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61. 发明申请

US20080096966A1 OPHTHALMIC COMPOSITIONS CONTAINING DIGLYCINE 有权
标题翻译：含有多糖的眼科组合物
公开(公告)号：US20080096966A1
公开(公告)日：2008-04-24
申请号：US11873703
申请日：2007-10-17
申请人： Susan Burke , Erning Xia , Catherine Scheuer , Srini Venkastesh
发明人： Susan Burke , Erning Xia , Catherine Scheuer , Srini Venkastesh
IPC分类号： A01N37/52 , A01P1/00
CPC分类号： A61K9/0048 , A61K31/194 , A61K47/183 , C11D3/0078 , C11D3/046 , C11D3/33 , Y10S514/912
摘要： Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the salts of each thereof and one or more boron buffering compounds. The ophthalmic composition will have an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.
摘要翻译：包含一种或多种选自二甘氨酸，三甘氨酸，四甘氨酸和五聚甘氨酸的聚甘氨酸或其各自的盐和一种或多种硼缓冲化合物的眼科组合物。眼用组合物的重量摩尔渗透压浓度为200mOsmol / kg至420mOsmol / kg。

62. 发明申请

US20070140897A1 PH STABLE BIGUANIDE COMPOSITION AND METHOD OF TREATMENT AND PREVENTION OF INFECTIONS 审中-公开
标题翻译： PH稳定的双胍组合物和治疗和预防感染的方法
公开(公告)号：US20070140897A1
公开(公告)日：2007-06-21
申请号：US11614504
申请日：2006-12-21
申请人： Hongna Wang , Erning Xia , Srini Venkatesh
发明人： Hongna Wang , Erning Xia , Srini Venkatesh
IPC分类号： A61L2/18
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention includes an ophthalmically acceptable composition for use in the ocular region of a patient, the ophthalmically acceptable composition comprising water, a biguanide containing antimicrobial agent and a pH adjusting agent to adjust the pH to a minimum of 4 and a maximum of 6. The invention further comprises administering the ophthalmically acceptable composition to the eye of a patient in need of treatment.
摘要翻译：本发明包括用于患者眼部区域的眼科可接受的组合物，包含水的眼科可接受的组合物，含双胍的抗微生物剂和pH调节剂，以将pH调节至最小值4和最多6。本发明还包括将眼科可接受的组合物施用于需要治疗的患者的眼睛。

63. 发明申请

US20070004672A1 Long lasting alginate dry eye, related methods of manufacture and methods of use 审中-公开
标题翻译：持久的藻酸盐干眼，相关制造方法和使用方法
公开(公告)号：US20070004672A1
公开(公告)日：2007-01-04
申请号：US11475277
申请日：2006-06-27
申请人： Dharmendra Jani , Erning Xia
发明人： Dharmendra Jani , Erning Xia
IPC分类号： A61K31/7012 , A61K31/715 , A61K31/05
CPC分类号： A61K9/0048 , A61K47/36
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, alginate and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括藻酸盐和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

64. 发明申请

US20060287278A1 Method for improving water solubility of chitosan 审中-公开
标题翻译：改善壳聚糖水溶性的方法
公开(公告)号：US20060287278A1
公开(公告)日：2006-12-21
申请号：US11472236
申请日：2006-06-21
申请人： Zhenze Hu , Erning Xia
发明人： Zhenze Hu , Erning Xia
IPC分类号： A01N43/04 , A01N37/44 , A01N37/12
CPC分类号： A61K9/0031 , A01N43/16 , A61L12/14 , C11D3/0078 , C11D3/227 , C11D3/48 , Y02A50/473 , A01N25/02 , A01N25/22 , A01N2300/00 , A01N61/00
摘要： The present invention is directed to a composition comprising: (a) at least one nonderivatized chitosan and (b) at least one solubilizing buffer, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.
摘要翻译：本发明涉及一种组合物，其包含：（a）至少一种非脱乙酰壳多糖和（b）至少一种增溶缓冲剂，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。

