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61. 发明授权

US5958731A Cell junction PDZ protein 失效
公开(公告)号：US5958731A
公开(公告)日：1999-09-28
申请号：US151611
申请日：1998-09-11
申请人： Henry Yue , Janice Au-Young , Chandra Patterson
发明人： Henry Yue , Janice Au-Young , Chandra Patterson
IPC分类号： C12N15/09 , A01K67/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P5/14 , A61P7/02 , A61P7/06 , A61P13/12 , A61P17/00 , A61P19/04 , A61P21/00 , A61P21/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/16 , A61P35/00 , A61P35/02 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C12N5/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The invention provides a human cell junction PDZ protein (CJPDZ) and polynucleotides which identify and encode CJPDZ. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CJPDZ.

62. 发明授权

US06265547B1 Cell junction PDZ protein 失效
标题翻译：细胞结PDZ蛋白
公开(公告)号：US06265547B1
公开(公告)日：2001-07-24
申请号：US09370102
申请日：1999-08-06
申请人： Henry Yue , Janice Au-Young , Chandra Patterson
发明人： Henry Yue , Janice Au-Young , Chandra Patterson
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , Y02A50/423
摘要： The invention provides a human cell junction PDZ protein (CJPDZ) and polynucleotides which identify and encode CJPDZ. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CJPDZ.
摘要翻译：本发明提供了人类细胞连接PDZ蛋白（CJPDZ）和识别和编码CJPDZ的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与CJPDZ表达相关的疾病的方法。

63. 发明授权

US06444430B1 Ndr2-related proteins 失效
标题翻译： Ndr2相关蛋白
公开(公告)号：US06444430B1
公开(公告)日：2002-09-03
申请号：US09812484
申请日：2001-03-19
申请人： Susan G. Stuart , Janice Au-Young , Jennifer L. Hillman , Purvi Shah , Henry Yue
发明人： Susan G. Stuart , Janice Au-Young , Jennifer L. Hillman , Purvi Shah , Henry Yue
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , C12N2799/026 , C12Q1/6886 , C12Q2600/158
摘要： The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.
摘要翻译：本发明提供了编码Ndr2相关蛋白的cDNA。它还提供使用cDNA，片段，补体及其变体，以及编码的蛋白质，其部分及其抗体用于诊断和治疗癌症，特别是肠，乳腺，子宫，肝，脑和/或癌的癌症肾。本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统。

64. 发明授权

US6080841A Human induced tumor protein 失效
标题翻译：人诱导的肿瘤蛋白
公开(公告)号：US6080841A
公开(公告)日：2000-06-27
申请号：US58376
申请日：1998-04-09
申请人： Janice Au-Young , Phillip R. Hawkins
发明人： Janice Au-Young , Phillip R. Hawkins
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K48/00 , A61P1/00 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/574 , C07K14/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.
摘要翻译：本发明提供鉴定和编码新型人诱导肿瘤蛋白（HITP）的多核苷酸。本发明提供了包含编码HITP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本上纯化的HITP以强制分化并停止癌细胞中的细胞分裂。本发明还描述了利用多核苷酸与编码HITP的转录物和特异性结合HITP的抗HITP抗体杂交的诊断测定法。

65. 发明授权

US6057110A Human hyaluronidase 失效
标题翻译：人透明质酸酶
公开(公告)号：US6057110A
公开(公告)日：2000-05-02
申请号：US213205
申请日：1998-12-17
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N1/21 , C12N9/26 , C12N15/56 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/2408 , A61K38/00
摘要： The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP. The invention also provides for the use of substantially purified HHP and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HHP. Additionally, the invention provides for the use of antisense molecules to hhp in pharmaceutical compositions for treatment of diseases associated with the expression of HHP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of hhp. The present invention also relates to anti-HHP antibodies which specifically bind to HHP.
摘要翻译：本发明提供鉴定和编码新型人透明质酸酶（HHP）的多核苷酸（hhp）。本发明提供了包含编码HHP的核酸序列的基因工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质和用于治疗与HHP表达相关的疾病的药物组合物中使用基本上纯化的HHP及其激动剂。另外，本发明提供了用于治疗与HHP表达相关的疾病的药物组合物中的反义分子在hhp中的用途。本发明还描述了使用包含其多核苷酸，片段或其互补序列的诊断组合物的诊断测定法，其与hhp的基因组序列或转录物杂交。本发明还涉及特异性结合HHP的抗HHP抗体。

66. 发明授权

US6023659A Database system employing protein function hierarchies for viewing biomolecular sequence data 失效
标题翻译：数据库系统采用蛋白质功能层次来观察生物分子序列数据
公开(公告)号：US6023659A
公开(公告)日：2000-02-08
申请号：US812290
申请日：1997-03-06
申请人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
发明人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
IPC分类号： G06F17/30 , G06F19/18 , G06F19/22 , G06F19/28 , G06F7/08
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22
摘要： Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. The hierarchies allow searches for sequences based upon a protein's biological function or molecular function. Also disclosed is a mechanism for automatically grouping new sequences into protein function hierarchies. This mechanism uses descriptive information obtained from "external hits" which are matches of stored sequences against gene sequences stored in an external database such as GenBank. The descriptive information provided with the external database is evaluated according to a specific algorithm and used to automatically group the external hits (or the sequences associated with the hits) in the categories. Ultimately, the biomolecular sequences stored in databases of this invention are provided with both descriptive information from the external hit and category information from a relevant hierarchy or hierarchies.
摘要翻译：公开了一种用于以允许根据一个或多个蛋白质功能层级对序列进行编目和搜索的方式存储生物分子序列信息的关系数据库系统。层次结构允许基于蛋白质的生物学功能或分子功能搜索序列。还公开了一种用于将新序列自动分组成蛋白质功能层级的机制。该机制使用从“外部命中”获得的描述性信息，其是存储在存储在诸如GenBank的外部数据库中的基因序列的存储序列的匹配。根据特定算法对外部数据库提供的描述性信息进行评估，并用于在类别中自动分组外部命中（或命中关联的序列）。最终，存储在本发明的数据库中的生物分子序列具有来自相关层级或等级的外部命中和类别信息的描述性信息。

