , Suntech Co., Ltd.
发明人： Hyung-Il Kim , Kazuhiko Ishihara
IPC分类号： A61L31/04 , A61L31/14
CPC分类号： A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.

65. 发明授权

US08795841B2 Graft polymerization method and product obtained thereby 有权
标题翻译：接枝聚合法和由此得到的产物
公开(公告)号：US08795841B2
公开(公告)日：2014-08-05
申请号：US13130125
申请日：2009-11-20
申请人： Masayuki Kyomoto , Kazuhiko Ishihara
发明人： Masayuki Kyomoto , Kazuhiko Ishihara
IPC分类号： B32B27/00 , F16C33/20 , C08J3/28
CPC分类号： C08F291/18 , C08F283/06 , Y10T428/31855 , C08F230/02 , C08F2/48
摘要： Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).
摘要翻译：公开了一种接枝聚合方法，其解决了当单体在聚合物基材的表面上接枝聚合时涉及使用溶剂，自由基引发剂和高能辐射的问题。接枝聚合方法的特征在于，通过将表面上具有酮基的聚合物基（ⅰ）浸渍到含有单体（ⅱ）的反应体系中，然后用光照射聚合物基体（i），得到聚合产物单体的聚合从聚合物基质（i）的表面开始。

66. 发明申请

US20120197407A1 HIGHLY LUBRICATING SLIDING MEMBER AND ARTIFICAL JOINT USING SAME 审中-公开
标题翻译：高润滑滑动构件和使用相同的人工接合
公开(公告)号：US20120197407A1
公开(公告)日：2012-08-02
申请号：US13390971
申请日：2010-08-18
申请人： Masayuki Kyomoto , Kazuhiko Ishihara
发明人： Masayuki Kyomoto , Kazuhiko Ishihara
IPC分类号： A61F2/30 , B05D1/18 , B05D3/06 , F16C33/20
CPC分类号： A61L27/14 , A61F2/30767 , A61F2/32 , A61F2002/30673 , A61L27/18 , A61L27/34 , A61L27/50 , A61L2400/10 , A61L2430/24 , C08L101/02 , C08L71/00 , C08L33/10
摘要： Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm3 on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.
摘要翻译：公开了一种能够长时间保持耐磨性的滑动构件; 聚合物基材的厚度减小的人造关节部件; 以及在体内具有高润滑性的人造关节，生物相容性和耐位错性。具体公开了一种聚合物滑动材料，其具有由聚合物基材的至少一部分表面上含有磷酸胆碱基并具有至少1.4g / cm 3的密度的接枝聚合物构成的涂层（B） A）表面上有一个酮基。滑动材料可以通过将聚合物基体（A）浸渍在具有磷酰胆碱基团的单体（C）的液体中，并通过照射光进行表面接枝聚合来获得。还具体公开了使用聚合物滑动材料的人造关节构件和人造关节。

67. 发明申请

US20090306781A1 High Wear-Resistant Bearing Material and Artificial Joint Replacement Using the Same 有权
标题翻译：高耐磨轴承材料和使用其的人造关节置换
公开(公告)号：US20090306781A1
公开(公告)日：2009-12-10
申请号：US12223669
申请日：2007-02-05
申请人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
发明人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
IPC分类号： A61F2/30 , B32B27/08 , C08J3/28
CPC分类号： A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4059 , A61F2/4081 , A61F2/4202 , A61F2/4241 , A61F2/4425 , A61F2/468 , A61F2002/3065 , A61F2002/30654 , A61F2002/30884 , A61F2002/30904 , A61F2002/30934 , A61F2002/3493 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/3682 , A61F2002/4018 , A61F2002/4051 , A61F2002/4062 , A61L27/34 , A61L27/50 , Y10T428/31913
摘要： The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
摘要翻译：本发明提供耐久性优异并能够长时间保持耐磨性的轴承材料。本发明的轴承材料是用于在潮湿环境下使用的高耐磨轴承材料10，包括：由具有亚甲基的聚合物材料制成的基体12; 以及覆盖基板12的支承面16的聚合物层30，聚合物层30包含具有磷酸胆碱基并且从支承表面16接枝的聚合物链，其中滑动表面16的磷酸指数通过除以在滑动面上测定的红外光谱中的亚甲基的峰强度的磷酸基的峰强度不小于0.28。

