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61. 发明申请

US20120214217A1 IN SITU TISSUE ENGINEERING USING MAGNETICALLY GUIDED THREE DIMENSIONAL CELL PATTERNING 有权
标题翻译：在使用磁性引导的三维细胞图案的现场组织工程
公开(公告)号：US20120214217A1
公开(公告)日：2012-08-23
申请号：US13402627
申请日：2012-02-22
申请人： Shawn Patrick Grogan , Darryl David D'Lima , Clifford W. Colwell, JR. , Sungho Jin
发明人： Shawn Patrick Grogan , Darryl David D'Lima , Clifford W. Colwell, JR. , Sungho Jin
IPC分类号： C12N13/00 , A61N2/10 , C12N5/07
CPC分类号： C12N5/0655 , A61K35/12 , C12N2529/00 , C12N2533/10 , C12N2533/74
摘要： Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a cell-hydrogel mixture, the at least a portion of the plurality of magnetically labeled cells are manipulated with a magnetic field to arrange the magnetically labeled cells into a specific cellular arrangement, and the hydrogel is crosslinked to form the organized engineered cell tissue. The approach presented herein offers a means to circumvent the deficiencies in the field of regenerative medicine, and allows for the production of organized tissues in situ with specific cellular organizations that mimic the native tissue.
摘要翻译：提供了用于细胞的三维操作以及形成有组织的工程细胞组织的方法。还提供了通过该方法生产的有组织的工程细胞组织。在一种方法中，将多个磁性标记的细胞与可交联水凝胶混合以形成细胞 - 水凝胶混合物，用磁场操纵多个磁性标记的细胞的至少一部分，以将磁性标记细胞进入特定的细胞布置，并且水凝胶被交联以形成有组织的工程细胞组织。本文提出的方法提供了一种方法来规避再生医学领域的缺陷，并且允许用模拟天然组织的特定细胞组织原位生产有组织的组织。

62. 发明授权

US08020216B2 Tapered probe structures and fabrication 有权
标题翻译：锥形探头结构和制造
公开(公告)号：US08020216B2
公开(公告)日：2011-09-13
申请号：US11914108
申请日：2006-05-10
申请人： Sungho Jin
发明人： Sungho Jin
IPC分类号： G01Q70/16
CPC分类号： G01Q70/12 , Y10S977/875 , Y10S977/878
摘要： Probe structures and fabrication techniques are described. The described probe structures can be used as probes for various applications such as conductance measurement probes, field emitter probes, nanofabrication probes, and magnetic bit writing or reading probes.
摘要翻译：描述了探头结构和制造技术。所描述的探针结构可用作各种应用的探针，例如电导测量探针，场致发射探针，纳米制造探针和磁头写入或读取探针。

63. 发明申请

US20070238184A1 Amyloid beta protein channel structure and uses thereof in identifying potential drug molecules for neurodegenerative diseases 审中-公开
标题翻译：淀粉样蛋白β蛋白通道结构及其在鉴定神经变性疾病潜在药物分子中的应用
公开(公告)号：US20070238184A1
公开(公告)日：2007-10-11
申请号：US11450146
申请日：2006-06-09
申请人： Ratnesh Lal , Arjan Quist , Sungho Jin , Hai Lin
发明人： Ratnesh Lal , Arjan Quist , Sungho Jin , Hai Lin
IPC分类号： G01N33/00 , B01J47/00 , C01B31/00
CPC分类号： C07K14/4711 , B01J20/205 , C01B32/18 , G01N33/6872 , G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2800/2821 , G01Q60/38 , G01Q70/12
摘要： The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the membrane AbP channels. The invention further relates to screening and identifying therapeutically relevant compounds for treating Alzheimer's disease and other disorders.
摘要翻译：本发明涉及脂质膜中人淀粉样蛋白β蛋白（AbP）的新型通道结构，以及用于筛选测试化合物如药物，配体（天然或合成），蛋白质，肽和小有机物的快速，定量和特异性测定分子能够结合和阻断膜的AbP通道。本发明还涉及筛选和鉴定用于治疗阿尔茨海默氏病和其他疾病的治疗相关化合物。

64. 发明授权

US07268475B1 Field emission devices having corrugated support pillars with discontinuous conductive coating 失效
标题翻译：具有不连续导电涂层的波纹支撑柱的场发射装置
公开(公告)号：US07268475B1
公开(公告)日：2007-09-11
申请号：US08771369
申请日：1996-12-16
申请人： Sungho Jin , Gregory Peter Kochanski , Wei Zhu
发明人： Sungho Jin , Gregory Peter Kochanski , Wei Zhu
IPC分类号： H01J1/88
CPC分类号： H01J9/242 , H01J29/864 , H01J31/123 , H01J2329/863 , H01J2329/8635 , H01J2329/864 , H01J2329/8645
摘要： In accordance with the invention, a field emission device is made by providing the device electrodes, forming a plurality of corrugated insulating rods with discontinuous coatings of conductive or semiconductive material with low secondary electron emission coefficient, adhering the rods to an electrode, cutting the rods to define corrugated pillars, and finishing the device. The result is low cost production of a field emission device having superior resistance to breakdown in high field operation.
摘要翻译：根据本发明，通过提供器件电极，形成具有低二次电子发射系数的导电或半导体材料的不连续涂层的多个波纹绝缘棒，将棒粘附到电极上，切割棒定义波纹柱，并整理设备。结果是在高场操作中具有优异的耐击穿性的场致发射装置的低成本生产。

