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61. 发明申请

US20090099618A1 Apparatus and Method for Delivering Electrical Signals to a Heart 有权
标题翻译：将电信号传递给心脏的装置和方法
公开(公告)号：US20090099618A1
公开(公告)日：2009-04-16
申请号：US11991481
申请日：2006-09-06
申请人： Benny Rousso , Netanel Eizenberg , David Prutchi , Yuval Mika , Yehuda Snir
发明人： Benny Rousso , Netanel Eizenberg , David Prutchi , Yuval Mika , Yehuda Snir
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/0464 , A61B5/7217 , A61N1/3622 , A61N1/36585 , A61N1/368 , A61N1/3684 , A61N1/3702
摘要： Devices, systems and methods for controlling (inhibiting or enabling) the delivery of electrotherapeutic signals to a heart using sensing of local and/or global ECG signals to detect ventricular arrhythmia or indication of possible ventricular arrhythmia in the heart. The devices, systems and methods process the sensed signals and are capable of delivering electroptherapeutic signals to the heart in the presence of a supra-ventricular arrhythmia such as atrial fibrillation and atrial flutter, while inhibiting the delivering electroptherapeutic signals in the presence of PVCs and/or extopic beats, and/or ventricular arrhythmia. The electrotherapeutic signals may include, among others, pacing signals and cardiac contractility modulating signals.
摘要翻译：用于通过感测局部和/或全局心电图信号来检测心室心律失常或指示心室心律失常的装置，系统和方法，用于控制（抑制或使能）向心脏递送电治疗信号。装置，系统和方法处理感测到的信号，并且能够在心室颤动和心房扑动等超心律失常的情况下向心脏递送电治疗信号，同时在存在PVC的情况下抑制递送电治疗信号和/ 或过度搏动，和/或室性心律失常。电疗信号可以包括起搏信号和心脏收缩调节信号。

62. 发明申请

US20070162079A1 Signal Delivery Through The Right Ventricular Septum 有权
标题翻译：通过右心室隔膜的信号传递
公开(公告)号：US20070162079A1
公开(公告)日：2007-07-12
申请号：US11673812
申请日：2007-02-12
申请人： Isaac (Yitzhak) Shemer , Yuval Mika , Benny Rousso
发明人： Isaac (Yitzhak) Shemer , Yuval Mika , Benny Rousso
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/32 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36585 , A61N1/368
摘要： A method is provided for use with a human subject. The method includes accessing a cardiac site via a vena cava of the subject, and alleviating heart failure of the subject by applying to the cardiac site, during a refractory period of the site, a refractory-period signal that affects the left ventricle of the subject's heart. Other embodiments are also described.
摘要翻译：提供了一种与人类受试者一起使用的方法。该方法包括通过受试者的腔静脉进入心脏部位，并通过在该部位的不应期内施用到心脏部位来减轻受试者的心力衰竭，该难治性期信号影响受试者的左心室心。还描述了其它实施例。

63. 发明授权

US06675043B1 Sensor-based regulation of excitable tissue control of the heart 有权
标题翻译：基于传感器的心脏可兴奋组织控制调节
公开(公告)号：US06675043B1
公开(公告)日：2004-01-06
申请号：US09831283
申请日：2001-09-10
申请人： David Prutchi , Yuval Mika
发明人： David Prutchi , Yuval Mika
IPC分类号： A61N1365
CPC分类号： A61N1/362 , A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： A method and apparatus is provided for modifying contractility of the heart of a patient. The method includes receiving signals from a sensor coupled to the body of the patient indicative of physical exertion by the patient. The signals are analyzed to estimate a metabolic demand of the patient, and excitable tissue control (ETC) stimulation is applied so as to enhance contractility of the heart muscle responsive to the metabolic need.
摘要翻译：提供了一种用于改善患者心脏的收缩性的方法和装置。该方法包括从耦合到患者身体的传感器接收指示患者体力消耗的信号。分析信号以估计患者的代谢需求，并施加可兴奋的组织控制（ETC）刺激，以便根据代谢需要增强心肌的收缩性。

64. 发明授权

US06459928B2 Apparatus and method for collecting data useful for determining the parameters of an alert window for timing delivery or ETC signals to a heart under varying cardiac conditions 有权
公开(公告)号：US06459928B2
公开(公告)日：2002-10-01
申请号：US09768968
申请日：2001-01-24
申请人： Yuval Mika , David Prutchi , Ziv Belsky , Andre G. Routh
发明人： Yuval Mika , David Prutchi , Ziv Belsky , Andre G. Routh
IPC分类号： A01B50402
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

65. 发明授权

US06424866B1 Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart 有权
公开(公告)号：US06424866B1
公开(公告)日：2002-07-23
申请号：US09841891
申请日：2001-04-25
申请人： Yuval Mika , David Prutchi , Ziv Belsky , Yoav Kimchy
发明人： Yuval Mika , David Prutchi , Ziv Belsky , Yoav Kimchy
IPC分类号： A61N136
摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.

