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61. 发明申请

US20120078352A1 STAGED DEPLOYMENT DEVICES AND METHODS FOR TRANSCATHETER HEART VALVE DELIVERY SYSTEMS 有权
标题翻译：分段部署装置和方法用于过渡式心脏瓣膜输送系统
公开(公告)号：US20120078352A1
公开(公告)日：2012-03-29
申请号：US13212442
申请日：2011-08-18
申请人： Huisun Wang , Ralph Joseph Thomas
发明人： Huisun Wang , Ralph Joseph Thomas
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2436 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9528 , A61F2002/9534
摘要： A delivery device for a collapsible heart valve includes an operating handle, including a frame defining a movement space therein, a carriage assembly moveable within the movement space, and a first resheathing lock having a locked position and an unlocked position. The delivery device further includes a catheter assembly, including a first shaft around which a valve-receiving compartment is defined, the first shaft being fixedly connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly. The distal sheath is moveable between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve. With the resheathing lock in the locked position, the distal sheath is unable to move to the open condition to fully deploy the valve.
摘要翻译：用于可折叠心脏瓣膜的递送装置包括操作手柄，其包括限定其中的移动空间的框架，可在移动空间内移动的滑架组件和具有锁定位置和解锁位置的第一再适配锁。输送装置还包括导管组件，其包括限定了阀接收室的第一轴，第一轴固定地连接到框架或托架组件中的一个，以及可操作地连接到托架组件的远侧护套。远侧护套可在适于维持隔室中的阀的关闭状态和适于完全展开阀的打开状态之间移动。随着再锁定锁定在锁定位置，远侧护套不能移动到打开状态以完全展开阀门。

62. 发明授权

US07824406B2 Irrigated ablation catheter having a valve to prevent backflow 有权
标题翻译：灌注消融导管具有防止回流的阀
公开(公告)号：US07824406B2
公开(公告)日：2010-11-02
申请号：US11646237
申请日：2006-12-28
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow produces the desired cooling effect and is accomplished, for example, by saline irrigation flow with a valve element to block flow of blood into the inner cavity of the electrode.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许盐水从电极的内腔流出的通道。该流体流产生期望的冷却效果，并且例如通过具有阀元件的盐水冲洗流来实现，以阻止血液流入电极的内腔。

63. 发明申请

US20100168736A1 CONTROLLED IRRIGATED CATHETER ABLATION SYSTEMS AND METHODS THEREOF 有权
标题翻译：控制灌溉导管系统及其方法
公开(公告)号：US20100168736A1
公开(公告)日：2010-07-01
申请号：US12345975
申请日：2008-12-30
申请人： Huisun Wang
发明人： Huisun Wang
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2018/00029 , A61B2218/002
摘要： The present invention relates to open irrigated catheter ablation systems and methods used in connection with open irrigated catheter systems. The systems and related methods can control irrigation fluid flow to obtain temperature responses indicative of temperatures associated with an ablation procedure. Embodiments of the present invention provide irrigated catheter ablation systems having controlled irrigation fluid flow that can be directed at target areas where coagulation is more likely to occur to help minimize blood coagulation and associated problems. The irrigated fluid flow may be regulated in connection with an established or predetermined temperature threshold to improve or better optimize cooling and ablation properties of the system. In embodiments, irrigation flow may be either delayed or intermitted.
摘要翻译：本发明涉及开放式灌溉导管消融系统和与开放式灌溉导管系统相关的方法。系统和相关方法可以控制灌溉流体流动以获得指示与消融过程相关的温度的温度响应。本发明的实施例提供了具有受控冲洗流体流动的灌注导管消融系统，其可以针对更可能发生凝结的目标区域，以帮助最小化凝血和相关问题。灌溉的流体流动可以结合已建立或预定的温度阈值来调节，以改善或更好地优化系统的冷却和消融性质。在实施例中，冲洗流可以是延迟的或中断的。

64. 发明申请

US20090204143A1 Distal Protection Filter with Improved Wall Apposition 审中-公开
标题翻译：具有改进墙壁配置的远端保护过滤器
公开(公告)号：US20090204143A1
公开(公告)日：2009-08-13
申请号：US12391732
申请日：2009-02-24
申请人： Jin S. Park , Huisun Wang , Christopher William Widenhouse
发明人： Jin S. Park , Huisun Wang , Christopher William Widenhouse
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , Y10T83/04
摘要： In accordance with the present invention, a distal protection and embolic material retrieval device with improved apposition to both large and small vessel walls of varying geometries for enhancing the filtering of embolic material during intravascular procedures while allowing for the passage of blood is provided. The device includes a filter basket designed to maximize apposition of the filtering portion to that of the vessel wall and may include struts which provide circumferential support to the filtering membrane and thereby minimizing or eliminating in-folding of the filter basket. Thin film materials may also be utilized for the filtering membrane of the filter basket. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.
摘要翻译：根据本发明，提供一种远程保护和栓塞材料回收装置，其具有改进的与不同几何形状的大血管壁和小血管壁的相适应，用于在血管内手术期间增强血栓过程中的过滤，同时允许血液通过。该装置包括过滤篮，该过滤篮设计成使过滤部分最大程度地与容器壁的配合最大化，并且可以包括为过滤膜提供圆周支撑并由此最小化或消除过滤篮的折叠的支柱。薄膜材料也可用于过滤篮的过滤膜。此外，可以结合本发明并入生物和/或药剂。