65. 发明申请

US20060054879A1 Article comprising gated field emission structures with centralized nanowires and method for making the same 失效
标题翻译：文章包括具有集中纳米线的门控场发射结构及其制作方法
公开(公告)号：US20060054879A1
公开(公告)日：2006-03-16
申请号：US11014534
申请日：2004-12-16
申请人： Sungho Jin
发明人： Sungho Jin
IPC分类号： H01L29/06 , H01L21/00
CPC分类号： B82Y10/00 , H01J1/304 , H01J3/022 , H01J9/025 , H01J2201/30469 , H01J2237/0635 , H01J2329/00 , Y10S977/939
摘要： This invention provides novel methods of fabricating novel gated field emission structures that include aligned nanowire electron emitters (individually or in small groups) localized in central regions within gate apertures. It also provides novel devices using nanoscale emitters for microwave amplifiers, electron-beam lithography, field emission displays and x-ray sources. The new emission structures are particularly useful in the new devices
摘要翻译：本发明提供了制造新型门控场发射结构的新方法，其包括定位在门孔内的中心区域中的排列的纳米线电子发射体（单独地或小组）。它还提供了使用微波放大器，电子束光刻，场发射显示器和x射线源的纳米尺度发射器的新型器件。新的发射结构在新器件中特别有用

66. 发明授权

US07012266B2 MEMS-based two-dimensional e-beam nano lithography device and method for making the same 有权
标题翻译：基于MEMS的二维电子束纳米光刻装置及其制造方法
公开(公告)号：US07012266B2
公开(公告)日：2006-03-14
申请号：US10350642
申请日：2003-01-24
申请人： Sungho Jin
发明人： Sungho Jin
IPC分类号： H01J37/065
CPC分类号： B82Y10/00 , B82Y40/00 , H01J37/3177 , H01J2201/30 , H01J2237/0635 , Y10S977/901
摘要： In accordance with the present invention, apparatus for performing electron beam lithography on selected portions of a substrate having a resist covered surface comprises a plurality of nanoscale electron emitters for emitting directional beams of electrons and, for each emitter, a directional control element to direct the emitted beam toward the selected portions. In a preferred embodiment the emitters comprise carbon nanotubes, and the directional control elements comprise micro-electro-mechanical disks in a two-dimensional array. In an alternative embodiment the directional control elements are electrodes.
摘要翻译：根据本发明，用于在具有抗蚀剂覆盖表面的衬底的选定部分上进行电子束光刻的装置包括用于发射电子的定向束的多个纳米级电子发射器，并且对于每个发射器，定向控制元件引导向所选择的部分发射光束。在优选实施例中，发射器包括碳纳米管，并且方向控制元件包括二维阵列中的微机电盘。在替代实施例中，方向控制元件是电极。

67. 发明授权

US06987027B2 Microscale vacuum tube device and method for making same 失效
标题翻译：微型真空管装置及其制作方法
公开(公告)号：US06987027B2
公开(公告)日：2006-01-17
申请号：US10646502
申请日：2003-08-23
申请人： Sungho Jin
发明人： Sungho Jin
IPC分类号： H01L21/00
CPC分类号： H01J3/021 , H01J9/025 , H01J21/10 , Y10S977/939
摘要： The invention comprises a method of fabricating a vacuum microtube device comprising the steps of forming a cathode layer comprising an array of electron emitters, forming a gate layer comprising an array of openings for passing electrons from the electron emitters, and forming an anode layer for receiving electrons from the emitters. The cathode gate layer and the anode layer are vertically aligned and bonded together with intervening spacers on a silicon substrate so that electrons from respective emitters pass through respective gate openings to the anode. The use of substrate area is highly efficient and electrode spacing can be precisely controlled. An optional electron multiplying structure providing secondary electron emission material can be disposed between the gate layer and the anode in the path of emitted electrons.
摘要翻译：本发明包括一种制造真空微管装置的方法，包括以下步骤：形成包括电子发射体阵列的阴极层，形成包含用于使来自电子发射体的电子的开口阵列的栅极层，以及形成用于接收的阳极层来自发射体的电子。阴极栅极层和阳极层与硅衬底上的中间间隔物垂直对准并结合在一起，使得来自各个发射体的电子通过相应的栅极开口到达阳极。衬底面积的使用是高效的，电极间距可以精确控制。提供二次电子发射材料的可选的电子倍增结构可以在发射电子的路径中设置在栅极层和阳极之间。

