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61. 发明申请

US20100203588A1 POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：诱导针对维生素A的保护性免疫应答的多肽
公开(公告)号：US20100203588A1
公开(公告)日：2010-08-12
申请号：US12720076
申请日：2010-03-09
申请人： Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
发明人： Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
IPC分类号： C12P21/00 , C12N15/31 , C12N15/63 , C12N1/00
CPC分类号： C07K14/31 , A61K39/00
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxylamino acids was found to produce a protective immune response against S. aureus.
摘要翻译：本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列或其片段，金黄色葡萄球菌AhpC-AhpF组合物以及这些多肽和组合物的用途的多肽。 SEQ ID NO：1具有全长金黄色葡萄球菌AhpC序列。发现含有氨基His-标签和三个另外的羧基氨基酸的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。

62. 发明申请

US20100113126A1 HIDING CARD INFORMATION 有权
标题翻译：隐藏卡信息
公开(公告)号：US20100113126A1
公开(公告)日：2010-05-06
申请号：US12263779
申请日：2008-11-03
申请人： Mark A. Miller
发明人： Mark A. Miller
IPC分类号： A63F9/24
CPC分类号： G07F17/32 , G07F17/3227 , G07F17/3293 , G07F19/207
摘要： Example methods and devices are set forth for playing a game. In some embodiments, an inventory of game indicia is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and game indicia are displayed in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any game, can order re-shuffling and re-constitute of the inventory. Other embodiments are described.
摘要翻译：规定了玩游戏的方法和设备。在一些实施例中，游戏标记的清单以随机但已建立的串行顺序排列。在一些实施例中，对于玩家的每一只手，玩家进行下注，并且从库存中顺序显示游戏标记以定义获胜或失败的结果。在一些实施例中，作为手的播放的显示器在任何游戏之前显示库存的剩余选区，并且玩家可以订购重新洗牌和重新组合库存。描述其他实施例。

63. 发明申请

US20100105605A1 FATTY ACID FORMULATIONS AND ORAL DELIVERY OF PROTEINS AND PEPTIDES, AND USES THEREOF 有权
标题翻译：脂肪酸制剂和口服递送蛋白质和肽，及其用途
公开(公告)号：US20100105605A1
公开(公告)日：2010-04-29
申请号：US12581953
申请日：2009-10-20
申请人： Balasingam Radhakrishnan , Diti Aggarwal , Michelle Ferro , Kenneth D. James , Navdeep B. Malkar , Mark A. Miller , Leo Pavliv , Karen Polowy , Monica Puskas , Nnochiri N. Ekwuribe
发明人： Balasingam Radhakrishnan , Diti Aggarwal , Michelle Ferro , Kenneth D. James , Navdeep B. Malkar , Mark A. Miller , Leo Pavliv , Karen Polowy , Monica Puskas , Nnochiri N. Ekwuribe
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： C07K14/62 , A61K9/0095 , A61K9/2013 , A61K9/2018 , A61K33/30 , A61K38/00 , A61K38/28 , A61K45/06 , A61K47/60 , A61K47/69 , A61K2300/00
摘要： Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated for oral administration by ingestion, having from about 0.1 to about 75% w/w fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent. Further, the invention provides a liquid pharmaceutical composition formulated for oral administration by ingestion, comprising: from about 0.1 to about 10% w/v fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent.
摘要翻译：用于施用药剂例如蛋白质和肽，蛋白质和肽缀合物和/或阳离子 - 多肽缀合物复合物的脂肪酸组合物。特别地，本发明提供了一种配制成通过摄取口服给药的固体药物组合物，其具有约0.1至约75％w / w脂肪酸组分，其中脂肪酸组分包含饱和或不饱和C4，C5，C6，C7，C8 ，C9，C10，C11或C12脂肪酸和/或这些脂肪酸的盐; 和治疗剂。此外，本发明提供配制成通过摄取口服给药的液体药物组合物，其包含：约0.1至约10％w / v脂肪酸组分，其中脂肪酸组分包含饱和或不饱和C4，C5，C6，C7，C8 ，C9，C10，C11或C12脂肪酸和/或这些脂肪酸的盐; 和治疗剂。

