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61. 发明授权

US6022949A Fungal aureobasidin sensitivity gene products 失效
标题翻译：真菌金黄色念珠菌敏感性基因产物
公开(公告)号：US6022949A
公开(公告)日：2000-02-08
申请号：US423752
申请日：1995-04-18
申请人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： A61K38/00 , C07K14/37 , C07K14/40 , C07K16/14 , C12N15/31 , C07K14/39
CPC分类号： C07K14/40 , C07K14/37 , C07K16/14 , A61K38/00 , Y10S435/822 , Y10S435/911 , Y10S530/824
摘要： A gene associated with sensitivity to the antimycotic agent, aureobasidin A, has been isolated. The gene can be detected in a variety of cell types, and variant forms of the gene have been identified in mutant yeast strains. The proteins encoded by these genes are useful in diagnosing and treating mycoses.
摘要翻译：已经分离了与抗真菌剂（aureobasidin A）的敏感性相关的基因。可以在多种细胞类型中检测该基因，并且在突变酵母菌株中鉴定出该基因的变体形式。这些基因编码的蛋白质可用于诊断和治疗真菌病。

62. 发明授权

US5824503A Gene encoding endoglycoceramidase activator 失效
标题翻译：基因编码神经酰胺糖内切酶激活物
公开(公告)号：US5824503A
公开(公告)日：1998-10-20
申请号：US672564
申请日：1996-06-28
申请人： Yoko Kurome , Hiroyuki Izu , Yoshiya Izumi , Mutsumi Sano , Ikunoshin Kato , Makoto Ito
发明人： Yoko Kurome , Hiroyuki Izu , Yoshiya Izumi , Mutsumi Sano , Ikunoshin Kato , Makoto Ito
IPC分类号： C07K14/36 , C12N1/21 , C12N15/31 , C12N15/00
CPC分类号： C07K14/36
摘要： An isolated DNA having a sequence encoding a polypeptide possessing endoglycoceramidase activator activity or functionally equivalent variants thereof; and a method for producing a polypeptide possessing endoglycoceramidase activator activity or functionally equivalent variants thereof by gene recombinant technology.
摘要翻译：具有编码具有神经酰胺糖内切酶激活剂活性的多肽的序列的分离的DNA或其功能上等同的变体; 以及通过基因重组技术产生具有神经酰胺糖内切酶激活剂活性或功能等同变体的多肽的方法。

63. 发明授权

US5744345A Hyperthermostable .beta.-galactosidase gene, enzyme encoded thereby, and process for production 失效
标题翻译：超热稳定性β-半乳糖苷酶基因，由此编码的酶，以及生产方法
公开(公告)号：US5744345A
公开(公告)日：1998-04-28
申请号：US489733
申请日：1995-06-14
申请人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
发明人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N9/38 , C12N15/56
CPC分类号： C12Y302/01023 , C12N9/2471
摘要： An isolated hyperthermostable .beta.-galactosidase gene derived from Pyrococcus furiosus is described. Examples include DNA sequences shown in SEQ ID NO. 2 and SEQ ID NO. 4 and DNAs hybridizable with these DNAs. A method of cloning the hyperthermostable .beta.-galactosidase gene in which each of the above sequences or portions thereof is used as a probe or primer is described. A process for producing a hyperthermostable .beta.-galactosidase by culturing a transformant into which a plasmid containing each of the above genes has been introduced is described. A particularly preferred gene encodes an SDS-resistant hyperthermostable .beta.-galactosidase.
摘要翻译：描述了源自激烈热球菌的分离的超热稳定性β-半乳糖苷酶基因。实例包括SEQ ID NO： 2和SEQ ID NO。 4和DNA可与这些DNA杂交。描述了将上述每个上述序列或其部分用作探针或引物的克隆超热稳定性β-半乳糖苷酶基因的方法。描述了通过培养其中已经引入了含有上述每种基因的质粒的转化体来生产超热稳定性β-半乳糖苷酶的方法。特别优选的基因编码SDS-抗性超热稳定性β-半乳糖苷酶。

