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61. 发明申请

US20100190750A1 GPR119 Receptor Agonists in Methods of Increasing Bone Mass and of Treating Osteoporosis and Other Conditions Characterized by Low Bone Mass, and Combination Therapy Relating Thereto 失效
标题翻译： GPR119受体激动剂在增加骨质量和治疗骨质疏松症等低体质量特征的方法中的作用及其相关疗法
公开(公告)号：US20100190750A1
公开(公告)日：2010-07-29
申请号：US12752671
申请日：2010-04-01
申请人： Zhi-Liang Chu , James N. Leonard , Juerg Lehmann , Robert M. Jones
发明人： Zhi-Liang Chu , James N. Leonard , Juerg Lehmann , Robert M. Jones
IPC分类号： A61K31/69 , A61K31/403 , A61K31/277 , A61K31/513 , A61K31/4985 , A61K31/40 , A61K31/426 , A61P19/00
CPC分类号： A61K31/00 , A61K31/4375 , A61K31/4439 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/522 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. The present invention further relates to the use of a GPR119 receptor agonist in combination with a dipeptidyl peptidase IV (DPP-IV) inhibitor for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. A GPR119 receptor agonist and the combination of a GPR119 receptor agonist and a DPP-IV inhibitor promote bone formation in an individual.
摘要翻译：本发明涉及GPR119受体激动剂用于治疗或预防以低骨量为特征的疾病，例如骨质疏松症，以及增加个体骨量。本发明还涉及GPR119受体激动剂与二肽基肽酶IV（DPP-IV）抑制剂组合用于治疗或预防以低骨量为特征的疾病如骨质疏松症以及增加个体中的骨量的用途。 GPR119受体激动剂和GPR119受体激动剂和DPP-IV抑制剂的组合促进个体中的骨形成。

62. 发明申请

US20100137293A1 COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL 审中-公开
公开(公告)号：US20100137293A1
公开(公告)日：2010-06-03
申请号：US12609599
申请日：2009-10-30
申请人： Zhi-Liang Chu , James N. Leonard , Hussein A. Al-Shamma , Robert M. Jones
发明人： Zhi-Liang Chu , James N. Leonard , Hussein A. Al-Shamma , Robert M. Jones
IPC分类号： C12Q1/68 , A61K31/505 , A61K31/4985 , A61K31/54 , A61P3/10
CPC分类号： G01N33/76 , A61K31/00 , A61K31/401 , A61K31/415 , A61K31/4196 , A61K45/06 , G01N33/74 , G01N2333/726 , G01N2800/042 , G01N2800/2814 , G01N2800/2835 , G01N2800/2857 , G01N2800/2871 , A61K2300/00
摘要： The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

63. 发明申请

US20100084936A1 Generic Crimped Rotor for an Electric Brushless Direct Current Motor 有权
标题翻译：用于电动无刷直流电动机的通用压接转子
公开(公告)号：US20100084936A1
公开(公告)日：2010-04-08
申请号：US12569890
申请日：2009-09-29
申请人： Robert M. Jones , Joseph M. Lisiecki
发明人： Robert M. Jones , Joseph M. Lisiecki
IPC分类号： H02K16/00 , H02K1/28
CPC分类号： H02K1/278 , H02K3/38 , H02K5/04 , H02K5/18 , H02K5/225 , H02K11/33 , H02K16/00 , H02K21/16 , H02K29/08 , H02K2213/12
摘要： A rotor having a substantially cylindrical configuration for use in a brushless direct current electric motor having a high torque to size ratio. The rotor has an outer peripheral surface. The rotor also has a central rotor shaft and a first and second retaining ends mounted on the central rotor shaft and spaced from one another. The rotor also has a plurality of magnets configured to provide a magnetic flux with a stator disposed around the central rotor shaft. The magnets are radially disposed on the shaft and the rotor also has a sheath. The sheath is crimped around the radially disposed permanent magnets, and holds the magnets around the shaft. The sheath is lightweight and minimizes a gap between the permanent magnets and the stator to provide for an electromagnetic flux between the magnets and the stator windings, and for rotation of the central rotor shaft.
摘要翻译：具有大体圆柱形构造的转子，用于具有高扭矩与大尺寸比的无刷直流电动机。转子具有外周面。转子还具有中心转子轴和安装在中心转子轴上并彼此间隔开的第一和第二保持端。转子还具有多个磁体，其被配置为提供磁通量，该定子设置在中心转子轴周围。磁体径向设置在轴上，转子也具有护套。鞘被卷绕在径向设置的永磁体周围，并将磁体保持在轴周围。护套是轻质的，并且使永磁体和定子之间的间隙最小化，以提供磁体和定子绕组之间的电磁通量，并且用于中心转子轴的旋转。

