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61. 发明授权

US5759841A Immunological composition of measles virus utilizing recombinant poxvirus 失效
标题翻译：使用重组痘病毒的麻疹病毒的免疫组成
公开(公告)号：US5759841A
公开(公告)日：1998-06-02
申请号：US487412
申请日：1995-06-07
申请人： Enzo Paoletti , Jill Taylor
发明人： Enzo Paoletti , Jill Taylor
IPC分类号： A61K39/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N15/863 , C12N7/00 , A61K39/12 , A61K39/155 , C12N15/00
CPC分类号： C07K14/005 , C07K14/33 , C12N15/86 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24122
摘要： What is described is a recombinant poxvirus, such as vaccinia virus or canarypox virus, containing foreign DNA from Morbillivirus. In one embodiment, the foreign DNA is expressed in a host by the production of a measles virus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two measles virus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, cross-protection of dogs against canine distemper is obtained by inoculating the dog with the recombinant poxvirus.
摘要翻译：描述的是重组痘病毒，例如痘苗病毒或金丝雀痘病毒，含有来自莫尔病毒的外来DNA。在一个实施方案中，外源DNA通过产生麻疹病毒糖蛋白在宿主中表达。在另一个实施方案中，外源DNA通过产生至少两种麻疹病毒糖蛋白在宿主中表达。还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。通过本发明，通过用重组痘病毒接种狗获得狗对犬瘟热的交叉保护。

62. 发明授权

US5756101A Malaria recombinant poxvirus 失效
标题翻译：疟疾重症痘病毒
公开(公告)号：US5756101A
公开(公告)日：1998-05-26
申请号：US178476
申请日：1994-01-07
申请人： Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim Siddiqui
发明人： Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim Siddiqui
IPC分类号： A61K39/00 , A61P33/06 , C07K14/445 , C12N7/01 , A61K39/015 , A61K39/285 , C12P21/02
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/00 , C12N2799/023
摘要： What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译：描述的是重组痘病毒，例如痘苗病毒，其含有来自裂殖酵母表面抗原的外源DNA 1.还描述了含有重组痘病毒的疫苗，用于在接种疫苗的宿主动物中诱导免疫应答。

63. 发明授权

US5688920A Nucleotide and amino acid sequences for canine herpesvirus GB, GC and GD and uses therefor 失效
标题翻译：犬疱疹病毒GB，GC和GD的核苷酸和氨基酸序列，并用于此
公开(公告)号：US5688920A
公开(公告)日：1997-11-18
申请号：US413118
申请日：1995-03-29
申请人： Enzo Paoletti , Keith J. Limbach
发明人： Enzo Paoletti , Keith J. Limbach
IPC分类号： A61K39/00 , C07K14/03
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2710/16722
摘要： Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DNA probes or, for preparing PCR primers. The polypeptides are useful in antigenic, immunological or vaccine compositions. The nucleotides can be expressed in any suitable vector system, allowing for production of the polypeptides. Additionally, the vector system containing any or any combination of the nucleotides can be employed in an antigenic, immunological or vaccine composition, such as a poxvirus vector system, e.g., a CHV-vaccinia or avipox virus recombinant, as can the products from expression, i.e., the gB, gC and gD glycoproteins. Antibodies elicited by the glycoproteins or from expression of the vector containing the nucleotide(s) are also useful. Methods for making and using the composition are also disclosed and claimed. Also, specific canarypox-CHV gB, gC and gD recombinants vCP 320, vCP322 and vCP294 and methods for making and using them are also disclosed and claimed.
摘要翻译：公开并要求保护的是用于编码犬疱疹病毒（CHV）gB，gC和gD同系物的基因的核苷酸。这些基因分别编码879,459和345个氨基酸的多肽，其也被公开和要求保护。这些基因可用作DNA探针，或用于制备PCR引物。多肽可用于抗原性，免疫学或疫苗组合物。核苷酸可以在任何合适的载体系统中表达，允许产生多肽。另外，含有任何或任何组合的核苷酸的载体系统可以用于抗原性，免疫学或疫苗组合物，例如痘病毒载体系统，例如CHV-痘苗或Avipox病毒重组体，以及来自表达的产物，即gB，gC和gD糖蛋白。由糖蛋白引起的抗体或含有该核苷酸的载体的表达也是有用的。还公开并要求保护和使用组合物的方法。此外，还公开并要求保护特定的金丝雀痘-GV，gC和gD重组体vCP 320，vCP322和vCP294及其制备和使用方法。

64. 发明授权

US5658572A Infectious bursal disease virus recombinant poxvirus vaccine 失效
标题翻译：传染性法氏囊病病毒重组痘病毒疫苗
公开(公告)号：US5658572A
公开(公告)日：1997-08-19
申请号：US204729
申请日：1994-02-28
申请人： Enzo Paoletti , Jill Taylor
发明人： Enzo Paoletti , Jill Taylor
IPC分类号： A61K39/00 , C07K14/08 , A61K39/275 , A61K39/12 , A61K39/295 , C12N7/01
CPC分类号： C07K14/005 , C12N15/86 , A61K39/00 , C12N2710/24043 , C12N2720/10022 , C12N2720/10034
摘要： What is described is a recombinant poxvirus, such as fowlpox virus, containing foreign DNA from infectious bursal disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译：描述的是重组痘病毒，如禽痘病毒，含有传染性法氏囊病病毒的外来DNA。还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。

65. 发明授权

US5641490A Infectious bursal disease virus recombinant poxvirus vaccine 失效
公开(公告)号：US5641490A
公开(公告)日：1997-06-24
申请号：US303124
申请日：1994-09-07
申请人： Enzo Paoletti , Jill Taylor , Russell Gettig
发明人： Enzo Paoletti , Jill Taylor , Russell Gettig
IPC分类号： A61K39/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/065 , C07K14/07 , C07K14/08 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N15/863 , A61K39/275 , A61K39/12 , A61K39/295 , C12N7/01
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24122
摘要： What is described is a recombinant poxvirus, such as fowlpox virus, containing foreign DNA from infectious bursal disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.

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