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61. 发明申请

US20100144554A1 METHODS FOR ASSEMBLING PANELS OF CANCER CELL LINES FOR USE IN TESTING THE EFFICACY OF ONE OR MORE PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：用于组装用于测试一种或多种药物组合物的效果的癌细胞细胞系的方法
公开(公告)号：US20100144554A1
公开(公告)日：2010-06-10
申请号：US12607077
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
IPC分类号： C40B50/02 , G06F15/18 , G05B13/00
CPC分类号： G06F19/24 , G06F17/10 , G06F17/11 , G06F17/15 , G06F17/16 , G06F17/17 , G06F19/12 , G06F19/18 , G16H50/50 , G16H50/70
摘要： The present invention relates to algorithms for use in defining genomic subgroups of tumors and cancer cell lines. The present invention also relates to methods for assembling panels of tumors and cancer cell lines according to genomic subgroups for use in testing the efficacy of one or more pharmaceutical compounds in the treatment of subjects suffering from at least one cancer.
摘要翻译：本发明涉及用于定义肿瘤和癌细胞系的基因组亚组的算法。本发明还涉及根据基因组亚组装配肿瘤和癌细胞系的组的方法，用于测试一种或多种药物化合物治疗患有至少一种癌症的受试者的功效。

62. 发明申请

US20100014037A1 Liquid crystal device and methods thereof 有权
标题翻译：液晶装置及其方法
公开(公告)号：US20100014037A1
公开(公告)日：2010-01-21
申请号：US12459153
申请日：2009-06-26
申请人： Ke Zhang , Philip J. Bos , Robert J. Twieg , Na Liu
发明人： Ke Zhang , Philip J. Bos , Robert J. Twieg , Na Liu
IPC分类号： G02F1/1337
CPC分类号： G02F1/133711 , G02F2001/133738 , G02F2001/133742 , Y10T428/1005 , Y10T428/1018 , Y10T428/1023
摘要： Provided is a liquid crystal (LC) device and method thereof. The device comprises (i) a body of liquid crystal, (ii) a first layer comprising a first material, and (iii) a second layer comprising a second material; wherein the first layer is located between the body of liquid crystal and the second layer; the first layer alone aligns the liquid crystal in a first orientation; the second layer alone aligns the liquid crystal in a second orientation; and the first orientation is different from the second orientation. With optimized first layer thickness, the invention can be used in sensor applications to improve detection sensitivity, and in LCD applications with enhanced control over LC pretilt transition.
摘要翻译：提供一种液晶（LC）装置及其方法。该装置包括（i）液晶体，（ii）包含第一材料的第一层，和（iii）包含第二材料的第二层; 其中所述第一层位于所述液晶体和所述第二层之间; 第一层单独将液晶以第一取向对准; 第二层单独使第二取向的液晶对准; 并且第一取向与第二取向不同。通过优化的第一层厚度，本发明可用于传感器应用中，以提高检测灵敏度，并且在液晶显示应用中可以增强对LC预倾斜转换的控制。

63. 发明申请

US20080045555A1 PURINONE DERIVATIVES AS HM74A AGONISTS 有权
公开(公告)号：US20080045555A1
公开(公告)日：2008-02-21
申请号：US11766990
申请日：2007-06-22
申请人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
IPC分类号： A61K31/505 , A61P7/00 , C07D239/00
CPC分类号： C07D487/14 , C07D403/14 , C07D487/04
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.

