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61. 发明授权

US06975118B2 Supersensitive nuclear magnetic resonance micro imaging apparatus 失效
标题翻译：超敏核磁共振微成像装置
公开(公告)号：US06975118B2
公开(公告)日：2005-12-13
申请号：US10326085
申请日：2002-12-23
申请人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzou Aihara
发明人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzou Aihara
IPC分类号： G01R33/465 , G01R33/30 , G01R33/34 , G01R33/3815 , G01R33/48 , G01R33/56 , G01V3/00
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： It is possible to grasp the behavior of a protein in a cell by realizing a nuclear magnetic resonance imaging method having spatial resolutions on the scale of a cell, and to provide an industrial measure for developing a high-quality protein utilizing this technology. In order to realize spatial resolutions in the order of one-tenth the size of a cell, a supersensitive measurement is realized by the combination of a solenoid detector coil and a high magnetic field NMR of not less than 14 Tesla, which has not been used so far. It is combined with the magnetic field uniformity of 0.001 ppm, so that the supersensitive NMR imaging of 0.5 μm, which has been impossible heretofore, is realized. The physico-chemical behavior of protein molecules can be easily clarified, and thus the bioinfomatic network or the process of metabolism of the cell can be brought out.
摘要翻译：通过实现在细胞尺度上具有空间分辨率的核磁共振成像方法，可以掌握细胞中蛋白质的行为，并提供利用该技术开发高质量蛋白质的工业测量方法。为了实现单元大小十分之一的空间分辨率，通过螺线管检测器线圈和尚未使用的不小于14特斯拉的高磁场NMR的组合来实现超敏感测量至今。它与0.001ppm的磁场均匀性相结合，从而实现了迄今为止不可能的0.5mum的超灵敏NMR成像。蛋白质分子的物理化学性质可以很容易地得到澄清，从而可以推出生物网络或细胞代谢过程。

62. 发明申请

US20050248349A1 Supersensitive nuclear magnetic resonance imaging apparatus 审中-公开
标题翻译：超敏核磁共振成像装置
公开(公告)号：US20050248349A1
公开(公告)日：2005-11-10
申请号：US11167185
申请日：2005-06-28
申请人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzou Aihara
发明人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzou Aihara
IPC分类号： G01R33/465 , G01R33/30 , G01R33/34 , G01R33/3815 , G01R33/48 , G01R33/56 , G01V3/00
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： A supersensitive nuclear magnetic resonance imaging apparatus includes a superconducting magnet, a gradient magnetic field coil, a high frequency emitting coil, and a receiving coil, wherein a biosample, including at least one of cells, organic tissues, and laboratory small animals, is inserted in a sample chamber of generally 1 to 30 mm in diameter. The superconducting magnet is formed of laterally divided split magnets, and the direction of the magnetic field generated by the magnet is generally horizontal. The receiving coil is in the form of a solenoid coil, and the biosample is inserted from a direction orthogonal to the direction of the magnetic field in a generally vertical direction. The spatial resolution in imaging of the biosample is not more than one-tenth of a cell that forms the biosample.
摘要翻译：超灵敏核磁共振成像装置包括超导磁体，梯度磁场线圈，高频发射线圈和接收线圈，其中包括细胞，有机组织和实验室小动物中的至少一个的生物样本被插入在通常为1至30mm直径的样品室中。超导磁体由横向分开的分割磁体形成，并且由磁体产生的磁场的方向大致水平。接收线圈是螺线管线圈的形式，并且生物样本沿着与大致垂直方向的磁场方向正交的方向插入。生物样品成像中的空间分辨率不超过形成生物样品的细胞的十分之一。