64. 发明申请

US20080016676A1 Automatic winder for an inside brushless stator 审中-公开
标题翻译：内置无刷定子自动络筒机
公开(公告)号：US20080016676A1
公开(公告)日：2008-01-24
申请号：US11607132
申请日：2006-11-30
申请人： Robert M. Jones , Joseph M. Lisiecki
发明人： Robert M. Jones , Joseph M. Lisiecki
IPC分类号： H01F7/06
CPC分类号： H02K15/085 , Y10T29/49009 , Y10T29/49071 , Y10T29/53143
摘要： An apparatus for manufacturing an internal wound stator includes a winding arbor configured to receive a conductive wire. The apparatus also has a stator loader with a stator having a generally cylindrical shape with an interior opening and having a plurality of axial slots formed therein. The interior dimension of the stator is larger than the exterior dimension of the winding arbor such that the winding arbor and stator may traverse with respect to one another. The apparatus also has a first movable member configured for moving at least one of the winding arbor and the stator. The apparatus also has a second rotating member configured to rotate at least one of the stator and the winding arbor. The conductive wire is introduced through an interior of the winding arbor. The first movable member is configured to move at least one of the winding arbor and the stator relative to one another to wind the conductive wire in a first longitudinal manner and into a first of the plurality of axial slots. The second rotating member is configured to rotate at least one of the first winding arbor or the stator relative to one another to align the wire relative to a second axial slot of the plurality of axial slots. The first movable member is configured to move at least one of the winding arbor and the stator relative to one another to wind the conductive wire in a second opposite longitudinal manner and into the second axial slot.
摘要翻译：一种用于制造内部缠绕定子的装置包括构造成接纳导线的绕线轴。该装置还具有定子装载机，该定子装载机具有大致圆柱形形状的定子，其具有内部开口并且在其中形成有多个轴向槽。定子的内部尺寸大于绕组心轴的外部尺寸，使得绕组心轴和定子可以相对于彼此横越。该装置还具有构造成用于移动绕组轴和定子中的至少一个的第一可动构件。该装置还具有构造成旋转定子和绕组心轴中的至少一个的第二旋转构件。导线通过绕组心轴的内部引入。第一可移动构件被构造成相对于彼此移动至少一个绕组心轴和定子，以使第一纵向方式缠绕导线并进入多个轴向槽中的第一个。第二旋转构件被配置为相对于彼此旋转第一卷绕心轴或定子中的至少一个，以使线相对于多个轴向槽中的第二轴向槽对准。第一可移动部件构造成相对于彼此移动绕组轴和定子中的至少一个，以使第二相对纵向方式缠绕导线并进入第二轴向槽。

65. 发明授权

US07122383B2 Fluorescent polymer superquenching-based bioassays 失效
公开(公告)号：US07122383B2
公开(公告)日：2006-10-17
申请号：US10098387
申请日：2002-03-18
申请人： Robert M. Jones , Sriram Kumaraswamy , Liangde Lu , Frauke Rininsland , Kevin Ley , Wensheng Xia , Duncan McBranch , David G. Whitten
发明人： Robert M. Jones , Sriram Kumaraswamy , Liangde Lu , Frauke Rininsland , Kevin Ley , Wensheng Xia , Duncan McBranch , David G. Whitten
IPC分类号： G01N33/543
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C12Q1/6834 , G01N33/533 , G01N33/542 , G01N33/54393 , G01N33/582 , Y10T428/2991 , Y10T436/143333 , C12Q2563/107
摘要： A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

66. 发明授权

US06767896B1 Conotoxin peptides 失效
标题翻译：芋螺毒素肽
公开(公告)号：US06767896B1
公开(公告)日：2004-07-27
申请号：US09580201
申请日：2000-05-26
申请人： J. Michael McIntosh , Baldomero M. Olivera , Lourdes J. Cruz , Gloria P. Corpuz , Robert M. Jones , James E. Garrett
发明人： J. Michael McIntosh , Baldomero M. Olivera , Lourdes J. Cruz , Gloria P. Corpuz , Robert M. Jones , James E. Garrett
IPC分类号： A61K3808
CPC分类号： C07K14/43504 , A61K38/00 , Y10S530/857
摘要： The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. These conotoxin peptides have analgesic activity and are thus useful for treating or preventing pain.
摘要翻译：本发明涉及相对较短的荚毒素肽，如本文所述，其长度约为10-20个残基，其可以在锥形蜗牛的毒液中以微量天然存在或类似于天然可得的肽，并且其优选包括两个二硫键。这些芋螺毒素肽具有止痛活性，因此可用于治疗或预防疼痛。

