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61. 发明申请

WO1993013093A1 OXIRANYL METHYL ETHERS EXHIBITING CHIRALITY, AND THEIR USE AS DOPANTS IN LIQUID-CRYSTAL MIXTURES 审中-公开
标题翻译： OXIRANYL METHYL ETHERS展览会，以及它们作为液晶混合物中的鞣剂使用
公开(公告)号：WO1993013093A1
公开(公告)日：1993-07-08
申请号：PCT/EP1992002855
申请日：1992-12-10
申请人： HOECHST AKTIENGESELLSCHAFT , SCHLOSSER, Hubert , WINGEN, Rainer , KALTBEITZEL, Anke , MANERO, Javier
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D405/14 , C07K16/2893 , C09K19/3405 , C09K19/3411 , C09K19/3466 , C09K19/588 , Y10T428/1041
摘要： The novel oxiranyl methyl ethers described are suitable for use in liquid-crystal mixtures since they have high spontaneous-polarization values and features in their molecular structure which make them miscible with other components of liquid-crystal system.

62. 发明申请

WO1993006219A1 SECONDARY-METABOLITE BIOSYNTHESIS GENES FROM ACTINOMYCETES, METHOD OF ISOLATING THEM, AND THEIR USE 审中-公开
标题翻译：来自ACTINOMYCETES的二次代谢生物合成基因，其分离方法及其使用
公开(公告)号：WO1993006219A1
公开(公告)日：1993-04-01
申请号：PCT/EP1992002111
申请日：1992-09-15
申请人： HOECHST AKTIENGESELLSCHAFT , PIEPERSBERG, Wolfgang , STOCKMANN, Michael , TALEGHANI, Kampiz, Mansouri , DISTLER, Jürgen , GRABLEY, Susanne , SICHEL, Petra , BRÄU, Barbara
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C12N15/52
CPC分类号： B82Y15/00 , C12N9/10 , C12N9/1241 , C12N9/92 , C12N15/52 , C12P19/62 , C12Q1/689
摘要： The invention concerns secondary-metabolite biosynthesis genes from actinomycetes, a method of isolating secondary-metabolite genes, in particular 6-deoxysugar biosynthesis genes, from actinomycetes using the gene probes strD, strE, strL and strM from Streptomyces griseus DSM40236, and structurally related genes, as gene probes to screen out the genes snoT (coding for amphotheronolide-B dTDP D-mycosaminyl transferase), snoD (coding for dTDP D-glucose synthase) and snoM (coding for dTDP 4-keto-6-deoxy-D-glucose isomerase) or one or more secondary-metabolite biosynthesis genes from actinomycetes. The invention also concerns the use of a secondary-metabolite biosynthesis genes thus isolated.
摘要翻译：本发明涉及来自放线菌的次级代谢物生物合成基因，使用来自灰色链霉菌DSM40236的基因探针strD，strE，strL和strM以及结构相关基因从放线菌分离次级代谢基因，特别是6-脱氧糖生物合成基因的方法作为筛选基因snoT（编码两性苯妥英B-DTDP D-半乳糖胺转移酶）的基因探针，snoD（编码dTDP D-葡萄糖合成酶）和snoM（编码dTDP 4-酮-6-脱氧-D-葡萄糖异构酶）或来自放线菌的一种或多种次级代谢物生物合成基因。本发明还涉及使用如此分离的次生代谢物生物合成基因。

63. 发明申请

WO1993004142A1 STABILIZED COMPLEX LIGANDS AND THEIR USE IN LIQUID CRYSTAL DISPLAYS 审中-公开
标题翻译：稳定的复合配体及其在液晶显示器中的应用
公开(公告)号：WO1993004142A1
公开(公告)日：1993-03-04
申请号：PCT/EP1992001895
申请日：1992-08-19
申请人： HOECHST AKTIENGESELLSCHAFT , MANERO, Javier , RÖSCH, Norbert
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C09K19/58
CPC分类号： C07D273/00 , C09K19/584 , G02F1/133711
摘要： Decomposable complex ligands may be stabilized by derivating them with blocking secondary or tertiary carbonic or sulfonic acids. Orientation layers and liquid crystal mixtures may be added to these stabilized derivates that cause in FLC displays an increase in contrast and luminosity.