66. 发明申请

US20150258342A1 Methods And Systems For Controlling Blood Pressure By Controlling Atrial Pressure 有权
标题翻译：通过控制心房压力控制血压的方法和系统
公开(公告)号：US20150258342A1
公开(公告)日：2015-09-17
申请号：US14667931
申请日：2015-03-25
申请人： Yuval Mika , Darren Sherman , Robert S. Schwartz , Robert A. Van Tassel , Daniel Burkhoff
发明人： Yuval Mika , Darren Sherman , Robert S. Schwartz , Robert A. Van Tassel , Daniel Burkhoff
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61F2/2412 , A61F2/2424 , A61F2250/0013 , A61N1/36117 , A61N1/36514 , A61N1/36528 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.
摘要翻译：公开了通过控制心房压力和心房伸展来控制血压的系统和方法。在一些实施例中，刺激电路可以被配置为将刺激脉冲传送到患者心脏的至少一个心室，并且至少一个控制器可以被配置为执行刺激脉冲的一个或多个刺激模式的传送到至少一个心室，其中所述刺激脉冲中的至少一个刺激心脏使得由心房的心房收缩引起的心房压力在时间上与心房的被动压力积聚重叠，使得心房的心房压力由刺激引起的是由心房收缩和被动压力积聚引起的心房压力的组合，并且高于心房的心房压力将没有刺激，并且使得患者的血压降低。

67. 发明授权

US08700161B2 Blood glucose level control 有权
标题翻译：血糖值控制
公开(公告)号：US08700161B2
公开(公告)日：2014-04-15
申请号：US10526708
申请日：2003-09-04
申请人： Tami Harel , Shai Policker , Radwan Khawaled , Yuval Mika , Offer Glasberg , Aharon Grossman
发明人： Tami Harel , Shai Policker , Radwan Khawaled , Yuval Mika , Offer Glasberg , Aharon Grossman
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0507 , A61N1/3606 , A61N1/36121 , A61N1/36178
摘要： A method of glucose level control, comprising providing at least one electrode adapted to apply an electric field to a pancreas; and applying an electric field to the pancreas using the above-mentioned at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased.
摘要翻译：一种葡萄糖水平控制方法，包括提供适于向胰腺施加电场的至少一个电极; 并使用上述至少一个电极向胰腺施加电场，使得血糖水平显着降低，并且血液胰岛素水平不显着增加。

68. 发明授权

US08666495B2 Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar 有权
标题翻译：用于治疗疾病和控制血糖的胃肠道方法和装置
公开(公告)号：US08666495B2
公开(公告)日：2014-03-04
申请号：US10599015
申请日：2005-03-18
申请人： Tami Harel , Yuval Mika
发明人： Tami Harel , Yuval Mika
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/20 , A61N1/32
摘要： A method of glucose level control comprising providing at least one electrode adapted to apply an electric field to a pancreas; and applying an electric field to the pancreas using said at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased compared to a regular insulin response in a same person.
摘要翻译：一种葡萄糖水平控制方法，包括提供适于向胰腺施加电场的至少一个电极; 以及使用所述至少一个电极向胰腺施加电场，使得相对于同一人中的正常胰岛素反应，血糖水平显着降低，并且血胰岛素水平不显着增加。

69. 发明授权

US08548583B2 Protein activity modification 有权
公开(公告)号：US08548583B2
公开(公告)日：2013-10-01
申请号：US11919491
申请日：2006-05-04
申请人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
发明人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
IPC分类号： A61N1/00
CPC分类号： G01N33/6893 , A61N1/205 , A61N1/32 , A61N1/362 , A61N1/3627 , A61N2/004 , C12N13/00 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/325
摘要： A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

70. 发明申请

US20090088816A1 Gastrointestinal Methods And Apparatus For Use In Treating Disorders And Controlling Blood Sugar 有权
标题翻译：用于治疗疾病和控制血糖的胃肠道方法和装置
公开(公告)号：US20090088816A1
公开(公告)日：2009-04-02
申请号：US10599015
申请日：2005-03-18
申请人： Tami Harel , Yuval Mika
发明人： Tami Harel , Yuval Mika
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/20 , A61N1/32
摘要： A method of glucose level control comprising providing at least one electrode adapted to apply an electric field to a pancreas; and applying an electric field to the pancreas using said at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased compared to a regular insulin response in a same person.
摘要翻译：一种葡萄糖水平控制方法，包括提供适于向胰腺施加电场的至少一个电极; 以及使用所述至少一个电极向胰腺施加电场，使得相对于同一人中的正常胰岛素反应，血糖水平显着降低，并且血胰岛素水平不显着增加。

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