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    • 62. 发明申请
    • 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents
    • 6-芳基-7-卤代 - 咪唑并[1,2-a]嘧啶作为抗癌剂
    • US20050065167A1
    • 2005-03-24
    • US10950542
    • 2004-09-24
    • Nan ZhangSemiramis Ayral-Kaloustian
    • Nan ZhangSemiramis Ayral-Kaloustian
    • A61K31/519A61P35/00C07D487/02C07D487/04
    • C07D487/04
    • This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.
    • 本发明涉及某些6-芳基-7-卤代咪唑并[1,2-a]嘧啶或其药学上可接受的盐,以及含有所述化合物或其药学上可接受的盐的组合物,其中所述化合物是可用于 通过促进微管聚合治疗哺乳动物的癌症。 本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,并进一步提供了治疗或预防表达多重耐药性(MDR)或耐多药耐药性的癌性肿瘤的方法 在有需要的哺乳动物中,所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。
    • 65. 发明授权
    • Semiconductor wafer
    • 半导体晶圆
    • US06469361B2
    • 2002-10-22
    • US09946390
    • 2001-09-04
    • Nan Zhang
    • Nan Zhang
    • H01L2900
    • H01L21/32139G03F7/095G03F7/16H01L21/0274H01L21/31144
    • Techniques for etching a wafer layer using multiple layers of the same photoresistant material and structures formed using such techniques are provided. In a method, first, multiple layers of the same photoresist material are formed over the wafer layer to form a composite photoresist layer. The composite photoresist layer is patterned and developed to form a patterned photoresist layer. Exposed portions of the wafer layer are then removed using the pattern photoresist layer. Each of the multiple layers of photoresist may, for example, be formed to a maximum rated thickness for the photoresist material. Structures formed using this process may have relatively small dimensions (e.g., widths of 5 microns or less or a spacing or pitch of 5 microns or less). In addition, structures may also have sidewalls which are relatively long, smooth, and/or vertical.
    • 提供了使用相同光致抗蚀剂材料的多层蚀刻晶片层的技术和使用这些技术形成的结构。 在一种方法中,首先在晶片层上形成多层相同的光致抗蚀剂材料以形成复合光致抗蚀剂层。 将复合光致抗蚀剂层图案化并显影以形成图案化的光致抗蚀剂层。 然后使用图案光致抗蚀剂层去除晶片层的暴露部分。 例如,可以将多层光致抗蚀剂中的每一层形成为光致抗蚀剂材料的最大额定厚度。 使用该方法形成的结构可以具有相对小的尺寸(例如,5微米或更小的宽度或5微米或更小的间距或间距)。 此外,结构还可以具有相对长,平滑和/或垂直的侧壁。
    • 67. 发明授权
    • Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents
    • 杂环芳基吡啶并喹唑啉酮衍生物作为抗癌剂
    • US5908840A
    • 1999-06-01
    • US965217
    • 1997-11-06
    • Michael P. TrovaNan Zhang
    • Michael P. TrovaNan Zhang
    • C07D471/04A61K31/505A61K31/55
    • C07D471/04
    • This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of H, (C.sub.1 -C.sub.4) straight-chain alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.5 and R.sub.6 are alkyl moieties which are taken together to form a 4-7 membered ring;or a pharmaceutically acceptable salt thereof which is useful as an antineoplastic agent.
    • 本发明提供具有下式的化合物:其中:(A)n = 2-4; (B)R 1和R 2相同或不同,选自H,(C 1 -C 3)烷基,-CH 2 CH 2 OH,-CH 2 CH 2 NH 2和-CH 2 CH 2 N(CH 3)2或R 1和R 2为被取代的烷基部分 一起形成4-至7-元环; (C)R 3选自H,-CH 3,-CH 2 CH 3和-CH 2 CH 2 NH 2; (D)Y是位于吡啶并喹啉酮核的2-或3-位的具有5-14个原子的杂环基,其中1-3个杂环环原子独立地是氮,氧或硫; 其中Y可任选被-OR 4,-NR 5 R 6,-CO 2 H,-CO 2 R 4或苯基单,二或三取代; R4是H或(C1-C4)直链烷基; R5和R6相同或不同,选自H,(C1-C4)直链烷基,-CH2CH2OH,-CH2CH2NH2和-CH2CH2N(CH3)2或R5和R6是烷基部分,它们是 一起形成4-7元环; 或其药学上可接受的盐,其可用作抗肿瘤剂。
    • 70. 发明申请
    • INTEGRATED CIRCUIT SIMULATION USING ANALOG POWER DOMAIN IN ANALOG BLOCK MIXED SIGNAL
    • 在模拟块混合信号中使用模拟电源域的集成电路仿真
    • US20130338991A1
    • 2013-12-19
    • US13523492
    • 2012-06-14
    • Qingyu LinPrabal Kanti BhattacharyaNan ZhangZhong Fan
    • Qingyu LinPrabal Kanti BhattacharyaNan ZhangZhong Fan
    • G06F17/50
    • G06F17/5081G06F17/5009G06F17/5022G06F17/5036G06F17/5045G06F2217/78Y02E60/76Y04S40/22
    • A method is provided that comprises a circuit design that includes multiple design blocks; a power intent specification file that defines a power domain within the circuit design and that identifies design instances within the power domain and that defines a control function to selectively transition the defined power domain between multiple respective power supply values; using a digital simulator to simulate operation of the digital representation while using an analog simulator to simulate operation of the analog representation; wherein simulating the digital representation includes transitioning the defined power domain between supply values from among the multiple respective supply values; wherein simulating the analog representation includes periodically storing in a storage location a power supply value currently in use during digital simulation of the digital representation; and wherein simulating the analog representation includes using the stored currently in use power supply value to supply voltage to the analog representation.
    • 提供一种包括包括多个设计块的电路设计的方法; 功率意图规范文件,其定义电路设计内的功率域,并且识别功率域内的设计实例,并定义控制功能以选择性地在多个相应电源值之间转换所定义的功率域; 使用数字模拟器来模拟数字表示的操作,同时使用模拟仿真器来模拟模拟表示的操作; 其中模拟所述数字表示包括在所述多个相应电源值中的电源值之间转换所述定义的电源域; 其中模拟所述模拟表示包括在所述数字表示的数字模拟期间周期性地存储在存储位置中当前正在使用的电源值; 并且其中模拟所述模拟表示包括使用所存储的当前使用中的电源值为所述模拟表示提供电压。