65. 发明申请

US20090143779A1 Irrigated ablation catheter having parallel external flow and proximally tapered electrode 有权
标题翻译：灌注消融导管具有平行的外部流动和近端锥形电极
公开(公告)号：US20090143779A1
公开(公告)日：2009-06-04
申请号：US11948429
申请日：2007-11-30
申请人： Huisun Wang , Christopher J. Geurkink , Harry Puryear
发明人： Huisun Wang , Christopher J. Geurkink , Harry Puryear
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00815 , A61B2018/00821
摘要： Embodiments of the present invention provide an irrigated catheter having irrigation fluid directed at a taper angle generally in parallel with a proximally tapered portion of the tip electrode to provide improved electrode surface cooling. In one embodiment, an irrigated ablation electrode assembly for use with an irrigated catheter device comprises a proximal member having at least one passageway for a fluid with an outlet disposed at an external surface of the proximal member; and a distal member connected with the proximal member and having an external surface, the distal member including an electrode. The external surface of the distal member has a tapered proximal portion narrowing toward the proximal member at a taper angle with respect to a longitudinal axis of the distal member. The at least one passageway of the proximal member is configured to direct a fluid flow through the outlet in a distal direction at an angle substantially equal to the taper angle to produce an external flow that is generally parallel to the tapered proximal portion of the external surface of the distal member.
摘要翻译：本发明的实施例提供了一种具有冲洗流体的灌溉导管，该冲洗流体以尖角大致平行于尖端电极的近端锥形部分的锥角定向，以提供改进的电极表面冷却。在一个实施例中，一种与灌溉导管装置一起使用的灌溉消融电极组件包括近端构件，其具有用于流体的至少一个通道，其中出口设置在近端构件的外表面处; 以及与所述近端构件连接并具有外表面的远侧构件，所述远端构件包括电极。远侧构件的外表面具有相对于远侧构件的纵向轴线以锥角朝向近端构件变窄的锥形近侧部分。近端构件的至少一个通道构造成以大致等于锥角的角度在远侧方向上引导流体流过出口，以产生大体平行于外表面的锥形近端部分的外部流动的远端构件。

66. 发明申请

US20090125017A1 IRRIGATED ABLATION ELECTRODE HAVING RECESSED SURFACE PORTIONS 有权
标题翻译：具有残余表面部分的灌注电极
公开(公告)号：US20090125017A1
公开(公告)日：2009-05-14
申请号：US11939206
申请日：2007-11-13
申请人： Huisun Wang , Jeremy Dando
发明人： Huisun Wang , Jeremy Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2218/002
摘要： The present invention relates to ablation electrode assemblies. The present invention further relates to an irrigated ablation electrode assembly that includes a recessed portion that can improve fluid flow around the irrigated ablation electrode. The electrode includes an outer body portion having an outer surface, and an inner cavity defined within the outer body portion. The electrode further includes at least one passageway for fluid flow from the inner cavity to the outer surface of the body of the electrode. The passageway further defines an outlet on the external surface of the electrode, therein allowing the fluid to flow on and/or around the electrode surface. The outer surface of the electrode further includes a recessed portion. The outlet of the passageway is disposed at least partially within the recessed portion. The fluid that exits the passageway may flow within the recessed portion to improve irrigation of the electrode.
摘要翻译：本发明涉及消融电极组件。本发明还涉及一种灌溉消融电极组件，其包括可以改善灌洗消融电极周围的流体流动的凹陷部分。电极包括具有外表面的外主体部分和限定在外主体部分内的内腔。电极还包括至少一个通道，用于流体从内腔流到电极主体的外表面。通道还限定了电极的外表面上的出口，其中允许流体在电极表面上和/或周围流动。电极的外表面还包括凹部。通道的出口至少部分地设置在凹部内。离开通道的流体可以在凹部内流动，以改善电极的冲洗。