64. 发明申请

US20100099479A1 STATE SAVE IN GAME 有权
标题翻译：状态保存在游戏中
公开(公告)号：US20100099479A1
公开(公告)日：2010-04-22
申请号：US12255123
申请日：2008-10-21
申请人： Mark A. Miller
发明人： Mark A. Miller
IPC分类号： A63F9/24
CPC分类号： G07F17/3239 , G07F17/32 , G07F17/3227 , G07F17/3286 , G07F17/3293
摘要： Embodiments related to conducting a wagering game according to the rules of a base game includes defining a finite set of game indicia. In some embodiments the player plays multiple sequential game hand by placing a wager, receiving game indicia from the finite set cumulatively excluding any game indicia previously dealt, playing the game hand to completion, collecting the game indicia from the player and excluding the dealt game indicia from further play, and displaying at least the excluded game indicia or any winning combinations precluded by the excluded game indicia. In some embodiments the game hands continue in sequence until a restoration event, which may include a manually triggered restoration or an automatic restoration event, that restores the excluded game indicia. Other embodiments are also described.
摘要翻译：根据基本游戏的规则进行投注游戏的实施例包括限定游戏标记的有限集合。在一些实施例中，玩家通过放置下注来播放多个顺序游戏手，从有限集合累积地接收游戏标记，累积地排除先前处理的任何游戏标记，玩游戏手完成，从玩家收集游戏标记并排除所处理的游戏标记进一步播放，并且至少显示被排除的游戏标记或排除的游戏标记排除的任何获奖组合。在一些实施例中，游戏手继续依次进行，直到恢复事件（其可以包括手动触发的恢复或自动恢复事件）来恢复排除的游戏标记。还描述了其它实施例。

65. 发明授权

US07662773B2 Natriuretic compounds, conjugates, and uses thereof 失效
标题翻译：利尿钠化合物，缀合物及其用途
公开(公告)号：US07662773B2
公开(公告)日：2010-02-16
申请号：US10723933
申请日：2003-11-26
申请人： Kenneth D. James , Balasingam Radhakrishnan , Navdeep B. Malkar , Mark A. Miller , Nnochiri N. Ekwuribe
发明人： Kenneth D. James , Balasingam Radhakrishnan , Navdeep B. Malkar , Mark A. Miller , Nnochiri N. Ekwuribe
IPC分类号： A61K38/03 , A61K8/64
CPC分类号： C08G65/329 , A61K47/60 , C07K14/58 , C07K14/72 , C08L2203/02
摘要： Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
摘要翻译：本发明公开了改良的利尿钠化合物及其缀合物。特别地，提供了缀合形式的hBNP，其包括与其连接的至少一个修饰部分。修饰的利钠化合物缀合物保留用于刺激cGMP产生，与NPR-A受体结合的活性，并且在一些实施方案中，与未修饰的对应利钠化合物相比，循环中的半衰期改善。可以将口服，胃肠外，皮下和静脉内形式的化合物和缀合物制备为用于心脏状况的治疗和/或治疗，特别是充血性心力衰竭。还公开了包含具有各种长度和构型的寡聚结构的修饰部分。还公开了利尿钠化合物的类似物，其具有不同于天然序列的氨基酸序列。

66. 发明申请

US20090104963A1 LASER LOT GENERATOR 审中-公开
标题翻译：激光发电机
公开(公告)号：US20090104963A1
公开(公告)日：2009-04-23
申请号：US11876302
申请日：2007-10-22
申请人： Kevin Burman , Geoffrey M. Gelman , Dean P. Alderucci , Mark A. Miller
发明人： Kevin Burman , Geoffrey M. Gelman , Dean P. Alderucci , Mark A. Miller
IPC分类号： A63F13/00
CPC分类号： G07F17/3244 , G07F17/3223 , G07F17/3279 , G07F17/3286
摘要： In various embodiments multiple numbers may be selected from a spinning roulette wheel.
摘要翻译：在各种实施例中，可以从旋转轮盘赌轮中选择多个数字。

67. 发明申请

US20080148195A1 METHOD AND SYSTEM FOR INSPECTION OPTIMIZATION 失效
标题翻译：检验优化方法与系统
公开(公告)号：US20080148195A1
公开(公告)日：2008-06-19
申请号：US11612439
申请日：2006-12-18
申请人： Kevin Chan , Emmanuel Drege , Nickhil Jakatdar , Svetlana Litvintseva , Mark A. Miller , Francis Raquel
发明人： Kevin Chan , Emmanuel Drege , Nickhil Jakatdar , Svetlana Litvintseva , Mark A. Miller , Francis Raquel
IPC分类号： G06F17/50
CPC分类号： G06F17/5081 , G06F2217/12 , Y02P90/265
摘要： A method and apparatus for inspection optimization is provided. Inspection optimization improves the parametric and functional yield using optimized inspection lists for in-line semiconductor manufacturing metrology and inspection equipment.
摘要翻译：提供了一种用于检查优化的方法和装置。检测优化通过使用优化的在线半导体制造计量和检测设备的检查列表来提高参数和功能产量。

