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61. 发明授权

US08368285B2 Electrochemical actuators 有权
标题翻译：电化学执行机构
公开(公告)号：US08368285B2
公开(公告)日：2013-02-05
申请号：US13328504
申请日：2011-12-16
申请人： Yet-Ming Chiang , Timothy E. Chin , Michael J. Cima , J. Richard Gyory
发明人： Yet-Ming Chiang , Timothy E. Chin , Michael J. Cima , J. Richard Gyory
IPC分类号： H91L41/08
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.
摘要翻译：本文描述了用于提供电化学致动的装置和方法。在一个实施例中，致动器装置包括包括负极和正极的电化学电池。负极的至少一部分由配制成插层，去插入，合金，氧化，还原的至少一种的材料形成或者具有与正极的第二部分不同的程度的正极的第一部分的板，使得在正极的第一部分和第二部分之间施加微分应变，使得至少一部分的电化学电池被移位。电化学电池包括沿着电化学电池的轴线预弯曲以限定折叠轴线的部分，并且电化学电池的至少一部分的位移沿折叠轴线最大化。

62. 发明授权

US08182464B2 Method for intravesical drug delivery 有权
标题翻译：膀胱内药物输送方法
公开(公告)号：US08182464B2
公开(公告)日：2012-05-22
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M31/00 , A01N43/04 , A01N37/12 , A01N37/44 , A01N43/38 , A01N37/18 , A01N59/02 , A61K31/24 , A61K31/40 , A61K31/16 , A61K33/04
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

63. 发明申请

US20110124744A1 Magnetic Resonance-Based Viscometers and Methods 有权
标题翻译：基于磁共振的粘度计和方法
公开(公告)号：US20110124744A1
公开(公告)日：2011-05-26
申请号：US12673866
申请日：2008-08-15
申请人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
发明人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
IPC分类号： A61K45/00 , G01N24/08
CPC分类号： G01N24/08 , G01N27/745 , G01R33/465 , G01R33/50 , G01R33/5601
摘要： This invention relates generally to magnetic resonance (MR)-based methods and kits for measuring the viscosity of liquid samples.
摘要翻译：本发明一般涉及基于磁共振（MR）的方法和用于测量液体样品粘度的试剂盒。

64. 发明授权

US07875290B2 Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
标题翻译：药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内
公开(公告)号：US07875290B2
公开(公告)日：2011-01-25
申请号：US11246910
申请日：2005-10-07
申请人： Francis C. Payumo , Jill K. Sherwood , Donald C. Monkhouse , Jaedeok Yoo , Christopher M. Gaylo , Chen-Chao Wang , Michael J. Cima
发明人： Francis C. Payumo , Jill K. Sherwood , Donald C. Monkhouse , Jaedeok Yoo , Christopher M. Gaylo , Chen-Chao Wang , Michael J. Cima
IPC分类号： A61K31/4745 , A61K31/198 , A61K9/48
CPC分类号： A61K9/2893 , A61K9/209 , A61K9/2886 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.
摘要翻译：药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。

65. 发明授权

US07828771B2 Systems and methods for delivering drugs 有权
标题翻译：递送药物的系统和方法
公开(公告)号：US07828771B2
公开(公告)日：2010-11-09
申请号：US12181085
申请日：2008-07-28
申请人： Yet-Ming Chiang , Michael J. Cima , J. Richard Gyory , Glenn R. Booma
发明人： Yet-Ming Chiang , Michael J. Cima , J. Richard Gyory , Glenn R. Booma
IPC分类号： A61M5/20
CPC分类号： A61M5/14248 , A61M5/1452 , A61M5/148 , A61M5/1723 , A61M2005/14204 , A61M2005/14252 , A61M2005/14268 , A61M2005/14513 , A61M2005/1726 , A61M2205/8231
摘要： A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator.
摘要翻译：贴剂泵装置通常包括至少一个流体源，流体通信器和电化学致动器。流体通信器与流体源流体连通。电化学致动器可操作以使流体从流体源输送到流体通信器中。

