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61. 发明授权

US09317941B2 Method of image reconstruction for a filtered back projection in limited angle tomography 有权
标题翻译：用于有限角度层析成像中滤波反投影的图像重建方法
公开(公告)号：US09317941B2
公开(公告)日：2016-04-19
申请号：US14344230
申请日：2012-08-27
申请人： Tim Nielsen , Sebastian Hitziger , Michael Grass
发明人： Tim Nielsen , Sebastian Hitziger , Michael Grass
IPC分类号： G06K9/00 , G06T11/00 , A61B6/03
CPC分类号： G06T11/006 , A61B6/035 , G06T2210/41 , G06T2211/421 , G06T2211/436
摘要： The present invention is directed to a limited angle tomography in combination with a filtered back projection using a special filter operator X. The filter operator X used within the present invention makes it possible to perform region of interest reconstructions although delivering high quality reconstruction images as generated by high effort SART methods. The used filter operator is purely and solely mathematically determined and defined by the spatial geometry which is used for the limited angle tomography. Without having the need to perform several iterations, the present invention directly calculates a solution, i.e. reconstructed image, equivalent to known iteratively construction methods. Although, incomplete projection data p may only be used, the present invention provides for a high image quality.
摘要翻译：本发明涉及一种与使用特殊滤波器操作器X的滤波反投影相结合的有限角度断层摄影。本发明中使用的滤波器操作器X可以执行感兴趣的重建区域，尽管传送高质量的重建图像产生通过高效的SART方法。所使用的过滤器操作员纯粹且仅在数学上由用于有限角度层析成像的空间几何来确定和限定。在不需要进行多次迭代的情况下，本发明直接计算与已知的迭代构造方法相当的解，即重构图像。尽管可以仅使用不完全的投影数据p，但是本发明提供了高图像质量。

62. 发明授权

US09087400B2 Reconstructing an object of interest 有权
标题翻译：重建感兴趣的对象
公开(公告)号：US09087400B2
公开(公告)日：2015-07-21
申请号：US13515830
申请日：2010-12-10
申请人： Klaus Erhard , Michael Grass , Thomas Buelow , Eberhard Sebastian Hansis
发明人： Klaus Erhard , Michael Grass , Thomas Buelow , Eberhard Sebastian Hansis
IPC分类号： G06K9/00 , G06T11/00
CPC分类号： G06T11/006 , G06T2211/436
摘要： A system for generating a reconstruction of an object of interest comprises a shape model generator (1) for generating a shape model representing a shape of the object in dependence on a plurality of projections of the object, and a reconstructor (2) for reconstructing the object, based on the projections, in dependence on the shape model to obtain the reconstruction of the object. The reconstructor (2) comprises a soft-tissue reconstructor (4) for generating a reconstruction favoring soft tissue, based on the plurality of projections, and a sparse reconstructor (5) for generating a reconstruction of sparse objects, based on the plurality of projections. The reconstructor (2) comprises a clipping subsystem (3) for clipping an outside of the object from the reconstruction, based on the shape model, or the reconstructor (2) is arranged for reconstructing only an inside and/or boundary of the object as defined by the shape model.
摘要翻译：用于生成感兴趣对象的重建的系统包括：形状模型生成器（1），用于根据对象的多个投影来生成表示对象的形状的形状模型;以及重建器（2），用于重建对象，根据投影，依靠形状模型获得物体的重建。重建器（2）包括一个软组织重构器（4），用于基于多个投影产生有利于软组织的重建，以及一个稀疏重建器（5），用于基于多个突起产生稀疏对象的重构。重建器（2）包括用于基于形状模型从重建中剪除对象外部的剪辑子系统（3），或者重建器（2）被布置为仅重构对象的内部和/或边界，由形状模型定义。