67. 发明申请

US20090125016A1 IRRIGATED ABLATION ELECTRODE HAVING PROXIMAL DIRECTION FLOW 有权
标题翻译：具有接近方向流的引流电极
公开(公告)号：US20090125016A1
公开(公告)日：2009-05-14
申请号：US11939195
申请日：2007-11-13
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2218/002
摘要： The present invention relates to improved ablation electrodes and catheter assemblies, as well as methods useful in conjunction with irrigated ablation catheters. Embodiments of the present invention further relate to an irrigated catheter having irrigation fluid directed at target areas where coagulation is more likely to occur to help minimize blood coagulation and the associated problems. The present invention further relates to an ablation electrode having an outer body with a proximal portion and a distal portion an inner cavity and at least one passageway that extends to an opening on the outer surface of the electrode, wherein the passageway is directed towards the proximal portion and/or proximal end of the electrode forming an acute angle with a longitudinal axis of the electrode.
摘要翻译：本发明涉及改进的消融电极和导管组件以及与冲洗消融导管结合使用的方法。本发明的实施例还涉及一种具有冲洗流体的灌溉导管，该冲洗流体指向更可能发生凝血的目标区域，以帮助最小化凝血和相关问题。本发明还涉及一种具有外主体的消融电极，该外体具有近端部分和远端部分，其具有内腔和至少一个延伸到电极外表面上的开口的通道，其中该通道朝向近端电极的部分和/或近端与电极的纵向轴线形成锐角。

68. 发明申请

US20080161797A1 Ablation catheter electrode having multiple thermal sensors and method of use 有权
标题翻译：消融导管电极具有多个热传感器和使用方法
公开(公告)号：US20080161797A1
公开(公告)日：2008-07-03
申请号：US11647282
申请日：2006-12-29
申请人： Huisun Wang , Hong Cao , Jeremy D. Dando
发明人： Huisun Wang , Hong Cao , Jeremy D. Dando
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , Y10T29/49117
摘要： The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.
摘要翻译：本发明涉及消融导管装置中使用的电极，其中电极在电极内的不同位置包含能够检测沿着电极外表面的温度差的两个或多个热传感器。在优选实施例中，热传感器被一个或多个绝热构件隔开，并且热传感器位于与电极端部大约相同距离处的电极的外表面附近，使得温度测量可以指示位置电极相对于希望烧蚀的组织。

69. 发明申请

US20080161792A1 Irrigated ablation catheter having a valve to prevent backflow 有权
标题翻译：灌注消融导管具有防止回流的阀
公开(公告)号：US20080161792A1
公开(公告)日：2008-07-03
申请号：US11646237
申请日：2006-12-28
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow produces the desired cooling effect and is accomplished, for example, by saline irrigation flow with a valve element to block flow of blood into the inner cavity of the electrode.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许盐水从电极的内腔流出的通道。该流体流产生期望的冷却效果，并且例如通过具有阀元件的盐水冲洗流来实现，以阻止血液流入电极的内腔。

70. 发明申请

US20080091193A1 Irrigated ablation catheter having magnetic tip for magnetic field control and guidance 审中-公开
标题翻译：灌注消融导管具有磁尖用于磁场控制和引导
公开(公告)号：US20080091193A1
公开(公告)日：2008-04-17
申请号：US11953615
申请日：2007-12-10
申请人： James Kauphusman , Huisun Wang , Jeremy Dando , Harry Puryear
发明人： James Kauphusman , Huisun Wang , Jeremy Dando , Harry Puryear
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00577 , A61B2018/00791 , A61B2034/2051 , A61B2218/002
摘要： Embodiments of the present invention provide an irrigated ablation electrode assembly for use with an irrigated catheter device comprises at least one passageway for a fluid with an outlet disposed at an external surface of the electrode assembly; a permanent magnet; a shield separating the permanent magnet from the at least one passageway and from an exterior, the shield being substantially less oxidizable than the permanent magnet; and an electrode having an external electrode surface. A catheter guidance control and imaging system drives the permanent magnet to guide and control the catheter tip. In specific embodiments, the irrigation fluid flow paths through the electrode assembly are thermally insulated from the electrode and temperature sensor. The irrigation fluid is directed at target areas where coagulation is more likely to occur. One or more monitoring electrodes are provided for mapping or other monitoring functions.
摘要翻译：本发明的实施例提供了一种与灌溉导管装置一起使用的灌溉消融电极组件，其包括用于流体的至少一个通道，其中出口设置在电极组件的外表面处; 永久磁铁将所述永磁体与所述至少一个通道和外部分离的屏蔽件，所述屏蔽件比所述永磁体基本上更不可氧化; 和具有外部电极表面的电极。导管引导控制和成像系统驱动永磁体引导和控制导管尖端。在具体实施例中，穿过电极组件的冲洗流体流动路径与电极和温度传感器热绝缘。冲洗液被引导到更可能发生凝结的目标区域。提供一个或多个监视电极用于映射或其他监视功能。

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