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    • 61. 发明申请
    • Refined royal jelly
    • 精制皇家果冻
    • US20060159834A1
    • 2006-07-20
    • US10525157
    • 2003-09-04
    • Takashi ShibuyaShigeharu FukudaToshio Miyake
    • Takashi ShibuyaShigeharu FukudaToshio Miyake
    • A23K1/00
    • A61K8/64A23G9/38A23K20/10A23K50/40A23L21/20A23L33/11A23L33/15A23V2002/00A61K8/988A61Q19/00A23V2200/304
    • The object of the present invention is to provide an allergen-reduced royal jelly, having less fear of causing allergic symptoms, obtained by reducing allergens and keeping the useful pharmacological actions of royal jelly, a process for producing the same, and its uses. The present invention solves the above object by providing an allergen-reduced royal jelly where the amount of water-soluble proteins is reduced to less than 50% (w/w) to the amount of total proteins; a process for producing the allergen-reduced royal jelly comprising the steps of separating a royal jelly into a precipitate and a supernatant comprising water-soluble proteins by adding water and centrifuging, collecting low molecular substances by eliminating high molecular substances comprising water-soluble proteins from the resulting supernatant using ultra-filtration or gel filtration chromatography, and mixing the resulting low molecular substances with the aforesaid precipitate; a composition comprising the allergen-reduced royal jelly; and the uses of the composition for foods, feeds, baits, pet foods, and cosmetics.
    • 本发明的目的是提供一种通过减少过敏原并保持蜂王浆的有用药理作用而获得的对过敏症状的恐惧较少的过敏原降低的蜂王浆,其制备方法及其用途。 本发明通过提供一种致敏剂降低的蜂王浆来解决上述目的,其中水溶性蛋白质的量降低到总蛋白质量的少于50%(w / w); 一种生产降解过敏原的蜂王浆的方法,包括以下步骤:将蜂王浆分离成沉淀物,通过加入水分和离心分离含有水溶性蛋白质的上清液,通过除去含有水溶性蛋白质的高分子物质来收集低分子物质 所得上清液使用超滤或凝胶过滤层析,并将得到的低分子物质与上述沉淀物混合; 包含变应原降低的蜂王浆的组合物; 以及食品,饲料,饵料,宠物食品和化妆品组合物的用途。
    • 65. 发明授权
    • Process for producing high 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid
    • 生产高2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的方法
    • US06576446B2
    • 2003-06-10
    • US09875963
    • 2001-06-08
    • Hiroshi YamasakiKoichi NishiToshio Miyake
    • Hiroshi YamasakiKoichi NishiToshio Miyake
    • C12P1944
    • C07H17/04
    • Disclosed is a process for producing a high &agr;G-AA content product, which comprises the steps of: contacting a solution as a material solution, containing &agr;G-AA, L-ascorbic acid, and a saccharide(s), with an anion exchange resin packed in a column to adsorb the &agr;G-AA and L-ascorbic acid on the anion exchanger; washing the anion exchanger with water to remove the saccharide(s) therefrom; feeding to the column an aqueous solution, as an eluent, of an acid and/or a salt with a concentration of less than 0.5 N to fractionate a fraction rich in 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid and a fraction rich in L-ascorbic acid; and collecting the former fraction.
    • 公开了一种制备高αG-AA含量产物的方法,其包括以下步骤:使含有αG-AA,L-抗坏血酸和糖的溶液与阴离子交换树脂接触 填充在柱中以吸附阴离子交换剂上的αG-AA和L-抗坏血酸; 用水洗涤阴离子交换剂以除去其中的糖类; 向柱中加入浓度小于0.5N的酸和/或盐的水溶液作为洗脱剂,以分级富含2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的级分和 级分富含L-抗坏血酸; 并收集前一部分。