63. 发明授权

US09053535B2 Adaptive roadmapping 有权
标题翻译：自适应路线图
公开(公告)号：US09053535B2
公开(公告)日：2015-06-09
申请号：US13810680
申请日：2011-07-15
申请人： Raoul Florent , Vincent Auvray , Michael Grass , Dirk Schaefer , Gert Schoonenberg
发明人： Raoul Florent , Vincent Auvray , Michael Grass , Dirk Schaefer , Gert Schoonenberg
IPC分类号： G06K9/00 , G06T7/00 , A61B6/12 , A61B6/00 , A61B19/00 , G06T19/00
CPC分类号： G06T7/0012 , A61B6/12 , A61B6/463 , A61B6/487 , A61B6/504 , A61B6/5235 , A61B90/37 , A61B2090/364 , A61B2090/365 , A61B2090/3764 , G06T7/32 , G06T19/00 , G06T2207/10121 , G06T2207/30101
摘要： An adaptive roadmapping device and method for examination of an object include providing pre-navigation image data representing part of the object being a vascular structure including an element of interest and having a tree-like structure with a plurality of sub-trees; generating a vessel representation based on the pre-navigation image data; acquiring live image data of the object; determining spatial relation of the pre-navigation image data and the live image data; analyzing the live image data by identifying and localizing the element in the live image data; determining a sub-tree in which the element is positioned, where the determining is based on the localization of the element and on the spatial relation; selecting a portion of the vascular structure based on the determined sub-tree; generating a combination of the live image data and an image of the selected portion of the vascular structure; and displaying the combination as a tailored roadmap.
摘要翻译：用于检查对象的自适应路线图设备和方法包括提供表示作为包括感兴趣元素并且具有多个子树的树状结构的血管结构的对象的一部分的导航前图像数据; 基于导航前图像数据生成船舶表示; 获取对象的实时图像数据; 确定所述导航前图像数据和实况图像数据的空间关系; 通过识别和定位实时图像数据中的元素来分析实况图像数据; 确定元素位于其中的子树，其中确定基于元素的定位和空间关系; 基于确定的子树选择血管结构的一部分; 生成活体图像数据和血管结构的所选部分的图像的组合; 并将该组合显示为定制的路线图。

64. 发明授权

US08977018B2 Multi-modality breast imaging 有权
标题翻译：多形态乳腺成像
公开(公告)号：US08977018B2
公开(公告)日：2015-03-10
申请号：US13384265
申请日：2010-07-12
申请人： Thomas Buelow , Michael Grass , Klaus Erhard
发明人： Thomas Buelow , Michael Grass , Klaus Erhard
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0032 , G06T7/344 , G06T2207/10088 , G06T2207/10116 , G06T2207/30068
摘要： A system for multi-modality breast imaging comprises a first shape model constructing sub-system (1) for constructing a first shape model of the breast as represented in a first image (9), in which the breast has its natural shape, a second shape model constructing sub-system (2) for constructing a second shape model of the breast as represented in a second image (10), in which the breast is compressed by using a compression paddle, and a deformation estimating sub-system (3) for estimating a volumetric deformation field (12) defining a mapping between the first image (9) and the second image (10) on the basis of the shape models and an elastic deformation model (11) of the breast, the deformation estimating sub-system (3) being arranged to estimate the volumetric deformation field (12) on the basis of a first tissue surface of the breast in the first image (9) and a second tissue surface of the breast in the second image (10).
摘要翻译：一种用于多模式乳房成像的系统，包括构成子系统（1）的第一形状模型，用于构建乳房的第一形状模型，如第一图像（9）所示，其中乳房具有其自然形状，第二形状模型用于构造乳房的第二形状模型的形状模型构造子系统（2），如第二图像（10）所示，其中通过使用压缩桨来压缩乳房，以及变形估计子系统（3）用于基于形状模型和乳房的弹性变形模型（11）来估计限定第一图像（9）和第二图像（10）之间的映射的体积变形场（12），变形估计子步骤系统（3）被布置为基于第一图像（9）中的乳房的第一组织表面和第二图像（10）中的乳房的第二组织表面来估计体积变形场（12）。