66. 发明申请

US20100093545A1 METHOD FOR MAKING HIGH JC SUPERCONDUCTING FILMS AND POLYMER-NITRATE SOLUTIONS USED THEREFORE 审中-公开
标题翻译：制备高JC超导膜的方法及其所用的聚合物 - 硝酸盐溶液
公开(公告)号：US20100093545A1
公开(公告)日：2010-04-15
申请号：US12306415
申请日：2007-06-29
申请人： Michael J. Cima , Masateru Yoshizumi , Daniel E. Wesolowski , Yoda R. Patta
发明人： Michael J. Cima , Masateru Yoshizumi , Daniel E. Wesolowski , Yoda R. Patta
IPC分类号： H01L39/24 , H01L39/12
CPC分类号： H01L39/2425 , C23C18/1216 , C23C18/1241 , C23C18/1245 , C23C18/1295 , H01L21/31691
摘要： 100-800 nm ReBCO films with critical current density (Jc) values in excess of 1 MA/cm2 were fabricated from aqueous nitrate precursor solutions with additives. Additives such as polyethylene glycol (PEG) and sucrose were selected to suppress crystallization of barium nitrate. This produces higher concentration solutions resulting in thicker crack-free single layers. Additional water-soluble viscosity modifiers, such as polyvinyl alcohol (PVA) or cellulose-derivatives, were used to increase thickness and allow wetting of ceramic surfaces. Water vapor present at higher temperatures during heat-treatment damaged the films, while the role of water vapor at lower temperatures is still under investigation.
摘要翻译：由具有添加剂的硝酸盐前体溶液制备具有超过1MA / cm 2的临界电流密度（Jc）值的100-800nm ReBCO膜。选择添加剂如聚乙二醇（PEG）和蔗糖以抑制硝酸钡的结晶。这产生更高的浓度溶液，导致更厚的无裂纹单层。使用额外的水溶性粘度调节剂，例如聚乙烯醇（PVA）或纤维素衍生物来增加厚度并允许陶瓷表面的润湿。在热处理过程中，较高温度下的水蒸汽会损坏膜，而在较低温度下的水蒸汽作用仍在调查之中。

67. 发明申请

US20090028824A1 SYSTEMS AND METHODS FOR DELIVERING DRUGS 有权
标题翻译：用于递送药物的系统和方法
公开(公告)号：US20090028824A1
公开(公告)日：2009-01-29
申请号：US12181085
申请日：2008-07-28
申请人： Yet-Ming Chiang , Michael J. Cima , J. Richard Gyory , Glenn R. Booma
发明人： Yet-Ming Chiang , Michael J. Cima , J. Richard Gyory , Glenn R. Booma
IPC分类号： A61K38/21 , A61M5/142 , A61M5/172 , A61K38/28 , A61K38/08 , A61K31/165 , A61K31/416 , A61P25/16 , A61P43/00 , A61P1/16 , A61P25/24 , A61K31/56 , A61K31/727 , A61K38/24 , A61K38/16 , A61K31/4468
CPC分类号： A61M5/14248 , A61M5/1452 , A61M5/148 , A61M5/1723 , A61M2005/14204 , A61M2005/14252 , A61M2005/14268 , A61M2005/14513 , A61M2005/1726 , A61M2205/8231
摘要： A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator.
摘要翻译：贴剂泵装置通常包括至少一个流体源，流体通信器和电化学致动器。流体通信器与流体源流体连通。电化学致动器可操作以使流体从流体源输送到流体通信器中。