65. 发明申请

US20060197067A1 Radiation-absorbing materials, ophthalmic compositions containing same, and method of treating ophthalmic devices 审中-公开
标题翻译：放射吸收材料，含有它的眼用组合物，以及治疗眼科装置的方法
公开(公告)号：US20060197067A1
公开(公告)日：2006-09-07
申请号：US11072783
申请日：2005-03-04
申请人： Erning Xia , Yu-Chin Lai , Edmond Quinn
发明人： Erning Xia , Yu-Chin Lai , Edmond Quinn
IPC分类号： G02F1/361
CPC分类号： C11D3/26 , A61L27/16 , C09D4/00 , C11D3/0063 , C11D3/0078 , C11D3/2072 , C11D3/28 , C08L33/06
摘要： An ophthalmic composition includes a hydrophilic radiation-absorbing material, which includes a radiation-absorbing moiety coupled with a hydrophilic moiety. An ophthalmic device immersed in such a composition can obtain a radiation-absorbing property and provide protection to the wearer against such radiation. The ophthalmic composition can be formulated to achieve an effect selected from cleaning, sterilizing, storing, and combinations thereof.
摘要翻译：眼科组合物包括亲水性辐射吸收材料，其包括与亲水部分偶联的辐射吸收部分。浸入这种组合物中的眼科装置可以获得吸收辐射的特性，并且防止穿戴者抵抗这种辐射。可以配制眼用组合物以获得选自清洁，消毒，储存及其组合的效果。

66. 发明申请

US20060134060A1 Ophthalmic compositions comprising Aloe Vera 审中-公开
标题翻译：包含芦荟的眼用组合物
公开(公告)号：US20060134060A1
公开(公告)日：2006-06-22
申请号：US11301378
申请日：2005-12-13
申请人： Erning Xia
发明人： Erning Xia
IPC分类号： A61K8/97 , A61K36/886
CPC分类号： A61K9/0048 , A61K31/565 , A61K36/886 , A61K2300/00
摘要： Disclosed herein are new formulations containing Aloe Vera. These formulations are useful as eye drops that provide high patient compliance as well as carriers for pharmaceuticals such as steroids and anti-allergy ophthalmic drugs.
摘要翻译：本文公开了含有芦荟的新配方。这些制剂可用作提供高患者依从性的滴眼剂以及用于药物如类固醇和抗过敏眼科药物的载体。

67. 发明授权

US06703039B2 Reversible gelling system for ocular drug delivery 失效
标题翻译：用于眼药物递送的可逆胶凝系统
公开(公告)号：US06703039B2
公开(公告)日：2004-03-09
申请号：US09731290
申请日：2000-12-06
申请人： Erning Xia , Richard V. Smerbeck
发明人： Erning Xia , Richard V. Smerbeck
IPC分类号： A61F200
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/36
摘要： The invention provides an ophthalmic aqueous composition for topical administration, comprising: (a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient; (b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer. The invention further provides a method for administering ophthalmic pharmaceuticals.
摘要翻译：本发明提供了一种用于局部给药的眼用含水组合物，其包含：（a）环氧丙烷和环氧乙烷的嵌段共聚物，其浓度足以在环境温度下提供小于约25厘泊的粘度，粘度为约25至约55厘泊当局部应用于患者时;（b）羟丙基甲基纤维素的浓度足以提高由嵌段共聚物形成的凝胶的耐久性。本发明还提供了一种眼科药物的给药方法。