65. 发明授权

US08923474B2 Visualization of the coronary artery tree 有权
标题翻译：冠状动脉树的可视化
公开(公告)号：US08923474B2
公开(公告)日：2014-12-30
申请号：US13131277
申请日：2009-11-20
申请人： Eberhard Sebastian Hansis , Michael Grass
发明人： Eberhard Sebastian Hansis , Michael Grass
IPC分类号： G01N23/083 , A61B6/00 , G06T11/00
CPC分类号： A61B6/504 , A61B6/4441 , A61B6/466 , A61B6/481 , A61B6/541 , G06T11/006 , G06T2211/404
摘要： The present invention is related to a method for reconstruction of the coronary arteries and an examination apparatus for reconstruction of the coronary arteries. To provide improved coronary artery information, an apparatus and a method are provided where a gating signal is provided (32) and a first gated X-ray image sequence of one of the left or right branches of the coronary arteries is acquired (34) with injected contrast agent into the one of the left or right branches of the coronary arteries. Further, a second gated X-ray image sequence of the other branch of the coronary arteries is acquired (36) with injected contrast agent into said other branch. Then, a gated reconstructing (38) of the left and the right coronary artery is suggested and a volume data (40, 42) of the coronary arteries is generated. The volume data of the left and right coronary arteries is registered (44) in relation to time and space. Further; the registered volume data (48, 50) of the left and the right coronary arteries is combined and a combined coronary artery tree volume data set (52) is generated (54). Finally, the combined coronary tree volume data set is visualized (56).
摘要翻译：本发明涉及冠状动脉重建方法和冠状动脉重建检查装置。为了提供改善的冠状动脉信息，提供了一种装置和方法，其中提供门控信号（32），并且获取冠状动脉的左分支或右分支之一的第一选通X射线图像序列（34），其中将注射的造影剂注射到冠状动脉的左侧或右侧分支中。此外，冠状动脉的另一个分支的第二选通X射线图像序列（36）被注入造影剂获取到所述另一分支中。然后，建议左冠状动脉和右冠状动脉的门控重建（38），并且产生冠状动脉的体积数据（40,42）。左冠状动脉和右冠状动脉的体积数据相对于时间和空间被记录（44）。进一步; 组合左冠状动脉和右冠状动脉的记录体数据（48,50），并且生成组合的冠状动脉树体积数据组（52）（54）。最后，组合冠状动脉树体数据集可视化（56）。

66. 发明授权

US08415520B2 Work-up of a 3-methyl-1-butene-containing mixture 失效
标题翻译：后处理含3-甲基-1-丁烯的混合物
公开(公告)号：US08415520B2
公开(公告)日：2013-04-09
申请号：US13375091
申请日：2010-04-29
申请人： Markus Winterberg , Alfred Kaizik , Armin Rix , Michael Grass , Wilfried Bueschken , Marc Becker
发明人： Markus Winterberg , Alfred Kaizik , Armin Rix , Michael Grass , Wilfried Bueschken , Marc Becker
IPC分类号： C07C7/04
CPC分类号： C07C7/04 , C07C1/24 , C07C7/06 , C07C11/10
摘要： The invention is a method for processing a mixture containing water, 3-methyl-1-butane and at least one other methylbutene. The method comprises primary distillation of the mixture, giving a gaseous primary overhead product containing methylbutene and water and a water-free primary bottom product containing 3-methyl-1-butene; condensation of the gaseous primary overhead product so as to give a condensate comprising a liquid aqueous phase and a liquid organic phase; separation of the condensate into a liquid aqueous phase and a liquid organic phase; discharge of the liquid aqueous phase; recirculation of the organic phase to the primary distillation; and finally secondary distillation of the water-free primary bottom product from the primary distillation so as to give a secondary overhead product comprising 3-methyl-1-butene and a secondary bottom product. The secondary overhead product obtained has a purity which enables it to be used directly as monomer or comonomer for preparing polymers or copolymers.
摘要翻译：本发明是一种处理含有水，3-甲基-1-丁烷和至少一种其它甲基丁烯的混合物的方法。该方法包括对该混合物进行一次蒸馏，得到含有甲基丁烯和水的气态初级塔顶馏出物和含有3-甲基-1-丁烯的无水初级底物产物; 气态一级塔顶产物的冷凝，以产生包含液态水相和液体有机相的冷凝物; 将冷凝物分离成液态水相和液体有机相; 液体水相的排出; 将有机相再循环至初级蒸馏; 最后从初级蒸馏二次蒸馏无水初级底部产物，得到包含3-甲基-1-丁烯和二级底部产物的二级塔顶产物。获得的二次塔顶产物具有使其能够直接用作制备聚合物或共聚物的单体或共聚单体的纯度。