64. 发明申请

WO1992016564A1 BINARY ALLOYS ON THE BASIS OF POLYETHER AMIDES AND CYCLOOLEFIN POLYMERS 审中-公开
标题翻译：基于聚合物和环烯烃聚合物的二元合金
公开(公告)号：WO1992016564A1
公开(公告)日：1992-10-01
申请号：PCT/EP1992000570
申请日：1992-03-16
申请人： HOECHST AKTIENGESELLSCHAFT , BREKNER, Michael-Joachim , HERRMANN-SCHÖNHERR, Otto
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C08C23/00
CPC分类号： C08L65/00 , C08L77/00 , C08L2666/22 , C08L2666/14
摘要： Polymer alloys are produced on the basis of (a) at least a thermoplastic aromatic polyether amide having a molecular weight between 5000 and 40000 and (b) at least a cycloolefin polymer. The percentages by weight of the components amount to 99-50 wt % (a) and 1-50 wt % (b), whereas both percentages add to 100 % of the total alloy. These polymer alloys may be used for producing mouldings.
摘要翻译：基于（a）至少一种分子量在5000和40000之间的热塑性芳族聚醚酰胺和（b）至少一种环烯烃聚合物的基础上生产聚合物合金。组分的重量百分比为99-50重量％（a）和1-50重量％（b），而两个百分数都加到总合金的100％。这些聚合物合金可用于生产模制品。

65. 发明申请

WO1992014775A1 AROMATIC COPOLYAMIDES, PROCESS FOR PRODUCING THE SAME AND THEIR USE FOR PRODUCING SHAPED STRUCTURES 审中-公开
标题翻译：芳香族共聚酰胺，其生产方法及其生产形状结构的用途
公开(公告)号：WO1992014775A1
公开(公告)日：1992-09-03
申请号：PCT/EP1992000392
申请日：1992-02-25
申请人： HOECHST AKTIENGESELLSCHAFT , DELIUS, Ulrich, M. , KREUDER, Willi , WIESNER, Matthias
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C08G69/32
CPC分类号： C08G69/32 , C08G69/265 , C08G69/28
摘要： An aromatic copolyamide that can be dissolved in an organic solvent is disclosed, as well as a process for producing it. The copolyamide has at least 90 mol % repetitive structural units (I), (II), (III), and 0 to 5 mol % terminal groups having the structural units (IV). The sum of the molar proportions of (II) and (III) lies in a ratio comprised between 0.9:1 and 1.1:1 to the molar proportion of (I). At the same time the mutual ratio between the molar proportions of (II) and (III) is comprised between 60:40 and 10:90. These copolyamides are suitable for producing shaped bodies or coatings, as well as for producing fibres, membranes and foils.
摘要翻译：公开了可以溶解在有机溶剂中的芳香族共聚酰胺，以及其制造方法。共聚酰胺具有至少90摩尔％的重复结构单元（I），（II），（III）和具有结构单元（IV）的0至5摩尔％的末端基团。（II）和（III）的摩尔比例之和与（I）的摩尔比例在0.9:1至1.1:1之间。同时，（II）和（III）的摩尔比例之间的相互比例在60:40和10:90之间。这些共聚酰胺适用于生产成型体或涂层，以及用于生产纤维，膜和箔。

66. 发明申请

WO1992013919A1 TERNARY POLYMER ALLOYS BASED ON POLYARYL ETHER KETONES WITH ONE GLASS TEMPERATURE 审中-公开
标题翻译：基于具有一个玻璃温度的聚醚醚酮的第三聚合物合金
公开(公告)号：WO1992013919A1
公开(公告)日：1992-08-20
申请号：PCT/EP1992000082
申请日：1992-01-17
申请人： HOECHST AKTIENGESELLSCHAFT , FALK, Uwe , HERRMANN-SCHÖNHERR, Otto , KREUDER, Willi
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C08L71/10
CPC分类号： C08L79/08 , C08L65/00 , C08L71/00 , C08L2666/18 , C08L2666/14 , C08L2666/22
摘要： Ternary alloys are produced from uniformly mixed polymers (a), (b) and (c) containing as component (a) at least one polyaryl ether ketone, (b) at least one polyimide and (c) at least one polyaryl ester. The limiting viscosity number of (a) is 0.2 to 5.0 dl/g, of (b) 0.1 to 3.0 dl/g and of (c) 0.1 to 2.0 dl/g and the proportions of the components are (a) 45 to 98, (b) 1 to 45 and (c) 1 to 45 % wt. in relation to the total quantity of components (a), (b) and (c) in the alloy. The alloys are especially useful in the production of solid solutions.
摘要翻译：三元合金由含有至少一种聚芳醚酮，（b）至少一种聚酰亚胺和（c）至少一种聚芳酯的组分（a））的均匀混合聚合物（a），（b）和（c）（a）的特性粘度数为0.2〜5.0dl / g，（b）为0.1〜3.0dl / g，（c）为0.1〜2.0dl / g，成分比例为（a）45〜98 ，（b）1〜45和（c）1〜45重量％相对于合金中组分（a），（b）和（c）的总量。该合金在固溶体的生产中特别有用。

