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61. 发明授权

US6090577A Disease associated acidic protein 失效
标题翻译：疾病相关酸性蛋白
公开(公告)号：US6090577A
公开(公告)日：2000-07-18
申请号：US859937
申请日：1997-05-22
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human disease associated acidic protein and polynucleotides which identify and encode DAAP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DAAP.
摘要翻译：本发明提供了一种人类疾病相关的酸性蛋白质和鉴定和编码DAAP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与DAAP表达相关的疾病的方法。

62. 发明授权

US6010852A Human proton atpase subunit 失效
标题翻译：人质子atpase亚基
公开(公告)号：US6010852A
公开(公告)日：2000-01-04
申请号：US807300
申请日：1997-02-27
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N9/14 , C12Q1/68 , C07H21/04 , C07K1/00
CPC分类号： C12N9/14
摘要： The present invention provides a human proton ATPase subunit (HPAS) and polynucleotides which encode HPAS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HPAS.
摘要翻译：本发明提供人质子ATP酶亚基（HPAS）和编码HPAS的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了治疗与HPAS表达相关的疾病的方法。

63. 发明授权

US05998371A Human selenoprotein 失效
标题翻译：人类硒蛋白
公开(公告)号：US05998371A
公开(公告)日：1999-12-07
申请号：US127289
申请日：1998-07-13
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human selenoprotein (HSEL) and polynucleotides which identify and encode HSEL. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEL and a method for producing HSEL. The invention also provides for agonists, antibodies, or antagonists specifically binding HSEL, and their use, in the prevention and treatment of diseases associated with expression of HSEL. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEL for the treatment of diseases associated with the expression of HSEL. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEL.
摘要翻译：本发明提供鉴定和编码HSEL的人类硒蛋白（HSEL）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSEL的核酸序列和生产HSEL的方法。本发明还提供特异性结合HSEL的激动剂，抗体或拮抗剂及其在预防和治疗与HSEL表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HSEL的多核苷酸用于治疗与HSEL表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HSEL的抗体的诊断测定法。

64. 发明授权

US5985635A Nucleic acids encoding novel human serine/threonine protein kinases 失效
标题翻译：编码新型人丝氨酸/苏氨酸蛋白激酶的核酸
公开(公告)号：US5985635A
公开(公告)日：1999-11-16
申请号：US749902
申请日：1996-11-15
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N9/12 , C12N15/54
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The present invention provides human serine/threonine kinase (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSTK and a method for producing HSTK. The invention also provides for use of HSTK and agonists, antibodies, or antagonists specifically binding HSTK, in the prevention and treatment of diseases associated with expression of HSTK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSTK for the treatment of diseases associated with the expression of HSTK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSTK.
摘要翻译：本发明提供了人类丝氨酸/苏氨酸激酶（HSTK）和识别和编码HSTK的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSTK的核酸序列和产生HSTK的方法。本发明还提供使用HSTK和特异性结合HSTK的激动剂，抗体或拮抗剂来预防和治疗与HSTK表达相关的疾病。另外，本发明提供了反义分子用于编码HSTK的多核苷酸用于治疗与HSTK表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HSTK的抗体的诊断测定法。

65. 发明授权

US5973130A Ras-like protein 失效
标题翻译： Ras样蛋白
公开(公告)号：US5973130A
公开(公告)日：1999-10-26
申请号：US846790
申请日：1997-04-30
申请人： Jennifer L. Hillman , Surya K. Goli , Neil C. Corley
发明人： Jennifer L. Hillman , Surya K. Goli , Neil C. Corley
IPC分类号： A61K38/00 , C07K14/82 , C12N1/21 , C07H21/00 , C07H21/02
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention provides a human Ras-like protein (RLP) and polynucleotides which identify and encode RLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing RLP and for treating or preventing disorders associated with expression of RLP.
摘要翻译：本发明提供了人Ras样蛋白（RLP）和识别并编码RLP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了产生RLP和治疗或预防与RLP表达相关的疾病的方法。

66. 发明授权

US5969104A Human C-type lectin 失效
公开(公告)号：US5969104A
公开(公告)日：1999-10-19
申请号：US113788
申请日：1998-07-10
申请人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.