64. 发明授权

US5698670A Aureobasidins 失效
公开(公告)号：US5698670A
公开(公告)日：1997-12-16
申请号：US505255
申请日：1995-08-16
申请人： Toru Kurome , Tetsuya Inoue , Kazutoh Takesako , Kaoru Inami , Ikunoshin Kato
发明人： Toru Kurome , Tetsuya Inoue , Kazutoh Takesako , Kaoru Inami , Ikunoshin Kato
IPC分类号： A61K38/00 , C07K11/02 , A61K38/12 , C07K5/00
CPC分类号： C07K11/02 , A61K38/00
摘要： This invention relates to Aureobasidins useful as an antifungal agent having broader spectrum. The compound according to this invention includes a cyclic depsipeptide consisting of one hydroxy acid residue having A.sup.1, 3 amino acid residues having C.sup.1, F.sup.1 and H.sup.1, respectively, 4 N-methylamino acid residues having B.sup.1, D.sup.1, G.sup.1 and I.sup.1, respectively, and 1 cyclic amino acid residue having E.sup.1. The typical compound includes one wherein A.sup.1 is CH.sub.3 CH.sub.2 CH(CH.sub.3)--, B.sup.1 is (CH.sub.3).sub.2 CH--, C.sup.1 is benzyl, cyclohexylmethyl, p-fluorobenzyl, benzyloxymethyl, benzyloxybenzyl, methoxybenzyl, cyclohexylmethyloxybenzyl or the like, D.sup.1 is methyl, benzyl, hydroxymethyl or the like, E.sup.1 is --(CH.sub.2).sub.3 --, F.sup.1 is CH.sub.3 CH.sub.2 CH(CH.sub.3)--, G.sup.1 is (CH.sub.3).sub.2 CH--, H.sup.1 is (CH.sub.3).sub.2 CHCH.sub.2 -- and I.sup.1 is (CH.sub.3).sub.2 C(OH)--. The compound according to this invention has an excellent activity against not only Candida but also Cryptococcus and Aspergillus.
摘要翻译： PCT No.PCT / JP94 / 02201 Sec。 371日期：1995年8月16日 102（e）日期1995年8月16日PCT 1994年12月26日PCT公布。出版物WO95 / 18147 日期1995年7月6日本发明涉及可用作具有更宽光谱的抗真菌剂的Aureobasidins。根据本发明的化合物包括由一个具有A1的羟基酸残基，具有C1，F1和H1的3个氨基酸残基，分别具有B1，D1，G1和I1的4个N-甲基氨基酸残基的环状缩肽，以及 1个具有E1的环状氨基酸残基。典型的化合物包括其中A 1为CH 3 CH 2 CH（CH 3） - ，B 1为（CH 3）2 CH-，C 1为苄基，环己基甲基，对氟苄基，苄氧基甲基，苄氧基苄基，甲氧基苄基，环己基甲氧基苄基等的化合物，D1为甲基，苄基，等等，E1是 - （CH 2）3 - ，F1是CH 3 CH 2 CH（CH 3） - ，G 1是（CH 3）2 CH-，H 1是（CH 3）2 CHCH 2 - 且I 1是（CH 3）2 C（OH） - 。根据本发明的化合物对假丝酵母不仅具有优异的活性，而且对隐球菌和曲霉也具有优异的活性。

65. 发明授权

US5532337A Proteins comprising calmodulin- and actin-binding human caldesmon polypeptide fragments 失效
标题翻译：蛋白质包含钙调蛋白和肌动蛋白结合的人钙二聚体多肽片段
公开(公告)号：US5532337A
公开(公告)日：1996-07-02
申请号：US285440
申请日：1994-08-04
申请人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
发明人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
IPC分类号： A61K38/00 , A61K31/00 , A61P35/00 , C07K14/435 , C07K14/47 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/53 , C07K14/46 , C07K19/00
CPC分类号： C07K14/47
摘要： Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.
摘要翻译：提供具有钙调素和肌动蛋白结合活性的人钙调蛋白的功能性肽片段，其氨基酸序列及其核酸序列。