64. 发明授权

US07135203B2 Flexible circuit with electrostatic damage limiting feature 失效
标题翻译：具有静电损伤限制功能的柔性电路
公开(公告)号：US07135203B2
公开(公告)日：2006-11-14
申请号：US10897139
申请日：2004-07-22
申请人： John B. Scheibner , Ke Zhang , Chee Tat Ee , Juang Meng Mok , Yong Peng Lee
发明人： John B. Scheibner , Ke Zhang , Chee Tat Ee , Juang Meng Mok , Yong Peng Lee
IPC分类号： B05D5/12 , B41M1/12
CPC分类号： G11B5/40 , G11B5/48 , G11B5/484 , H05K1/0259 , H05K1/0393 , H05K1/167 , H05K3/0091 , H05K3/1275 , H05K3/28 , H05K9/0067 , H05K2201/0323 , H05K2201/0329 , H05K2203/0534 , H05K2203/095 , H05K2203/1545
摘要： A flexible circuit incorporating an electrostatic discharge limiting feature, comprising a dielectric substrate selected from polyimide or liquid crystal polymer film having at least one conductive trace coated on at least one surface of the substrate wherein the discharge limiting feature includes a thin conductive polymer coating selectively applied over a at least a portion of the non-critical region of the circuit, said feature reducing the surface resistivity of the circuit to about 104 ohms to about 108 ohms and having tribocharging of less than about 50 V.
摘要翻译：一种包含静电放电限制特征的柔性电路，包括选自聚酰亚胺或液晶聚合物膜的电介质基底，其具有涂覆在基底的至少一个表面上的至少一个导电迹线，其中放电限制特征包括选择性施加的薄导电聚合物涂层在电路的非临界区域的至少一部分上，所述特征将电路的表面电阻率降低到约10欧姆至约10欧姆，并且摩擦充量小于约50V。

65. 发明申请

US20050118643A1 Specific binding agents to hepatocyte growth factor 有权
标题翻译：特异性结合剂对肝细胞生长因子
公开(公告)号：US20050118643A1
公开(公告)日：2005-06-02
申请号：US10893576
申请日：2004-07-16
申请人： Teresa Burgess , Angela Coxon , Larry Green , Ke Zhang
发明人： Teresa Burgess , Angela Coxon , Larry Green , Ke Zhang
IPC分类号： C07K14/74 , C07K16/22 , C07K16/28 , C12N20060101 , G01N33/53
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.
摘要翻译：描述了与肝细胞生长因子（HGF）相互作用的特异性结合剂。描述了通过向HGF施用药学有效量的特异性结合剂来治疗癌症的方法。描述了使用特异性结合剂向HGF检测样品中HGF的量的方法。

66. 发明授权

US5814308A Methods for the treatment of gastrointestinal tract disorders 失效
标题翻译：治疗胃肠道疾病的方法
公开(公告)号：US5814308A
公开(公告)日：1998-09-29
申请号：US622720
申请日：1996-03-26
申请人： Ke Zhang
发明人： Ke Zhang
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61P1/00 , A61P43/00 , A61K38/19 , A61K38/20 , A61K38/30
CPC分类号： A61K38/1833
摘要： Methods for treating gastrointestinal tract disorders by protection, regeneration and repair of intestinal epithelium are described. Macrophage stimulating protein is found to promote colony formation by crypt cells and may be involved in stimulating proliferation of intestinal crypt cells. Also described are pharmaceutical compositions for MSP and methods for identifying substances that stimulate crypt cell proliferation.
摘要翻译：描述了通过保护，再生和修复肠上皮来治疗胃肠道疾病的方法。发现巨噬细胞刺激蛋白促进隐窝细胞的集落形成，并且可能参与刺激肠隐窝细胞的增殖。还描述了用于MSP的药物组合物和用于鉴定刺激隐窝细胞增殖的物质的方法。

67. 发明授权

US09758790B2 Modulating the level of components within plants 有权
公开(公告)号：US09758790B2
公开(公告)日：2017-09-12
申请号：US13584421
申请日：2012-08-13
申请人： Steven Craig Bobzin , Nestor Apuya , Karen Chiang , Elena Doukhanina , Kenneth Feldmann , Boris Jankowski , Daniel Mumenthaler , Joon-Hyun Park , Amr Saad Ragab , Joel Cruz Rarang , Richard Schneeberger , Jennifer E. Van Fleet , Ke Zhang
发明人： Steven Craig Bobzin , Nestor Apuya , Karen Chiang , Elena Doukhanina , Kenneth Feldmann , Boris Jankowski , Emilio Margolles-Clark , Daniel Mumenthaler , Jack Okamuro , Joon-Hyun Park , Amr Saad Ragab , Joel Cruz Rarang , Richard Schneeberger , Jennifer E. Van Fleet , Ke Zhang
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8241 , C07K14/415 , C12N15/8247 , C12N15/8255
摘要： Materials and Methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed. In addition, methods and materials for modulating (e.g., increasing or decreasing) the level of a component (e.g., protein, oil, lignin, carbon, a carotenoid, or a triterpenoid) in plants are disclosed.