68. 发明授权

US06706260B1 Wound-covering preparation, wound-covering material, and method of wound healing 有权
标题翻译：伤口覆盖制剂，伤口覆盖材料和伤口愈合方法
公开(公告)号：US06706260B1
公开(公告)日：2004-03-16
申请号：US09743357
申请日：2001-01-05
申请人： Shinji Tanaka , Ken Suzuki , Kenshiro Shuto , Akio Hayashi , Nobuo Nakabayashi , Kazuhiko Ishihara
发明人： Shinji Tanaka , Ken Suzuki , Kenshiro Shuto , Akio Hayashi , Nobuo Nakabayashi , Kazuhiko Ishihara
IPC分类号： A61K3174
CPC分类号： C08F230/02 , A61L15/24 , A61L15/26 , A61L27/16 , C08F30/02 , C08L43/02 , C08F2220/1825 , C08F2222/108 , C08F2222/1013 , C08F2220/1858 , C08F2220/325 , C08L101/02
摘要： A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R1, R2 and R3 are the same or different and each represents hydrogen atom or C1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.
摘要翻译：含有具有式（I）表示的基团的聚合物的伤口覆盖剂（其中R 1，R 2和R 3相同或不同，各自表示氢原子或C 1-4烷基， m为2〜4的整数）; 含有该制剂的伤口覆盖材料; 以及伤口愈合方法，其包括用伤口覆盖材料覆盖受试者的伤口以保护伤口的步骤。

69. 发明授权

US06258371B1 Method for making biocompatible medical article 失效
标题翻译：制作生物相容性医疗用品的方法
公开(公告)号：US06258371B1
公开(公告)日：2001-07-10
申请号：US09054389
申请日：1998-04-03
申请人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
发明人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
IPC分类号： A61F1300
CPC分类号： A61L33/0047 , A61L27/34 , A61L31/10 , A61L33/0029 , C08L33/14
摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
摘要翻译：通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和肝素生物活性。一旦制成共聚物涂层，医用制品被涂覆。然后将涂层干燥并加入肝素。以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。

70. 发明授权

US5576182A Anti-mucus glycoprotein monoclonal antibody 失效
标题翻译：抗粘蛋白糖蛋白单克隆抗体
公开(公告)号：US5576182A
公开(公告)日：1996-11-19
申请号：US373220
申请日：1995-01-18
申请人： Makoto Kurihara , Kazuhiko Ishihara , Kyoko Hotta , Hiromi Tanaka , Shiro Shimauchi
发明人： Makoto Kurihara , Kazuhiko Ishihara , Kyoko Hotta , Hiromi Tanaka , Shiro Shimauchi
IPC分类号： C07K16/18 , C12N5/10 , C12N5/20 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , Y10S435/96
摘要： An IgM class monoclonal antibody which specifically reacts with mucus glycoproteins produced by human gastric gland-type mucous cells is provided. By performing immunohistochemical staining using a labeled derivative of the monoclonal antibody, human gastric gland-type mucous cells as well as mucus secreted by these cells can be specifically stained. The monoclonal antibody can also be used for the analysis of gastric gland-type mucous cell-derived mucus glycoproteins in human body fluids as well as for the examination or diagnosis of cancer.
摘要翻译： PCT No.PCT / JP94 / 00838 Sec。 371日期1995年1月19日 102（e）1995年1月19日PCT PCT 1994年5月26日PCT公布。公开号WO94 / 28158 PCT 日期1994年12月8日提供了与人胃腺型粘液细胞产生的粘液糖蛋白特异性反应的IgM类单克隆抗体。通过使用单克隆抗体的标记衍生物进行免疫组织化学染色，可以特异性地染色人胃腺型粘液细胞以及由这些细胞分泌的粘液。单克隆抗体也可用于分析人体液中的胃腺粘液细胞来源的粘液糖蛋白以及癌症的检查或诊断。

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