67. 发明授权

US06727226B2 Mu-conopeptides 有权
公开(公告)号：US06727226B2
公开(公告)日：2004-04-27
申请号：US09910009
申请日：2001-07-23
申请人： Baldomero M. Olivera , J. Michael McIntosh , James E. Garrett , Lourdes J. Cruz , Robert M. Jones , G. Edward Cartier , John D. Wagstaff
发明人： Baldomero M. Olivera , J. Michael McIntosh , James E. Garrett , Lourdes J. Cruz , Robert M. Jones , G. Edward Cartier , John D. Wagstaff
IPC分类号： C07K708
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is to &mgr;-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the &mgr;-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The &mgr;-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the &mgr;-conopeptides and encoding propeptides, as well as the propeptides.

68. 发明授权

US06684502B2 Method and apparatus for aligning a circular recuperator core 有权
标题翻译：用于对准圆形换热器芯的方法和装置
公开(公告)号：US06684502B2
公开(公告)日：2004-02-03
申请号：US10053203
申请日：2001-11-09
申请人： Douglas R. Ervin , Leonard Holman , Robert M. Jones
发明人： Douglas R. Ervin , Leonard Holman , Robert M. Jones
IPC分类号： B23P1500
CPC分类号： B23P19/10 , F28D9/0018 , Y10T29/49357 , Y10T29/49895
摘要： A method for aligning a circular core. The method has a work station which defines an inner chucking portion being movable between a lower position and an upper position and a retracted position and an expanded position. The work station defines an upper portion being movable between a first position and a second position and a loading position and a clamping position. The clamping position has a plurality of positions. The circular core being aligned during at least a portion of the plurality of positions. And, the work station having a welding station.
摘要翻译：一种用于对准圆形芯的方法。该方法具有工作台，该工作台限定可在下部位置和上部位置以及缩回位置和展开位置之间移动的内部夹持部分。工作站限定了可在第一位置和第二位置以及装载位置和夹紧位置之间移动的上部。夹持位置具有多个位置。圆形芯在多个位置的至少一部分期间对齐。而且，工位有焊台。

69. 发明授权

US06489298B1 Contulakin-G, analogs thereof and uses thereof 有权
标题翻译： Contulakin-G，其类似物及其用途
公开(公告)号：US06489298B1
公开(公告)日：2002-12-03
申请号：US09605991
申请日：2000-06-29
申请人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
发明人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
IPC分类号： A61K3800
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
摘要翻译：本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及到前体肽。本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和神经精神药理学障碍。

70. 发明授权

US4442665A Coal gasification power generation plant 失效
标题翻译：煤气化发电厂
公开(公告)号：US4442665A
公开(公告)日：1984-04-17
申请号：US198059
申请日：1980-10-17
申请人： Bruce R. Fick , Robert M. Jones
发明人： Bruce R. Fick , Robert M. Jones
IPC分类号： F02C3/28 , F02C9/40
CPC分类号： F02C9/40 , F02C3/28 , Y02E20/16 , Y02E20/18
摘要： A combined cycle coal gasification power plant includes a coal gasifier which generates low BTU coal gas for consumption by a gas turbine. Before being applied to the gas turbine, the coal gas is passed through a clean-up system which removes undesirable constituents from the coal gas. Efficient operation of the clean-up system requires that a predetermined discharge pressure of clean coal gas leaving the clean-up system must be maintained. A control system controls the coal gasifier according to either one of the discharge pressure of clean coal gas and the turbine power output requirement while maintaining the clean coal gas discharge pressure and power output at predetermined values.
摘要翻译：联合循环煤气化发电厂包括产生低燃气涡轮机消耗的低BTU煤气的煤气化炉。在应用于燃气轮机之前，煤气通过清理系统，其从煤气中除去不需要的成分。清理系统的高效运行要求必须保持离开净化系统的清洁煤气的预定排放压力。控制系统根据清洁煤气的排放压力和涡轮功率输出要求之一控制煤气化炉，同时保持清洁煤气排放压力和功率输出为预定值。

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