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61. 发明授权

US4748257A 4-fluoro-3-phenoxy-benzaldehyde acetals 失效
标题翻译： 4-氟-3-苯氧基 - 苯甲醛缩醛
公开(公告)号：US4748257A
公开(公告)日：1988-05-31
申请号：US887471
申请日：1986-07-21
申请人： Rainer Fuchs , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Erich Klauke
发明人： Rainer Fuchs , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Erich Klauke
IPC分类号： C07B61/00 , C07C41/00 , C07C41/48 , C07C41/50 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/59 , C07C45/63 , C07C47/55 , C07C47/575 , C07C67/00 , C07D317/16 , C07D317/22 , C07D319/06 , C07C43/303
CPC分类号： C07D317/22 , C07C45/292 , C07C45/305 , C07C45/59 , C07C45/63 , C07C47/55 , C07C47/575 , C07D317/16
摘要： The new compound ##STR1## is prepared and converted to the new acetal ##STR2## which is reacted with an alkali phenolate or alkaline earth metal phenolate in the presence of copper or a copper compound as a catalyst and in the presence of a diluent at a temperature between about 100.degree. and 200.degree. C. to produce the new acetal ##STR3## which can be hydrolyzed to the corresponding aldehyde which is a known intermediate for pyrethroid-like insecticides.
摘要翻译：制备新的化合物＆lt; IMAGE＆gt;并将其转化成新的缩醛＆lt; IMAGE＆gt;其在铜或铜化合物作为催化剂的存在下与碱性酚盐或碱土金属酚盐反应，并在稀释剂温度在约100℃至200℃之间，以产生可以水解成相似的醛的新的缩醛“IMAGE”，其是拟除虫菊酯类杀虫剂的已知中间体。

62. 发明授权

US4424166A Preparation of 1,1-dihalogeno-alkenes 失效
标题翻译：制备1,1-二卤代烯烃
公开(公告)号：US4424166A
公开(公告)日：1984-01-03
申请号：US237005
申请日：1981-02-23
申请人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C69/743 , C07C17/00 , C07C17/26 , C07C17/263 , C07C21/02 , C07C21/17 , C07C22/00 , C07C22/02 , C07C22/04 , C07C22/08 , C07C45/00 , C07C49/567 , C07C51/00 , C07C61/40 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/38 , C07C253/00 , C07C255/48 , C07C121/48 , C07C61/35 , C07C121/66
CPC分类号： C07C17/263
摘要： In the preparation of a 1,1-dihalogenoalkene of the formula ##STR1## in which R.sup.1 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, and R.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, or R.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain, and X.sup.1 and X.sup.2 each independently is a halogen atom, wherein a carbonyl compound of the formula ##STR2## is reacted with a trihalogenoacetate of the formula ##STR3## in which X.sup.3 is a halogen atom, and M.sup..sym. is an alkali metal ion or one equivalent of an alkaline earth metal ion, in the presence of an approximately equimolar amount of a phosphorus-containing compound, the improvement which comprises employing as said phosphorus-containing compound a phosphorous acid trialkyl ester or a phosphorous acid triamide and effecting the reaction at a temperature between about 0.degree. and 200.degree. C. A preferred end product is ##STR4## and the preferred phosphorus-containing compound is trimethyl phosphite, triethyl phosphite, tripropyl phosphite or phosphorous acid tris-dimethyl-amide.
摘要翻译：在制备其中R 1为氢原子或任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基的式“IMAGE”的1,1-二卤代烯烃中，R 2为任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基，或R 1和R 2一起形成任选支链和/或任选的苯并稠合烃链，并且X 1和X 2各自独立地为卤素原子，其中式与式（X3）中的X为卤素原子的式（III）的三卤代乙酸酯反应，M（+）为碱金属离子或1当量碱土金属离子，在大约等摩尔量存在下的含磷化合物，其改进包括使用磷酸三烷基酯或亚磷酸三酰胺作为所述含磷化合物，并在约0℃至200℃的温度下进行反应。优选的最终产物是“IMAGE”，优选的含磷化合物是亚磷酸三甲酯，亚磷酸三乙酯，亚磷酸三丙酯或亚磷酸三 - 二甲基 - 酰胺。