67. 发明申请

US20120302876A1 OBJECT LOCALIZATION APPARATUS 审中-公开
标题翻译：对象本地化设备
公开(公告)号：US20120302876A1
公开(公告)日：2012-11-29
申请号：US13575828
申请日：2011-01-31
申请人： Udo Van Stevendaal , Michael Grass
发明人： Udo Van Stevendaal , Michael Grass
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B6/12 , A61B6/466 , A61B6/504 , A61B6/547 , A61B34/20 , A61B2034/2065 , A61M25/0108
摘要： The invention relates to an object localization apparatus for localizing an object having markers based on a projection image. An object function (8) is provided along x-z positions (9, 20 . . . 25), wherein the x-z positions (9, 20 . . . 25) are defined by pairs of an x position being a position of a recognized projected marker along a fictive line on the recognized projected object in a projection plane and a z position defining a position in a direction being outside the projection plane. The position is determined based on the object function (8) which is modified by varying the z positions such that distances between the x-z positions along the object function (8) are adapted to distances between the markers of the object. This allows the object localization apparatus to determine the position with a reduced number of projection images, in particular, with only a single projection image.
摘要翻译：本发明涉及一种用于基于投影图像来定位具有标记的物体的物体定位装置。沿xz位置（9,20,25）提供对象功能（8），其中xz位置（9,20,25）由x位置的对定义，该位置是识别的投影标记的位置沿着在投影平面中识别的投影物体上的假想线，并且限定在投影平面外的方向上的位置的az位置。基于通过改变z位置来修改的对象函数（8）确定位置，使得沿着对象函数（8）的x-z位置之间的距离适合于对象的标记之间的距离。这允许物体定位装置确定具有减少数量的投影图像的位置，特别是仅使用单个投影图像。

68. 发明申请

US20120172624A1 PROCESS FOR PREPARING DECANECARBOXYLIC ACIDS 有权
标题翻译：制备癸酰氧基酸的方法
公开(公告)号：US20120172624A1
公开(公告)日：2012-07-05
申请号：US13386523
申请日：2010-05-25
申请人： Michael Grass , Alfred Kaizik , Hans-Gerd Lueken , Wilfried Bueschken
发明人： Michael Grass , Alfred Kaizik , Hans-Gerd Lueken , Wilfried Bueschken
IPC分类号： C07C51/373
CPC分类号： C07C45/74 , C07C45/50 , C07C45/62 , C07C51/235 , C07C47/02 , C07C47/21 , C07C53/128
摘要： The invention relates to a process for preparing a mixture of isomeric decane-carboxylic acids, which comprises the following steps:a) hydroformylation of a hydrocarbon mixture containing linear C4-olefins using a rhodium-containing catalyst system;b) aldol condensation of a mixture of aliphatic C5-aldehydes obtained from step a);c) selective hydrogenation of the mixture of unsaturated C10-aldehydes from step b) to aliphatic C10-aldehydes;d) uncatalysed oxidation of the mixture of aliphatic C10-aldehydes from step c) to give a mixture having a proportion of at least 70% by mass of 2-propylheptanoic acid, based on the total content of isomeric decanecarboxylic acids.
摘要翻译：本发明涉及一种制备异构癸烷 - 羧酸的混合物的方法，其包括以下步骤：a）使用含铑催化剂体系加氢甲酰化含有线性C 4 - 烯烃的烃混合物; b）从步骤a）获得的脂族C 5 - 醛的混合物的醛醇缩合; c）选自氢化来自步骤b）的不饱和C10-醛的混合物至脂族C 10 - 醛; d）来自步骤c）的脂族C 10 - 醛混合物的未催化氧化，得到基于异构癸烷羧酸的总含量的至少70质量％的2-丙基庚酸的混合物。