63. 发明申请

US20050068034A1 Nuclear magnetic resonance measuring apparatus 失效
标题翻译：核磁共振测量仪器
公开(公告)号：US20050068034A1
公开(公告)日：2005-03-31
申请号：US10791806
申请日：2004-03-04
申请人： Hiroshi Morita , Michiya Okada , Masae Kiryu , Hiromitsu Seino
发明人： Hiroshi Morita , Michiya Okada , Masae Kiryu , Hiromitsu Seino
IPC分类号： G01R33/34 , F25B9/00 , G01R33/31 , G01R33/32 , G01R33/36 , G01V3/00
CPC分类号： G01R33/31
摘要： A double-tubular third transfer tube 38 is provided in the transfer tube storage conduit, and a first transfer tube, second transfer tube and fourth transfer tube 40 are installed in its interior. Further, pressure control valves are arranged in the portion of normal temperature, thereby reducing the amount of heat intrusion and the coolant temperature. This arrangement cryogenically cools down the irradiation coil and reception coil, without damaging the compressor, and ensures a low-temperature probe to be manufactured.
摘要翻译：在输送管存储管道中设置有双管状第三输送管38，在其内部安装有第一输送管，第二输送管和第四输送管40。此外，压力控制阀布置在常温部分，从而减少热侵入量和冷却剂温度。这种布置低温冷却照射线圈和接收线圈，而不损坏压缩机，并且确保制造低温探针。

64. 发明授权

US06194985B1 Oxide-superconducting coil and a method for manufacturing the same 失效
标题翻译：氧化物超导线圈及其制造方法
公开(公告)号：US06194985B1
公开(公告)日：2001-02-27
申请号：US08736695
申请日：1996-10-25
申请人： Kazuhide Tanaka , Michiya Okada , Keiji Fukushima
发明人： Kazuhide Tanaka , Michiya Okada , Keiji Fukushima
IPC分类号： H01P500
CPC分类号： H01F6/06
摘要： A method for manufacturing an oxide superconducting coil can suppress deterioration of superconducting characteristics caused by a strong electromagnetic force and deformation and a reaction during heat treatment. The oxide superconducting coil is manufactured by a wind-and-react (W&R) method using a metal sheathed oxide superconducting wire material and an insulator, wherein an oxide film formed on a surface of a heat resistant alloy during a heat treatment is used for insulating the coil, and the heat resistant alloy has a sufficient strength to prevent the deformation of the coil generated by the weight of the coil itself during the heat treatment and to endure a strong electromagnetic force. An oxide superconducting coil operable with a coolant, such as liquid nitrogen, liquid helium, and the like, or a refrigerator, can be realized.
摘要翻译：氧化物超导线圈的制造方法可以抑制由强电磁力，变形和热处理时的反应引起的超导特性的劣化。氧化物超导线圈通过使用金属护套氧化物超导线材和绝缘体的风和反应（W＆R）法制造，其中在热处理期间在耐热合金的表面上形成的氧化膜用于绝缘线圈和耐热合金具有足够的强度，以防止在热处理期间由线圈本身的重量产生的线圈的变形并且承受强的电磁力。可以实现与诸如液氮，液氦等的冷却剂可操作的氧化物超导线圈或冰箱。

65. 发明授权

US6133814A Oxide superconductor wire material and method for jointing the same together 失效
标题翻译：氧化物超导体线材及其连接方法
公开(公告)号：US6133814A
公开(公告)日：2000-10-17
申请号：US921366
申请日：1997-08-29
申请人： Michiya Okada , Keiji Fukushima , Kazuhide Tanaka
发明人： Michiya Okada , Keiji Fukushima , Kazuhide Tanaka
IPC分类号： H01L39/02 , H01F6/06 , H01B12/00
CPC分类号： H01L39/02 , Y10S505/879 , Y10S505/884 , Y10S505/887
摘要： Structure for joining together metal-coated multi-core oxide superconductor wire material parts in a tape shape. The C axis of a oxide superconductor crystal is substantially oriented along the longitudinal (length) direction that the wire material extends. The end faces of the wire material parts contact each other at the joint part; and the C face of the oxide superconductor crystal is continuously oriented at the joint part.
摘要翻译：用于将金属涂覆的多芯氧化物超导体线材的部件接合在一起的结构。氧化物超导体晶体的C轴基本上沿着线材延伸的纵向（长度）方向取向。线材部件的端面在接合部分处彼此接触; 并且氧化物超导体晶体的C面在接合部处连续取向。

