专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明专利

AU2006265840A1 Pyrimidine-substituted benzimidazole derivatives as protein kinase inhibitors 未知
公开(公告)号：AU2006265840A1
公开(公告)日：2007-01-11
申请号：AU2006265840
申请日：2006-06-30
申请人： IRM LLC
发明人： ZHANG GUOBAO , SIM TAEBO , WANG XIA , REN PINGDA , GRAY NATHANAEL S
IPC分类号： C07D403/14 , A61K31/495 , A61P35/00 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14
摘要： The invention provides a novel class of compounds having Formula Ia, wherein each variable is as defined; and pharmaceutical compositions comprising such compounds and methods of using such compounds for inhibiting c-Src, FGFR3, KDR and/or Lck.

62. 发明专利

CA2608333A1 PYRROLOPYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2608333A1
公开(公告)日：2006-11-23
申请号：CA2608333
申请日：2006-05-15
申请人： IRM LLC , SCRIPPS RESEARCH INST
发明人： REN PINGDA , GRAY NATHANAEL S , OKRAM BARUN
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the CDKs, Aurora, Jak2, Rock, CAMKII, FLT3, Tie2, TrkB, FGFR3 and KDR kinases.

63. 发明专利

CO5680404A2 ANILINO PURINAS SUSTITUIDAS EN LA POSICION 6 UTILES COMO INHIBIDORES DE RTK 未知
公开(公告)号：CO5680404A2
公开(公告)日：2006-09-29
申请号：CO06016491
申请日：2006-02-20
申请人： IRM LLC
发明人： CHENG DAI , DING QIANG , HANG DONG , GRAY NATHANAEL S , ZHANG GUOBAO
IPC分类号： A61K31/52 , A61K31/522 , A61P9/10 , A61P11/06 , A61P17/06 , A61P35/00 , A61P35/02 , C07D473/04 , C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
摘要： 1.- Un compuesto de la fórmula: en la cual:R1 se selecciona a partir de hidrógeno, halógeno, alquilo de C1-6, alquilo de C1-6 sustituido con halógeno, alcoxi de C1-6, alcoxi de C1-6 sustituido con halógeno, -OXOR5, -OXR6, -OXNRsR6, -OXONR5R6, -XR6,- XNR5R6 y -XNR7XNR7R7; en los cuales X se selecciona a partir de un enlace, alquileno de C1-6, alquenileno de C2-6 y alquinileno de C2-6; en los cuales R7 se selecciona de manera independiente a partir de hidrógeno o alquilo de C1-6;R5 se selecciona a partir de hidrógeno, alquilo de C1-6 y -XOR7; en el cual X se selecciona a partir de un enlace, alquileno de C1-6, alquenileno de C2-6 y alquinileno de C2-6; y R7 se selecciona de manera independiente a partir de hidrógeno o alquilo de C1-6;R6 se selecciona a partir de hidrógeno, alquilo de C1-6, cicloalquil(C3-12)-alquilo de C0-4, heterocicloalquil(C3-8)-alquilo de C0-4, aril(C6-10)-alquilo de C0-4 y heteroaril(C5-10)-alquilo de C0-4; o R5 y R6 junto con el átomo de nitrógeno al cual están unidos ambos R5 y R6 forman heterocicloaIquilo de C3-8 o heteroarilo d e C5-8; en eI cuaI un metileno de cuaIquier heterocicloalquilo formado por R5 y R6 puede estar reemplazado opcionalmente con -C(O)- o S(O)2-;en la cual cualquier arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R6 o la combinación de R5 y R6 puede estar sustituido opcionalmente con 1 a 3 radicales que se seleccionan de manera independiente a partir de -XNR7R7, -XOR7, -XNR7R7, -XC(O)NR7R7, -XNR7C(O)R7, -XOR7, -XC(O)OR7, -XC(O)R7, alquilo de C1-6, heterocicloalquilo de C3-8, heteroarilo de C5-10, cicloalquilo de C3-12 y aril(C6-10)-alquilo de C0-4; en los cuales cualquier alquilo o alquileno de R1 puede tener opcionalmente un metileno reemplazado por un radical divalente que se selecciona a partir de -NR7C(O)-, -C(O)NR7-, -NR7-, -C(O)-, -O-, -S-, -S(O)- y -S(O)2-; y en el cual cualquier alquilo o alquileno de R6 puede estar sustituido opcionalmente con 1 a 3 radicales que se seleccionan de manera independiente a partir de heteroarilo de C5-8, -NR7R7, -C(O)NR7R7, -NR7C(O)R7, ...

64. 发明专利

CA2600144A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2600144A1
公开(公告)日：2006-09-28
申请号：CA2600144
申请日：2006-03-10
申请人： IRM LLC
发明人： REN PINGDA , GRAY NATHANAEL S , WANG XIA , ZHANG GUOBAO
IPC分类号： A61K31/519
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKalpha, IKKbeta, JNK2alpha2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRbeta, PKA, PKBbeta, PKD2, Rsk1, SAPK2alpha, SAPK2beta, SAPK3, SGK, Tie2 and TrkB kinases.

