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61. 发明授权

US5423870A Rate responsive cardiac pacemaker 失效
标题翻译：速率响应心脏起搏器
公开(公告)号：US5423870A
公开(公告)日：1995-06-13
申请号：US155482
申请日：1993-11-22
申请人： Arthur L. Olive , Rodney W. Salo
发明人： Arthur L. Olive , Rodney W. Salo
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36585
摘要： A cardiac pacemaker having an automatic pulse rate response gain factor responsive to at least one cardiac-related physiological characteristic of a patient. The pacemaker includes a rate controller that comprises a detector for detecting a plurality of individual measurements of at least one physiological characteristic over each of a plurality of pre-determined time periods, with each of the individual measurements being an average of values detected over each of a respective multiple number of incremental time periods occurring within each of the pre-determined time periods. The pacemaker saves the highest measurement from one incremental time period of each of several consecutive pre-determined time periods, and these highest measurements are averaged. Thereafter, the rate controller adjusts the rate response gain factor or slope of the pulse rate in relation to the physiological characteristic measurement and a pre-determined target pulse rate. In a preferred embodiment, two physiological characteristics are measured, with high values averaged of only one characteristic when that characteristic exceeds a threshold level of the other characteristic. One embodiment is pulse rate responsive to minute volume measurement in combination with accelerometer measurement, with accelerometer measurement requiring a threshold value over an increment of time prior to minute volume recordation for input toward rate response gain factor.
摘要翻译：一种心脏起搏器，其具有响应于患者的至少一个心脏相关生理特征的自动脉搏响应增益因子。起搏器包括速率控制器，其包括用于在多个预定时间段中的每一个上检测至少一个生理特性的多个单独测量值的检测器，其中每个单独测量值是在在每个预定时间周期内出现的相应的多个增量时间段。起搏器从几个连续预定时间段的每个增量时间段节省最高测量值，并对这些最高测量值进行平均。此后，速率控制器相对于生理特征测量和预定的目标脉率调节脉率的速率响应增益因子或斜率。在优选实施例中，测量两个生理特征，当该特征超过另一个特征的阈值水平时，仅测量一个特征的高值。一个实施例是响应于微小体积测量的脉冲速率与加速度计测量结合，加速度计测量需要在微小体积记录之前的时间上增加阈值，以便向速率响应增益因子输入。

62. 发明授权

US08369948B2 Apparatus for reversal of myocardial remodeling with pre-excitation 有权
标题翻译：用于预激发反转心肌重塑的装置
公开(公告)号：US08369948B2
公开(公告)日：2013-02-05
申请号：US13279493
申请日：2011-10-24
申请人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

63. 发明授权

US08204599B2 System for anchoring an implantable sensor in a vessel 有权
标题翻译：将植入式传感器固定在容器中的系统
公开(公告)号：US08204599B2
公开(公告)日：2012-06-19
申请号：US12103963
申请日：2008-04-16
申请人： Wangcai Liao , Bin Mi , Rodney W. Salo
发明人： Wangcai Liao , Bin Mi , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61B5/02152 , A61B5/6862 , A61B5/6876 , A61B5/6882
摘要： A system and a method of disposing a second sensor module overlying a first sensor module system is described. A first assembly including an expandable anchor and a sensor module is at least partially overlapped by a second assembly including an expandable anchor and a sensor module. If necessary or desired, the functions of the second sensor module can replace the functions of the first sensor module. The sensor module may include a blood pressure sensor.
摘要翻译：描述了布置覆盖在第一传感器模块系统上的第二传感器模块的系统和方法。包括可扩张锚和传感器模块的第一组件至少部分地由包括可扩张锚和传感器模块的第二组件重叠。如果需要或需要，第二传感器模块的功能可以替代第一传感器模块的功能。传感器模块可以包括血压传感器。

64. 发明授权

US07991480B2 Medical device electrodes having cells disposed on nanostructures 失效
标题翻译：具有设置在纳米结构上的细胞的医疗装置电极
公开(公告)号：US07991480B2
公开(公告)日：2011-08-02
申请号：US11846280
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0565
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

65. 发明授权

US07941216B2 Method and device for treating myocardial ischemia 有权
标题翻译：治疗心肌缺血的方法和装置
公开(公告)号：US07941216B2
公开(公告)日：2011-05-10
申请号：US11561049
申请日：2006-11-17
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

66. 发明授权

US07899532B2 Method and apparatus for minimizing post-infarct ventricular remodeling 有权
标题翻译：用于最小化梗死后心室重塑的方法和装置
公开(公告)号：US07899532B2
公开(公告)日：2011-03-01
申请号：US12396115
申请日：2009-03-02
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

67. 发明授权

US07894914B2 Medical device electrodes including nanostructures 失效
标题翻译：包括纳米结构在内的医疗器械电极
公开(公告)号：US07894914B2
公开(公告)日：2011-02-22
申请号：US11846246
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/0565 , A61N1/375 , Y10S977/931
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

68. 发明授权

US07869871B2 Pacing therapy for diastolic heart failure 有权
标题翻译：起搏治疗舒张性心力衰竭
公开(公告)号：US07869871B2
公开(公告)日：2011-01-11
申请号：US11278330
申请日：2006-03-31
申请人： Rodney W. Salo , Guy Alvarez , Eric G. Lovett
发明人： Rodney W. Salo , Guy Alvarez , Eric G. Lovett
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36528 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： Described herein are methods and systems for delivering pacing therapy to HF patients who do not exhibit a reduced EF. Such patients do not have systolic dysfunction and generally do not benefit from established HF therapies that either augment contractile function or counteract conduction abnormalities. In one embodiment, a HF patient with a normal EF is tested for the adequacy of heart rate response during exercise. If the patient is found to be chronotropically incompetent, a rate-adaptive pacing mode is employed in order to improve functional capacity.
摘要翻译：本文描述的是用于向没有显示减少的EF的HF患者输送起搏治疗的方法和系统。这些患者没有收缩功能障碍，一般不会从建立的HF疗法中获益，既可增强收缩功能，又可抵消传导异常。在一个实施例中，测试具有正常EF的HF患者在运动期间心率反应的适当性。如果患者被发现是顺应性不足的，则采用速率自适应起搏模式来提高功能能力。

69. 发明授权

US07778707B2 Method and device for myocardial stress redistribution 有权
标题翻译：心肌应激再分配的方法和装置
公开(公告)号：US07778707B2
公开(公告)日：2010-08-17
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/368
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such as the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可以用于故意地减压可能预期会发生有害重建的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或者故意强迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

70. 发明授权

US07668595B2 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US07668595B2
公开(公告)日：2010-02-23
申请号：US11619391
申请日：2007-01-03
申请人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
发明人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。微控制器可操作以调节起搏器的起搏模式和站间延迟，以达到最佳的血液动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

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