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61. 发明申请

WO2009059945A2 NEW CARBOHYDRATE DERIVATIVES 审中-公开
标题翻译：新型碳水化合物衍生物
公开(公告)号：WO2009059945A2
公开(公告)日：2009-05-14
申请号：PCT/EP2008/064873
申请日：2008-11-03
申请人： Glycom A/S , DEKANY, Gyula , BAJZA, István , BØJSTRUP, Marie , AGOSTON, Karoly , KRÖGER, Lars , PERÉZ, Ignacio Figueroa , RÖHRIG, Christoph , VITAL, Paulo , CZINEGE, Erzsébet
发明人： DEKANY, Gyula , BAJZA, István , BØJSTRUP, Marie , AGOSTON, Karoly , KRÖGER, Lars , PERÉZ, Ignacio Figueroa , RÖHRIG, Christoph , VITAL, Paulo , CZINEGE, Erzsébet
IPC分类号： C07H5/06 , C07H15/12
CPC分类号： C07H15/12 , C07H5/06 , C07H15/203
摘要： 1,2-Dideoxy-1,2-diamino oligosaccharides and polysaccharides as shown in General Formula (1) and derivatives thereof are described, and methods suitable for their preparation in free-base, salt or metal-complexed form. In addition, new uses of 1,2-dideoxy-1,2-diamino oligosaccharides, including the large-scale production of 2-deoxy-2-amino oligosaccharides, are described. General Formula (1) wherein : R 1 , R 2 and R 3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R 1 , R 2 or R 3 is a carbohydrate moiety; R 4 is selected from the group consisting of : H, optionally substituted C 1-20 -alkyl, optionally substituted heteroalkyl, optionally substituted C 2-20 -alkenyl, optionally substituted C 2-20 -alkynyl, optionally substituted C 3-10 -cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
摘要翻译：描述了通式（1）所示的1,2-二脱氧-1,2-二氨基寡糖和多糖及其衍生物，以及适于其以游离碱，盐或金属络合形式制备的方法。此外，还描述了包括大规模生产2-脱氧-2-氨基寡糖的1,2-二脱氧-1,2-二氨基寡糖的新用途。通式（1）其中：R 1，R 2和R 3各自独立地选自H和碳水化合物部分，条件是基团R 1，R 2或R 3中的至少一个是碳水化合物部分; R 4选自：H，任选取代的C 1-20 - 烷基，任选取代的杂烷基，任选取代的C 2-20 - 烯基，任选取代的C 2-20 - 炔基，任选取代的C 3-10 - 环烷基，任选取代的杂环基，任选取代的芳基和任选取代的杂芳基。

62. 发明公开

EP3744725A1 DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOS) OR PRECURSORS THEREOF 审中-公开
公开(公告)号：EP3744725A1
公开(公告)日：2020-12-02
申请号：EP20182361.4
申请日：2012-05-14
申请人： Glycom A/S
发明人： DEKANY, Gyula , CHAMPION, Elise , SCHROVEN, Andreas , JONDELIUS HEDEROS, Markus
IPC分类号： C07H5/04 , C07H1/00 , C07H13/04 , C12P19/04 , C12P19/12 , C12P19/14
摘要： A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises the steps of
a) providing at least one compound or a mixture of the compounds selected from the group consisting of:
- optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof:

wherein
R is a group removable by hydrogenolysis,
R 1 independently of each other is fucosyl or H
R 4 independently of each other is sialyl or H,
provided that the compound of general formula 2 is not R-glycoside of lactose, if provided alone;

- optionally sialylated and/or fucosylated lactose derivatives of general formula 4 and salts thereof:

wherein
R 1 independently of each other is fucosyl or H
R 4 independently of each other is sialyl or H,
provided that the compound of general formula 4 is not lactose, if provided alone;

- lacto-N-tetraose (LNT):

- lacto-N-tetraose (LNT) derivatives of the following formula:

wherein R is a group removable by hydrogenolysis;
- lacto-N-neotetraose (LNnT):

- lacto-N-neotetraose (LNnT) derivatives of the following formula:

wherein R is a group removable by hydrogenolysis;

b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and
c) incubating the mixture obtained according to step b).