66. 发明授权

US5798312A Elongate superconductor elements comprising oxide superconductors, superconducting coils and methods of making such elements 失效
标题翻译：包括氧化物超导体，超导线圈和制造这些元件的方法的细长超导元件
公开(公告)号：US5798312A
公开(公告)日：1998-08-25
申请号：US267003
申请日：1994-06-21
申请人： Michiya Okada , Kazuhide Tanaka , Toyotaka Yuasa , Toshimi Matsumoto , Katsuzo Aihara , Shinpei Matsuda
发明人： Michiya Okada , Kazuhide Tanaka , Toyotaka Yuasa , Toshimi Matsumoto , Katsuzo Aihara , Shinpei Matsuda
IPC分类号： C04B35/00 , C01G1/00 , C04B35/45 , C30B29/22 , H01B12/10 , H01B13/00 , H01F6/06 , H01L39/14 , H01L39/24 , H01B12/00
CPC分类号： H01L39/143 , H01F6/06 , H01L39/248 , Y10S428/93 , Y10S505/704 , Y10S505/705 , Y10T428/2927 , Y10T428/2933
摘要： An elongate superconductor wiring element having, as seen in section, oxide superconductor material regions in each of which the c-axes of the oxide superconductor crystals are aligned with each other and are transverse to the longitudinal axis of the element. To reduce the dependence of critical current density on angular position of the element relative to a magnetic field, there are a plurality of said regions whose alignment directions of the c-axes are different as between different ones of said regions, so that the wiring element comprises a plurality of said regions having respectively different c-axis alignment directions.
摘要翻译：细长超导体布线元件具有如图所示的氧化物超导体材料区域，其中氧化物超导体晶体的c轴彼此对准并且横向于元件的纵向轴线。为了减小临界电流密度对元件相对于磁场的角位置的依赖性，存在多个所述区域，其中c轴的取向方向在不同的所述区域之间不同，使得布线元件包括具有分别不同c轴对准方向的多个所述区域。

67. 发明授权

US07898256B2 Nuclear magnetic resonance measurement apparatus and measuring method using the same 有权
标题翻译：核磁共振测量装置及其测量方法
公开(公告)号：US07898256B2
公开(公告)日：2011-03-01
申请号：US12371963
申请日：2009-02-17
申请人： Isao Kitagawa , Michiya Okada , Kazuo Saitoh
发明人： Isao Kitagawa , Michiya Okada , Kazuo Saitoh
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N24/087 , G01N24/088 , G01R33/465
摘要： An NMR measurement apparatus adopts a circulation flow scheme using a sample solution containing a high molecular compound representing a measuring object and a low molecular compound solution containing a low molecular compound representing a ligand. The measurement apparatus comprises a mixing filter 32 for mixing the sample solution and the low molecular compound solution, a separation filter 34 for performing separation therebetween, a flow channel 1 through which the sample solution drained out of the separation filter 34 is injected to the mixing filter 32, a flow channel 2 through which the low molecular compound solution drained out of the separation filter 34 is injected to the mixing filter 32, and a flow channel 3 through which the mixture solution drained out of the mixing filter 32 is injected to the separation filter 34 by way of a reservoir 10.
摘要翻译： NMR测定装置采用使用含有表示测定对象的高分子化合物的样品溶液和含有表示配体的低分子化合物的低分子化合物溶液的循环流程图。测量装置包括用于混合样品溶液和低分子化合物溶液的混合过滤器32，用于在其间进行分离的分离过滤器34，将从分离过滤器34排出的样品溶液注入混合物的流动通道1 过滤器32将从分离过滤器34排出的低分子化合物溶液注入到流通道2中，并将混合溶液排出混合过滤器32的流路3注入到混合过滤器32中，分离过滤器34通过储存器10。