67. 发明授权

US6008039A Polynucleotide encoding a novel purinergic P.sub.2U receptor 失效
标题翻译：编码新型嘌呤能P2U受体的多核苷酸
公开(公告)号：US6008039A
公开(公告)日：1999-12-28
申请号：US459046
申请日：1995-06-02
申请人： Roger Coleman , Janice Au-Young , Susan G. Stuart , Karl J. Guegler
发明人： Roger Coleman , Janice Au-Young , Susan G. Stuart , Karl J. Guegler
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/12 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/92 , G01N33/53 , G01N33/566 , C12N15/63 , C12N15/85 , C12P19/34
CPC分类号： C12N15/1096 , C07K14/47 , C07K14/705 , C12N9/6472 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic P.sub.U2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.
摘要翻译：本发明提供鉴定和编码在人胎盘中表达的新型嘌呤能PU2受体（PNR）的核苷酸和氨基酸序列。本发明还提供了编码PNR的核苷酸序列的反义分子，用于产生纯化的PNR的表达载体，能够特异性结合PNR的抗体，用于检测PNR编码核苷酸序列的杂交探针或寡核苷酸的遗传工程化宿主用于表达PNR的细胞，以及基于编码PNR的核酸分子或针对多肽PNR产生的抗体的诊断测试。

68. 发明授权

US5958750A Human hyaluronidase 失效
标题翻译：人透明质酸酶
公开(公告)号：US5958750A
公开(公告)日：1999-09-28
申请号：US675507
申请日：1996-07-03
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N1/21 , C12N9/26 , C12N15/56 , C12N15/11 , C12N15/63 , C12N15/85
CPC分类号： C12N9/2408 , A61K38/00
摘要： The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP, and a method for making HHP with the host cells.
摘要翻译：本发明提供鉴定和编码新型人透明质酸酶（HHP）的多核苷酸（hhp）。本发明提供了包含编码HHP的核酸序列的遗传工程表达载体和宿主细胞，以及与宿主细胞一起制备HHP的方法。

69. 发明授权

US5955303A Human chemokine receptor-like protein 失效
标题翻译：人趋化因子受体样蛋白
公开(公告)号：US5955303A
公开(公告)日：1999-09-21
申请号：US812871
申请日：1997-03-06
申请人： Janice Au-Young , Karl J. Guegler , Muzong Cheng
发明人： Janice Au-Young , Karl J. Guegler , Muzong Cheng
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P31/12 , A61P43/00 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7158 , A61K38/00
摘要： The present invention provides a human chemokine receptor-like, protein (NHCR) and polynucleotides which identify and encode NHCR. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of NHCR.
摘要翻译：本发明提供了人类趋化因子受体样蛋白（NHCR）和识别和编码NHCR的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与NHCR表达相关的疾病的方法。

70. 发明授权

US5912130A Human Homolog of the rat G protein gamma-5 subunit 失效
标题翻译：大鼠G蛋白γ-5亚基的人类同源物
公开(公告)号：US5912130A
公开(公告)日：1999-06-15
申请号：US111348
申请日：1998-07-07
申请人： Janice Au-Young , Susan G. Stuart , Lynn E. Murry , Karl J. Guegler , Jeffrey J. Seilhamer
发明人： Janice Au-Young , Susan G. Stuart , Lynn E. Murry , Karl J. Guegler , Jeffrey J. Seilhamer
IPC分类号： A61K48/00 , C07K14/315 , C12N15/12 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/315 , A61K48/00
摘要： The present invention provides a nucleic acid sequence which identifies and encodes a G protein gamma subunit (gpg) which was isolated from human pituitary gland. The invention provides for genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding GPG and for gpg antisense molecules. The invention also provides for purified GPG; antibodies, antagonists and inhibitors which specifically bind GPG; and pharmaceutical compositions and methods of treatment based on GPG antagonists and inhibitors. The invention provides for diagnostic assays which utilize diagnostic compositions comprising nucleic acid sequences, or complements thereof, encoding GPG, purified GPG to be used as a positive control, and antibodies which specifically bind to GPG.
摘要翻译：本发明提供鉴定和编码从人垂体腺分离的G蛋白γ亚基（gpg）的核酸序列。本发明提供了包含编码GPG的核酸序列和gpg反义分子的基因工程表达载体和宿主细胞。本发明还提供纯化的GPG; 特异性结合GPG的抗体，拮抗剂和抑制剂; 以及基于GPG拮抗剂和抑制剂的药物组合物和治疗方法。本发明提供了使用包含核酸序列或其补体的编码GPG，用作阳性对照的纯化GPG以及特异性结合GPG的抗体的诊断组合物的诊断测定。

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