63. 发明授权

EP2576578B1 POLYMORPHS OF 2'-O-FUCOSYLLACTOSE AND PRODUCING THEREOF 有权转让
公开(公告)号：EP2576578B1
公开(公告)日：2018-09-19
申请号：EP11789282.8
申请日：2011-06-01
申请人： Glycom A/S
发明人： ÁGOSTON, Károly , BAJZA, István , DEKANY, Gyula , TRINKA, Péter , ÁGOSTON, Ágnes , KÁDÁR, Gábor , DEMKÓ, Sándor , FIGUEROA PÉREZ, Ignacio , JONDELIUS HEDEROS, Markus , HORVÁTH, Ferenc , SCHROVEN, Andreas , VRASIDAS, Ioannis , KOVÁCS-PÉNZES, Piroska , RISINGER, Christian , KALMÁR, László , PIPA, Gergely , BOUTET, Julien , KRÖGER, Lars , RÖHRIG, Christoph
IPC分类号： C07H3/06 , C07H1/06 , A61K31/702 , A61P31/00
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , C07H1/06
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.

64. 发明公开

EP3209673A1 MIXTURES OF HMOs 有权转让
标题翻译： HMOs的混合物
公开(公告)号：EP3209673A1
公开(公告)日：2017-08-30
申请号：EP15852675.6
申请日：2015-10-23
申请人： Glycom A/S
发明人： CHAMPION, Elise , MCCONNELL, Bruce , DEKANY, Gyula
IPC分类号： C07H3/06 , A61K31/702 , A61K31/715 , A61P1/00 , A61P31/00 , A61P37/04 , C07H15/12 , C12P19/18
摘要： The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a)a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2'-FL, a component C, which is -LNFP-II when component B is LNT, or -LNFP-III when component B is LNnT, or -LNDFH-I when component B is LNFP-I, or -DFL when component B is 2'-FL, and a component D, which is -lactose when component A is 3-FL, or -2'-FL when component A is DFL, with the proviso that if component B is 2'-FL,then component A is 3-FL; or consists essentially of: b)3-FL, a component Ewhich is LNT, LNnT or LNFP-I, and a component F, which is -LNFP-II when component E is LNT, or -LNFP-III when component Eis LNnT, or -LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.
摘要翻译：本发明涉及基本上由以下成分组成的人乳寡糖的混合物：a）为3-FL或DFL的组分A，为LNT的组分B，LNnT，LNFP-1或2'-FL，组分C，当组分B是LNT时是-LNFP-II，或当组分B是LNnT时是-LNFP-III，或当组分B是LNFP-1时是-LNDFH-I，或当组分B是2'-FL时是-DFL，当组分A为3-FL时为 - 乳糖的组分D，或当组分A为DFL时为-2'-FL，条件是如果组分B为2'-FL，则组分A为3-FL; 或基本上由以下组成：b）3-FL，作为LNT，LNnT或LNFP-I的组分E，和当组分E是LNT时为-LNFP-II的组分F，或当组分E为LNnT时为-LNFP-III，或当组分E是LNFP-1时的-LNDFH-I，以及制备它们的方法及其用途。

65. 发明授权

EP2536736B1 PRODUCTION OF 6'-O-SIALYLLACTOSE AND INTERMEDIATES 有权
标题翻译：生产6'-O-唾液酸糖和中间体
公开(公告)号：EP2536736B1
公开(公告)日：2017-08-16
申请号：EP11744297.0
申请日：2011-02-21
申请人： Glycom A/S
发明人： PÉREZ FIGUEROA, Ignacio , HORVÁTH, Ferenc , DEKANY, Gyula , ÁGOSTON, Károly , ÁGOSTON, Ágnes , BAJZA, István , BOUTET, Julien , HEDEROS, Markus , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis , RISINGER, Christian
IPC分类号： C07H1/00 , C07H13/04 , C07H15/18
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18

66. 发明公开

EP3161143A1 OLIGOSACCHARIDE PRODUCTION 有权转让
标题翻译：低聚糖生产
公开(公告)号：EP3161143A1
公开(公告)日：2017-05-03
申请号：EP15811450.4
申请日：2015-06-29
申请人： Glycom A/S
发明人： SAMAIN, Eric , PELTIER-PAIN, Pauline , BYCH, Katrine , JOHANSON, Ted , CHAMPION, Elise , DEKANY, Gyula
IPC分类号： C12P19/18 , C12N1/21
CPC分类号： C12P19/18 , C07K14/245 , C12N9/1029 , C12N9/1051 , C12N9/1205 , C12N9/2402 , C12N9/2471 , C12N15/52 , C12Y203/01018 , C12Y204/01149 , C12Y302/01023 , C12Y302/01026
摘要： The invention relates to a genetically modified microorganism for making a recombinant oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source. The one or more genes encoding a sucrose utilization system are preferably one or more genes encoding a heterologous PTS-dependent sucrose utilization transport system, such as the scr genes.
摘要翻译：本发明涉及用于制备重组寡糖的遗传修饰的微生物，优选3-8个单糖单位，更优选3-5个单糖单位，尤其是HMO，其包含一个或多个编码蔗糖利用系统的基因，因此微生物可以使用蔗糖作为碳源和能源。编码蔗糖利用系统的一个或多个基因优选为编码异源PTS依赖性蔗糖利用转运系统的一个或多个基因，例如scr基因。