67. 发明申请

WO1992013845A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS 审中-公开
标题翻译： ARYL SULPHONYL UREA化合物，其制备方法及其作为除草剂和生长调节剂的用途
公开(公告)号：WO1992013845A1
公开(公告)日：1992-08-20
申请号：PCT/EP1992000304
申请日：1992-02-12
申请人： HOECHST AKTIENGESELLSCHAFT , ORT, Oswald , BAUER, Klaus , BIERINGER, Hermann
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07D239/42
CPC分类号： C07D521/00 , A01N47/36 , C07C311/16 , C07C311/65
摘要： The invention concerns new herbicidal and plant-growth regulation compounds of formula (I), in which Q, W, R , R , R , Y and Z as shown in formula (I) are as defined in claim 1, as well as salts of these compounds. They can be prepared by reacting new compounds of formula (II) with a heterocyclic carbamate of formula (III), in which R' is a substituted or unsubstituted alkyl or aryl group. Also possible is an analogue preparation by reacting a phenyl sulphonyl carbamate or sulphonyl isocyanate corresponding to formula (II) with a compound of formula (V). Such herbicides are particularly suited for the selective control of weeds.
摘要翻译：本发明涉及式（I）的新的除草和植物生长调节化合物，其中式（I）中所示的Q，W，R 1，R 2，R 3，Y和Z如权利要求1中所定义的盐，以及这些化合物的盐。它们可以通过使式（II）的新化合物与式（III）的杂环氨基甲酸酯反应制备，其中R'是取代或未取代的烷基或芳基。还可能的是通过使式（II）化合物与式（Ⅴ）化合物反应的苯基磺酰基氨基甲酸酯或磺酰基异氰酸酯或式（Ⅳ）化合物。这些除草剂特别适用于选择性地控制杂草。

68. 发明申请

WO1992012116A1 PROCESS FOR PRODUCING 2-(DIALKYLOXY METHYL)-CARBOXYLIC ACID ESTERS 审中-公开
标题翻译： 2-（二烷基甲基） - 羧酸酯的制备方法
公开(公告)号：WO1992012116A1
公开(公告)日：1992-07-23
申请号：PCT/EP1991002388
申请日：1991-12-12
申请人： HOECHST AKTIENGESELLSCHAFT , STRUTZ, Heinz
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07C69/708
CPC分类号： C07C67/31 , C07C69/708
摘要： Process for producing 2-(dialkyloxy methyl)-carboxylic acid esters of formula (I) in which: R is a non-aromatic hydrocarbon radical or a heterocyclic non-aromatic radical which, besides O, N and/or S atoms, contains only C and H atoms in the ring, with 1 to 20 C atoms, where radical R can accept 1 to 5 substituents and the substituents may be the same or different and are halogen, an aryl, carbalkoxy, dialkylamino, diarylamino or cyano group or an alkoxy group, where the alkyl is substituted or unsubstituted C1 to C12-alkyl, or an aryloxy group, where the aryl is substituted or unsubstituted C6 to C14-aryl, a substituted or unsubstituted benzyl or phenethyl radical or an R O-(R O)x-R group, where R is substituted or unsubstituted C1 to C12-alkyl or C6 to C14-aryl, R is a branched or unbranched hydrocarbon radical with 1 to 4 C atoms or phenylene and x = 1 to 6, R is hydrogen or alkyl with 1 to 5 C atoms, and R is unsubstituted or substituted C6 to C14-aryl or a radical listed under R , by the oxidising beta acetalisation of acrylic acid esters with R OH alcohols, where R has the significance given, in the presence of oxygen as the oxidising agent and a catalyst system based on one or more metals of the platinum group and/or their compounds and a copper compound, in which the reaction is conducted at a temperature of up to 80 DEG C and the catalyst system contains 1 to 4 equivalent anions related to the sum of the metal atoms and cations, of which at most 3 are equivalent halide ions, where the halogen has a molecular weight of at least 35.
摘要翻译：制备式（I）的2-（二烷基氧基甲基） - 羧酸酯的方法，其中：R 1是非芳族烃基或杂环非芳族基团，除了O，N和/或S原子在环中仅含有C和H原子，具有1至20个C原子，其中基团R 1可以接受1至5个取代基，取代基可以相同或不同，为卤素，芳基，烷氧羰基，二烷基氨基，二芳基氨基或氰基或烷氧基，其中烷基是取代或未取代的C1至C12-烷基或芳氧基，其中芳基是取代或未取代的C6至C14-芳基，取代或未取代的苄基或苯乙基或 R 4 O-（R 5 O）x R 5基团，其中R 4是取代或未取代的C 1至C 12 - 烷基或C 6至C 14 - 芳基，R 5是支链或非支链烃具有1至4个C原子或亚苯基且x = 1至6的基团，R 2为氢或具有1至5个C原子的烷基，R 3为未取代的或取代的C 6至C 14 - 芳基或在R 1所列的基团中，通过丙烯酸酯与R 1 OH醇的氧化β-缩醛化，其中R 1在氧气作为氧化剂存在下具有重要性，并且基于一种或多种铂族金属和/或其化合物的金属和铜化合物，其中反应在高达80℃的温度下进行，并且催化剂体系含有与金属之和相关的1至4当量阴离子原子和阳离子，其中至多3是相当的卤离子，其中卤素的分子量至少为35。

