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61. 发明申请

US20090088338A1 MULTI-CHANNEL MICROARRAY APPARATUS AND METHODS 审中-公开
标题翻译：多通道微型计算机和方法
公开(公告)号：US20090088338A1
公开(公告)日：2009-04-02
申请号：US12325913
申请日：2008-12-01
申请人： Xuanbin Liu , Zhen Hong Sun , Wendy Wang , Tao Pan
发明人： Xuanbin Liu , Zhen Hong Sun , Wendy Wang , Tao Pan
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N21/6452 , G01N21/648
摘要： A multi-channel microarray reader has a light source carried by a first supporting stage, a second supporting stage having a plurality of reaction assembly receiving positions, each position to receive a reaction assembly, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution. The reader also includes an imaging sensor positioned to detect fluorescence emitted from a single microarray chip and a motion control module to position at least one of the first and second supporting stages to cause a selected microarray chip to receive energy emitted from the light source and to position the imaging sensor to receive fluorescence from that microarray chip.
摘要翻译：多通道微阵列读取器具有由第一支撑台承载的光源，具有多个反应组件接收位置的第二支撑台，每个位置接收反应组件，其中每个反应组件包括反应室和光学基板以支持微阵列芯片，并且其中所述反应室和所述光学基板封装缓冲溶液。读取器还包括成像传感器，其定位成检测从单个微阵列芯片发射的荧光和运动控制模块以定位第一和第二支持级中的至少一个，以使选定的微阵列芯片接收从光源发射的能量，将成像传感器定位成从该微阵列芯片接收荧光。

62. 发明申请

US20080057523A1 Detection of Protein Aggregates by Homologous Elisa 审中-公开
标题翻译：通过同源Elisa检测蛋白质聚集体
公开(公告)号：US20080057523A1
公开(公告)日：2008-03-06
申请号：US11575230
申请日：2005-09-16
申请人： Man-Sun Sy , Tao Pan , Ruliang Li
发明人： Man-Sun Sy , Tao Pan , Ruliang Li
IPC分类号： G01N33/00 , G01N33/53
CPC分类号： G01N33/53 , G01N33/6896 , G01N2800/2828
摘要： A method of detecting disease related protein aggregate in a sample comprises using a capture monoclonal antibody and detecting-monoclonal antibody. The capture monoclonal antibody and the detecting monoclonal antibody are identical.
摘要翻译：检测样品中疾病相关蛋白聚集体的方法包括使用捕获单克隆抗体和检测单克隆抗体。捕获单克隆抗体和检测单克隆抗体是相同的。

63. 发明授权

US07199975B1 Magnetic head for perpendicular recording with hard bias structure for write pole tip 有权
标题翻译：磁头用于垂直记录，具有用于写入极尖的硬偏置结构
公开(公告)号：US07199975B1
公开(公告)日：2007-04-03
申请号：US10846040
申请日：2004-05-15
申请人： Tao Pan
发明人： Tao Pan
IPC分类号： G11B5/147
CPC分类号： G11B5/1278 , G11B5/17 , G11B5/312 , G11B2005/0008
摘要： A magnetic head for writing information on a relatively-moving medium is disclosed, the head having a leading end, a trailing end and a medium-facing surface, the head comprising: a soft magnetic write pole that terminates in a pole tip that is disposed adjacent to the medium-facing surface; at least one coil section that is disposed adjacent to the write pole to induce a magnetic flux in the write pole; and a hard magnetic bias structure disposed within one micron of the pole tip to magnetically bias the pole tip.
摘要翻译：公开了一种用于在相对移动的介质上写入信息的磁头，头部具有前端，后端和面向中间的表面，头部包括：终止于设置在磁极尖端的软磁性写入磁极邻近中等面积的表面; 至少一个线圈部分，被布置成与所述写入极相邻以在所述写入极中引起磁通量; 以及设置在极尖的一微米内的硬磁偏置结构，以磁极偏置极尖。