67. 发明公开

EP2935301A1 METHOD FOR MAKING N-SUBSTITUTED MANNOSAMINE DERIVATIVES 审中-公开
标题翻译：工艺制备N-取代衍生物MANNO SAMI
公开(公告)号：EP2935301A1
公开(公告)日：2015-10-28
申请号：EP13814546.1
申请日：2013-12-20
申请人： Glycom A/S
发明人： VRASIDAS, Ioannis , VLÁD, Gábor , DEKANY, Gyula
IPC分类号： C07H15/18
CPC分类号： C07H5/06 , C07H15/18
摘要： The invention relates to a method for making an
N -substituted D-mannosamine derivative of the following formula 1 and its salts wherein R
1 is a non-electron-withdrawing group,and wherein R
2 is -OH or R
2 is –NHR
3 wherein R
3 is a group removable by hydrogenolysis; by epimerizingan
N -substituted D-glucosamine derivative of the following formula 2 wherein R
1 and R
2 are as defined above.

68. 发明公开

EP2864492A1 MODIFIED GALACTOOLIGOSACCHARIDES 审中-公开
标题翻译：改进的低聚半乳糖
公开(公告)号：EP2864492A1
公开(公告)日：2015-04-29
申请号：EP13806185.8
申请日：2013-06-24
申请人： Glycom A/S
发明人： CHAMPION, Elise , MOLNÁR-GÁBOR, Dóra , DEKANY, Gyula
IPC分类号： C12P19/18 , A23L1/09 , A61K31/702
CPC分类号： C07H3/06 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/40 , A23V2002/00 , C12P19/04 , C12P19/18
摘要： The invention relates to a method for making modified galactooligosaccharides comprising the step of enzymatic glycosylation, the modified galactooligosaccharides obtainable by the method and consumable products containing them.

69. 发明公开

EP2707493A1 METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF 审中-公开
标题翻译：用于生产人乳寡糖或其前体
公开(公告)号：EP2707493A1
公开(公告)日：2014-03-19
申请号：EP12785846.2
申请日：2012-05-14
申请人： Glycom A/S
发明人： DEKANY, Gyula , CHAMPION, Elise , SCHROVEN, Andreas , HEDEROS, Markus
IPC分类号： C12P19/18 , C07H5/04 , C07H17/02 , C07H17/04 , C12P19/44
CPC分类号： C12P19/14 , A23L33/40 , C07H9/06 , C07H17/02 , C07H17/04 , C07H17/075 , C07H19/01 , C08B37/006 , C12P19/04 , C12P19/12 , C12P19/18 , C12Y302/0114
摘要： A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method and uses and compositions involving such compounds. The method comprising the steps of a) Providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) Providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) Providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) Preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a),b) and c); and e) Incubating the mixture prepared according to step d).

70. 发明公开

EP2678348A1 NOVEL GLYCOSYL PHOSPHITES 审中-公开
标题翻译：新的糖基磷酸酯
公开(公告)号：EP2678348A1
公开(公告)日：2014-01-01
申请号：EP12749547.1
申请日：2012-02-21
申请人： Glycom A/S
发明人： FIGUEROA PÉREZ, Ignacio , HORVÁTH, Ferenc , DEKANY, Gyula , RISINGER, Christian , HEDEROS, Markus
IPC分类号： C07H11/04
CPC分类号： A61K31/702 , C07H3/06 , C07H11/04 , C07H13/04 , C07H15/18
摘要： The present invention relates to providing compounds of general formula (1) wherein A is glycosyl residue of a mono-, di- or oligosaccharide in protected form and R is selected from optionally substituted aryl or optionally substituted heteroaryl, methods for their preparation and their use in glycosidation reactions.
摘要翻译：本发明涉及提供通式（1）的化合物，其中A为被保护形式的单糖，二糖或寡糖的糖基残基，并且R选自任选取代的芳基或任选取代的杂芳基，它们的制备方法和它们的用途在糖苷化反应中。

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