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61. 发明专利

PH12015501996B1 HETEROCYCLIC COMPOUNDS AND USES THEREOF 未知
公开(公告)号：PH12015501996B1
公开(公告)日：2016-01-11
申请号：PH12015501996
申请日：2015-09-08
申请人： PLEXXIKON INC
发明人： ZHANG JIAZHONG , BUELL JOHN , CHAN KATRINA , IBRAHIM PRABHA N , LIN JACK , PHAM PHUONGLY , SHI SONGYUAN , SPEVAK WAYNE , WU GUOXIAN , WU JEFFREY
IPC分类号： A61K31/437 , A61P35/00 , C07D471/04
摘要： Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

62. 发明专利

PH12015501996A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF 未知
公开(公告)号：PH12015501996A1
公开(公告)日：2016-01-11
申请号：PH12015501996
申请日：2015-09-08
申请人： PLEXXIKON INC
发明人： JIAZHONG ZHANG , JOHN BUELL , KATRINA CHAN , IBRAHIM PRABHA N , JACK LIN , PHUONGLY PHAM , SONGYUAN SHI , WAYNE SPEVAK , GUOXIAN WU , JEFFREY WU
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

64. 发明专利

AU2015238857A1 Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof 未知
公开(公告)号：AU2015238857A1
公开(公告)日：2015-10-29
申请号：AU2015238857
申请日：2015-10-08
申请人： PLEXXIKON INC , HOFFMANN LA ROCHE
发明人： DESAI DIPEN , DIODONE RALPH , GO ZENAIDA , IBRAHIM PRABHA N , IYER RAMAN MAHADEVAN , MAIR HANS-JUERGEN , SANDHU HARPREET K , SHAH NAVNIT HARGOVINDAS , VISOR GARY CONARD , WYTTENBACH NICOLE , LAUPER STEPHAN , PUDEWELL JOHANNES , WIERSCHEM FRANK
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Propane-I-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b] pyridine-3 carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof Abstract Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-I-sulfonic acid 13-[5-(4-chloro-phenyl)-1H-pyrrolo [2,3-b] pyridine-3-carbonyl]-2,4-difluoro-phenylI -amide compositions and uses thereof. N,9 N I | O'O

65. 发明专利

AU2011242778B2 Compounds and methods for kinase modulation, and indications therefor 未知
公开(公告)号：AU2011242778B2
公开(公告)日：2015-09-03
申请号：AU2011242778
申请日：2011-04-20
申请人： PLEXXIKON INC
发明人： ZHANG JIAZHONG , IBRAHIM PRABHA N , SPEVAK WAYNE , TSAI JAMES , EWING TODD , ZHANG YING , ZHANG CHAO
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/519 , A61P19/00 , A61P25/00 , A61P35/00 , C07D487/04
摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.

66. 发明专利

AU2012200933B2 Pyrrolo [2, 3-B] pyridine derivatives as protein kinase inhibitors 未知
公开(公告)号：AU2012200933B2
公开(公告)日：2015-04-30
申请号：AU2012200933
申请日：2012-02-17
申请人： PLEXXIKON INC
发明人： WEST BRIAN , SUZUKI YOSHIHISA , ARTIS DEAN R , HABETS GASTON , BOLLAG GIDEON , WU GUOXIAN , CHO HANNA , ZHU HONGYAO , TSAI JAMES , ZHANG JIAZHONG , HIRTH KLAUS-PETER , NESPI MARIKA , IBRAHIM PRABHA N , ZUCKERMAN REBECCA , BREMER RYAN , GILLETTE SAMUEL J , SHI SHENGHUA , MAMO SHUMEYE , SPEVAK WAYNE , ZHU YONG-LIANG , ZHANG CHAO
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00 , C07C49/517
摘要： Pyrrolo [2,3-B]pyridine derivatives As Protein Kinase Inhibitors Compounds of formula IlI which are active on protein kinases are descrbed, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. s (Formula Ill).

67. 发明专利

CL2014003228A1 Sintesis e intermediarios de compuestos heterocíclicos biologicamente activas. 未知
公开(公告)号：CL2014003228A1
公开(公告)日：2015-02-27
申请号：CL2014003228
申请日：2014-11-27
申请人： PLEXXIKON INC
发明人： IBRAHIM PRABHA N
IPC分类号： C07D471/04

68. 发明专利

NZ603087A Compounds and methods for kinase modulation, and indications therefor 未知
公开(公告)号：NZ603087A
公开(公告)日：2015-01-30
申请号：NZ60308711
申请日：2011-04-20
申请人： PLEXXIKON INC
发明人： ZHANG YING , SPEVAK WAYNE , TSAI JAMES , ZHANG JIAZHONG , IBRAHIM PRABHA N , EWING TODD , ZHANG CHAO
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/519 , A61P19/00 , A61P25/00 , A61P35/00 , C07D487/04
摘要： Disclosed are substituted fused bicyclic compounds which are pyrrole fused with either pyridine or pyrimidine of formula (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, global ischemia, ulcerative colitis, Crohn’s disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors. Examples of compounds of formula (I) are: [5-(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3 -ylmethyl)-pyrimidin-2-yl]-cyclohexyl-amine, [5-(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyrimidin-2-yl]-cyclopentyl-amine, [5-(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyrimidin-2-yl]-cyclobutyl-amine, and Cyclohexyl-[6-fluoro-5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-amine.

69. 发明专利

CR20140576A SINTESIS DE COMPUESTOS HETEROCICLICOS 未知
公开(公告)号：CR20140576A
公开(公告)日：2015-01-30
申请号：CR20140576
申请日：2014-12-15
申请人： PLEXXIKON INC
发明人： IBRAHIM PRABHA N
IPC分类号： C07D471/04
摘要： Intermediarios y procesos útiles para la síntesis sencilla de moléculas biológicamente activas.

70. 发明专利

AU2013235298A1 Compounds and methods for kinase modulation, and indications therefor 未知
公开(公告)号：AU2013235298A1
公开(公告)日：2014-10-30
申请号：AU2013235298
申请日：2013-03-18
申请人： PLEXXIKON INC
发明人： BOLLAG GIDEON , HIRTH KLAUS-PETER , IBRAHIM PRABHA N , LIN PAUL , WEST BRIAN
IPC分类号： A61K45/06 , A61K31/436 , A61K31/437 , A61K31/4545 , A61K31/506 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00
摘要： The present disclosure provides methods of using protein kinase inhibitors for treating diseases and conditions, including diseases and conditions associated with activity of any protein kinase selected from Fms protein kinase including any mutations thereof, Kit protein kinase any mutations thereof, Flt-3 protein kinase any mutations thereof and combinations thereof.

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