69. 发明申请

WO1992011227A1 METHOD FOR THE CONTINUOUS NITRATION OF NITRABLE AROMATIC COMPOUNDS 审中-公开
标题翻译：硝酸芳香化合物连续硝化方法
公开(公告)号：WO1992011227A1
公开(公告)日：1992-07-09
申请号：PCT/EP1991002357
申请日：1991-12-10
申请人： HOECHST AKTIENGESELLSCHAFT , DETTMEIER, Udo , LANDGRAF, Walter
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07C201/08
CPC分类号： C07C201/08 , C07C205/12
摘要： In a method for continuous nitration of a nitrable aromatic compound, which forms an azeotrope with water, by treating with nitric acid in the presence of nitrating acids, the reaction is carried out with a molar ratio of nitric acid to the aromatic compound of at least 1:1, the temperature and the pressure being coordinated so that the reaction mixture boils, the nitrating acid is recycled without further intermediate treatment, the resulting mixture is extracted with water and the eluate is returned to the reaction to restore the nitrating acid.
摘要翻译：在与硝酸形成共沸物的硝化芳族化合物的连续硝化的方法中，通过在硝酸存在下用硝酸处理，使硝酸至芳族化合物的摩尔比至少为如图1：1所示，温度和压力协调使得反应混合物沸腾，硝酸在不进一步中间处理的情况下再循环，所得混合物用水萃取，洗脱液返回反应以还原硝酸。

70. 发明申请

WO1992007585A1 THE USE OF ANTIBODIES TO TNF OR FRAGMENTS DERIVED THEREOF AND XANTHINE DERIVATIVES FOR COMBINATION THERAPY AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：抗体对TNF或其衍生物的片段的使用和用于组合治疗的Xanthine衍生物及其组合物
公开(公告)号：WO1992007585A1
公开(公告)日：1992-05-14
申请号：PCT/GB1991001907
申请日：1991-10-30
申请人： CELLTECH LIMITED , HOECHST AKTIENGESELLSCHAFT , ANAGNOSTOPULOS, Hiristo , GEBERT, Ulrich , HANEL, Heinz , LIMBERT, Michael , BODMER, Mark, William , HIGGS, Gerald, Anthony
发明人： CELLTECH LIMITED , HOECHST AKTIENGESELLSCHAFT
IPC分类号： A61K39/395
CPC分类号： A61K39/395 , A61K31/52 , A61K2300/00
摘要： A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy or prophylaxis of disorders associated with undesirably high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1-(5-oxo-hexyl)xanthine (known as Pentoxifylline or Trental) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanised recombinant antibody or fragment. The ratio of xanthine derivative to anti-TNF antibody component used may be in the range between 450:1 and 1:10 and doses of anti-TNF component in the range 0.001-30mg/kg/day and doses of xanthine derivative in the range 0.5 to 100mg/kg/day may be administered during treatment of human or animal subjects. It has been found that when an anti-TNF antibody and a xanthine derivative are used together in some experimental models of septic shock, a surprising combination effect is observed.
摘要翻译：用于同时组合，同时分开或顺序使用的联合制剂，用于治疗或预防与不期望的高水平的TNF相关的病症，例如，脓毒性或内毒素性休克和免疫调节性和炎症性疾病，其包含TNF抗体或其TNF结合片段和黄嘌呤衍生物。特别优选的黄嘌呤衍生物是3,7-二甲基-1-（5-氧代 - 己基）黄嘌呤（称为己酮可可碱或特伦塔尔）和1-（5-羟基-5-甲基己基）-3-甲基黄嘌呤和类似化合物。抗TNF抗体或片段优选是单特异性的，特别是人源化的重组抗体或片段。黄嘌呤衍生物与抗TNF抗体组分的比例可以在450:1至1:10的范围内，抗TNF成分的剂量范围为0.001-30mg / kg /天，黄嘌呤衍生物的剂量范围为在人或动物受试者的治疗期间可以施用0.5至100mg / kg /天。已经发现，当在一些感染性休克的实验模型中一起使用抗TNF抗体和黄嘌呤衍生物时，观察到惊人的组合效应。

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