63. 发明授权

US4348538A Preparation of 3-bromo-4-fluoro-benzaldehyde acetals and intermediates therefor 失效
标题翻译：制备3-溴-4-氟 - 苯甲醛缩醛及其中间体
公开(公告)号：US4348538A
公开(公告)日：1982-09-07
申请号：US302913
申请日：1981-09-16
申请人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Bernd Gallenkamp , Erich Klauke
发明人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Bernd Gallenkamp , Erich Klauke
IPC分类号： C07C41/00 , C07C41/50 , C07C43/30 , C07C43/313 , C07C51/00 , C07C59/84 , C07C59/88 , C07C67/00 , C07C241/00 , C07C251/24 , C07C253/00 , C07C255/40 , C07C255/56 , C07C59/153 , C07C119/10 , C07C121/76
CPC分类号： C07C255/00 , C07C41/50 , C07C59/88
摘要： A process for the preparation of a 3-bromo-4-fluoro-benzaldehyde acetal of the formula: ##STR1## in which R each independently is a C.sub.1 to C.sub.4 alkyl group or the radicals R together are a C.sub.2 to C.sub.5 alkanediyl radical,comprising reacting 3-bromo-4-fluoro-phenylglyoxylic acid of the formula: ##STR2## with an amine of the formula:H.sub.2 N--R.sup.1in whichR.sup.1 is an alkyl, cycloalkyl or aryl radical, at a temperature between about 0.degree. and 200.degree. C. to produce a 3-bromo-4-fluoro-benzaldimine of the formula: ##STR3## and reacting that with an alcohol or alkanediol of the formula:(HO).sub.n --Rin which n is 1 or 2 in the presence of sulphuric acid at a temperature between about 0.degree. and 100.degree. C. Various of the reactants are new and syntheses are given.
摘要翻译：制备下式的3-溴-4-氟 - 苯甲醛缩醛的方法：其中R各自独立地为C1至C4烷基或基团R一起为C 2至C 5烷二基，其包含将下式的3-溴-4-氟 - 苯基乙醛酸与下式的胺反应：其中R1是烷基，环烷基或芳基，在约0〜200℃的温度下，式：H 2 N-R 1 得到下式的3-溴-4-氟 - 苯甲醛二亚胺，并使其与硫酸存在下，其中n为1或2的式（HO）n R的醇或链烷二醇反应在约0℃和100℃之间的温度下进行。各种反应物是新的并且给出合成。

64. 发明授权

US4342704A Process for the preparation of 1,1-dichloroalkenes 失效
标题翻译：制备1,1-二氯烯烃的方法
公开(公告)号：US4342704A
公开(公告)日：1982-08-03
申请号：US165872
申请日：1980-07-02
申请人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C17/263 , C07B31/00 , C07B37/04 , C07C17/00 , C07C17/26 , C07C21/19 , C07C22/00 , C07C22/04 , C07C25/28 , C07C45/00 , C07C45/41 , C07C45/54 , C07C45/68 , C07C49/355 , C07C49/557 , C07C62/18 , C07C67/00 , C07C253/00 , C07C255/48 , C07F9/40 , C07F9/42 , C07C120/00 , C07C45/61 , C07C102/00 , C07C121/48
CPC分类号： C07C17/2635 , C07C21/19 , C07C22/00 , C07C22/04 , C07C25/28 , C07C45/41 , C07C45/54 , C07C45/68 , C07C49/355 , C07C62/18 , C07F9/4006 , C07F9/4018 , C07F9/4065 , C07F9/42
摘要： A process for the preparation of a 1,1-dichloroalkene of the formula ##STR1## in which R.sup.1 is hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, aralkyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, aralkyl, aralkenyl or aryl radical, or cycloalkyl which is optionally substituted by halogen, alkyl, alkanoyl, carbamoyl, cyano or phenyl, orR.sup.1 and R.sup.2 together form a hydrocarbon chain which is optionally branched and/or optionally contains a fused benzene ring,comprising reacting an aldehyde or ketone of the formula ##STR2## with a dichloromethane-phosphonic acid ester of the formula ##STR3## in which R.sup.3 each independently is alkyl or phenyl or the two radicals R.sup.3 together are alkanediyl,in the presence of a base at a temperature between about -50.degree. and +50.degree. C. Preferably either the base is metered into a mixture of the aldehyde or ketone and phosphonic acid ester or the ester is added to a mixture of the base and aldehyde or ketone.
摘要翻译：制备式“IMAGE”的1,1-二氯烯烃的方法，其中R 1为氢或任选取代的烷基，烯基，炔基，芳烷基或芳基，R 2为任选取代的烷基，烯基，炔基，芳烷基，芳烯基或芳基，或任选被卤素，烷基，烷酰基，氨基甲酰基，氰基或苯基取代的环烷基，或R 1和R 2一起形成任选支链和/或任选地含有稠合苯环的烃链，包括使式“IMAGE”的醛或酮与式“IMAGE”的二氯甲烷 - 膦酸酯反应，其中R 3各自独立地为烷基或苯基，或两个基团R 3一起为烷二基，在碱的存在下，温度在约-50℃和+ 50℃之间。优选地将碱定量为醛或酮和膦酸酯的混合物，或将酯加入到碱和醛或酮的混合物中。