68. 发明授权

US07492159B2 Nuclear magnetic resonance spectrometer for liquid-solution 失效
标题翻译：用于液体溶液的核磁共振光谱仪
公开(公告)号：US07492159B2
公开(公告)日：2009-02-17
申请号：US11708028
申请日：2007-02-20
申请人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzo Aihara
发明人： Michiya Okada , Tsuyoshi Wakuda , Shigeru Kakugawa , Hiroshi Morita , Katsuzo Aihara
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/34092 , G01R33/3806 , G01R33/3815 , G01R33/465
摘要： In a nuclear magnetic resonance spectrometer, the shape of a detection coil is changed from a conventional cage type to a solenoid type of higher sensitivity. Accordingly, differing from the conventional superconductive magnet of multilayer air core solenoids, a superconductive magnet is right and left divided to split magnets for generating 11 T preferably, 14.1 T in the horizontal direction, and the magnetic field uniformity is set to 0.001 ppm or less and the temporal stability is set to 0.001 ppm or less.
摘要翻译：在核磁共振光谱仪中，检测线圈的形状从传统的笼型改变为更高灵敏度的螺线管型。因此，与传统的多层空心螺线管的超导磁体不同，超导磁体被左右划分成用于在水平方向上产生11T最好为11.1T的分割磁体，并且将磁场均匀性设定为0.001ppm以下时间稳定度设定为0.001ppm以下。

69. 发明申请

US20080290872A1 Apparatus of nuclear magnetic resonance measurement for continuous sample injection 审中-公开
标题翻译：用于连续样品注射的核磁共振测量装置
公开(公告)号：US20080290872A1
公开(公告)日：2008-11-27
申请号：US12153349
申请日：2008-05-16
申请人： Isao Kitagawa , Michiya Okada , Kazuo Saitoh
发明人： Isao Kitagawa , Michiya Okada , Kazuo Saitoh
IPC分类号： G01R33/30
CPC分类号： G01R33/307
摘要： A sample tube is used to ensure uniformity in a static magnetic field and uniformity in electromagnetic wave irradiation for NMR measurement for continuous sample injection. The sample tube is formed of a signal detecting tube having a length lying between 80% and 100% of the length of an antenna, the signal detecting tube accommodating a sample at the position of the antenna; first and second joint tubes each having an outside diameter equal to the outside diameter of the signal detecting tube and having an inside diameter smaller than the inside diameter of the signal detecting tube; and injection and ejection supporting tubes each having an inside diameter smaller than the inside diameter of the signal detecting tube. The first and second joint tubes have magnetic susceptibility matched to or brought close to that of a sample solvent.
摘要翻译：使用样品管来确保静电磁场的均匀性和用于连续样品注入的NMR测量的电磁波照射的均匀性。样品管由长度位于天线长度的80％至100％之间的信号检测管形成，信号检测管在天线的位置容纳样品; 第一和第二接头管的外径等于信号检测管的外径，内径小于信号检测管的内径; 以及各自具有小于信号检测管的内径的内径的注射和喷射支撑管。第一和第二接合管具有与样品溶剂匹配或接近的磁化率。

70. 发明申请

US20080284470A1 Direct Digital Synthesizer and Nuclear Magnetic Resonance Instrument Using the Same 失效
标题翻译：直接数字合成器和使用它的核磁共振仪器
公开(公告)号：US20080284470A1
公开(公告)日：2008-11-20
申请号：US12120385
申请日：2008-05-14
申请人： Minseok Park , Michiya Okada , Shuya Hagiwara , Hideki Tanaka
发明人： Minseok Park , Michiya Okada , Shuya Hagiwara , Hideki Tanaka
IPC分类号： H03B21/00 , G01V3/14
CPC分类号： G01R33/3607
摘要： A DDS (direct digital synthesizer) remarkably increased in the number of frequencies which can be output while maintaining the phase coherency, and an NMR instrument using such a DDS are provided. A DDS including phase accumulators and a phase-to-amplitude modulator is provided with a plurality of phase accumulators operating with fixed phase implements which are equal to powers of 2, a controller for outputting each bit of a frequency tuning word as control data, a plurality of switches for outputting an output of an associated one of the phase accumulators when an associated one of the control data supplied from the controller is 1 and outputting 0 when the associated one of the control data is 0, and an adder for adding up outputs of the switches.
摘要翻译： DDS（直接数字合成器）在保持相位一致性的同时可以输出的频率数量显着增加，并且提供使用这种DDS的NMR仪器。包括相位累加器和相位到幅度调制器的DDS设置有多个相位累加器，其以等于2的功率的固定相位工具操作;控制器，用于输出频率调谐字的每个位作为控制数据; 多个开关，用于当从所述控制器提供的所述控制数据中的相关一个之一输出相关联的一个所述相位累加器的输出，并且当所述控制数据中的相关一个为0时输出0;以及加法器，的开关。

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