66. 发明授权

US5516694A Endo-xyloglucan transferase 失效
公开(公告)号：US5516694A
公开(公告)日：1996-05-14
申请号：US381280
申请日：1995-01-31
申请人： Kazuhiko Nishitani , Kazuhide Okazawa , Kiyozo Asada , Ikunoshin Kato
发明人： Kazuhiko Nishitani , Kazuhide Okazawa , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N9/10 , C12N9/24 , C12N9/42 , C12N15/82 , C12N15/14 , C07H21/04
CPC分类号： C12N9/1051 , C12N15/8241 , C12N15/8261 , C12Y204/01207
摘要： Endo-xyloglucan transferases responsible for growth of plant cell wall, genes coding for the enzymes, a method of transferring xyloglucan molecules by using the enzyme, and methods of using the gene are described.

67. 发明授权

US5475100A Artificial antibody 失效
标题翻译：人造抗体
公开(公告)号：US5475100A
公开(公告)日：1995-12-12
申请号：US109106
申请日：1993-08-19
申请人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
发明人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/00 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , C07H21/00
CPC分类号： C07K16/00 , A61K38/00 , C07K2317/77
摘要： This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.
摘要翻译：本发明提供具有抗原结合活性的抗体，其具有重链恒定区，其中已引入RGDS氨基酸序列，其给予对包括巨噬细胞的细胞的抗体亲和力。抗体表现出人工细胞粘附活性，其是由RGDS氨基酸序列的插入引起的新表达的活性。具有人造细胞粘附活性的该抗体可以加速巨噬细胞的吞噬作用，并可以激活其他效应细胞。因此，该抗体有助于自卫机制。

68. 发明授权

US5189144A Human calpastatin-like polypeptide 失效
标题翻译：人类钙蛋白酶抑制素样多肽
公开(公告)号：US5189144A
公开(公告)日：1993-02-23
申请号：US852343
申请日：1992-03-17
申请人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
发明人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
IPC分类号： C07K7/08 , C07K14/81
CPC分类号： C07K7/08 , C07K14/8139
摘要： Polypeptides are provided which have a calpain inhibitory activity. The polypeptides have an activity like that of natural human calpastatin but are significantly shorter in length than natural human calpastatin. The polypeptides are suited for synthetic manufacture.
摘要翻译：提供具有钙蛋白酶抑制活性的多肽。多肽具有类似于天然人钙蛋白酶抑制剂的活性，但其长度明显短于天然人钙蛋白酶抑制剂。该多肽适用于合成制造。

69. 发明授权

US5179016A Restriction enzyme Sse 8387I 失效
标题翻译：限制版ZE 8387I
公开(公告)号：US5179016A
公开(公告)日：1993-01-12
申请号：US698780
申请日：1991-05-13
申请人： Hirokazu Kotani , Fusao Kimizuka , Ikunoshin Kato
发明人： Hirokazu Kotani , Fusao Kimizuka , Ikunoshin Kato
IPC分类号： C12N9/16 , C12N1/20 , C12N9/22 , C12R1/465
CPC分类号： C12N9/22 , Y10S435/886
摘要： The class II restriction endonuclease Sse 8387I is obtained from Streptomyces Sp 837 (FERM BP-3028). It recognizes the nucleotide sequence 5'-CCTGCA.dwnarw.GG-3' and cleaves at the position indicated by the arrow.

70. 发明授权

US4981595A Process for the purification of spergualin-related compounds 失效
标题翻译：纯化与精毒素相关的化合物的方法
公开(公告)号：US4981595A
公开(公告)日：1991-01-01
申请号：US370746
申请日：1989-06-20
申请人： Yoshihisa Umeda , Makoto Moriguchi , Keiko Miyazaki , Toru Kurome , Ikunoshin Kato , Tetsushi Saino
发明人： Yoshihisa Umeda , Makoto Moriguchi , Keiko Miyazaki , Toru Kurome , Ikunoshin Kato , Tetsushi Saino
IPC分类号： C07C279/14 , C07B63/00 , C07C231/24 , C07C235/10 , C07C277/06 , C07C277/08 , C07C279/18
CPC分类号： C07C277/08
摘要： Process for purifying spergualin-related compounds and their synthetic intermediates, by subjecting a solution containing such spergualin-related compounds or intermediates to electrodialysis and/or reverse osmosis.

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