69. 发明授权

US08202959B2 Process for preparing polymers from 3-methylbut-1-ene 有权
公开(公告)号：US08202959B2
公开(公告)日：2012-06-19
申请号：US13095541
申请日：2011-04-27
申请人： Michael Grass , Franz Nierlich , Walter Kaminsky , Stefanie Derlin , Klaus-Diether Wiese , Dagmara Ortmann
发明人： Michael Grass , Franz Nierlich , Walter Kaminsky , Stefanie Derlin , Klaus-Diether Wiese , Dagmara Ortmann
IPC分类号： C08F4/642 , C08F4/6592 , C08F210/14
CPC分类号： C08F210/16 , C08F4/65912 , C08F4/6592 , C08F10/00 , C08F210/06 , Y10S526/943 , C08F4/65927 , C08F210/14 , C08F2500/03 , C08F2500/20
摘要： The present invention relates to a copolymer which contains 3-methylbut-1-ene as a comonomer and which contains ethene or propene as a further monomer, the proportion of the incorporated 3-methylbut-1-ene being 0.1 to 40 mol %, and to a process for preparing such copolymers, the polymerization being performed in the presence of a catalyst which comprises at least one cyclopentadienyl group.

70. 发明申请

US20120136190A1 PRODUCTION OF 3-METHYLBUT-1-EN BY MEANS OF DEHYDRATION OF 3-METHYLBUTANE-1-OL 审中-公开
标题翻译：通过3-甲基丁-1-醇脱水制备3-甲基-1-
公开(公告)号：US20120136190A1
公开(公告)日：2012-05-31
申请号：US13322527
申请日：2010-04-28
申请人： Alfred Kaizik , Thomas Quandt , Michael Grass , Markus Winterberg , Wilfried Bueschken
发明人： Alfred Kaizik , Thomas Quandt , Michael Grass , Markus Winterberg , Wilfried Bueschken
IPC分类号： C07C1/20
CPC分类号： C07C1/24 , C07C11/10
摘要： The invention relates to a process for preparing 3-methyl-1-butene by dehydration of 3-methyl-1-butanol over an aluminium-containing oxide in the temperature range from 200 to 450° C. in the gas phase or mixed liquid/gas phase, characterized in that an aluminium-containing oxide having a predominantly mesoporous pore structure whose:a) relative proportion of macropores is less than 15%;b) distribution of the pore diameter has a monomodal maximum in the range of mesopores from 3.6 to 50 nm;c) average pore diameter of all pores is in the range of mesopores and macropores from 5 to 20 nm;d) composition comprises more than 80% of gamma-aluminium oxide, is used.
摘要翻译：本发明涉及通过在气相或混合液体/液体中在200-450℃的含铝氧化物上脱水3-甲基-1-丁醇来制备3-甲基-1-丁烯的方法，气相，其特征在于具有主要介孔孔结构的含铝氧化物：a）大孔相对比例小于15％; b）孔径分布在介孔范围为3.6〜50nm的单峰最大值; c）所有孔的平均孔径在5〜20nm的介孔和大孔的范围内; d）组合物包含大于80％的γ-氧化铝。

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