65. 发明授权

US4626601A Preparation of 4-fluoro-3-phenoxy-benzal-dehyde acetals and intermediates therefor 失效
标题翻译：制备4-氟-3-苯氧基 - 苯甲醛 - 脱水缩醛及其中间体
公开(公告)号：US4626601A
公开(公告)日：1986-12-02
申请号：US303657
申请日：1981-09-18
申请人： Rainer Fuchs , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Erich Klauke
发明人： Rainer Fuchs , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Erich Klauke
IPC分类号： C07B61/00 , C07C41/00 , C07C41/48 , C07C41/50 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/59 , C07C45/63 , C07C47/55 , C07C47/575 , C07C67/00 , C07D317/16 , C07D317/22 , C07D319/06 , C07C47/52
CPC分类号： C07D317/22 , C07C45/292 , C07C45/305 , C07C45/59 , C07C45/63 , C07C47/55 , C07C47/575 , C07D317/16
摘要： The new compound ##STR1## is prepared and converted to the new acetal ##STR2## which is reacted with an alkali phenolate or alkaline earth metal phenolate in the presence of copper or a copper compound as a catalyst and in the presence of a diluent at a temperature between about 100.degree. and 200.degree. C. to produce the new acetal ##STR3## which can be hydrolyzed to the corresponding aldehyde which is a known intermediate for pyrethroid-like insecticides.
摘要翻译：制备新的化合物＆lt; IMAGE＆gt;并将其转化成新的缩醛＆lt; IMAGE＆gt;其在铜或铜化合物作为催化剂的存在下与碱性酚盐或碱土金属酚盐反应，并在稀释剂温度在约100℃至200℃之间，以产生可以水解成相似的醛的新的缩醛“IMAGE”，其是拟除虫菊酯类杀虫剂的已知中间体。