68. 发明授权

US06852526B2 Transdermal assay with magnetic clamp 失效
标题翻译：用磁夹进行透皮测定
公开(公告)号：US06852526B2
公开(公告)日：2005-02-08
申请号：US10282505
申请日：2002-10-28
申请人： Michael J. Cima , Hongming Chen , J. Richard Gyory
发明人： Michael J. Cima , Hongming Chen , J. Richard Gyory
IPC分类号： B01L3/00 , C12M1/34 , C12M3/00 , G01N13/00 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5088 , B01L3/50255 , G01N13/00 , G01N33/5008 , G01N33/5044 , G01N2500/00
摘要： The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.
摘要翻译：透皮测定装置包括第一，第二和第三构件。第一构件具有一个或多个样品表面，每个样品表面被配置为在其上接收样品。第二构件限定一个或多个储存器，每个储存器在第二构件的表面上具有开口。每个样品表面的大小与每个开口大致相同。透皮测定装置还包括构造成在样品表面和开口之间夹持组织样本的磁性夹具。磁夹具优选地包括具有基于第一构件和第二构件之间所需的夹紧力选择的强度的磁体。本发明还提供了一种使用透皮测定装置的方法。

69. 发明授权

US06686207B2 Manipulating micron scale items 失效
公开(公告)号：US06686207B2
公开(公告)日：2004-02-03
申请号：US09976835
申请日：2001-10-12
申请人： Malinda M. Tupper , Michael J. Cima , Marjorie E. Chopinaud
发明人： Malinda M. Tupper , Michael J. Cima , Marjorie E. Chopinaud
IPC分类号： G01N100
CPC分类号： G01N35/10 , B01D17/04 , B01D17/06 , B01D21/0009 , B01J2219/00274 , B01J2219/00315 , B01J2219/00387 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5085 , B03C5/026 , B03C5/028 , C40B30/08 , C40B40/10 , C40B40/14 , C40B40/18 , C40B60/14 , G01N2035/00188 , G01N2035/00237 , Y10T436/25 , Y10T436/25375
摘要： Micron scale dielectric items are manipulated by methods and apparatus taking advantage of spatially non-uniform field. Such fields give rise to a force on dielectric items, directing them generally toward regions of more concentrated field. The electrode may be elongated, either unitary, with a generally planar counter electrode, or dual, such as parallel pins, loops or plates. If dual, particles are generally attracted to regions of high field concentration, including tips, edges and spaces between electrode conductors. Items can be granular, threadlike, or sheets, and microelectronic parts and other shapes. Items can also be collected directly into a recess of a pharmaceutical material delivery microchip, with a conductive membrane of the microchip acting as a manipulating electrode. Items are attracted without regard to their surface charge, or the polarity of the field, which can be AC or DC. Charging, or knowing the charge of items to be manipulated is not necessary. The amount of material collected can be precisely controlled by varying parameters of collection, such as distance between the electrode and the items, distance between dual conductors, size (diameter, length) of the conductors, any dielectric sheathing thereof, and voltage. Elongated electrodes can be used to manipulate items into and from recesses, such as wells of microtitre trays, microchips, and semiconductor chips. Several recesses can be used to calibrate an array of collecting and depositing electrodes and deposits. Items can be removed from fluids, such as aerosol dispersions, and an air cleaner is also disclosed. Dielectrophoretic forces are exploited. Techniques and apparatus for depositing such items include charged targets and targets with electrodes designed to create a non-uniform field.

70. 发明授权

US06514518B2 Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof 失效
公开(公告)号：US06514518B2
公开(公告)日：2003-02-04
申请号：US09932245
申请日：2001-08-17
申请人： Donald Monkhouse , Jaedeok Yoo , Jill K. Sherwood , Michael J. Cima , Esteban Bornancini
发明人： Donald Monkhouse , Jaedeok Yoo , Jill K. Sherwood , Michael J. Cima , Esteban Bornancini
IPC分类号： A61F214
CPC分类号： A61K9/0024 , A61F2/02 , A61F2/28 , A61F2/3094 , A61F2002/009 , A61F2002/30032 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/003 , A61F2250/0067 , A61K9/0051 , A61K9/14 , A61K9/1647 , A61K9/1694 , A61K9/20 , A61K9/2086 , A61K9/2095 , B29C64/00 , B29C64/165 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.

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