68. 发明授权

US06915046B2 Optical systems comprising curved MEMs mirrors and methods for making same 失效
标题翻译：包括弯曲MEMs的光学系统和其制造方法
公开(公告)号：US06915046B2
公开(公告)日：2005-07-05
申请号：US10054499
申请日：2002-01-22
申请人： Sungho Jin , Hareesh Mavoori , Roland Ryf
发明人： Sungho Jin , Hareesh Mavoori , Roland Ryf
IPC分类号： G02B6/35 , G02B26/08 , G02B6/26
CPC分类号： G02B6/3518 , G02B6/352 , G02B6/3546 , G02B6/3556 , G02B6/357 , G02B26/0841
摘要： A MEMs mirror device comprises a mirror layer, a frame structure, and an actuator layer. At least one mirror is movably coupled to the frame. The actuator layer includes at least one conductive path for moving the mirror. In accordance with the invention, the mirror is curved for efficiently directing and focusing reflected light. The mirror comprises a metal-coated base, and curvature can be achieved by doping selected regions of the base or by using coating/base combinations with sufficient mismatch that they be curved by differential thermal expansion. The resulting MEMs devices are advantageous for optical switching, variable attenuation and power gain equalization.
摘要翻译： MEM镜装置包括镜层，框架结构和致动器层。至少一个反射镜可移动地联接到框架。致动器层包括用于移动反射镜的至少一个导电路径。根据本发明，镜子是弯曲的，以有效地引导和聚焦反射光。反射镜包括金属涂覆的基底，并且可以通过掺杂基底的选定区域或通过使用具有足够的不匹配的涂层/基底组合来实现曲率，使得它们通过差分热膨胀而弯曲。所得到的MEMs器件对于光开关，可变衰减和功率增益均衡是有利的。

69. 发明申请

US20050054128A1 Electro-mechanical device having a charge dissipation layer and a method of manufacture therefor 有权
标题翻译：具有电荷耗散层的机电装置及其制造方法
公开(公告)号：US20050054128A1
公开(公告)日：2005-03-10
申请号：US10967900
申请日：2004-10-18
申请人： Arman Gasparyan , Sungho Jin , Herbert Shea , Robert Van Dover , Wei Zhu
发明人： Arman Gasparyan , Sungho Jin , Herbert Shea , Robert Van Dover , Wei Zhu
IPC分类号： B81B3/00 , G02B6/32 , G02B6/35 , H01L21/00 , H01L31/0232
CPC分类号： G02B6/3518 , B81B3/0035 , B81B2201/042 , G02B6/32 , G02B6/3544 , G02B6/356 , G02B6/357 , G02B6/3584 , G02B6/3594
摘要： The present invention provides a micro-electro-mechanical system (MEMS) device, a method of manufacture therefore, and an optical communications system including the same. The device includes an electrode located over a substrate and a charge dissipation layer located proximate and electrically coupled to the substrate. The device may further include a moveable element located over the electrode.
摘要翻译：本发明提供一种微电子机械系统（MEMS）装置，因此制造方法以及包括该微机电系统的光通信系统。该器件包括位于衬底上方的电极和位于接近并电耦合到衬底的电荷耗散层。该装置还可以包括位于电极上方的可移动元件。

70. 发明授权

US06711317B2 Resiliently packaged MEMs device and method for making same 有权
标题翻译：弹性封装的MEMs器件及其制造方法
公开(公告)号：US06711317B2
公开(公告)日：2004-03-23
申请号：US09769193
申请日：2001-01-25
申请人： Sungho Jin , Hareesh Mavoori , Hyongsok Soh
发明人： Sungho Jin , Hareesh Mavoori , Hyongsok Soh
IPC分类号： G02B635
CPC分类号： G02B6/3582 , G02B6/266 , G02B6/3518 , G02B6/3556 , G02B6/356 , G02B6/357 , G02B6/3584 , G02B26/0841 , G02B2006/12104
摘要： In accordance with the invention, a MEMs device comprises a component layer, an actuator layer and an intervening spacer. The component layer, the spacer and the actuator layer are assembled at ambient temperature and held together in lateral alignment by resilient spring members. The spacer provides the walls of a cavity between a component and an actuator to permit movement of the component. The walls are advantageously conductive and cover the bulk of the peripheral boundary of the cavity to provide electrostatic isolation and aerodynamic isolation.
摘要翻译：根据本发明，MEMs器件包括组件层，致动器层和中间间隔件。组件层，间隔件和致动器层在环境温度下组装并通过弹性弹簧构件横向对准地保持在一起。间隔件在部件和致动器之间提供空腔的壁以允许部件移动。壁有利地是导电的并且覆盖空腔的外围边界的大部分以提供静电隔离和空气动力隔离。

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