65. 发明专利

BRPI0410454A 未知
公开(公告)号：BRPI0410454A
公开(公告)日：2006-06-13
申请号：BRPI0410454
申请日：2004-05-19
申请人： IRM LLC
发明人： MARSILJE THOMAS H , GRAY NATHANAEL S , JIANG TAO , LU WENSHUO , PAN SHIFENG
IPC分类号： A61K20060101 , A61K31/195 , A61K31/216 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/675 , C07C323/63 , C07D205/04 , C07D207/12 , C07D211/32 , C07D241/04 , C07F9/22 , C07F9/28
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

66. 发明专利

PE06262005A1 COMPUESTOS OXIIMINOS COMO MODULADORES DEL RECEPTOR EDG 未知
公开(公告)号：PE06262005A1
公开(公告)日：2005-09-23
申请号：PE0005132004
申请日：2004-05-19
申请人： IRM LLC
发明人： FAN YI , GAO WENQI , GRAY NATHANAEL S , MI YUAN , PAN SHIFENG
IPC分类号： A61K20060101 , A61K31/135 , A61K31/195 , A61K31/41 , A61K31/66 , C07D211/28 , C07F9/28
CPC分类号： C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要： SE REFIERE A COMPUESTOS DE FORMULA (Ia) Y (Ib), EN DONDE A ES -C(O)OR5, -OP(O)(OR5)2, -P(O)(OR5)2, -S(O)2OR5, -P(O)(R5)OR5 Y 1H-TETRAZOL-5-ILO; W ES UN ENLACE, ALQUILENO(C1-C3), ALQUENILENO(C2-C3); Y ES ARILO(C6-C10), HETEROARILO(C2-C9) OPCIONALMENTE SUSTITUIDOS POR HALOGENO, OH, NITRO, ENTRE OTROS; Z ES -N(R6)(C1-C4)-, N-PIRROLIDINIL, N-AZETIDINIL, -N(R6)-CH2-CHOH-, N-ETIL-PIPERIDINIL, ENTRE OTROS; R1 ES UN ARILO(C6-C10) O HETEROARILO(C2-C9) COMO FENILO, NAFTILO, TIENILO OPCIONALMENTE SUSTITUIDOS POR ARILO(C6-C10), ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ALQUENILO O ALQUINILO(C2-C6) Y ALQUILO(C1-C6) SUSTITUIDOS CON HALOGENO; R3 Y R4 SON H, ALQUILO(C1-C6), HALOGENO, OH, ALCOXI, ENTRE OTROS. SON COMPUESTOS CONOCIDOS: ACIDO 3-({6-[1-(4-CICLOHEXIL-3-TRIFLUOROMETIL-BENCILOXIIMINO)-ETIL]-2-ETIL]-2-ETIL-PIRIDIN-3-ILMETIL}-AMINO)PROPIONICO, ACIDO 3-{4-[1-(4-CICLOHEXIL-3-METOXIBENCILOXIIMINO)-ETIL]-2-ETIL-BENCILAMINO}-PROPIONICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO O PREVENCION DE ENFERMEDADES MEDIADOS POR INTERACCIONES DE LINFOCITOS ASOCIADOS CON LA TRANSDUCCION DE SENAL MEDIADA POR EL RECEPTOR DE EDG COMO ENFERMEDADES AUTOINMUNES, INFLAMATORIAS, INFECCIOSAS, RECHAZO DE TRANSPLANTES Y CANCER

67. 发明专利

AU2003301407A1 COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS 未知
公开(公告)号：AU2003301407A1
公开(公告)日：2004-05-04
申请号：AU2003301407
申请日：2003-10-15
申请人： IRM LLC
发明人： WU XU , DING SHENG , GRAY NATHANAEL S
IPC分类号： A61K31/52 , A61K31/522 , A61N20060101 , A61N1/00 , A61P7/00 , C07D473/12 , C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
摘要： The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage.

68. 发明专利

CA2463563A1 KINASE INHIBITOR SCAFFOLDS AND METHODS FOR THEIR PREPARATION 未知
公开(公告)号：CA2463563A1
公开(公告)日：2003-04-17
申请号：CA2463563
申请日：2002-10-12
申请人： IRM LLC , SCRIPPS RESEARCH INST
发明人： DING QIANG , GRAY NATHANAEL S , DING SHENG
IPC分类号： A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/522 , A61P43/00 , C07B61/00 , C07D239/42 , C07D239/94 , C07D241/20 , C07D241/44 , C07D473/16 , C07D473/18 , C07D473/34
摘要： General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines a t elevated temperature or by anilines, boronic acids and phenols via palladium catalyzed cross-coupling reactions.

69. 发明专利

BRPI0813216A2 未知
公开(公告)号：BRPI0813216A2
公开(公告)日：2014-12-23
申请号：BRPI0813216
申请日：2008-06-18
申请人： IRM LLC
发明人： SIM TAEBO , NGUYEN TRUC NGOC , WU BAOGEN , HE YUN , XE YONGPING , WANG XING , ZHANG GUOBAO , GRAY NATHANAEL S
IPC分类号： C07D239/88 , A61K31/33 , A61P35/00 , A61P37/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFR&bgr;, PKCα, p38, Src, SIK, Syk, Tie2 and TrkB kinases.

70. 发明专利

MY150088A IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS 未知
公开(公告)号：MY150088A
公开(公告)日：2013-11-29
申请号：MYPI20041871
申请日：2004-05-18
申请人： IRM LLC
发明人： FAN YI , GAO WENQI , GRAY NATHANAEL S , MI YUAN , PAN SHIFENG
IPC分类号： C07D211/28 , A41H43/04 , A61K20060101 , A61K31/135 , A61K31/195 , A61K31/41 , A61K31/66 , B29C65/50 , C07F9/28 , D06H5/00
摘要： THE PRESENT INVENTION RELATES TO IMMUNOSUPPRESANT, PROCESS FOR THEIR PRODUCTION, THEIR USES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. THE INVENTION PROVIDES A NOVEL CLASS OF COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF DISEASES OR DISORDERS MEDIATED BY LYMPHOCYTE INTERACTIONS, PARTICULARLY DISEASES ASSOCIATED WITH EDG RECEPTOR MEDIATED SIGNAL TRANSDUCTION.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式