68. 发明授权

US08719421B2 Cross domain interaction of a web application 有权
标题翻译： Web应用程序的跨域互动
公开(公告)号：US08719421B2
公开(公告)日：2014-05-06
申请号：US12490577
申请日：2009-06-24
申请人： Xinshen Mao , Li Yi , Ke Zhang
发明人： Xinshen Mao , Li Yi , Ke Zhang
IPC分类号： G06F15/16 , G06F17/00 , G06F3/00 , G06F9/46
CPC分类号： G06F17/3089
摘要： A method and system for cross domain interaction of a Web application are proposed, wherein a Web application belonging to a first domain needs to interact with a service belonging to a second domain. The method comprises: by the Web application, creating an iFrame in a webpage, wherein the iFrame is belonging to the first domain; creating a form in the iFrame; submitting the form to a Web server providing a service belonging to the second domain; and refreshing the iFrame by receiving a response from the Web server, changing the domain, to which the iFrame is belonging, to the second domain, and performing cross domain interaction with the service belonging to the second domain with the information contained in the form.
摘要翻译：提出了一种用于Web应用的跨域交互的方法和系统，其中属于第一域的Web应用需要与属于第二域的服务进行交互。该方法包括：通过Web应用，在网页中创建iFrame，其中iFrame属于第一域; 在iFrame中创建一个表单; 将表单提交给提供属于第二域的服务的Web服务器; 并通过接收来自Web服务器的响应来刷新iFrame，将iFrame所属的域更改为第二个域，并使用表单中包含的信息执行与属于第二个域的服务的跨域交互。

69. 发明申请

US20130229967A1 METHOD AND SYSTEM FOR NETWORK HANDOVER 有权
标题翻译：网络切换的方法和系统
公开(公告)号：US20130229967A1
公开(公告)日：2013-09-05
申请号：US13885397
申请日：2011-02-03
申请人： Ke Zhang
发明人： Ke Zhang
IPC分类号： H04W52/02
CPC分类号： H04W52/0225 , H04W36/0066 , H04W36/14 , H04W52/0238 , H04W76/27 , Y02D70/146
摘要： The disclosure provides a method and a system for network handover. The method includes: during a process that equipment hands over from a current network to another network, a driver receiving a network-disconnected message, and judging whether the network-disconnected message is sent from a Connection Manager (CM); if the network-disconnected message is sent from the CM, the driver reporting, to an operating system, a first signalling which identifies that the current network is disconnected; and if the network-disconnected message is not sent from the CM, the driver reporting, to the operating system, a second signalling which identifies that the current network is connected. By the adoption of the method and the system, power consumption of the equipment can be reduced.
摘要翻译：本公开提供了一种用于网络切换的方法和系统。该方法包括：在设备从当前网络切换到另一网络的过程中，接收网络断开的消息的驾驶员，以及是否从连接管理器（CM）发送所述网络断开的消息; 如果从CM发送网络断开的消息，则驱动程序向操作系统报告标识当前网络断开的第一信令; 并且如果没有从CM发送网络断开的消息，则驱动程序向操作系统报告标识当前网络连接的第二信令。通过采用该方法和系统，可以降低设备的功耗。

70. 发明授权

US08362322B2 Modulating lignin in plants 有权
标题翻译：调节植物中的木质素
公开(公告)号：US08362322B2
公开(公告)日：2013-01-29
申请号：US12446929
申请日：2007-10-26
申请人： Nestor Apuya , Steven Craig Bobzin , Jack Okamuro , Ke Zhang
发明人： Nestor Apuya , Steven Craig Bobzin , Jack Okamuro , Ke Zhang
IPC分类号： A01H5/00 , C12N15/63 , C12N15/82
CPC分类号： C12N15/8255 , C07K14/415
摘要： Materials and methods for modulating (e.g., increasing or decreasing) lignin content in plants are disclosed. For example, nucleic acids encoding lignin-modulating polypeptides are disclosed as well as methods for using such nucleic acids to generate transgenic plants having a modulated lignin content.
摘要翻译：公开了调节（如增加或减少）植物中木质素含量的材料和方法。例如，公开了编码木质素调节多肽的核酸以及使用此类核酸产生具有调节的木质素含量的转基因植物的方法。

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