68. 发明授权

US06374779B1 Leash and collar having quick connect/disconnect connector with disconnect control in handle 失效
标题翻译：皮带和衣领具有快速连接/断开连接器，带手柄中的断开控制
公开(公告)号：US06374779B1
公开(公告)日：2002-04-23
申请号：US09357517
申请日：1999-07-19
申请人： Mark A. Miller
发明人： Mark A. Miller
IPC分类号： A01K300
CPC分类号： A01K27/005
摘要： The collar is disconnected from the leash by activating the mechanism in the handle assembly of the leash. The collar is fitted with a short cable which extends generally radially from the collar. A small cylinder or sphere is attached to the free end of this cable. There is a flared fitting at the end of the leash opposite to the handle end. The collar and leash are connected by trapping the cylinder or sphere in the flared fitting. The leash is a sheathed cable. The tension loads in the leash are carried by the cable. One end of the cable is anchored in the leash handle. There is a second cylinder or sphere attached to its other end and located in the flared fitting when the leash and collar are connected. The second cylinder or sphere retains the first in the flared fitting which is attached to the sheath. When the mechanism in the handle is activated, the mechanism moves the sheath along the cable so that the flared fitting is moved and no longer surrounds the cylinders (or spheres) and the one can no longer retain the other and disconnection is effected. In one embodiment of the invention the mechanism in the handle is reset by pulling the sheath out of the handle.
摘要翻译：通过激活皮带手柄组件中的机构，套环与皮带分离。套环配有从套环大致径向延伸的短电缆。一个小圆柱体或球体连接到该电缆的自由端。皮带末端有一个喇叭形的配件，与手柄端相对。套环和皮带通过将圆柱体或球体捕获在扩口配件中而连接。皮带是护套电缆。皮带中的拉力负载由电缆承载。电缆的一端固定在皮带手柄中。当连接皮带和衣领时，有一个连接到另一端的第二个圆柱体或球体，并位于喇叭形配件中。第二圆柱体或球体将第一圆柱体或球体保持在附接到护套的扩口配件中。当手柄中的机构被激活时，机构沿着电缆移动护套，使得扩口配件移动并且不再包围气缸（或球体），并且不再保持另一个并且断开连接。在本发明的一个实施例中，通过将护套从手柄拉出来来复位手柄中的机构。

69. 发明授权

US06244311B1 Method and apparatus for removing and disposing of body fluids 有权
标题翻译：去除和处理体液的方法和装置
公开(公告)号：US06244311B1
公开(公告)日：2001-06-12
申请号：US09239841
申请日：1999-01-29
申请人： Joseph M. Hand , Barry G. Anderson , Michael C. Hollen , Mark A. Miller
发明人： Joseph M. Hand , Barry G. Anderson , Michael C. Hollen , Mark A. Miller
IPC分类号： B65B104
CPC分类号： A61M1/0001 , A61M1/0005
摘要： A medical apparatus and method for draining bodily fluid from a container, such as a suction canister.
摘要翻译：一种用于从诸如抽吸罐的容器排出体液的医疗装置和方法。

70. 发明授权

US5637226A Magnetic fluid treatment 失效
标题翻译：磁流体处理
公开(公告)号：US5637226A
公开(公告)日：1997-06-10
申请号：US516755
申请日：1995-08-18
申请人： LaVern L. Adam , Harley J. Adam , Jimmy D. Adam , Mark A. Miller
发明人： LaVern L. Adam , Harley J. Adam , Jimmy D. Adam , Mark A. Miller
IPC分类号： B01J19/08 , C02F1/48 , F02M27/04 , B01D35/06
CPC分类号： C02F1/481 , B01J19/087 , F02M27/045 , B01J2219/0852
摘要： A fluid is circulated through a region of single magnetic polarity within a complex magnetic field and with increased exposure time as compared to prior art devices. The fluid travels through a coil of tubing arranged between two magnetic fields that interact to form the region of single polarity. In a preferred embodiment, the fields are generated by two sets of magnets, one on the inside of the coil and one on the outside of the coil. The magnets are arranged such that like poles of all the magnets face the tubing in the coil, creating the region of single polarity. Treating fuel or recirculated exhaust gases prior to burning in internal combustion engines results in improved engine output characteristics.
摘要翻译：与现有技术的装置相比，流体在复磁场内循环通过单个磁极区域并且与现有技术的装置相比具有增加的曝光时间。流体穿过布置在两个磁场之间的管线圈，其相互作用以形成单极性区域。在一个优选实施例中，场由两组磁体产生，一组在线圈的内侧，一组位于线圈的外侧上。磁体被布置成使得所有磁体的相似磁极面对线圈中的管道，从而产生单极性的区域。在内燃机燃烧之前对燃料或再循环废气进行处理可改善发动机输出特性。

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