66. 发明授权

US4492800A Process for the preparation of 1,1-dichloro-alkenes 失效
标题翻译： 1,1-二氯 - 烯烃的制备方法
公开(公告)号：US4492800A
公开(公告)日：1985-01-08
申请号：US468786
申请日：1983-02-22
申请人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C69/743 , C07C17/00 , C07C17/26 , C07C17/263 , C07C21/04 , C07C21/19 , C07C22/00 , C07C22/02 , C07C22/04 , C07C45/00 , C07C49/567 , C07C51/00 , C07C61/40 , C07C67/00 , C07C253/00 , C07C255/48 , C07C69/74 , C07C121/48 , C07C121/60
CPC分类号： C07C17/2635 , C07C21/19
摘要： A process for the preparation of a 1,1-dichloro-alkene of the formula ##STR1## in which R.sup.1 is hydrogen, or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain,comprising reacting a carbonyl compound of the formula ##STR2## with a trichloromethanephosphonic acid ester of the formula ##STR3## in which R.sup.3 each individually is an alkyl or phenyl radical, or together are alkanediyl,in the presence of at least an equimolar amount of magnesium. Advantageously,R.sup.1 is hydrogen,R.sup.2 is a C.sub.2 to C.sub.5 alkenyl radical or a radical of the formula ##STR4## Z is a cyano, acetal, carboxyl or C.sub.1 to C.sub.4 alkoxycarbonyl radical, or a radical of the formula COOM, andM is sodium or potassium,R.sup.3 each individually is a C.sub.1 to C.sub.4 alkyl or phenyl radical, or the two radicals R.sup.3 together are C.sub.2 to C.sub.5 alkanediyl,about 0.95 to 1.4 moles of the trichloromethanephosphonic acid ester and about 1.5 to 4 moles of magnesium are employed per mole of the carbonyl compound, and the reaction is carried out at a temperature between about 0.degree. and 150.degree. C. in a polar aprotic solvent. The products are known intermediates, especially for insecticides.
摘要翻译：制备其中R 1为氢或任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基的式“IMAGE”的1,1-二氯 - 烯烃的方法，R 2为任选地取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基，或者R 1和R 2一起形成任选支链和/或任选的苯并稠合烃链，包括使式IMA的羰基化合物与三氯甲烷膦酸酯，其中R 3各自独立地是烷基或苯基，或者在至少等摩尔量的镁的存在下一起是烷二基。有利地，R 1是氢，R 2是C 2至C 5链烯基或下式的基团Z是氰基，缩醛，羧基或C 1至C 4烷氧基羰基，或式COOM的基团，M是钠或钾，R 3各自独立地为C 1至C 4烷基或苯基，或两个基团R 3一起为C 2至C 5烷二基，每摩尔使用约0.95至1.4摩尔三氯甲烷膦酸酯和约1.5至4摩尔镁的羰基化合物，并且反应在极性非质子溶剂中在约0℃至150℃的温度下进行。该产品是已知的中间体，特别是杀虫剂。

67. 发明授权

US4420435A Alpha-hydroxy-phosphonic acid esters 失效
标题翻译： α-羟基膦酸酯
公开(公告)号：US4420435A
公开(公告)日：1983-12-13
申请号：US391092
申请日：1982-06-22
申请人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C17/26 , C07C25/24 , C07C45/41 , C07C45/54 , C07C45/56 , C07C45/68 , C07C49/355 , C07C49/567 , C07C61/40 , C07F9/40
CPC分类号： C07C17/2635 , C07C25/24 , C07C45/41 , C07C45/54 , C07C45/56 , C07C45/68 , C07C49/355 , C07C49/567 , C07C61/40 , C07F9/4018 , C07F9/4056 , C07F9/4065
摘要： Styryl-cyclopropane derivatives of the formula ##STR1## in which R.sup.9 represents independently of one another when n=2, halogen, cyano, nitro, or an optionally halogen-substituted alkyl, alkoxy, alkylthio or alkylenedioxy radical,n represents zero, 1, 2, 3, 4 or 5,R.sup.10 represents hydrogen or halogen, and,Y represents acetyl, cyano or carbamoyl, are produced by reacting a benzylphosphonic acid ester of the formula ##STR2## in which R.sup.4 each independently represents alkyl or phenyl or together represent alkylene,with a formylcyclopropane derivative of the formula ##STR3## or by reacting an .alpha.-hydroxyphosphonic acid ester of the formula ##STR4## with an olefinating agent of the formula ##STR5## in which Z' represents a phosphorus-containing radical ##STR6## or --P(R.sup.7).sub.3.sup..sym. X.sup..crclbar. whereinR.sup.5 and R.sup.6 are identical or different and individually represent alkyl, phenyl, alkoxy or phenoxy or R.sup.5 and R.sup.6 together represent alkanedioxy,R.sup.7 represents alkyl or phenyl andX represents halogen,in the presence of a base at a temperature between about -70 and +150.degree. C. Other olefins can be similarly prepared. Many intermediates are new and the end products are themselves intermediates for insecticides.
摘要翻译： n = 2时，R 9彼此独立地表示卤素，氰基，硝基或任选卤素取代的烷基，烷氧基，烷硫基或亚烷基二氧基，其中R 1表示0， 2，3，4或5，R 10表示氢或卤素，Y表示乙酰基，氰基或氨基甲酰基，是通过使式“IMAGE”的苄基膦酸酯反应而得的，其中R4各自独立地表示烷基或苯基，亚烷基与式IMAMA的甲酰基环丙烷衍生物反应，或通过使式“IMAGE”的α-羟基膦酸酯与式“IMAGE”的烯烃化剂反应，其中Z'代表含磷基团“IMAGE” 或-P（R 7）3（+）X（ - ）其中R 5和R 6相同或不同，并且各自表示烷基，苯基，烷氧基或苯氧基或R 5和R 6一起表示烷二氧基，R 7表示烷基或苯基，X表示卤素，在presen ce在约-70至+ 150℃之间的温度下进行。其它烯烃可以类似地制备。许多中间体是新的，最终产品本身是杀虫剂的中间体。

