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61. 发明授权

US10052481B2 Visual prosthesis 有权
公开(公告)号：US10052481B2
公开(公告)日：2018-08-21
申请号：US11926051
申请日：2007-10-28
申请人： Kelly H. McClure , Arup Roy , Sumit Yadav , Richard Agustin Castro , Susan McCord
发明人： Kelly H. McClure , Arup Roy , Sumit Yadav , Richard Agustin Castro , Susan McCord
IPC分类号： A61N1/36 , A61N1/378 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/3787
摘要： A visual prosthesis apparatus and a method for providing artificial vision are disclosed in the present disclosure. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured stimulate neural tissue in a subjects eye based on the stimulation patterns. An artificial vision may be provided by capturing a video image, converting the video image to stimulation patterns, and stimulating neural tissue in a subjects eye based on the stimulation patterns.

62. 发明授权

US09393421B2 Controlling charge flow in the electrical stimulation of tissue 有权
标题翻译：控制电刺激组织中的电荷流
公开(公告)号：US09393421B2
公开(公告)日：2016-07-19
申请号：US12836440
申请日：2010-07-14
申请人： Rafael Carbunaru , Kelly H. McClure , Jordi Parramon
发明人： Rafael Carbunaru , Kelly H. McClure , Jordi Parramon
IPC分类号： A61N1/08 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36146 , A61N1/36103 , A61N1/36107 , A61N1/37247 , A61N1/37264
摘要： Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.
摘要翻译：在电刺激组织期间控制电荷流动的技术系统。一方面，一种方法包括接收描述在电刺激组织的刺激脉冲期间流动的电荷量的电荷设置，以及产生和递送刺激脉冲，使得递送到组织的电荷量在刺激脉冲期间符合充电设置。

63. 外观设计

USD688294S1 Visor for a visual prosthetic apparatus 有权
标题翻译：视觉假肢器具遮阳板
公开(公告)号：USD688294S1
公开(公告)日：2013-08-20
申请号：US29429348
申请日：2012-08-09
申请人： Arup Roy , Sanjay Gaikwad , Kelly H. McClure , Timothy M. Nugent
设计人： Arup Roy , Sanjay Gaikwad , Kelly H. McClure , Timothy M. Nugent

64. 发明授权

US08364280B2 Engagement tool for implantable medical devices 有权
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US08364280B2
公开(公告)日：2013-01-29
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

65. 发明授权

US07177698B2 Telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US07177698B2
公开(公告)日：2007-02-13
申请号：US10607962
申请日：2003-06-27
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

66. 发明授权

US06970741B1 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US06970741B1
公开(公告)日：2005-11-29
申请号：US10246554
申请日：2002-09-17
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
IPC分类号： A61M5/00 , A61M5/142 , A61M5/172 , A61N1/00 , A61N1/30 , A61N1/32
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

67. 发明授权

US06711438B1 Method and apparatus for blanking T-waves from combipolar atrial cardiac signals based on expected T-wave locations 有权
标题翻译：基于预期的T波位置从组合极心房心脏信号消隐T波的方法和装置
公开(公告)号：US06711438B1
公开(公告)日：2004-03-23
申请号：US10033410
申请日：2001-10-25
申请人： Kelly H. McClure , Joseph J. Florio , Gene A. Bornzin
发明人： Kelly H. McClure , Joseph J. Florio , Gene A. Bornzin
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3704
摘要： The stimulation device blanks T-waves from the atrial channel of an electrical cardiac signal by employing a T-wave blanking interval localized to the expected location and duration of the T-wave. To this end, the stimulation device determines the average interval between an R-wave and a T-wave in the patient in which the device is implanted and also determines the average duration of a T-wave within the patient. A T-wave blanking interval is initiated following the average R-T interval subsequent to detection of an R-wave and lasts for a period of time equal to the average T-wave duration. In this manner, highly localized T-wave blanking is achieved permitting P-waves or other atrial signals to be detected during remaining non-blanked portions of the atrial channel of the cardiac signal at least for the purposes of atrial rate detection. The relatively short T-wave blanking interval of the invention is particularly well suited for use in combipolar sensing systems. Method and apparatus implementations are described.
摘要翻译：刺激装置通过采用局限于T波的预期位置和持续时间的T波消隐间隔来消除来自心电信号心房通道的T波。为此，刺激装置确定在其中植入装置的患者中的R波和T波之间的平均间隔，并且还确定患者内的T波的平均持续时间。在检测到R波之后的平均R-T间隔之后开始T波消隐间隔，并且持续一段时间等于平均T波持续时间。以这种方式，实现高度局部化的T波消隐，允许在心脏信号的心房通道的剩余非消隐部分期间检测P波或其他心房信号，至少用于心房率检测。本发明的相对较短的T波消隐间隔特别适用于组合极检测系统。描述了方法和装置实现。

68. 发明授权

US5549652A Cardiac wall motion-based automatic capture verification system and method 失效
标题翻译：基于心脏壁运动的自动捕获验证系统及方法
公开(公告)号：US5549652A
公开(公告)日：1996-08-27
申请号：US152659
申请日：1993-11-15
申请人： Kelly H. McClure , Sheldon B. Moberg
发明人： Kelly H. McClure , Sheldon B. Moberg
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3712 , A61N1/36578
摘要： An improved implantable cardiac stimulating device that performs cardiac wall motion-based automatic capture verification system is provided. Pacing pulses of varying energy content are administered to a patient's heart, and the response of the patient's heart is sensed by a cardiac wall motion sensor. The cardiac wall motion sensor provides a signal which is analyzed to determine the patient's capture threshold, defined as the minimum amount of electrical stimulation required to evoke a cardiac contraction. The device then sets the amount of electrical stimulation at a level safely above the measured capture threshold. Capture verification may be performed at predetermined time intervals, on demand, or upon the occurrence of a significant cardiac event. Capture verification can also be performed on every pacing pulse delivered by the implantable cardiac stimulating device.
摘要翻译：提供了一种改进的可植入心脏刺激装置，其执行基于心脏壁运动的自动捕获验证系统。将不同能量的起搏脉冲施用于患者的心脏，并且由心脏壁运动传感器感测患者心脏的反应。心脏壁运动传感器提供被分析的信号以确定患者的捕获阈值，定义为唤起心脏收缩所需的最小电刺激量。然后，该装置将电刺激的量设置在高于所测量的捕获阈值的水平。捕获验证可以按照预定的时间间隔，按需或者发生重要的心脏事件进行。捕获验证也可以在可植入心脏刺激装置递送的每个起搏脉冲上进行。

69. 发明授权

US10055827B2 Digital image filters and related methods for image contrast enhancement 有权
公开(公告)号：US10055827B2
公开(公告)日：2018-08-21
申请号：US12560581
申请日：2009-09-16
申请人： Chunhong Zhou , Arup Roy , Kelly H. McClure
发明人： Chunhong Zhou , Arup Roy , Kelly H. McClure
IPC分类号： G06K9/00 , G06T5/40 , G06T5/00 , A61N1/36
CPC分类号： G06T5/40 , A61N1/36046 , G06T5/009 , G06T2207/10016
摘要： Digital image filters and related methods for image contrast enhancement are disclosed. According to one aspect of the method, an invariant brightness level is initially determined. For each pixel of an input image, the invariant brightness level is subtracted from the input brightness of the pixel. The resulting value is multiplied with a contrast adjustment constant. After that, the invariant brightness level is added. Further aspects of the method can involve histogram equalization.

70. 发明授权

US08655451B2 Telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US08655451B2
公开(公告)日：2014-02-18
申请号：US13016246
申请日：2011-01-28
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

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