64. 发明授权

US07054117B2 Method of making a read head having a tunnel junction sensor with a free layer biased by exchange coupling with insulating antiferromagnetic (AFM) layers 失效
标题翻译：制造具有通过与绝缘反铁磁（AFM）层的交换耦合偏置的自由层的隧道结传感器的读取头的方法
公开(公告)号：US07054117B2
公开(公告)日：2006-05-30
申请号：US10826945
申请日：2004-04-17
申请人： Kuok San Ho , Tao Pan
发明人： Kuok San Ho , Tao Pan
IPC分类号： G11B5/127 , G11B5/39 , H04R31/00
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G01R33/098 , G11B5/3932 , G11B2005/3996 , Y10T29/49044
摘要： Longitudinal biasing of a free layer in a current perpendicular to the planes of the layers (CPP) type of sensor in a read head is implemented by pinning magnetic moments of first and second side portions of the free layer beyond the track width of the read head with first and second insulating antiferromagnetic (AFM) layers which are exchange coupled thereto. The pinning of the magnetic moments of the first and second side portions of the free layer pin and longitudinally bias the central active portion of the free layer within the track width so that the central portion of the free layer is magnetically stable.
摘要翻译：通过将自由层的第一和第二侧部分的磁矩固定在读取磁头的磁道宽度上来实现垂直于读取头中的层（CPP）类型的传感器平面的电流中的自由层的纵向偏置具有与其交换耦合的第一和第二绝缘反铁磁（AFM）层。自由层销的第一和第二侧面部分的磁矩的钉扎，并且将自由层的中心有效部分纵向偏置在轨道宽度内，使得自由层的中心部分是磁性稳定的。

65. 发明申请

US20060057671A1 Immobilized probes and methods of detecting conformationally altered prion proteins 审中-公开
标题翻译：固定化探针和检测构象改变的朊病毒蛋白的方法
公开(公告)号：US20060057671A1
公开(公告)日：2006-03-16
申请号：US11030300
申请日：2005-01-07
申请人： Cindy Orser , Tao Pan
发明人： Cindy Orser , Tao Pan
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： G01N33/6896 , G01N33/54393 , G01N2800/2828
摘要： The present invention provides methods of making immobilized probes that are specific for prion proteins, methods of using such probes to bind, detect, and remove prion proteins from samples, and kits for practicing the invention. The invention discloses immobilized probes that are locked into a particular, pre-determined configuration and that retain their activity and specificity even when exposed to conditions that would typically alter their activity and specificity.
摘要翻译：本发明提供了制备对朊病毒蛋白特异的固定化探针的方法，使用这些探针结合，检测和从样品中除去朊病毒蛋白的方法，以及用于实施本发明的试剂盒。本发明公开了固定化的探针，其被锁定在特定的预定构型中，并且即使当暴露于通常会改变其活性和特异性的条件时也保持其活性和特异性。

66. 发明申请

US20050175287A1 Mode size converter for a planar waveguide 有权
公开(公告)号：US20050175287A1
公开(公告)日：2005-08-11
申请号：US11100856
申请日：2005-04-06
申请人： Tao Pan , Richard Demaray , Yu Chen , Yong Xie , Rajiv Pethe
发明人： Tao Pan , Richard Demaray , Yu Chen , Yong Xie , Rajiv Pethe
IPC分类号： C23C14/04 , G02B6/12 , G02B6/122 , G02B6/132 , G02B6/26 , G02B6/42
CPC分类号： C23C14/044 , G02B6/1228 , G02B6/132 , G02B2006/12195
摘要： A process for forming a mode size converter with an out-of-plane taper formed during deposition with a shadow mask is disclosed. Mode-size converters according to the present invention can have any number of configurations. Measured coupling efficiencies for waveguides with mode size converters according to the present invention show marked improvement.

67. 发明授权

US06888705B2 High linear density tunnel junction flux guide read head with in-stack longitudinal bias stack (LBS) 失效
标题翻译：具有堆叠纵向偏置叠层（LBS）的高线性密度隧道结通磁导读头
公开(公告)号：US06888705B2
公开(公告)日：2005-05-03
申请号：US10054352
申请日：2002-01-18
申请人： Robert Edward Fontana, Jr. , Kuok San Ho , Tao Pan , Ching Hwa Tsang
发明人： Robert Edward Fontana, Jr. , Kuok San Ho , Tao Pan , Ching Hwa Tsang
IPC分类号： G01R33/09 , G11B5/39
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G01R33/098 , G11B5/3932 , G11B2005/3996 , Y10T29/49044 , Y10T29/49046
摘要： Several embodiments of a sense current perpendicular to the planes of the sensor (CPP) and flux guide type of read head has a gap between first and second shield layers at an air bearing surface (ABS) where the flux guide is located which is less than a gap between the first and second shield layers at a recessed location where the sensor is located. This reduced gap increases the linear bit density capability of the read head. A longitudinal bias stack (LBS) is located in the sensor stack. Several unique methods of construction are described for forming the magnetic head assemblies.
摘要翻译：垂直于传感器（CPP）的平面的感测电流和读取头的通量引导类型的几个实施例在通量指示器所在的空气轴承表面（ABS）处具有小于第一和第二屏蔽层的空隙第一和第二屏蔽层之间在传感器所在的凹陷位置处的间隙。这种减小的间隙增加了读取头的线性位密度能力。纵向偏置堆栈（LBS）位于传感器堆叠中。描述了用于形成磁头组件的几种独特的结构方法。

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