68. 发明授权

US4386035A Intermediates for preparation of 3-bromo-4-fluoro-benzyl alcohol 失效
标题翻译：用于制备3-溴-4-氟 - 苄醇的中间体
公开(公告)号：US4386035A
公开(公告)日：1983-05-31
申请号：US301510
申请日：1981-09-14
申请人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Rainer Fuchs , Erich Klauke
发明人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel , Rainer Fuchs , Erich Klauke
IPC分类号： C07C29/136 , B01J27/00 , C07C27/00 , C07C29/147 , C07C33/46 , C07C63/70 , C07C67/00 , C07C69/96
CPC分类号： C07C29/147 , C07C51/56
摘要： A process for the preparation of 3-bromo-4-fluoro-benzyl alcohol of the formula ##STR1## comprising reacting 3-bromo-4-fluoro-benzoic acid or a derivative thereof of the formula ##STR2## in which R is a hydrogen atom, an alkyl radical or an alkoxycarbonyl radical,with a complex hydride of the formulaM(M'H.sub.4)in whichM is lithium, sodium or potassium, andM' is boron or aluminum,at a temperature between about -20.degree. and +150.degree. C. When R is alkoxycarbonyl the starting material can be produced by reacting the corresponding free acid with a chloroformic acid ester. Compounds wherein R is alkyl or alkoxycarbonyl are new. The end product is a known intermediate for insecticides.
摘要翻译：制备式“IMAGE”的3-溴-4-氟 - 苯甲醇的方法，包括使3-溴-4-氟 - 苯甲酸或其中R为氢的式“IMAGE”的衍生物原子，烷基或烷氧基羰基与式M（M'H4）的复合氢化物，其中M是锂，钠或钾，M'是硼或铝，在约-20℃和 +150℃。当R为烷氧基羰基时，可通过使相应的游离酸与氯甲酸酯反应来制备原料。其中R是烷基或烷氧基羰基的化合物是新的。最终产品是已知的杀虫剂中间体。