67. 发明授权

US5955429A Human apoptosis-associated protein 失效
标题翻译：人类凋亡相关蛋白
公开(公告)号：US5955429A
公开(公告)日：1999-09-21
申请号：US213398
申请日：1998-12-15
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C07K14/435 , A61K38/17
CPC分类号： C07K14/4747 , C07K14/4746 , A61K38/00
摘要： The present invention provides a novel human apoptosis-associated protein (NHAAP) and polynucleotides which identify and encode NHAAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHAAP and a method for producing NHAAP. The invention also provides for agonists, antibodies, or antagonists specifically binding NHAAP, and their use, in the prevention and treatment of diseases associated with expression of NHAAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHAAP for the treatment of diseases associated with the expression of NHAAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHAAP.
摘要翻译：本发明提供了新的人凋亡相关蛋白（NHAAP）和识别和编码NHAAP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHAAP的核酸序列和生产NHAAP的方法。本发明还提供特异性结合NHAAP的激动剂，抗体或拮抗剂及其在预防和治疗与NHAAP表达有关的疾病中的用途。此外，本发明提供了反义分子用于编码NHAAP的多核苷酸用于治疗与NHAAP表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHAAP的抗体的诊断测定法。

68. 发明授权

US5919659A Human phosphatidylinositol transfer protein gamma 失效
公开(公告)号：US5919659A
公开(公告)日：1999-07-06
申请号：US872961
申请日：1997-06-11
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a new human phosphatidylinositol transfer protein gamma (PITP.gamma.) and polynucleotides which identify and encode PITP.gamma.. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PITP.gamma..

69. 发明授权

US5919629A Polynucleotide probe and detection method for novel human clathrin-associated protein 失效
标题翻译：新型人类网格蛋白相关蛋白的多核苷酸探针和检测方法
公开(公告)号：US5919629A
公开(公告)日：1999-07-06
申请号：US98900
申请日：1998-06-17
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides a human clathrin-associated protein (HAP19) and polynucleotides which identify and encode HAP19. The invention also provides expression vectors and host cells and a method for producing HAP19. The invention also provides antibodies or antagonists specifically binding HAP19, and their use, in the prevention and treatment of diseases associated with expression of HAP19. The invention also provides diagnostic assays.
摘要翻译：本发明提供了人类网格蛋白相关蛋白（HAP19）和识别和编码HAP19的多核苷酸。本发明还提供表达载体和宿主细胞以及生产HAP19的方法。本发明还提供了特异性结合HAP19的抗体或拮抗剂及其在预防和治疗与HAP19表达相关的疾病中的用途。本发明还提供诊断测定。

70. 发明授权

US5889170A Human integral membrane protein 失效
标题翻译：人体内膜蛋白
公开(公告)号：US5889170A
公开(公告)日：1999-03-30
申请号：US791338
申请日：1997-01-31
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human integral membrane (IMP-2) and polynucleotides which identify and encode IMP-2. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP-2 and a method for producing IMP-2. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP-2, and their use, in the prevention and treatment of diseases associated with expression of IMP-2. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP-2 for the treatment of diseases associated with the expression of IMP-2. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP-2.
摘要翻译：本发明提供了一种新型人体内膜（IMP-2）和识别和编码IMP-2的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码IMP-2的核酸序列和产生IMP-2的方法的宿主细胞。本发明还提供特异性结合IMP-2的激动剂，抗体或拮抗剂及其在预防和治疗与IMP-2表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码IMP-2的多核苷酸用于治疗与IMP-2表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合IMP-2的抗体的诊断测定法。

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