68. 发明授权

US06309658B1 Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning 有权
标题翻译：用包含碳酸盐的水溶液处理隐形眼镜以增强清洁
公开(公告)号：US06309658B1
公开(公告)日：2001-10-30
申请号：US09190790
申请日：1998-11-12
申请人： Erning Xia , Lisa C. Simpson , John Denick, Jr.
发明人： Erning Xia , Lisa C. Simpson , John Denick, Jr.
IPC分类号： A01N2500
CPC分类号： A61L12/141
摘要： The present invention provides methods and compositions for cleaning and disinfecting contact lenses, which compositions comprise a carbonate or bicarbonate salt, a non-carbonate buffer system, an antimicrobial agent, and a non-ionic surfactant. Products according to the present invention, especially multi-purpose solutions, provide simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein and lipid deposits and other debris.
摘要翻译：本发明提供了用于清洁和消毒隐形眼镜的方法和组合物，该组合物包含碳酸盐或碳酸氢盐，非碳酸盐缓冲体系，抗微生物剂和非离子表面活性剂。根据本发明的产品，特别是多用途溶液，提供了隐形眼镜的同时消毒和清洁，包括防止或去除蛋白质和脂质沉积物以及其它碎屑。

69. 发明授权

US06309596B1 Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by a poloxamine 有权
标题翻译：用包含由泊洛沙胺稳定的双胍消毒剂的水溶液处理隐形眼镜
公开(公告)号：US06309596B1
公开(公告)日：2001-10-30
申请号：US09211547
申请日：1998-12-15
申请人： Erning Xia , David J. Heiler
发明人： Erning Xia , David J. Heiler
IPC分类号： A01N208
CPC分类号： A61L12/141 , A61L12/142 , A61L12/145
摘要： The present invention is directed to a biguanide-containing disinfecting solution containing a particular type of poloxamine for stabilizing a polymeric biguanide. The poloxamine surfactant comprises at least about 90 weight percent of poly(oxyethylene) and poly(oxypropylene) segments, in one or more copolymer chains, wherein the weight average molecular weight of said surfactant is from about 10,000 to about 30,000 and wherein at least about 70 weight percent of said poly(oxyethylene) and poly(oxypropylene) segments are poly(oxyethylene) segments, and wherein the HLB value is at least 27. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution. Products according to the present invention provide enhanced cleaning while maintaining biocidal efficacy.
摘要翻译：本发明涉及含有特定类型的泊洛沙胺以稳定聚合双胍的含双胍类消毒溶液。泊洛沙胺表面活性剂在一个或多个共聚物链中包含至少约90重量％的聚（氧乙烯）和聚（氧化丙烯）链段，其中所述表面活性剂的重均分子量为约10,000至约30,000，并且其中至少约 70重量％的所述聚（氧乙烯）和聚（氧化丙烯）链段是聚（氧化乙烯）链段，其中HLB值至少为27.本发明的方法包括用上述方法清洁和消毒隐形眼镜解。根据本发明的产品提供增强的清洁，同时保持杀生物效力。

70. 发明授权

US06143244A Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant and a complementary phosphate-borate buffer system 有权
标题翻译：用包含双胍消毒剂和互补磷酸盐 - 硼酸盐缓冲体系的水溶液处理隐形眼镜
公开(公告)号：US06143244A
公开(公告)日：2000-11-07
申请号：US190690
申请日：1998-11-12
申请人： Erning Xia , Jill Short Rogalskyj , Lisa C. Simpson
发明人： Erning Xia , Jill Short Rogalskyj , Lisa C. Simpson
IPC分类号： A61L12/14 , C11D3/00 , C11D3/30 , C11D3/37 , C11D3/48 , A61L2/00 , A61L9/00 , A61L12/00 , B08B3/04 , B08B3/08
CPC分类号： C11D3/48 , A61L12/141 , C11D3/0078 , C11D3/30 , C11D3/3723 , Y10S134/902
摘要： The present invention is directed to aqueous biguanide-containing disinfecting solutions containing an improved buffer system including both a phosphate and borate buffer. Preferred embodiments of the invention include methods and compositions for simultaneously cleaning and disinfecting contact lenses.
摘要翻译：本发明涉及含有双胍类含水消毒溶液，其含有包括磷酸盐和硼酸盐缓冲液的改进的缓冲系统。本发明的优选实施方案包括用于同时清洁和消毒隐形眼镜的方法和组合物。

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