69. 发明授权

US4350824A Process for the preparation of 1,1-dichloro-alkenes 失效
标题翻译： 1,1-二氯 - 烯烃的制备方法
公开(公告)号：US4350824A
公开(公告)日：1982-09-21
申请号：US236484
申请日：1981-02-23
申请人： Hans-Jochem Riebel , Fritz Maurer , Uwe Priesnitz
发明人： Hans-Jochem Riebel , Fritz Maurer , Uwe Priesnitz
IPC分类号： C07C69/013 , C07C17/00 , C07C17/26 , C07C17/263 , C07C21/073 , C07C21/19 , C07C21/22 , C07C22/00 , C07C22/02 , C07C22/04 , C07C25/24 , C07C41/00 , C07C43/225 , C07C45/00 , C07C49/567 , C07C51/00 , C07C61/40 , C07C67/00 , C07C201/00 , C07C205/09 , C07C231/00 , C07C231/12 , C07C233/38 , C07C253/00 , C07C255/48 , C07C255/50 , C07C21/20 , C07C67/307
CPC分类号： C07C21/19 , C07C17/2635
摘要： A process for the preparation of a 1,1-dichloroalkene of the formula ##STR1## in which R.sup.1 is hydrogen, or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain,comprising reacting a carbonyl compound of the formula ##STR2## with a trichloromethanephosphonic acid ester of the formula ##STR3## in which R.sup.3 each individually is an alkyl or phenyl radical, or the two radicals R.sup.3 together are alkanediyl,in the presence of at least an equimolar amount of a phosphorous acid triamide of the formulaP(NR.sup.4.sub.2).sub.3in whichR.sup.4 each independently is an alkyl radical, or the two radicals R.sup.4 together are alkanediyl.Advantageously,R.sup.1 is hydrogen,R.sup.2 a C.sub.2 to C.sub.5 alkenyl radical, or a radical of the formula ##STR4## Z is a cyano, acetyl, carboxyl or C.sub.1 to C.sub.4 alkoxycarbonyl radical, or a radical of the formula --COOM,M is sodium or potassium, andR.sup.3 each individually is a C.sub.1 to C.sub.4 alkyl or phenyl radical,or the two radicals R.sup.3 together are C.sub.2 to C.sub.5 alkandiyl, the phosphorous acid triamide is phosphorous acid tris-dimethylamide or tris-diethylamide, about 0.94 to 1.1 moles of each of trichloromethanephosphonic acid ester and of the phosphorous acid triamide are employed per mole of the carbonyl compound, and the reaction is effected at about 10.degree. to 100.degree. C. in a polar aprotic solvent.
摘要翻译：制备其中R 1为氢或任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基的式“IMAGE”的1,1-二氯烯的方法，R 2为任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基，或者R 1和R 2一起形成任选支链和/或任选的苯并稠合烃链，包括使下式的羰基化合物与下式的三氯甲烷膦酸酯在其中R 3各自独立地为烷基或苯基，或两个基团R 3一起为烷二基的式“IMAGE”中，在至少等摩尔量的式P（NR42）3的亚磷酸三酰胺存在下，式 R4各自独立地是烷基，或者两个基团R4一起是烷二基。有利地，R 1是氢，R 2是C 2至C 5链烯基，或下式的基团Z是氰基，乙酰基，羧基或C 1至C 4烷氧基羰基，或式-COOM基团，M是钠或钾，R3各自为C1至C4烷基或苯基，或两个基团R3一起为C 2至C 5亚烷基，亚磷酸三酰胺为亚磷酸三 - 二甲基酰胺或三 - 二乙基酰胺，约0.94至1.1摩尔每摩尔羰基化合物使用三氯甲烷膦酸酯和亚磷酸三酰胺中的每一种，并且在极性非质子溶剂中在约10℃至100℃下进行反应。

70. 发明授权

US4332745A Preparation of 2-cyano-3,3-dimethyl-cyclopropane-1-carboxylic acid esters and intermediates therefor 失效
标题翻译：制备2-氰基-3,3-二甲基 - 环丙烷-1-羧酸酯及其中间体
公开(公告)号：US4332745A
公开(公告)日：1982-06-01
申请号：US153298
申请日：1980-05-27
申请人： Fritz Maurer , Hans-Jochem Riebel , Uwe Priesnitz
发明人： Fritz Maurer , Hans-Jochem Riebel , Uwe Priesnitz
IPC分类号： C07C255/48 , C07C20060101 , C07C61/04 , C07C67/00 , C07C69/74 , C07C253/00 , C07C255/45 , C07C120/00 , C07C121/16 , C07C121/46
CPC分类号： C07C255/00
摘要： A process for the preparation of a 2-cyano-3,3-dimethyl-cyclopropane-1-carboxylic acid ester of the formula ##STR1## in which R is optionally substituted alkyl,comprising reacting a 3-halogeno-3-cyano-2,2-dimethyl-propane-1-carboxylic acid ester of the formula ##STR2## in which X is halogen,with a base at a temperature from about 0 to 100.degree. C. The starting esters are new and may be prepared by halogenating a compound of the formula ##STR3## and decarboxylating.
摘要翻译：制备式“IMAGE”的2-氰基-3,3-二甲基 - 环丙烷-1-羧酸酯的方法，其中R是任选取代的烷基，包括使3-卤代-3-氰基-2- ，其中X为卤素的式“IMAGE”的2-二甲基 - 丙烷-1-羧酸酯与碱在约0至100℃的温度下反应。起始酯是新的，可以通过将式“IMAGE”的化合物和脱羧基。

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